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1. 发明申请

WO2021053100A1 TECHNIQUES FOR CHECKING A VALIDITY OF A MASS AXIS CALIBRATION OF A MASS SPECTROMETER OF AN ANALYZER SYSTEM 审中-公开
公开(公告)号：WO2021053100A1
公开(公告)日：2021-03-25
申请号：PCT/EP2020/076027
申请日：2020-09-17
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： QUINT, Stefan , SCHWEINBERGER, Florian
IPC分类号： H01J49/00
摘要： In one aspect, the present disclosure relates to a method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, the method comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the mass spectrometer and automatically processing the mass axis check sample, comprising performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points within the predetermined m/z measurement range of the MS to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode or at least a first full scan measurement for a first mass filter or the mass spectrometer and a second full scan mode for a second mass filter of the mass spectrometer; wherein the multiple different full scan MS measurements are selected so that a maximum measurement time in the mass spectrometer is below 5 minutes, comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a mass axis calibration condition is out of specification based on a result of the comparing steps.

2. 发明申请

WO2017129803A1 ELECTROCHEMILUMINESCENCE METHOD AND APPARATUS FOR DETECTING AN ANALYTE IN A LIQUID SAMPLE 审中-公开
标题翻译：用于检测液体样品中分析物的电化学发光方法和装置
公开(公告)号：WO2017129803A1
公开(公告)日：2017-08-03
申请号：PCT/EP2017/051868
申请日：2017-01-27
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： QUINT, Stefan , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C12Q1/00 , G01N33/543 , G01N33/58
CPC分类号： C12Q1/00 , G01N33/5438 , G01N33/582
摘要： The application relates to an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell (108), the measuring cell (108) comprising a working electrode (120) for detecting the analyte using an electrochemiluminescence measurement cycle, the method comprising a. carrying out the measurement cycle in a calibration process using a liquid sample void of the analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode (120), b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second E!S being performed using the working electrode (120), c. comparing the result of the first EIS and the second EIS, providing an indication of a measurement state indicating if the comparison results that a deviation between the first EIS and the second EIS is exceeding a predefined threshold.
摘要翻译：本申请涉及使用测量单元（108）检测液体样品中的分析物的电化学发光方法，所述测量单元（108）包括工作电极（120），所述工作电极用于使用电化学发光测量周期，该方法包括a。在使用分析物的液体样品空隙的校准过程中执行测量循环，并且在测量循环的给定点执行第一电化学阻抗谱EIS，第一EIS使用工作电极（120），b 。在使用含有分析物的液体样品的分析过程中执行测量循环，并且在测量循环的给定点处执行第二EIS，第二EIS使用工作电极（120）进行，c。比较第一EIS和第二EIS的结果，提供测量状态的指示，指示比较是否导致第一EIS和第二EIS之间的偏差超过预定义的阈值。

3. 发明申请

WO2023012112A1 METHOD FOR DETERMINING LIFETIME OF AT LEAST ONE CHROMATOGRAPHY COLUMN 审中-公开
公开(公告)号：WO2023012112A1
公开(公告)日：2023-02-09
申请号：PCT/EP2022/071568
申请日：2022-08-01
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： LAUBENDER, Ruediger , QUINT, Stefan , WAGNER, Marius
IPC分类号： G01N30/86
摘要： A computer implemented method (140) for determining lifetime of at least one chromatography column (116) of at least one chromatography device (110), wherein the method (140) comprises the following steps: i) receiving model input chromatography data via at least one communication interface (128); ii) determining at least one state variable indicative of lifetime of the chromatography column (116) using at least one data driven model based on the model input chromatography data using at least one processing device (130); iii) evaluating the determined state variable thereby determining information about lifetime by using the processing device (130), wherein the evaluation comprises comparing the determined state variable to at least one threshold. Further, a test system (112), a computer program and a method for operating a chromatography column (116) are disclosed.

4. 发明申请

WO2021209373A1 ANALYTICAL SYSTEM AND METHOD INCLUDING SWITCHING BETWEEN LIQUID CHROMATOGRAPHY FLUIDIC STREAMS 审中-公开
公开(公告)号：WO2021209373A1
公开(公告)日：2021-10-21
申请号：PCT/EP2021/059412
申请日：2021-04-12
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： QUINT, Stefan , TOTH, Tibor , VAN DOORN, Aart Pieter
IPC分类号： G01N30/46
摘要： The present disclosure is related to an analytical system (100) comprising a liquid chromatographic (LC) system (10) comprising a plurality of fluidic streams (11, 12, 13, Sn-1, Sn, Sn+1) alternately connectable to a common detector (60) via a stream-selection valve (20) connected to the detector (60) via a valve-to-detector conduit (30). The analytical system (100) further comprises a wash pump (40) fluidically connected to the stream-selection valve (20) and configured to connect to the valve-to-detector conduit (30) between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to- detector conduit (30) before liquid from a subsequent fluidic stream enters the valve-to- detector conduit (30). An analytical method comprising switching between the fluidic streams (11, 12, 13, Sn-1, Sn, Sn+1) and washing in between is also disclosed.

5. 发明申请

WO2021122730A1 METHOD AND DEVICE FOR MULTIPLE TRANSITION MONITORING 审中-公开
公开(公告)号：WO2021122730A1
公开(公告)日：2021-06-24
申请号：PCT/EP2020/086399
申请日：2020-12-16
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： QUINT, Stefan , SCHWEINBERGER, Florian , TIEMANN, Benjamin
IPC分类号： H01J49/42 , H01J49/421 , H01J49/427
摘要： A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer (110) is disclosed. The method comprising the following steps: a) at least one voltage application step (112), wherein in the voltage application step a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes (114) of at least one mass filter (116) of the quadrupole mass analyzer (110), wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ΔVDC of the supplementary AC voltage is ≤ (I), wherein VDC, max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board (118) of the mass filter (116) of the quadrupole mass analyzer (110); b) at least one measurement step (122), wherein at least one transition of the analyte is determined with at least one detector (120) of the quadrupole mass analyzer (110).

6. 发明申请

WO2017153574A1 BRANCHED-CHAIN AMINES IN ELECTROCHEMILUMINESCENCE DETECTION 审中-公开
标题翻译：电化学发光检测中的分支链胺
公开(公告)号：WO2017153574A1
公开(公告)日：2017-09-14
申请号：PCT/EP2017/055671
申请日：2017-03-10
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： JOSEL, Hans-Peter , ANDRES, Herbert , WINDFUHR, Michaela , LARBOLETTE, Oliver , QUINT, Stefan
IPC分类号： B01L3/00 , G01N21/76 , G01N33/543 , G01N35/00
CPC分类号： G01N21/76 , C07F15/0033 , C07F15/0046 , G01N21/66 , G01N27/308 , G01N33/5438 , G01N2458/30
摘要： The invention concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the invention relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
摘要翻译：本发明涉及使用新的试剂组合物通过电化学发光来检测样品中的分析物的方法。公开了新的试剂组合物，用于测量电化学发光（ECL）的试剂盒和使用该新试剂组合物的电化学发光检测方法。特别地，本发明涉及可用于所述测量中的化合物的新组合的用途，以提供改进的测定性能。

7. 发明公开

EP3786634A1 TECHNIQUES FOR CHECKING STATE OF ANALYZERS 审中-公开
公开(公告)号：EP3786634A1
公开(公告)日：2021-03-03
申请号：EP19193864.6
申请日：2019-08-27
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KAMINSKI, Mark , QUINT, Stefan , TIEMANN, Benjamin
IPC分类号： G01N30/32 , G01N30/86 , G01N30/20 , G01N30/24
摘要： In one general aspect, the present invention relates to a method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer. The method includes automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.

8. 发明公开

EP4006952A1 ANOMALY DETECTION OF GAS FLOW PARAMETERS IN MASS SPECTROMETRY 审中-公开
公开(公告)号：EP4006952A1
公开(公告)日：2022-06-01
申请号：EP20209866.1
申请日：2020-11-25
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： LANG, Robert , PUNZMANN, Gabriele , QUINT, Stefan
IPC分类号： H01J49/00 , H01J49/04 , H01J49/10
摘要： In one general aspect, the present disclosure relates to a mass spectrometry (MS) apparatus. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.

9. 发明授权

EP3408401B1 ELECTROCHEMILUMINESCENCE METHOD AND APPARATUS FOR DETECTING AN ANALYTE IN A LIQUID SAMPLE 有权
公开(公告)号：EP3408401B1
公开(公告)日：2019-11-20
申请号：EP17702082.3
申请日：2017-01-27
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： QUINT, Stefan , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C12Q1/00 , G01N33/543 , G01N33/58

10. 发明公开

EP4381289A1 METHOD FOR DETERMINING LIFETIME OF AT LEAST ONE CHROMATOGRAPHY COLUMN 审中-实审
公开(公告)号：EP4381289A1
公开(公告)日：2024-06-12
申请号：EP22748388.0
申请日：2022-08-01
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： LAUBENDER, Ruediger , QUINT, Stefan , WAGNER, Marius
IPC分类号： G01N30/86
CPC分类号： G01N30/8658

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