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1. 发明授权

US5985372A Method for preparing antibacterial/antifungal inorganic matter-composited wood 失效
标题翻译：制备抗菌/抗真菌无机物质复合木材的方法
公开(公告)号：US5985372A
公开(公告)日：1999-11-16
申请号：US90338
申请日：1998-06-04
申请人： Shiro Saka , Fumie Tanno , Akira Yamamoto , Masaki Tanaka , Koichi Higuchi
发明人： Shiro Saka , Fumie Tanno , Akira Yamamoto , Masaki Tanaka , Koichi Higuchi
IPC分类号： B27K3/15 , B27K3/36 , B27K3/50 , B05D3/02
CPC分类号： B27K3/15 , A01N59/00 , C08L97/02 , C08L83/04
摘要： An antibacterial/antifungal inorganic matter is composited with wood by impregnating wood with a solution containing a silicon alkoxide and an antibacterial/antifungal organic silicon compound having a hydrolyzable alkoxysilyl group, and subjecting the silicon compounds within the cell walls (inter- and intracellular) spaces to hydrolysis at various temperatures and polycondensation. The same is prepared by treating wood with a siloxane oligomer and curing the oligomer. The antibacterial/antifungal component is prevented from being leached out.
摘要翻译：通过用含有硅烷醇盐和具有可水解烷氧基甲硅烷基的抗菌/抗真菌有机硅化合物的溶液浸渍木材，将抗菌/抗真菌无机物质与木材复合，并将硅化合物在细胞壁（细胞间和细胞内）空间在各种温度下进行水解和缩聚。通过用硅氧烷低聚物处理木材并固化低聚物来制备。防止抗菌/抗真菌成分被浸出。

2. 发明授权

US5652026A Modification of wood 失效
标题翻译：修改木材
公开(公告)号：US5652026A
公开(公告)日：1997-07-29
申请号：US653026
申请日：1996-05-24
申请人： Shiro Saka , Hisashi Miyafuji , Fumie Tanno , Akira Yamamoto , Masaki Tanaka , Kenji Yamamoto
发明人： Shiro Saka , Hisashi Miyafuji , Fumie Tanno , Akira Yamamoto , Masaki Tanaka , Kenji Yamamoto
IPC分类号： B27K3/15 , B05D7/06
CPC分类号： B27K3/15 , C08L97/02 , C08L83/08
摘要： Wood is modified by impregnating wood with a methylsiloxane oligomer and heating the impregnated wood to cure the oligomer. The oligomer is of the average compositional formula: (CH.sub.3 SiO.sub.3/2).sub.m (MO.sub.3/2).sub.n or [CH.sub.3 SiO.sub.3/2 ].sub.x [(CH.sub.3).sub.a SiO.sub.(4-a)/2 ].sub.y [MO .sub.3/2 ].sub.z wherein M is P, PO and/or B, m and n are positive numbers with an average ratio of m:n ranging from 99:1 to 50:50, x, y, and z are positive numbers with an average ratio of (x+y):z ranging from 99:1 to 50:50 and an average ratio of x:y ranging from 99:1 to 50:50, and a is 2 or 3, and has a hydroxyl group and/or an alkoxyl group at a terminal end. This treatment of wood is safe. Since the methylsilicone resins thus incorporated and fixed within wood are not leached out in water, the modified wood maintains flame retardance for a very long time upon exposure to rain and dew and has water repellence, decay resistance and dimensional stability.
摘要翻译：木材通过用甲基硅氧烷低聚物浸渍木材进行改性，并加热浸渍的木材以固化低聚物。低聚物具有平均组成式：（CH 3 SiO + E，3/2 + EE）m（MO + E，3/2 + EE）n或[CH 3 SiO + E，3/2 + EE] （CH3）aSiO（4-a）/ 2] y [MO + E，fra 3/2 + EE] z其中M是P，PO和/或B，m和n是正数， n的范围从99:1至50:50，x，y和z是正数，平均比例为（x + y）：z为99:1至50:50，平均比例x:y范围为 99:1-50:50，a为2或3，末端具有羟基和/或烷氧基。这种木材的处理是安全的。由于在木材中结合并固定的甲基硅氧烷树脂不会在水中浸出，所以改性木材在暴露于雨水和露水后保持很长时间的阻燃性，并具有防水性，耐腐蚀性和尺寸稳定性。

3. 发明授权

US06872336B2 Process for producing a pharmaceutical solid preparation containing a poorly soluble drug 失效
标题翻译：制备含有难溶性药物的药物固体制剂的方法
公开(公告)号：US06872336B2
公开(公告)日：2005-03-29
申请号：US10232631
申请日：2002-08-30
申请人： Fumie Tanno , Yuichi Nishiyama
发明人： Fumie Tanno , Yuichi Nishiyama
IPC分类号： A61J3/06 , A61K9/14 , A61K9/16 , A61K31/4422 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , B29B9/00
CPC分类号： A61K9/1652 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1676
摘要： Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in products, environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events. The present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods. Specifically, the present invention provides a process for producing a pharmaceutical solid preparation, which is formulated by spraying a solution wherein a poorly soluble drug is dissolved in a plasticizer, and an aqueous solution and/or water dispersion of a water-soluble polymer from nozzle outlets simultaneously and separately in the process for producing the pharmaceutical solid preparation.
摘要翻译：在固体分散体的常规方法中，通过溶剂法得到的固体分散体在难溶性药物的溶解性和生物利用度方面是优异的。然而，由于溶剂法中有机溶剂的使用频繁，产生有机溶剂残留，环境污染，作业安全等问题，以及避免此类事件所需的企业资本投入等问题。本发明提供了制备药物固体制剂的方法，而不使用常规溶剂方法中常用的有机溶剂。具体地说，本发明提供一种药物固体制剂的制造方法，其通过将难溶性药物溶解于增塑剂中的溶液喷雾而制备，将来自喷嘴的水溶性聚合物的水溶液和/或水分散体出口在生产药物固体制剂的过程中同时和分开。

4. 发明授权

US06171616B2 Solid preparation and a method of manufacturing it 有权
标题翻译：固体制剂及其制造方法
公开(公告)号：US06171616B2
公开(公告)日：2001-01-09
申请号：US09287640
申请日：1999-04-07
申请人： Fumie Tanno , Hiroyasu Kokubo
发明人： Fumie Tanno , Hiroyasu Kokubo
IPC分类号： A61K916
CPC分类号： A61K9/2054 , Y10S514/961
摘要： A solid preparation characteristically containing for a binder methyl cellulose whose MeO content is 27.5-31.5 wt % and whose 2 wt % aqueous solution has a viscosity of 2-12 cP at 20° C. The present invention can provide a solid preparation which has an adequate hardness and at the same time disintegrates quickly for easy absorption.
摘要翻译：一种固体制剂，其特征在于，其含有MeO含量为27.5〜31.5重量％的粘合剂甲基纤维素，其20重量％的水溶液在20℃下的粘度为2-12cP。本发明可提供一种固体制剂，其具有足够的硬度，同时快速分解，便于吸收。

5. 发明授权

US06525192B2 Low-substituted hydroxypropyl cellulose and process for producing same 有权
标题翻译：低取代羟丙基纤维素及其制备方法
公开(公告)号：US06525192B2
公开(公告)日：2003-02-25
申请号：US09309532
申请日：1999-05-11
申请人： Sakae Obara , Hiroshi Umezawa , Naosuke Maruyama , Fumie Tanno
发明人： Sakae Obara , Hiroshi Umezawa , Naosuke Maruyama , Fumie Tanno
IPC分类号： C08B1120
CPC分类号： A61K9/2054 , C08B11/08
摘要： The present invention provides a low-substituted hydroxypropyl cellulose having a loose bulk density of not less than 0.40 g/mL and a tap bulk density of not less than 0.60 g/mL and a process for producing the same.
摘要翻译：本发明提供松散堆积密度不低于0.40g / mL，堆积密度不小于0.60g / mL的低取代羟丙基纤维素及其制备方法。

6. 发明申请

US20050158386A1 Process for producing a pharmaceutical solid preparation containing a poorly soluble drug 审中-公开
公开(公告)号：US20050158386A1
公开(公告)日：2005-07-21
申请号：US11061995
申请日：2005-02-21
申请人： Fumie Tanno , Yuichi Nishiyama
发明人： Fumie Tanno , Yuichi Nishiyama
IPC分类号： A61J3/06 , A61K9/14 , A61K9/16 , A61K31/4422 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , A61K9/22
CPC分类号： A61K9/1652 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1676
摘要： Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in products, environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events. The present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods. Specifically, the present invention provides a process for producing a pharmaceutical solid preparation, which is formulated by spraying a solution wherein a poorly soluble drug is dissolved in a plasticizer, and an aqueous solution and/or water dispersion of a water-soluble polymer from nozzle outlets simultaneously and separately in the process for producing the pharmaceutical solid preparation.

7. 发明授权

US06559134B2 Solid preparation containing low-substituted hydroxypropyl cellulose and production process thereof 有权
标题翻译：含有低取代羟丙基纤维素的固体制剂及其制备方法
公开(公告)号：US06559134B2
公开(公告)日：2003-05-06
申请号：US09811046
申请日：2001-03-16
申请人： Fumie Tanno , Sakae Obara
发明人： Fumie Tanno , Sakae Obara
IPC分类号： A61K31715
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/2054
摘要： Provided are a solid preparation which rapidly disintegrates in the oral cavity when taken together with the saliva in the oral cavity or a small amount of water, can be prepared easily and has strength enough to retain its formability upon production or during distribution; and a production process of the solid preparation. Specifically, provided are a solid preparation comprising a low-substituted hydroxypropyl cellulose having a loose bulk density of 0.40 g/ml or greater and a tapped bulk density of 0.60 g/ml or greater, and a sugar and/or sugar alcohol; and a production process of the solid preparation. Also provided are a solid preparation comprising a low-substituted hydroxypropyl cellulose having a volume-average particle size as measured by the dry laser diffraction method of 25 &mgr;m or less which is obtained by pulverizing a low-substituted hydroxypropyl cellulose having a loose bulk density of 0.40 g/ml or greater, a tapped bulk density of 0.60 g/ml or greater, and a volume average particle size of 30 &mgr;m or greater—and a sugar and/or sugar alcohol; and a production process of the solid preparation.
摘要翻译：提供了一种固体制剂，其与口腔中的唾液或少量的水一起在口腔中快速崩解，并且具有足够的强度以在生产或分配期间保持其成型性; 和固体制剂的生产方法。具体地说，提供了一种固体制剂，其包含松散堆积密度为0.40g / ml或更高的松散堆积密度为0.60g / ml或更大的低取代羟丙基纤维素，以及糖和/或糖醇; 和固体制剂的生产方法。还提供了一种固体制剂，其包含通过干激光衍射法测量的体积平均粒径为25μm或更小的低取代羟丙基纤维素，其通过粉碎具有松散体积密度的低取代羟丙基纤维素 0.40g / ml或更大，堆芯密度为0.60g / ml或更大，体积平均粒径为30μm或更大，以及糖和/或糖醇; 和固体制剂的生产方法。

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