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1. 发明申请

US20080242688A1 Method 741 审中-公开
标题翻译：方法741
公开(公告)号：US20080242688A1
公开(公告)日：2008-10-02
申请号：US12049731
申请日：2008-03-17
申请人： Stacy A. Castner , Thomas Hudzik , Donna L. Maier , Ladislav Mrzljak , Timothy Piser , Jeff S. Smith , Dan Widzowski , Graham V. Williams
发明人： Stacy A. Castner , Thomas Hudzik , Donna L. Maier , Ladislav Mrzljak , Timothy Piser , Jeff S. Smith , Dan Widzowski , Graham V. Williams
IPC分类号： A61K31/4353 , A61P25/28
CPC分类号： A61K31/438 , A61K31/439
摘要： Methods of treatment and pharmaceutical compositions for providing improved cognition in subjects suffering from schizophrenia, Alzheimer's disease or other conditions with impaired cognitive function.
摘要翻译：治疗方法和药物组合物，用于在患有精神分裂症，阿尔茨海默氏病或具有认知功能受损的其他病症的受试者中提供改善的认知。

2. 发明申请

US20100168146A1 Composition Comprising (R)-Spiro[L-Azabicyclo[2.2.2]Octane-3,2'(3'H)-Furo[2,3-B]Pyridine (AZD0328) and its Use in the Treatment of Alzheimer's Disease, ADHD or Cognitive Dysfunction 审中-公开
标题翻译：包含（R）-Spiro [L-Azabicyclo [2.2.2] Octane-3,2'（3'H）-Furo [2,3-B]吡啶（AZD0328）及其在治疗阿尔茨海默病中的用途的组合物， ADHD或认知功能障碍
公开(公告)号：US20100168146A1
公开(公告)日：2010-07-01
申请号：US12531802
申请日：2008-03-18
申请人： Stacy A. Castner , Thomas Hudzik , Donna L. Maier , Ladislav Mrzljak , Timothy Piser , Jeff S. Smith , Dan Widzowski , Graham Williams
发明人： Stacy A. Castner , Thomas Hudzik , Donna L. Maier , Ladislav Mrzljak , Timothy Piser , Jeff S. Smith , Dan Widzowski , Graham Williams
IPC分类号： A61K31/438 , A61P25/28 , A61P25/18
CPC分类号： A61K31/438 , A61K31/439
摘要： A pharmaceutical composition comprising (R)-spiro[1-azabicyclo[2.2.2]octane-3,2′(3′H)-furo[2,3-b]pyridine (AZD0328) and its use in the treatment of subjects suffering from schizophrenia, Alzheimer's disease or other conditions with impaired cognitive function.
摘要翻译：包含（R） - 螺[1-氮杂双环[2.2.2]辛烷-3,2'（3'H） - 呋喃并[2,3-b]吡啶（AZD0328）的药物组合物及其用于治疗受试者患有精神分裂症，阿尔茨海默病或其他具有认知功能受损的病症。

3. 发明申请

US20080085888A1 Therapeutic Combinations 审中-公开
标题翻译：治疗组合
公开(公告)号：US20080085888A1
公开(公告)日：2008-04-10
申请号：US11855175
申请日：2007-09-14
申请人： Scott Breining , John Evenden , Edwin Johnson , Kristen Jordan , Sharon Letchworth , Craig Miller , Ladislav Mrzljak , James Wamsley , Dan Widzowski , Yun-De Xiao
发明人： Scott Breining , John Evenden , Edwin Johnson , Kristen Jordan , Sharon Letchworth , Craig Miller , Ladislav Mrzljak , James Wamsley , Dan Widzowski , Yun-De Xiao
IPC分类号： A61K31/44 , A61K31/451 , A61K31/554 , A61P25/18
CPC分类号： A61K31/44 , A61K31/451 , A61K31/554 , A61K45/06 , A61K2300/00
摘要： The present invention provides a combination of (a) an antipsychotic and (b) an alpha4/beta2 (α4β2)-neuronal nicotinic receptor agonist. The invention further relates to pharmaceutical compositions comprising said combination and to the use of the combination in therapy. The invention further relates to a kit comprising the combination and use of said kit in therapy.
摘要翻译：本发明提供了（a）抗精神病药和（b）α4/β2（α4β2） - 神经元烟碱受体激动剂的组合。本发明还涉及包含所述组合的药物组合物和在治疗中使用该组合物。本发明还涉及一种试剂盒，其包括在治疗中组合和使用所述试剂盒。

4. 发明申请

US20110160184A1 Dibenzothiazepine Derivatives and Use Thereof 审中-公开
标题翻译：二苯并硫氮杂衍生物及其用途
公开(公告)号：US20110160184A1
公开(公告)日：2011-06-30
申请号：US12999808
申请日：2009-06-18
申请人： Dean Brown , Steven Wesolowski , Dan Widzowski , James R. Damewood , M. Edward Pierson, Jr. , Michael Wood , Philip Edwards , James Hulsizer , Ashokkumar Bhikkappa Shenvi , James Campbell Muir
发明人： Dean Brown , Steven Wesolowski , Dan Widzowski , James R. Damewood , M. Edward Pierson, Jr. , Michael Wood , Philip Edwards , James Hulsizer , Ashokkumar Bhikkappa Shenvi , James Campbell Muir
IPC分类号： A61K31/554 , C07D417/04 , A61P25/18 , A61P25/22
CPC分类号： C07D417/04 , A61K31/554 , C07D281/16
摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.
摘要翻译：下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

5. 发明申请

US20100093700A1 Methods of Treating Mood Disorders 审中-公开
标题翻译：治疗情绪障碍的方法
公开(公告)号：US20100093700A1
公开(公告)日：2010-04-15
申请号：US12531717
申请日：2008-03-21
申请人： Greg Christoph , Scott W. Grimm , Dan Widzowski
发明人： Greg Christoph , Scott W. Grimm , Dan Widzowski
IPC分类号： A61K31/554 , A61P25/00 , A61P25/24
CPC分类号： A61K31/554
摘要： A method of treating at least one symptom or condition associated with but not limited to: Mood Disorders including but not limited to a) Depressive Disorders, including but not limited to, Major Depressive Disorder and Dysthymic Disorder and b) Bipolar Depression and/or Bipolar mania including but not limited to Bipolar I Disorder, including but not limited to those with manic, depressive or mixed episodes, and Bipolar II Disorder, c) Cyclothymic Disorder, and d) Mood Disorder Due to a General Medical Condition, comprising administering an effective amount of formula (I) or its pharmaceutically acceptable salt. In another aspect of the invention a pharmaceutical composition is provided comprising an effective amount of formula (I) or its pharmaceutically acceptable salt and at least one pharmaceutically acceptable carrier or diluent.
摘要翻译：治疗与但不限于以下症状或症状的至少一种症状或症状的方法：心境障碍包括但不限于：a）抑郁障碍，包括但不限于主要抑郁障碍和抑郁障碍，以及b）双相抑郁和/或双极性躁狂症包括但不限于双相I障碍，包括但不限于躁狂，抑郁或混合发作的那些，以及双相II障碍，c）循环障碍，以及d）由于一般医学状况引起的心境障碍，包括施用有效的式（I）的量或其药学上可接受的盐。在本发明的另一方面，提供了包含有效量的式（I）或其药学上可接受的盐和至少一种药学上可接受的载体或稀释剂的药物组合物。

6. 发明授权

US08653257B2 Dibenzothiazepine derivatives and uses thereof—424 失效
标题翻译：二苯并硫氮杂衍生物及其用途424
公开(公告)号：US08653257B2
公开(公告)日：2014-02-18
申请号：US13445347
申请日：2012-04-12
申请人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
发明人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
IPC分类号： A61P25/00 , A61K31/554 , C07D281/02
CPC分类号： C07D417/04 , A61K31/554 , C07D281/16
摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.
摘要翻译：下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

7. 发明申请

US20120202991A1 DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 失效
标题翻译：二苯并噻吩衍生物及其用途 - 424
公开(公告)号：US20120202991A1
公开(公告)日：2012-08-09
申请号：US13445347
申请日：2012-04-12
申请人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, JR. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
发明人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, JR. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , A61K31/554 , C07D281/16
摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.
摘要翻译：下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

8. 发明授权

US08389510B2 Crystalline forms 失效
标题翻译：结晶形式
公开(公告)号：US08389510B2
公开(公告)日：2013-03-05
申请号：US12726619
申请日：2010-03-18
申请人： Simon N. Black , Simon D. Broady , Alan S. Kirschner , James A. Osborn , Stewart D. Jolly , Dan B. Brown , Daniel Korey , Karen B. Main , Richard J. R. Creekmore , Jean M. Surian , Vivian Y. Bi , Peter Bernstein , James B. Campbell , Greg Christoph , Scott W. Grimm , Dan Widzowski , James Hulsizer , Phil Edwards
发明人： Simon N. Black , Simon D. Broady , Alan S. Kirschner , James A. Osborn , Stewart D. Jolly , Dan B. Brown , Daniel Korey , Karen B. Main , Richard J. R. Creekmore , Jean M. Surian , Vivian Y. Bi , Peter Bernstein , James B. Campbell , Greg Christoph , Scott W. Grimm , Dan Widzowski , James Hulsizer , Phil Edwards
IPC分类号： A61P25/18 , A61K31/554 , C07D281/02
CPC分类号： C07D281/16 , A61K31/554
摘要： 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine, compositions thereof, preparations thereof, formulations thereof, prodrugs thereof and pharmaceutical uses thereof.
摘要翻译： 11-哌嗪-1-基二苯并[b，f] [1,4]硫氮杂，其组合物，其制剂，其制剂，其前药及其药物用途。

9. 发明授权

US08158618B2 Dibenzothiazepine derivatives and uses thereof—424 有权
标题翻译：二苯并硫氮杂衍生物及其用途424
公开(公告)号：US08158618B2
公开(公告)日：2012-04-17
申请号：US12487725
申请日：2009-06-19
申请人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
发明人： Dean Brown , James R. Damewood , Phil Edwards , James Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
IPC分类号： A61P25/00 , A61K31/554 , C07D281/02
CPC分类号： C07D417/04 , A61K31/554 , C07D281/16
摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.
摘要翻译：下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

10. 发明申请

US20090318415A1 DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 有权
标题翻译：二苯并噻吩衍生物及其用途 - 424
公开(公告)号：US20090318415A1
公开(公告)日：2009-12-24
申请号：US12487725
申请日：2009-06-19
申请人： Dean Brown , James R. Damewood , Phil Edwards , James M. Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
发明人： Dean Brown , James R. Damewood , Phil Edwards , James M. Hulsizer , James Campbell Muir , M. Edward Pierson, Jr. , Ashokkumar Bhikkappa Shenvi , Steven Wesolowski , Dan Widzowski , Michael Wood
IPC分类号： A61K31/554 , C07D417/04 , A61P25/00
CPC分类号： C07D417/04 , A61K31/554 , C07D281/16
摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.
摘要翻译：下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

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