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1. 发明申请

US20070117143A1 ATM RELATED KINASE ATX, NUCLEIC ACIDS ENCODING SAME AND METHODS OF USE 失效
标题翻译： ATM相关激素ATX，编码其的核酸和使用方法
公开(公告)号：US20070117143A1
公开(公告)日：2007-05-24
申请号：US11643551
申请日：2006-12-20
申请人： Robert Abraham , Diane Otterness
发明人： Robert Abraham , Diane Otterness
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/12 , C12P21/06
CPC分类号： C07H21/04 , C07K2319/00 , C12N9/1205
摘要： The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as SEQ ID NO:2 is further provided as well as an antibody, or antigen binding fragment thereof, which specifically binds to an ATX polypeptide and has an amino acid sequence as referenced in SEQ ID NO:2. A method for identifying an ATX-modulatory compound is additionally provided. The method consists of measuring the level of an ATX polypeptide in the presence of a test compound, wherein a difference in the level of said ATX polypeptide in the presence of said test compound compared to in the absence of said test compound indicating that said test compound is an ATX-modulatory compound, and wherein said ATX-modulatory compound is not caffeine or wortmannin.
摘要翻译：本发明提供具有与SEQ ID NO：1基本相同的核苷酸序列的分离的核酸分子。还提供了具有SEQ ID NO：11所示的核苷酸序列的至少15个连续核苷酸的分离的寡核苷酸。还提供具有与SEQ ID NO：2基本上相同的氨基酸序列的分离的多肽以及特异性结合ATX多肽并具有SEQ ID NO：2所述的氨基酸序列的抗体或其抗原结合片段：2。另外提供了鉴定ATX调节化合物的方法。所述方法包括在存在测试化合物的情况下测量ATX多肽的水平，其中所述ATX多肽在所述测试化合物存在下的水平与不存在所述测试化合物相比的差异表明所述测试化合物是ATX调节化合物，其中所述ATX调节化合物不是咖啡因或渥曼青霉素。

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