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1. 发明申请

WO2005085440A8 METHOD FOR ENRICHING AND/OR SEPARATING PROKARYOTIC DNA USING A PROTEIN THAT SPECIFICALLY BONDS TO UNMETHYLATED DNA CONTAINING CPG-MOTIVES 审中-公开
标题翻译：富集和/或原核分离DNA由蛋白质的方式方法，它不会甲基化CpG基序含有DNA的特异性结合
公开(公告)号：WO2005085440A8
公开(公告)日：2005-12-15
申请号：PCT/EP2005002198
申请日：2005-03-02
申请人： SIRS LAB GMBH , SCHMIDT KARL-HERMANN , STRAUBE EBERHARD , RUSSWURM STEFAN , DEIGNER HANS-PETER , SACHSE SVEA , LEHMANN MARC
发明人： SCHMIDT KARL-HERMANN , STRAUBE EBERHARD , RUSSWURM STEFAN , DEIGNER HANS-PETER , SACHSE SVEA , LEHMANN MARC
IPC分类号： C12N15/10
CPC分类号： C12N15/1006 , C12N15/1003
摘要： The invention relates to a method for separating and/or enriching prokaryotic DNA, comprising the following steps: a) contacting of at least one prokaryotic DNA that is in solution with a protein that bonds specifically to prokaryotic DNA, said protein being 25 %-35 % homologous with the wild-type CGPB protein, thus forming a protein-DNA complex; and b) separation of the complex. The invention also relates to a kit for carrying out said method.
摘要翻译：它是用于分离和/或富集的原核DNA包含描述的以下步骤的方法。接触在溶液中的至少一种原核DNA与具有25％至35％同源性的野生型蛋白CGPB，由此形成的蛋白质-DNA复合物，和b的特定原核DNA结合蛋白。 Komplexes.Weiterhin的分离描述用于执行该方法的试剂盒。

2. 发明申请

WO2004087949A3 METHOD FOR RECOGNISING ACUTE GENERALISED INFLAMMATORY CONDITIONS (SIRS), SEPSIS, SEPSIS-LIKE CONDITIONS AND SYSTEMIC INFECTIONS 审中-公开
标题翻译：于检测急性方法广义炎症状态（SIRS），败血症，败血症样条件和全身感染
公开(公告)号：WO2004087949A3
公开(公告)日：2005-10-06
申请号：PCT/EP2004003419
申请日：2004-03-31
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , REINHART KONRAD , SALUZ HANS-PETER , STRAUBE EBERHARD , ZIPFEL PETER F , DEIGNER HANS-PETER
发明人： RUSSWURM STEFAN , REINHART KONRAD , SALUZ HANS-PETER , STRAUBE EBERHARD , ZIPFEL PETER F , DEIGNER HANS-PETER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , C12Q2600/158 , Y10T436/143333
摘要： The invention relates to a method for in vitro recognition of SIRS, sepsis and/or sepsis-like conditions. Said method enables the degree of severity to be evaluated and/or assessment during the course of therapy of sepsis and serious infections, especially sepsis-like systemic infections. The invention also relates to the use of recombinant or synthetically produced nucleic acid sequences or peptide sequences derived therefrom as a calibrator in sepsis-assays and/or in order to assess the effect and toxicity in active substance screening and/or in the production of therapeutics in order to prevent and treat SIRS, sepsis, sepsis-like systemic inflammatory conditions and sepsis-like systemic infections.
摘要翻译：本发明涉及一种用于SIRS的体外检测，败血症和/或败血症样条件的方法，这使得有可能的严重性和/或治疗，伴随脓毒症和严重感染的过程中，以评估特定败血症样全身性感染。此外，本发明涉及使用重组或合成产生的核酸序列的或从肽序列推导为脓毒症测定校准器和/或评估在药物筛选和/或用于SIRS，败血症的预防和治疗的治疗剂的制造中的效果和毒性，败血症样全身性炎症条件和败血症样全身性感染。

3. 发明申请

WO2006133758A2 DEVICE FOR ENRICHING/SEPARATING DNA CONTAINING UNMETHYLATED CPG MOTIVES 审中-公开
标题翻译： DEVICE FOR的富集/分离非甲基化的CpG基序含有DNA
公开(公告)号：WO2006133758A2
公开(公告)日：2006-12-21
申请号：PCT/EP2006003328
申请日：2006-04-11
申请人： SIRS LAB GMBH , STRAUBE EBERHARD , RUSSWURM STEFAN , LEHMANN MARC
发明人： STRAUBE EBERHARD , RUSSWURM STEFAN , LEHMANN MARC
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , C12N15/1006
摘要： Disclosed is an apparatus for enriching and/or separating DNA containing unmethylated CpG motives. Said apparatus comprises a) a reaction vessel with at least one opening, and b) a protein that specifically recognizes unmethylated CpG motives via a bonding point. The protein is homologous by 25 to 35 percent to the wild-type CGPB protein, is shorter than the same, and is located within the reaction vessel.
摘要翻译：提供了一种用于富集和/或含DNA的非甲基化的CpG基序的分离的装置，包括a）具有至少一个开口，和b的反应容器中）特异性识别的蛋白的非甲基化的CpG基序具有的结合位点，其中所述蛋白质是25％至35％同源性的野生型蛋白具有CGPB和比该短，其中所述蛋白质位于反应容器内。

4. 发明申请

WO2005083115A2 METHOD FOR THE IDENTIFICATION OF SEPSIS 审中-公开
标题翻译：检测脓毒症的过程
公开(公告)号：WO2005083115A2
公开(公告)日：2005-09-09
申请号：PCT/EP2004014310
申请日：2004-12-15
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , DEIGNER HANS-PETER
发明人： RUSSWURM STEFAN , DEIGNER HANS-PETER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , C12Q2600/158 , Y10T436/143333
摘要： The invention relates to a method for the in vitro distinction between systemic inflammatory non-infectious conditions and systemic inflammatory infectious conditions. Said method comprises the following steps: a) sample RNA is isolated from a biological sample; b) the sample RNA and/or at least one DNA which represents a gene activity that is specific for distinguishing between SIRS and sepsis and/or a specific gene or gene fragment, is marked with a detectable marker; c) the sample RNA is brought in contact with the DNA in hybridization conditions; d) control RNA is brought in contact with at least one DNA in hybridization conditions, said DNA representing a gene or gene fragment that is specific for distinguishing between SIRS and sepsis; e) the marking signals of the hybridized sample RNA and control RNA are quantitatively recorded; and f) the quantitative data of the marking signals is compared in order to make a statement as to whether genes or gene fragments that are specific for distinguishing between SIRS and sepsis are expressed more prominently or less prominently in the sample than in the control RNA.
摘要翻译：本发明涉及一种用于全身性的，炎症，非感染性的条件和全身性的，炎症性，感染性条件之间的体外分化的方法，包括以下步骤：a）从生物样品中分离样品RNA，b）中的标记的样品的RNA和/ 或至少一种对SIRS脓毒症和/或特定基因或基因片段具有特异性的基因活性的DNA与可检测标记物，c）在杂交条件下使样品RNA与DNA接触，d）In - 接触使控制RNA，用至少一种DNA，杂交条件下，其中所述DNA为SIRS和脓毒症特定基因或基因片段，E之间有区别）定量检测所述杂交RNA样品和对照RNA的标记信号 ; 和，f）比较，以使无论是SIRS和脓毒症的特定基因或基因片段之间进行区分所表达的样品中比对照更多或更少的声明标记信号的定量数据。

5. 发明申请

WO2008107114A2 CONTROL GENES FOR THE NORMALIZATION OF GENE EXPRESSION ANALYSIS DATA 审中-公开
标题翻译：用于基因表达分析数据正常化的控制基因
公开(公告)号：WO2008107114A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008001582
申请日：2008-02-28
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , SALUZ HANS PETER , DEIGNER HANS-PETER
发明人： RUSSWURM STEFAN , SALUZ HANS PETER , DEIGNER HANS-PETER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/158 , C12Q2600/166 , C12Q2545/101
摘要： The present invention relates to control genes, primers, and probes for the normalization of gene expression analysis data from the blood samples of a patient. The invention further relates to a method for the normalization of gene expression analysis data using control genes, primers, or probes.
摘要翻译：本发明涉及用于使来自患者血液样品的基因表达分析数据标准化的对照基因，引物和探针。本发明还涉及用对照基因，引物或探针标准化基因表达分析数据的方法。

6. 发明申请

WO2007144105A3 METHOD FOR ESTABLISHING THE SOURCE OF INFECTION IN A CASE OF FEVER OF UNCLEAR AETIOLOGY 审中-公开
标题翻译：方法确定感染源不明原因发热
公开(公告)号：WO2007144105A3
公开(公告)日：2008-02-14
申请号：PCT/EP2007005043
申请日：2007-06-06
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , REINHART KONRAD , BAUER MICHAEL
发明人： RUSSWURM STEFAN , REINHART KONRAD , BAUER MICHAEL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： The use of gene expression profiles obtained in vitro from a patient's sample for establishing the local inflammation of a "fever of unclear aetiology", where the gene expression profiles are specific for local inflammations of a "fever of unclear aetiology", such as peritonitis, pneumonia, endocarditis or urinary tract infections.
摘要翻译：使用从一个“不明原因发热”的局部炎症的识别患者样品的基因表达图谱在体外获得的结果，其中，对于一个“未知原因的发热”为腹膜炎，肺炎，心内膜炎，或尿路感染的局部炎症的基因表达谱，是特定的。

7. 发明申请

WO2009115478A3 METHOD FOR IN VITRO DETECTION AND DIFFERENTIATION OF PATHOPHYSIOLOGICAL STATES 审中-公开
标题翻译：方法体外检测和病理生理条件的歧视
公开(公告)号：WO2009115478A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009053042
申请日：2009-03-16
申请人： SIRS LAB GMBH , RUSSWURM STEFAN
发明人： RUSSWURM STEFAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： The invention relates to a method for in vitro detection and/or differentiation and/or observation of the progression of pathophysiological states (e.g. SIRS or SEPSIS) by way of nucleic acid samples, determination of gene activities by way of a plurality of polynucleotides, determination of gene activity of at least one internal reference gene and formation of an index value from the individually determined, normalized gene activities of a multi-gene biomarker which indicates the pathophysiological state.
摘要翻译：本发明涉及一种用于体外检测和/或分化和/或后续通过的样品核酸装置的病理生理条件（例如，SIRS或败血症）的方法，基因活性的由多个多核苷酸的判定，判定基因活性的至少一种内部参照基因的并形成一个索引从指示所述病理生理状态包括的多基因生物标志物的单一特定归一化的基因活性值。

8. 发明申请

WO2007124820A3 METHOD FOR IN VITRO MONITORING OF POSTOPERATIVE CHANGES FOLLOWING LIVER TRANSPLANTATION 审中-公开
标题翻译：程序的体外监测术后更改后，肝脏移植
公开(公告)号：WO2007124820A3
公开(公告)日：2008-01-17
申请号：PCT/EP2007002705
申请日：2007-04-11
申请人： SIRS LAB GMBH , RUSSWURM STEFAN
发明人： RUSSWURM STEFAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for detecting any postoperative tissue incompatibility reactions following a liver transplantation, wherein in patients the gene activity of a plurality of specific genes relevant to a liver transplantation is determined in a patient sample, and the specific genes and/or gene fragments for monitoring of postoperative states are selected from the group consisting of: SEQ-ID No. 1 to SEQ-ID No. 532, these preferably being subdivided into several clusters.
摘要翻译：本发明涉及到使用效果在体外从患者样品的基因表达图谱，用于检测任何术后出现的成功的肝脏移植后组织不耐受反应获得的，其中在多个特定的患者基因活性测定，患者样品和所述与肝移植相关基因被选择用于从包括以下各项的组中选择的特定基因和/或基因片段的手术后状态的监测：SEQ ID号 1至SEQ ID号 532，其优选分为若干簇。

9. 发明申请

WO2007085459A2 METHOD FOR THE IN VITRO DIAGNOSIS OF CHLAMYDOPHILA PNEUMONIAE INFECTIONS 审中-公开
标题翻译：体外诊断CHLAMYDOPHILA PNEUMONIA感染的方法
公开(公告)号：WO2007085459A2
公开(公告)日：2007-08-02
申请号：PCT/EP2007000650
申请日：2007-01-25
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , OSTERLOH DIRK
发明人： RUSSWURM STEFAN , OSTERLOH DIRK
IPC分类号： G01N33/569 , A61K39/118 , A61K39/42 , C12Q1/42
CPC分类号： G01N33/56927 , G01N2333/295
摘要： The invention relates to a method for the in vitro diagnosis of a Chlamydia pneumoniae-specific infection. Said method is characterized in that the presence of at least one of the proteins dnaJ and hydrolase/phosphatase homolog and/or derivatives thereof and/or at least one antibody directed against said proteins and/or derivatives thereof is detected in a patient's sample. Also disclosed are a kit for carrying out the in vitro diagnostic method as well as the preventive and therapeutic use of said biomarkers.
摘要翻译：本发明涉及一种用于特定在肺炎衣原体感染的体外诊断的方法，其特征在于患者中的蛋白的dnaJ和水解酶/磷酸酶同源和/或衍生物中的至少一种的存在由其衍生的和/或至少一个样品中的针对这些蛋白质的抗体和/或由其衍生的衍生物。还描述了用于进行所述生物标志物的体外诊断方法和预防和治疗用途的试剂盒。

10. 发明申请

WO2006100203A3 USE OF GENE ACTIVITY CLASSIFIERS FOR THE IN VITRO CLASSIFICATION OF GENE EXPRESSION PROFILES OF PATIENTS WITH INFECTIOUS/NON-INFECTIOUS MULTIPLE ORGAN FAILURE 审中-公开
标题翻译：使用基因活性分类器传染性/非感染性多器官衰竭患者的基因表达谱的体外分类
公开(公告)号：WO2006100203A3
公开(公告)日：2007-07-05
申请号：PCT/EP2006060780
申请日：2006-03-16
申请人： SIRS LAB GMBH , RUSSWURM STEFAN , REINHART KONRAD
发明人： RUSSWURM STEFAN , REINHART KONRAD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The invention relates to the use of gene activity markers for the classification of patients suffering from infectious or non-infectious multiple organ failure. The invention especially relates to gene activity markers for classifying patients as "non-infected without multiple organ failure" or as "not suffering from multiple organ failure" or as "suffering from infectious multiple organ failure . The gene activity markers are polynucleotides selected from the group consisting of: SEQ ID I.1, SEQ ID I.2, SEQ ID I.3, SEQ ID I.4, SEQ ID I.5, SEQ ID I.6, SEQ ID I.7, SEQ ID I.8 and SEQ ID I.9 or partial sequences thereof.
摘要翻译：本发明涉及使用基因活性标志物的谁是来自感染或非感染性多器官功能衰竭的患者的分类。特别地，本发明提供了基因活性标志物的患者分类涉及为“未感染无多器官功能衰竭的”或“不从感染性多器官功能衰竭患”，或“生病感染性多器官功能衰竭”，如，与基因活性标记物是选自由以下组成的组中选择的多核苷酸： SEQ ID I.1，SEQ ID I.2，SEQ ID I.3，SEQ ID I.4，SEQ ID I.5，SEQ ID I.6，SEQ ID I.7，SEQ ID I.8和SEQ ID I.9或其部分序列。

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