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1. 发明申请

US20080146489A1 Regional delivery of therapeutic agents for the treatment of vascular diseases 审中-公开
标题翻译：用于治疗血管疾病的治疗剂的区域递送
公开(公告)号：US20080146489A1
公开(公告)日：2008-06-19
申请号：US11639512
申请日：2006-12-15
申请人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
发明人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
IPC分类号： A61F2/06 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/02 , A61P9/00
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译：本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织受影响组织的外围也是如此。

2. 发明申请

US20100100169A1 Medical devices containing biobeneficial particles 有权
标题翻译：包含生物有益颗粒的医疗器械
公开(公告)号：US20100100169A1
公开(公告)日：2010-04-22
申请号：US11809045
申请日：2007-05-30
申请人： Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis , Fozan El-Nounou
发明人： Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis , Fozan El-Nounou
IPC分类号： A61F2/82 , B05D3/00 , A61L33/00
CPC分类号： B05D1/18 , A61F2/82 , A61F2250/0067 , A61L31/022 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/624 , A61L2400/12 , B05D3/101 , B05D2401/32 , B05D2602/00
摘要： A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first fluid into a second fluid having a suspension of nano-constructs; and removing the stent from the second fluid and allowing the first and second fluid to be removed such that the nano-constructs are carried by the stent for in vivo application of the constructs to a target location of a mammalian subject. The nano-constructs can be attached to the surface of the stent, can be attached to a surface of the coating of the stent, can be embedded into the stent, or can be embedded into the coating.
摘要翻译：公开了一种用纳米结构修饰诸如支架的医疗装置的方法。该方法包括将第一流体施加到支架上; 将从第一流体湿润的支架浸入具有纳米结构物悬浮液的第二流体中; 以及从所述第二流体移除所述支架并且允许所述第一和第二流体被移除，使得所述纳米构建体由所述支架携带，用于体内施用所述构建体到哺乳动物受试者的目标位置。纳米结构可以连接到支架的表面，可以附着在支架的涂层表面，可以嵌入到支架中，或者可以嵌入到涂层中。

3. 发明申请

US20070282425A1 Drug delivery spiral coil construct 有权
标题翻译：药物输送螺旋线圈构造
公开(公告)号：US20070282425A1
公开(公告)日：2007-12-06
申请号：US11445079
申请日：2006-05-31
申请人： Klaus Kleine , David C. Gale , Fozan El-Nounou , Syed F.A. Hossainy , Florian Ludwig
发明人： Klaus Kleine , David C. Gale , Fozan El-Nounou , Syed F.A. Hossainy , Florian Ludwig
IPC分类号： A61F2/06
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译：公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。该装置可用于治疗血管疾病如再狭窄和易损斑块。

4. 发明授权

US09242005B1 Pro-healing agent formulation compositions, methods and treatments 有权
标题翻译：预愈合剂配方组合物，方法和治疗
公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
IPC分类号： A61M31/00 , A61K47/42 , A61K47/48 , A61M5/178
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译：本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。在一些应用中，前修复剂可以帮助恢复内皮功能。制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。

5. 发明申请

US20070142819A1 Bifurcated catheter for agent delivery and method of agent delivery 审中-公开
标题翻译：用于药剂分送的分叉导管和药剂递送方法
公开(公告)号：US20070142819A1
公开(公告)日：2007-06-21
申请号：US11314059
申请日：2005-12-20
申请人： Fozan El-Nounou , Florian Ludwig
发明人： Fozan El-Nounou , Florian Ludwig
IPC分类号： A61M31/00
CPC分类号： A61M25/1011 , A61F2/958 , A61F2002/065 , A61M2025/0057 , A61M2025/0183 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1077
摘要： A bifurcated catheter having a branched distal shaft section and one or more porous or nonporous balloons, and combinations thereof, which is configured for delivery of an agent to a patient's bifurcated body lumen. Another aspect of the invention is directed to a method of delivering an agent to a patient's body lumen which facilitates maximizing the efficiency of drug uptake into the tissue at the desired site within the patient's body lumen.
摘要翻译：具有分支远端轴部分和一个或多个多孔或无孔球囊及其组合的分叉导管，其构造成将药剂递送到患者的分叉体腔。本发明的另一方面涉及一种将药剂递送到患者体腔，其有助于最大限度地提高药物在患者体腔内所需部位的摄取进入组织的效率。

6. 发明申请

US20060184111A1 Method of making a catheter ballon using a tapered mandrel 审中-公开
标题翻译：使用锥形心轴制造导管气囊的方法
公开(公告)号：US20060184111A1
公开(公告)日：2006-08-17
申请号：US11344692
申请日：2006-01-31
申请人： Florencia Lim , Fozan El-Nounou , Alfredo Bayot
发明人： Florencia Lim , Fozan El-Nounou , Alfredo Bayot
IPC分类号： A61M29/00 , A61M37/00 , A61M31/00
CPC分类号： A61M25/1029 , A61M25/1034 , A61M25/1036 , A61M2025/1075 , B29C55/22 , B29C67/0014 , B29K2027/18 , B29L2031/7542
摘要： A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by decreasing the inner diameter of a first end section of a polymeric tube, so that the tube has a reduced diameter first end section with an inner diameter less than the inner diameter of a central section of the tube. The reduced diameter first end section of the tube is bonded to a catheter shaft to form at least a portion of a skirt section of the balloon, and the skirt section has an improved high rupture pressure.
摘要翻译：制造导管球囊的方法和由此形成的气囊导管，其中通过降低聚合物管的第一端部部分的内径而形成导管囊的层，使得管具有缩径的第一端内径小于管中心部分的内径。管的直径缩小的第一端部结合到导管轴以形成气囊的裙部的至少一部分，并且裙部具有改善的高破裂压力。

7. 发明申请

US20070250035A1 Devices and methods for intravascular drug delivery 审中-公开
标题翻译：用于血管内药物递送的装置和方法
公开(公告)号：US20070250035A1
公开(公告)日：2007-10-25
申请号：US11407707
申请日：2006-04-19
申请人： Fozan El-Nounou , Paul Consigny , Florian Ludwig
发明人： Fozan El-Nounou , Paul Consigny , Florian Ludwig
IPC分类号： A61M31/00
CPC分类号： A61M25/0082 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/04 , A61M25/10 , A61M2025/0057 , A61M2025/0096 , A61M2025/0681 , A61M2025/105
摘要： A catheter configured for delivering an agent to a patient's vessel wall, having self-expanding frame, and a method of delivering an agent to a patient's vessel wall. A first catheter has an elongated shaft with an agent delivery lumen and self-expanding frame on a distal shaft section formed of plurality of hollow tubes having joined first ends and free second ends, the free end of each hollow tube having an agent delivery port in fluid communication with the shaft agent delivery lumen and having a hooked tip configured for penetrating the vessel wall in the expanded configuration. Another catheter has a frame around the outer surface of a lining member such as a balloon or a tubular sleeve, such that the frame expanded against the vessel wall and the lining member together define a plurality of pockets between the vessel wall and the outer surface of the lining member.
摘要翻译：导管，其构造成将药剂递送到患者的血管壁，具有自扩张框架，以及将药剂递送至患者血管壁的方法。第一导管具有细长轴，其具有代理输送管腔和远端轴部分上的自膨胀框架，所述远端轴部分由多个具有接合的第一端和自由的第二端的中空管形成，每个中空管的自由端具有代理输送口与轴剂输送管腔的流体连通并且具有被配置为在扩张构型中穿透血管壁的钩状末端。另一导管具有围绕诸如球囊或管状套筒的衬里构件的外表面的框架，使得框架相对于容器壁膨胀并且衬里构件一起在容器壁和外表面的外表面之间限定多个袋衬里构件。

8. 发明授权

US06733486B1 Catheter having a reinforcing mandrel 有权
标题翻译：导管具有加强心轴
公开(公告)号：US06733486B1
公开(公告)日：2004-05-11
申请号：US09470519
申请日：1999-12-22
申请人： Jeong Soo Lee , Tim Geiser , Sandra K. Schenk , Terry Freeman , Cheri Stiger , Fozan El-Nounou
发明人： Jeong Soo Lee , Tim Geiser , Sandra K. Schenk , Terry Freeman , Cheri Stiger , Fozan El-Nounou
IPC分类号： A61M2500
CPC分类号： A61M25/0029 , A61M25/0032 , A61M25/0054 , A61M2025/0004
摘要： A catheter having a mandrel secured to the catheter or constrained within a dedicated lumen. In one embodiment, the catheter has an inner tubular member and an outer tubular member with a sidewall configured to define a mandrel lumen longitudinally along an inner surface of the outer tubular member or along an outer surface of the inner tubular member. The mandrel lumen may be configured to allow the mandrel to be exchanged to adjust the handling characteristics of the catheter. The mandrel may occupy an intermediate portion of the catheter shaft, or may extend from the proximal end to within proximal or distal shaft sections of the catheter. In coronary artery applications, the mandrel is configured to support the catheter as it bends through the aortic arch and enters the coronary artery.
摘要翻译：导管，其具有固定到导管或限制在专用管腔内的心轴。在一个实施例中，导管具有内部管状构件和外部管状构件，其具有被配置为沿着外部管状构件的内表面或沿着内部管状构件的外表面纵向地限定心轴腔的外部管状构件。心轴腔可以被配置为允许心轴被更换以调节导管的操作特性。心轴可以占据导管轴的中间部分，或者可以从近端延伸到导管的近侧或远端轴部分。在冠状动脉应用中，心轴构造成当导管弯曲穿过主动脉弓并进入冠状动脉时支撑导管。

9. 发明授权

US07351238B2 Catheter having a reinforcing mandrel 有权
标题翻译：导管具有加强心轴
公开(公告)号：US07351238B2
公开(公告)日：2008-04-01
申请号：US10692365
申请日：2003-10-22
申请人： Jeong Soo Lee , Tim Geiser , Sandra K. Schenk , Terry Freeman , Cheri Stiger , Fozan El-Nounou
发明人： Jeong Soo Lee , Tim Geiser , Sandra K. Schenk , Terry Freeman , Cheri Stiger , Fozan El-Nounou
IPC分类号： A61M25/00
CPC分类号： A61M25/0029 , A61M25/0032 , A61M25/0054 , A61M2025/0004
摘要： A catheter having a mandrel secured to the catheter or constrained within a dedicated lumen. In one embodiment, the catheter has an inner tubular member and an outer tubular member with a sidewall configured to define a mandrel lumen longitudinally along an inner surface of the outer tubular member or along an outer surface of the inner tubular member. The mandrel lumen may be configured to allow the mandrel to be exchanged to adjust the handling characteristics of the catheter. The mandrel may occupy an intermediate portion of the catheter shaft, or may extend from the proximal end to within proximal or distal shaft sections of the catheter. In coronary artery applications, the mandrel is configured to support the catheter as it bends through the aortic arch and enters the coronary artery.
摘要翻译：导管，其具有固定到导管或限制在专用管腔内的心轴。在一个实施例中，导管具有内部管状构件和外部管状构件，其具有被配置为沿着外部管状构件的内表面或沿着内部管状构件的外表面纵向地限定心轴腔的外部管状构件。心轴腔可以被配置为允许心轴被更换以调节导管的操作特性。心轴可以占据导管轴的中间部分，或者可以从近端延伸到导管的近侧或远端轴部分。在冠状动脉应用中，心轴构造成当导管弯曲穿过主动脉弓并进入冠状动脉时支撑导管。

10. 发明授权

US06589207B1 Rapid exchange catheter having a support mandrel 有权
标题翻译：具有支撑心轴的快速交换导管
公开(公告)号：US06589207B1
公开(公告)日：2003-07-08
申请号：US09468741
申请日：1999-12-21
申请人： Fozan El-Nounou
发明人： Fozan El-Nounou
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/0054 , A61M2025/0183
摘要： Rapid exchange catheters having improved pushability and trackability due to a support mandrel disposed within the inflation lumen. The mandrel is secured at the proximal end of the catheter shaft while the free distal end extends beyond the proximal guidewire port. In an alternative embodiment, the catheter shaft further comprises a sleeve in the inflation lumen that secures a distal section of the support mandrel. The distal end of the mandrel extends beyond the sleeve.
摘要翻译：快速交换导管由于设置在充气腔内的支撑心轴而具有改进的推进性和可追踪性。心轴固定在导管轴的近端处，而自由远端延伸超过近端导丝端口。在替代实施例中，导管轴还包括在充气腔中的套筒，其固定支撑心轴的远侧部分。心轴的远端延伸超过套筒。

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