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1. 发明专利

AT381563T 未知
公开(公告)号：AT381563T
公开(公告)日：2008-01-15
申请号：AT04713356
申请日：2004-02-20
申请人： TARGACEPT INC
发明人： MAZUROV ANATOLY , KLUCIK JOZEF , MIAO LAN , SEAMANS ANGELA , PHILLIPS TERESA , SCHMITT JEFFREY , MILLER CRAIG
IPC分类号： C07D453/00 , A61K51/00 , C07D453/02 , C07D453/04 , C07D471/08 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.

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