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1. 发明申请

WO1988005777A1 CEPHALOSPORIN COMPOUNDS OR THEIR SALTS, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： CEPHOROSPORIN化合物或其盐，其制备方法和药物组合物
公开(公告)号：WO1988005777A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000090
申请日：1988-02-02
申请人： TEIJIN LIMITED , HARADA, Toshiaki , YOSHISATO, Eishin , IMAI, Hiroshi , TAKANO, Yasunobu , ICHIKAWA, Yataro , SUZUKI, Yoji
发明人： TEIJIN LIMITED
IPC分类号： C07D501/46
CPC分类号： C07D501/46 , C07D501/57
摘要： Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein X represents -CH= or -N=; Y represents an optionally protected amino group; Z represents a hydrogen atom, a methoxy group or a formylamino group; R1 represents an optionally substituted aromatic hydrocarbyl group; R2 and R3, which may be the same or different, each represents a hydrogen atom or a hydroxy group protecting group; W represents a substituent; and n represents an integer of 0 to 5.

2. 发明申请

WO1988005776A1 CEPHALOSPORIN COMPOUNDS OR THEIR SALTS, PROCESS FOR THEIR PREPARATION, AND PARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： CEPHOROSPORIN化合物或其盐，其制备方法和制剂组合物
公开(公告)号：WO1988005776A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000089
申请日：1988-02-02
申请人： TEIJIN LIMITED , HARADA, Toshiaki , YOSHISATO, Eishin , IMAI, Hiroshi , TAKANO, Yasunobu , ICHIKAWA, Yataro , SUZUKI, Yoji
发明人： TEIJIN LIMITED
IPC分类号： C07D501/46
CPC分类号： C07D501/46 , C07D501/57 , Y02P20/55
摘要： Cephalosporin compounds represented by general formula (I) or their salts, a process for their preparation, and antibacterial agents containing them as active ingredients, wherein Y represents an optionally protected amino group; Z represents a hydrogen atom, a methoxy group or a formamino group; R1 represents an optionally substituted alkyl group or a hydrogen atom; R2 and R3, which may be the same or different, each represents a hydrogen atom or a hydroxy group protecting group; W represents a substituent; and n represents an integer of 0 to 5.

3. 发明申请

WO1989009774A1 3,4-DIHYDROISOQUINOLINE DERIVATIVES, ISOQUINOLINE DERIVATIVES, AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译： 3,4-二氢喹啉衍生物，异喹啉衍生物及其制备方法
公开(公告)号：WO1989009774A1
公开(公告)日：1989-10-19
申请号：PCT/JP1989000360
申请日：1989-04-04
申请人： TEIJIN LIMITED , ICHIKAWA, Yataro , YOKOYAMA, Seiichi , HARADA, Toshiaki , YOSHISATO, Eishin , IMAI, Hiroshi , TAKANO, Yasunobu
发明人： TEIJIN LIMITED
IPC分类号： C07F07/18
CPC分类号： C07F7/1804 , C07F7/0838
摘要： Novel 3,4-dihydroisoquinoline derivatives represented by general fomula (I-a) or (I-b), novel isoquinoline derivatives derived therefrom, and processes for preparing the isoquinoline derivatives are disclosed. In the formula, X and X may be the same or different and each represents a group represented by alpha provided that one of X and X may be a hydrogen atom, X represents a group represented by beta (wherein R , R and R may be the same or different and each represents a group selected from among alkyl, alkenyl and alkoxy groups containing 1 to 20 carbon atoms and optionally substituted and an aryl group containing 6 to 20 carbon atoms), and m represents 0 to 5.
摘要翻译：公开了由通式（I-a）或（I-b）表示的新型3,4-二氢异喹啉衍生物，衍生自其的新型异喹啉衍生物，以及异喹啉衍生物的制备方法。在该式中，X 1和X 2可以相同或不同，并且各自表示由α表示的基团，条件是X 1和X 2之一可以是氢原子，X 3，表示由β表示的基团（其中R 1，R 2和R 3可以相同或不同，各自表示选自含有1至20个碳原子的烷基，烯基和烷氧基的基团，取代基和含有6〜20个碳原子的芳基），m表示0〜5。

4. 发明申请

WO1985005107A1 CEPHALOSPORIN DERIVATIVES 审中-公开
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：WO1985005107A1
公开(公告)日：1985-11-21
申请号：PCT/JP1985000250
申请日：1985-05-01
申请人： TEIJIN LIMITED , ICHIKAWA, Yataro , YOSHISATO, Eishin , HARADA, Toshiaki , IMAI, Hiroshi , SUZUKI, Yoji
发明人： TEIJIN LIMITED
IPC分类号： C07D519/00
CPC分类号： C07D501/46 , C07D519/00 , Y02P20/55
摘要： Crystalline anhydrides, hemihydrates, monohydrates or trihydrates of (6R, 7R)-7- AD(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido BD-3-(1-quinuclidiniummethyl)-3-cephem-4-carboxylate or derivatives thereof.

5. 发明申请

WO1985003938A1 CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译： CEPHOROSPORIN衍生物，其制备方法及其药物使用
公开(公告)号：WO1985003938A1
公开(公告)日：1985-09-12
申请号：PCT/JP1985000101
申请日：1985-03-01
申请人： TEIJIN LIMITED , ICHIKAWA, Yataro , YOSHISATO, Eishin , HARADA, Toshiaki , IMAI, Hiroshi , SUZUKI, Yoji , MIYANO, Seiji , SUMOTO, Kunihiro
发明人： TEIJIN LIMITED
IPC分类号： C07D519/00
CPC分类号： C07D501/46 , C07D519/00 , Y02P20/55
摘要： Cephalosporin derivatives represented by formula (I), (wherein R1 represents a hydrogen atom or a protective group, R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted heterocyclic group, R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a cyano group, a carboxy group, an alkoxycarbonyl group, a carbomoyl group, a carbanolyloxy group, a heterocyclic ring, a hydroxy group, an alkoxy group or a halogen atom, R4 and R5 may be the same or different and each represents hydrogen or alkyl, $(1,3)$ represents 0, 1 or 2, m and n each represents 1 or 2 when $(1,3)$ is O, or represents O when $(1,3)$ is 1 or 2, and X represents methylene when $(1,3)$ is O or 1 or represents methylene, substituted methylene or oxo when $(1,3)$ is 2, provided that X does not represent methylene when R3, R4, and R5 all represent hydrogen), salts or esters thereof have strong antibacterial activity, and are useful for treatment and prevention of various bacteria-induced diseases.

6. 发明申请

WO1993024493A1 CEPHALOSPORIN DERIVATIVE 审中-公开
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：WO1993024493A1
公开(公告)日：1993-12-09
申请号：PCT/JP1993000708
申请日：1993-05-27
申请人： TEIJIN LIMITED , HARADA, Toshiaki , IMAI, Hiroshi , TAKANO, Yasunobu
发明人： TEIJIN LIMITED
IPC分类号： C07D501/36
CPC分类号： C07D501/00
摘要： A novel cephalosporin compound represented by general formula (I), wherein R represents -CX 3, X representing H or halogen; R represents -O-Q-Z , Q representing a C3-C6 linking group present between O and Z , Z representing -COOH, -SO3H, -OH, -CONH-(CH2)1-3-Z or -SO2NH-(CH2)1-3-Z , Z representing -COOH or -SO3H; R represents H, -OH, -OCOR , -OR , -OCONH2, (II), (III), (IV), (V), (VI), (VII) or (VIII), X representing -S- or -NH-, X representing H, -CH3, -NH2 or -S-CH2COOH, and X representing H, -COOH or -N(CH3)2; and R represents C1-C6 alkyl.
摘要翻译：一种由通式（I）表示的新型头孢菌素化合物，其中R 1表示-CX 3，X 1表示H或卤素; R 2表示-OQZ 1，Q表示O和Z 1之间存在的C 3 -C 6连接基，Z 1表示-COOH，-SO 3 H，-OH，-CONH-（CH 2） 3-Z 2或-SO 2 NH-（CH 2）1-3 -Z 2，Z 2表示-COOH或-SO 3 H; R 3表示H，-OH，-OCOR 4，-OR 4，-OCONH 2，（II），（III），（IV），（V），（VI），（VII） VIII）表示-S-或-NH-的X 2，代表H，-CH 3，-NH 2或-S-CH 2 COOH的X 3和表示H，-COOH或-N（CH 3） 2; R 4表示C 1 -C 6烷基。

7. 发明申请

WO1990008956A1 DETECTION OF HUMAN TISSUE FACTOR ACTIVATOR 审中-公开
标题翻译：检测人体组织因子激活剂
公开(公告)号：WO1990008956A1
公开(公告)日：1990-08-09
申请号：PCT/JP1990000127
申请日：1990-02-02
申请人： TEIJIN LIMITED , KOIKE, Yukiya , SUMI, Yoshihiko , ICHIKAWA, Yataro
发明人： TEIJIN LIMITED
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , C07K14/4705
摘要： This invention relates to an immunoassay of a human tissue factor activator originating in the human urine by utilizing an antihuman tissue factor activator monoclonal antibody, which is useful for diagnosing, for example, renal diseases. The tissue factor activator originating in the human urine is a new material. The invention also discloses the antihuman tissue factor activator monoclonal antibody to be used in the above assay and hybridoma cells which produce said antibody.

8. 发明申请

WO1991007484A1 PROTEIN HAVING ACTIVITY LIKE THAT OF HUMAN PROTEIN C AND/OR ACTIVATED HUMAN PROTEIN C 审中-公开
标题翻译：具有人类蛋白C和/或活化人蛋白C的活性的蛋白
公开(公告)号：WO1991007484A1
公开(公告)日：1991-05-30
申请号：PCT/JP1990001471
申请日：1990-11-13
申请人： TEIJIN LIMITED , SUZUKI, Masahiko , WAKABAYASHI, Kenji , SUMI, Yoshihiko , ICHIKAWA, Yataro
发明人： TEIJIN LIMITED
IPC分类号： C12N09/64
CPC分类号： C12N9/6464 , C12Y304/21069
摘要： A human protein C or an activated human protein C having the carboxyl terminal of the light chain thereof deleted so as to form an amino acid sequence as indicated in Table 1 or having the twelve amino acids of the heavy chain as counted from the amino terminal modified into a combination selected from among amino acids as indicated in Table 2; a DNA sequence coding for the same; an expression vector; and a transfected cell.
摘要翻译：缺少具有如表1所示的氨基酸序列的人蛋白质C或其轻链的羧基末端的活化的人蛋白质C，或者具有从氨基末端修饰的重链的十二个氨基酸成为从表2所示的氨基酸中选择的组合; 编码该DNA序列的DNA序列; 表达载体和转染细胞。

9. 发明申请

WO1990002113A1 OXIME DERIVATIVES AND HERBICIDES CONTAINING SAME AS ACTIVE INGREDIENTS 审中-公开
标题翻译：含有活性成分的OXIME衍生物和除草剂
公开(公告)号：WO1990002113A1
公开(公告)日：1990-03-08
申请号：PCT/JP1988000837
申请日：1988-08-24
申请人： TEIJIN LIMITED , AZUMA, Shizuo , HIRAMATSU, Toshiyuki , NAKAGAWA, Koji , ICHIKAWA, Yataro
发明人： TEIJIN LIMITED
IPC分类号： C07C131/00
CPC分类号： C07C251/48 , C07C251/50
摘要： Compounds of specific oxime derivatives or salts thereof and herbicidal compounds containing said compounds as herbicidal ingredients are disclosed. The oxime derivatives show an excellent weed-killing effect against both of broadleaf and narrowleaf weeds, and their effect is rapid even when used only in small amounts.
摘要翻译：公开了特定肟衍生物或其盐的化合物和含有所述化合物作为除草成分的除草化合物。肟衍生物对阔叶杂草和窄叶杂草均显示出优异的除草效果，即使少量使用，其效果也很快。

10. 发明申请

WO1988010302A1 NOVEL PLASMID, MICROBIAL CELLS, PROCESS FOR PREPARING POLYPEPTIDE WITH ONCOSTATIC ACTIVITY, AND SECRETED POLYPEPTIDE WITH ONCOSTATIC ACTIVITY 审中-公开
标题翻译：新型PLASMID，微生物细胞，制备具有止痛活性的多肽的方法和具有呼吸活性的分泌的多肽
公开(公告)号：WO1988010302A1
公开(公告)日：1988-12-29
申请号：PCT/JP1988000595
申请日：1988-06-17
申请人： TEIJIN LIMITED , RIKAGAKU KENKYUSHO , NAKAMURA, Satoshi , ICHIKAWA, Yataro , HORIKOSHI, Koki
发明人： TEIJIN LIMITED , RIKAGAKU KENKYUSHO
IPC分类号： C12N15/00
CPC分类号： C12N15/70 , C07K14/525 , C12N15/67
摘要： A plasmid containing: (1) a first DNA region having a DNA sequence coding a polypeptide with an oncostatic activity, a DNA sequence having the promoter function of controlling expression of the polypeptide, and a DNA sequence coding a signal peptide, and (2) a second DNA region having a DNA sequence giving host cells the action of accelerating extracellular secretion and a DNA sequence having the promoter function of controlling expression of the DNA sequence; microbial cells transformed by said plasmid; a process for producing a polypeptide with an oncostatic activity through extracellular secretion using said cells; and a polypeptide with an oncostatic activity secreted from said cells are disclosed.

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