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1. 发明申请

WO2008024977A2 ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES 审中-公开
标题翻译：异喹啉，喹唑啉和酞嗪衍生物
公开(公告)号：WO2008024977A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076769
申请日：2007-08-24
申请人： SERENEX INC , HUANG KENNETH HE , VEAL JAMES , BARTA THOMAS , SMITH EMILIE D , MA WEI , OMMEN ANDY
发明人： HUANG KENNETH HE , VEAL JAMES , BARTA THOMAS , SMITH EMILIE D , MA WEI , OMMEN ANDY
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein R 0 , R 5 , R 6 , R 7 , n, Q 1 -Q 5 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula (I) are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式（I）的化合物和可药用盐，其中R 0，R 5，R 6，R 7， / SUB>，n，Q _{1 -Q _{5 ，Y和X _{1 -X _{3 在此定义。式（I）化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物以及使用这些化合物治疗上述病症的方法。}}}}

2. 发明申请

WO2008024970A2 BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES 审中-公开
标题翻译：苯醌，吡啶和吡啶衍生物
公开(公告)号：WO2008024970A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076755
申请日：2007-08-24
申请人： SERENEX INC , HUANG KENNETH HE , HUGHES PHILIP , MA WEI , OMMEN ANDY , WOODWARD ANGELA , VEAL JAMES , BARTA THOMAS
发明人： HUANG KENNETH HE , HUGHES PHILIP , MA WEI , OMMEN ANDY , WOODWARD ANGELA , VEAL JAMES , BARTA THOMAS
CPC分类号： C07D209/34 , C07D235/26
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 3 , and R 4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式I的化合物和药学上可接受的盐，其中A 1，Q 1，Q 2，Q 3，R 3，且R 4和R 4如本文所定义。式I化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

3. 发明申请

WO2007035620A3 CARBAZOLE DERIVATIVES 审中-公开
标题翻译：卡博唑衍生物
公开(公告)号：WO2007035620A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036258
申请日：2006-09-15
申请人： SERENEX INC , HANSON GUNNAR J , BARTA THOMAS E , GENG LIFENG , HUANG KENNETH HE , VEAL JAMES
发明人： HANSON GUNNAR J , BARTA THOMAS E , GENG LIFENG , HUANG KENNETH HE , VEAL JAMES
IPC分类号： C07D209/04 , A61K31/404 , A61P35/00 , C07D209/56 , C07D401/12 , C07D471/04
CPC分类号： C07D209/88 , C07D209/12 , C07D209/14 , C07D401/12 , C07D471/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula I: wherein n, R1, R2, R 3 , X, R4, R 5 , R 6 , R8, R 9 , and Y are as Defined herein. Compounds of Formula I am useful in the treatment of diseases and/or conditions related to cell proliferation and/or abnormal cell mitosis, such as cancer, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式I的化合物和药学上可接受的盐：其中n，R 1，R 2，R 3，X，R 4，R 5，R 6， >，R8，R 9和Y如本文所定义。式I的化合物可用于治疗与细胞增殖和/或异常细胞有丝分裂相关的疾病和/或病症，例如癌症，炎症和炎症相关疾病以及与血管发生相关的病症。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

4. 发明申请

WO2008024978A3 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES 审中-公开
标题翻译：四氢吲哚酮和四氢呋喃衍生物衍生物
公开(公告)号：WO2008024978A3
公开(公告)日：2008-08-21
申请号：PCT/US2007076770
申请日：2007-08-24
申请人： SERENEX INC , HUANG KENNETH HE , MANGETTE JOHN , BARTA THOMAS , HUGHES PHILIP , HALL STEVEN E , VEAL JAMES
发明人： HUANG KENNETH HE , MANGETTE JOHN , BARTA THOMAS , HUGHES PHILIP , HALL STEVEN E , VEAL JAMES
IPC分类号： C07D231/56 , A61K31/416 , A61P35/00 , C07D207/02 , C07D209/04 , C07D209/14 , C07D231/22 , C07D231/38 , C07D333/22 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号： C07D207/02 , C07D209/04 , C07D231/22 , C07D231/38 , C07D231/56 , C07D333/22 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) wherein A, Q 1 , Q 2 , Q 3 , R 31 , and R 41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式（I）的化合物和药学上可接受的盐，其中A，Q 1，Q 2，Q 3，R 31 和/或R 41如本文所定义。式I化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

5. 发明申请

WO2008024980A2 PYRROLE, THIOPHENE, FURAN, IMIDAZOLE, OXAZOLE, AND THIAZOLE DERIVATIVES 审中-公开
标题翻译：吡咯，噻吩，呋喃，咪唑，恶唑和噻唑衍生物
公开(公告)号：WO2008024980A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076772
申请日：2007-08-24
申请人： SERENEX INC , HUANG KENNETH HE , HALL STEVEN E , VEAL JAMES
发明人： HUANG KENNETH HE , HALL STEVEN E , VEAL JAMES
CPC分类号： C07D409/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) wherein R Q , R 7 , n, Q 2 , Q 3 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula (I) are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式（I）的化合物和可药用盐，其中R Q，R 7，n，Q 2，Q 3， Y，和X _{-X _{3 如本文所定义。式（I）化合物可用于治疗与细胞增殖相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物以及使用这些化合物治疗上述病症的方法。}}

6. 发明专利

ES2527770T3 Derivados de tetrahidroindolona y tetrahidroindazolona 未知
公开(公告)号：ES2527770T3
公开(公告)日：2015-01-29
申请号：ES06736330
申请日：2006-02-27
申请人： SERENEX INC
发明人： HUANG KENNETH HE , EAVES JERON , VEAL JAMES , BARTA THOMAS , GENG LIFENG , HINKLEY LINDSAY , HANSON GUNNAR
IPC分类号： C07D231/56 , A61K31/416 , A61P35/00 , C07D209/14
摘要： Un compuesto de fórmula XXV, **Fórmula** o una de sus sales farmacéuticamente aceptable, en donde R3 y R4 son independientemente (a) H, (b) halo o (c) un grupo alquilo C1-C15 en donde hasta seis de los átomos de carbono en dicho grupo alquilo están opcionalmente reemplazados independientemente por R22, carbonilo, etenilo, etinilo o un resto seleccionado entre N, O, S, SO2 o SO, con la condición de que dos átomos de O, dos átomos de S, o un átomo de O y S 10 no sean inmediatamente adyacentes entre sí, en donde R22 es (i) heteroarilo, (ii) arilo, (iii) cicloalquilo C3-C10 saturado o insaturado, o (iv) heterocicloalquilo C2-C10 saturado o insaturado, en donde cada arilo, heteroarilo, cicloalquil saturado o insaturado, o heterocicloalquilo saturado o insaturado, independientemente, está opcionalmente sustituido con al menos un grupo, que es independientemente hidroxi, halo, amino, ciano, carboxi, carboxamido, nitro, oxo, -S-alquilo (C1-C6), -SO2-alquilo (C1-C6), -SO2-arilo, -SO-alquilo (C1-C6), -SO-arilo, -SO2NH2, -SO2NH-alquilo (C1-C6), -SO2NH-arilo, alcoxi (C1-C6) o mono- o di-alquilamino (C1-C10); y cada R22 está opcionalmente condensado con un grupo arilo C6-C10, grupo cíclico C5-C8 saturado o un grupo heterocicloalquilo C5-C10; en donde cada (c) está opcionalmente sustituido en cualquier posición disponible con alquil C1-C10, haloalquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, hidroxi, carboxi, carboxamido, oxo, halo, amino, ciano, nitro, -SH, -S-alquilo (C1-C6), -SO2-alquilo (C1-C6), -SO2NH2, -SO2NH-alquilo (C1-C6), -SO2NH-arilo, -SO2-arilo, - SO-alquilo (C1-C6), -SO2-arilo, alcoxi C1-C6, alqueniloxi C2-C10, alquiniloxi C2-C10, mono o di-alquilamino (C1-C10), -Oalquil C1-C10-Z o R23, en donde Z es OR0 o -N(R30)2, en donde cada R30 es independientemente -H o alquilo C1-C6, o N(R30)2 representa pirrolidinilo, piperidinilo, piperazinilo, 30 azepanilo, 1,3- o 1,4-diazepanilo, o morfolinilo, cada uno de los cuales está opcionalmente sustituido con hidroxi, amino, aminoalquilo, alquilo C1-C6, mono- o di-alquilamino (C1-C6), alcoxi C1-C6 o halógeno; R0 es -H, -alquilo C1-C10, -alquenilo C2-C10, -alquinilo C2-C10, arilo, heteroarilo o -acilo C1-C6; R23 es (1) heteroarilo, (2) arilo.

7. 发明专利

AU2011201700B2 Tetrahydroindolone and tetrahydroindazolone derivatives 未知
公开(公告)号：AU2011201700B2
公开(公告)日：2013-08-22
申请号：AU2011201700
申请日：2011-04-15
申请人： SERENEX INC
发明人： HUANG KENNETH HE , EAVES JERON , VEAL JAMES , BARTA THOMAS E , GENG LIFENG , HINKLEY LINDSAY , HANSON GUNNAR J
IPC分类号： C07D231/56 , A61K31/416 , A61P35/00 , C07D209/14
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula (I): wherein R1 , R2 , R3 , R4 , R5 , R6 , R7 , n, Qi, Q2, Q3, Y, and X1 -X 4 are as defined herein. Compounds of Formula s (I) are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions LO using such compounds.

8. 发明专利

MY143583A TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES 未知
公开(公告)号：MY143583A
公开(公告)日：2011-05-31
申请号：MYPI20071433
申请日：2007-08-24
申请人： SERENEX INC
发明人： HUANG KENNETH HE , EAVES JERON , VEAL JAMES , BARTA THOMAS E , GENG LIFENG , HINKLEY LINDSAY , HANSON GUNNAR J
IPC分类号： C07D231/54
摘要： DISCLOSED ARE COMPOUNDS AND PHARMACEUTICALLY ACCEPTABLE SALTS OF FORMULA I WHEREIN R1, R2, R3, R4, R5, R6, R7, N, Q1, Q2, Q3, Y, AND X1- X4 ARE AS DEFINED HEREIN. COMPOUNDS OF FORMULA I ARE USEFUL IN THE TREATMENT OF DISEASES AND/OR CONDITIONS RELATED TO CELL PROLIFERATION, SUCH AS CANCER, INFLAMMATION, ARTHRITIS, ANGIOGENESIS, OR THE LIKE. ALSO DISCLOSED ARE PHARMACEUTICAL COMPOSITIONS COMPRISING COMPOUNDS OF THE INVENTION AND METHODS OF TREATING THE AFOREMENTIONED CONDITIONS USING SUCH COMPOUNDS.

9. 发明专利

AP2007004125A0 Tetrahydroindolone and tetrahydroindazolone derivatives 未知
公开(公告)号：AP2007004125A0
公开(公告)日：2007-08-31
申请号：AP2007004125
申请日：2006-02-27
申请人： SERENEX INC
发明人： HUANG KENNETH HE , EAVES JERON , VEAL JAMES
IPC分类号： C07D231/56 , A61K31/416 , A61P35/00 , C07D209/14

10. 发明专利

AU2006292429A1 Carbazole derivatives 未知
公开(公告)号：AU2006292429A1
公开(公告)日：2007-03-29
申请号：AU2006292429
申请日：2006-09-15
申请人： SERENEX INC
发明人： VEAL JAMES , BARTA THOMAS E , HANSON GUNNAR J , HUANG KENNETH HE , GENG LIFENG
IPC分类号： C07D209/04 , A61K31/404 , A61P35/00 , C07D209/56 , C07D401/12 , C07D471/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of Formula I: wherein n, R 1 , R 2 , R 3 , X, R 4 , R 5 , R 6 , R 8 , R 9 , and Y are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation and/or abnormal cell mitosis, such as cancer, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

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