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1. 发明授权

US06609071B2 System for monitoring and controlling pressure and concentration values in a fluid conduit 失效
公开(公告)号：US06609071B2
公开(公告)日：2003-08-19
申请号：US09729703
申请日：2000-12-06
申请人： Philip Shapiro , John Davis-Reinhold , Julian Warhurst , Charles Daniel Hayes
发明人： Philip Shapiro , John Davis-Reinhold , Julian Warhurst , Charles Daniel Hayes
IPC分类号： G06F1900
CPC分类号： A61M5/142 , A61B5/0215 , A61M5/007 , A61M2205/3355 , G01N27/10
摘要： A system for monitoring and regulating pressure and concentration in a moving fluid stream inside of a conduit is provided. The fluid stream includes a first fluid. The system comprises an infusion assembly that includes a catheter having a series of holes distributed around an exterior surface and a pumping system for introducing a second fluid into said catheter to create a solution mixture. A data collection system is provided for collecting data indicative of pressure and conductivity values. Data from the data collection system is forwarded to a data processing and control apparatus. The data processing and control apparatus comprises conversion means for converting the measured conductivity into a concentration value and control means for controlling operation of the infusion assembly based on a comparison of selected values with data received from the data collection system. A user control and analysis system allows user interaction. The system allows complete automatic control over the fluid distribution within a fluid conduit in response to measured values.

2. 发明申请

US20110296931A1 Pipette Tip Positioning For Manually-Directed, Multi-Channel Electronic Pipettor 有权
标题翻译：手持式多通道电子移液器移液器尖端定位
公开(公告)号：US20110296931A1
公开(公告)日：2011-12-08
申请号：US13099854
申请日：2011-05-03
申请人： Julian Warhurst
发明人： Julian Warhurst
IPC分类号： B01L3/02
CPC分类号： B01L3/0234 , B01L3/0227 , B01L3/0237 , B01L2200/025 , B01L2200/087 , B01L2200/14 , B01L2300/027 , B01L2300/0829 , B01L2400/0487
摘要： A manually directed, multi-channel electronic pipettor includes a software biasing mode to assure proper alignment over wells in the 96-well plate and the 384-well plate. The system also includes manual repositioning levers for nesting receptacles which are customized for 96 well-plates and 384 well-plates respectively.
摘要翻译：手动导向的多通道电子移液器包括软件偏置模式，以确保在96孔板和384孔板中的孔正确对准。该系统还包括针对96孔板和384孔板定制的嵌套容器的手动重新定位杆。

3. 发明授权

US07861540B2 Automated storage and retrieval system for storing biological or chemical samples at ultra-low temperatures 有权
标题翻译：用于在超低温下存储生物或化学样品的自动存储和检索系统
公开(公告)号：US07861540B2
公开(公告)日：2011-01-04
申请号：US12020246
申请日：2008-01-25
申请人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
发明人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
IPC分类号： F25D13/06 , F25D25/02
CPC分类号： F25D17/06 , F25D11/04 , F25D13/04 , F25D23/025 , F25D25/04 , F25D2317/0666 , G01N1/42
摘要： An automated storage and retrieval system stores containers, typically containing biological or chemical samples, at ultra-low temperatures, i.e., from about −50° C. to about −90° C., preferably about −80° C. under normal operating conditions. Dry gas air flows are used to reduce moisture and the consequential frost within the freezer compartment. A custom insulated door is provided with an access module and a tube picking compartment as well as servo motors for controlling a robot within the ultra-low temperature freezer compartment. The robot automatically places sample storage containers in stationary storage racks within the freezer compartment. Magnetic couplings are used to transmit mechanical power from outside of the freezer compartment to the robot inside of the freezer compartment. The robot has a simplified mechanical configuration. The custom door can be readily attached to standard freezer bodies.
摘要翻译：自动存储和检索系统通常包含生物或化学样品的容器，在正常操作条件下，超低温即约-50℃至约-90℃，优选约-80℃ 。干气体气流用于减少冷冻室内的水分和结霜。定制绝缘门设有一个进出口模块和一个采摘隔间，以及用于控制超低温冷冻室内机器人的伺服电机。机器人将样品储存容器自动放置在冷冻室内的固定储物架中。磁耦合用于将冷冻室外部的机械动力传递到冷冻室内的机器人内部。机器人具有简化的机械配置。定制门可以很容易地连接到标准的冷冻机身上。

4. 发明授权

US09163869B2 Tube picking mechanisms with an ultra-low temperature or cryogenic picking compartment 有权
标题翻译：具有超低温或低温采摘隔室的管采摘机构
公开(公告)号：US09163869B2
公开(公告)日：2015-10-20
申请号：US13193838
申请日：2011-07-29
申请人： Julian Warhurst , Bruce Zandi , Alexander Carbone , Frank Hunt , Robert Cloutier , James O'Toole , Elizabeth Alexander
发明人： Julian Warhurst , Bruce Zandi , Alexander Carbone , Frank Hunt , Robert Cloutier , James O'Toole , Elizabeth Alexander
IPC分类号： G01N21/00 , F25D13/06 , F25D13/04 , G01N1/42 , G01N35/00 , F25D11/04 , F25D25/04
CPC分类号： F25D13/06 , F25D11/04 , F25D13/04 , F25D25/04 , G01N1/42 , G01N35/0099
摘要： A tube picking mechanism is designed for use in an automated, ultra-low temperature (e.g. −80° C. or −135° C.) or cryogenic (e.g., about −140° C. to −196° C.) storage and retrieval system that stores biological or chemical samples. The samples are contained in storage tubes held in SBS footprint storage racks that are normally stored within an ultra-low temperature or cryogenic freezer compartment. The tube picking mechanism includes a tube picking chamber that is maintained at about −80° C., about −135° C. or at cryogenic temperatures in cryogenic applications. Active electrical and mechanical components are maintained in a compartment above and separate from the refrigerated, ultra-low temperature or cryogenic compartment. Thermal stratification inhibits heat transfer into the lower, ultra-low temperature or cryogenic compartment in which tube picking occurs from the upper compartment in which active electrical and mechanical components are located, and also inhibits heat transfer into the lower, ultra-low temperature or cryogenic compartment via an access door for tube storage racks.
摘要翻译：管采摘机构设计用于自动化，超低温（例如-80℃或-135℃）或低温（例如约-140℃至-196℃）的储存和存储生物或化学样品的检索系统。样品包含在通常存储在超低温或低温冷冻室内的SBS足迹存储架中的储存管中。管拾取机构包括在低温应用中保持在约-80℃，约-135℃或低温温度下的管采集室。主动的电气和机械部件保持在冷藏的，超低温或低温隔室的上方并与其分离的隔室中。热分层抑制热量传递到下层，超低温或低温隔室，其中管采摘从其中有效的电气和机械部件所在的上隔室发生，并且还抑制热传递到较低的，超低温或低温隔间通过管子储存架的检修门。

5. 发明申请

US20120060541A1 Sample Storage Cassette for Ultra-Low or Cryogenic Temperatures 有权
标题翻译：样品储存盒用于超低温或低温温度
公开(公告)号：US20120060541A1
公开(公告)日：2012-03-15
申请号：US13228662
申请日：2011-09-09
申请人： Frank Hunt , Julian Warhurst , Bruce Zandi , Robert Cloutier
发明人： Frank Hunt , Julian Warhurst , Bruce Zandi , Robert Cloutier
IPC分类号： F25D3/10 , A47B96/02 , A47B87/00 , F17C3/00 , F25D13/02
CPC分类号： G01N35/04 , A01N1/0236 , A01N1/0252 , B01L7/50 , B01L9/06 , B01L2200/026 , B01L2200/04 , B01L2300/021 , B01L2300/04 , B65G1/00 , F17C3/085 , F25D25/00 , F25D25/04 , G01N1/42 , G01N35/0099 , G01N2035/00346 , G01N2035/00435 , G01N2035/042 , G01N2035/0425 , G01N2035/0462
摘要： A storage cassette including a plurality of generally vertical compartments for storing sample tube racks and/or SBS formatted plates is constructed to be flexible along its substantially vertical axis thereby facilitating reliable robotic placement and retrieval of the cassette from nesting tubes located within a horizontal freezer compartment. Insulated walls and solid shelves minimize heat transfer from storage racks or plates placed in the storage cassette when the cassette is removed from an ultra-low temperature or cryogenic freezer. The outer walls of the cassette includes mechanical indexing locations to ensure appropriate positioning when robotically removing storage racks or plates from the cassette.
摘要翻译：包括用于存储样品管架和/或SBS格式化板的多个大致垂直的隔室的存储盒被构造成沿其基本垂直的轴线是柔性的，从而便于从位于水平冷冻室内的嵌套管的可靠的机器人放置和取出盒。当超低温或低温冷冻箱中取出盒子时，绝缘墙和固体搁板可最大限度地减少从存储盒中放置的存储架或板的热传递。盒子的外壁包括机械分度位置，以确保在将存储架或板从盒中机械地移除时的适当定位。

6. 发明申请

US20120060514A1 Tube Picking Mechanisms with an Ultra-Low Temperature or Cryogenic Picking Compartment 有权
标题翻译：具有超低温或低温采摘室的管采摘机制
公开(公告)号：US20120060514A1
公开(公告)日：2012-03-15
申请号：US13193838
申请日：2011-07-29
申请人： Julian Warhurst , Bruce Zandi , Alexander Carbone , Frank Hunt , Robert Cloutier , James O'Toole , Elizabeth Alexander
发明人： Julian Warhurst , Bruce Zandi , Alexander Carbone , Frank Hunt , Robert Cloutier , James O'Toole , Elizabeth Alexander
IPC分类号： F25D25/00 , F25B9/04 , B66F11/00 , F25B21/02
CPC分类号： F25D13/06 , F25D11/04 , F25D13/04 , F25D25/04 , G01N1/42 , G01N35/0099
摘要： A tube picking mechanism is designed for use in an automated, ultra-low temperature (e.g. −80° C. or −135° C.) or cryogenic (e.g., about −140° C. to −196° C.) storage and retrieval system that stores biological or chemical samples. The samples are contained in storage tubes held in SBS footprint storage racks that are normally stored within an ultra-low temperature or cryogenic freezer compartment. The tube picking mechanism includes a tube picking chamber that is maintained at about −80° C., about −135° C. or at cryogenic temperatures in cryogenic applications. Active electrical and mechanical components are maintained in a compartment above and separate from the refrigerated, ultra-low temperature or cryogenic compartment. Thermal stratification inhibits heat transfer into the lower, ultra-low temperature or cryogenic compartment in which tube picking occurs from the upper compartment in which active electrical and mechanical components are located, and also inhibits heat transfer into the lower, ultra-low temperature or cryogenic compartment via an access door for tube storage racks.
摘要翻译：管采摘机构设计用于自动化，超低温（例如-80℃或-135℃）或低温（例如约-140℃至-196℃）的储存和存储生物或化学样品的检索系统。样品包含在通常存储在超低温或低温冷冻室内的SBS足迹存储架中的储存管中。管拾取机构包括在低温应用中保持在约-80℃，约-135℃或低温温度下的管采集室。主动的电气和机械部件保持在冷藏的，超低温或低温隔室的上方并与其分离的隔室中。热分层抑制热量传递到下层，超低温或低温隔室，其中管采摘从其中有效的电气和机械部件所在的上隔室发生，并且还抑制热传递到较低的，超低温或低温隔间通过管子储存架的检修门。

7. 发明申请

US20110088424A1 Automated Storage and Retrieval System for Storing Biological or Chemical Samples at Ultra-Low Temperatures 审中-公开
标题翻译：用于在超低温下储存生物或化学样品的自动存储和检索系统
公开(公告)号：US20110088424A1
公开(公告)日：2011-04-21
申请号：US12977371
申请日：2010-12-23
申请人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
发明人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
IPC分类号： F25C5/18 , F25D25/00
CPC分类号： F25D17/06 , F25D11/04 , F25D13/04 , F25D23/025 , F25D25/04 , F25D2317/0666 , G01N1/42
摘要： An automated storage and retrieval system stores containers, typically containing biological or chemical samples, at ultra-low temperatures, i.e., from about −50° C. to about −90° C., preferably about −80° C. under normal operating conditions. A robot automatically places sample storage containers in stationary storage racks within the freezer compartment. Magnetic couplings are used to transmit mechanical power from outside of the freezer compartment to the robot inside of the freezer compartment. The robot has a simplified mechanical configuration.
摘要翻译：自动存储和检索系统通常包含生物或化学样品的容器，在正常操作条件下，超低温即约-50℃至约-90℃，优选约-80℃ 。机器人将样品储存容器自动放置在冷冻室内的固定储物架内。磁耦合用于将冷冻室外部的机械动力传递到冷冻室内的机器人内部。机器人具有简化的机械配置。

8. 发明授权

US08372356B2 Manually directed, multi-channel electronic pipetting system 有权
标题翻译：手动导向，多通道电子移液系统
公开(公告)号：US08372356B2
公开(公告)日：2013-02-12
申请号：US13099782
申请日：2011-05-03
申请人： Julian Warhurst , Gary Nelson , Richard Cote
发明人： Julian Warhurst , Gary Nelson , Richard Cote
IPC分类号： B01L3/02
CPC分类号： B01L3/0227 , B01L3/0234 , B01L3/0237 , B01L9/523 , B01L2200/087 , B01L2200/146 , B01L2300/027 , B01L2300/06 , B01L2300/0829 , B01L2400/0478
摘要： A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.
摘要翻译：手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。优选的移液头包括96针头配件的阵列。具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。

9. 发明授权

US08176747B2 Tube picking mechanism for an automated, ultra-low temperature storage and retrieval system 有权
标题翻译：用于自动化，超低温存储和检索系统的管拾取机构
公开(公告)号：US08176747B2
公开(公告)日：2012-05-15
申请号：US12184025
申请日：2008-07-31
申请人： Raymond T. Howard , Julian Warhurst , Behrouz Zandi , Michael A. Carman , James O'Toole
发明人： Raymond T. Howard , Julian Warhurst , Behrouz Zandi , Michael A. Carman , James O'Toole
IPC分类号： F25D25/00
CPC分类号： F25D13/06 , A01N1/0252 , B01L7/50 , G01N1/42 , G01N2035/00445
摘要： A tube picking mechanism is designed for use in an automated, ultra-low temperature (e.g., −80° C.) storage and retrieval systems which stores biological or chemical samples. The samples are contained in storage tubes held in SBS footprint storage racks that are loaded into trays located within an ultra-low temperature freezer compartment (−80° C.). A tube picking mechanism resides in a tube picking chamber that is located adjacent the freezer compartment. The tube picking chamber is maintained at about −20° C. when the tube picking mechanism is in operation. The tube picking mechanism includes a cache within the tube picking chamber to facilitate fast paced shuttling of the tube racks from the freezer compartment into the tube picking chamber. The shuttle has a clamping mechanism to secure a tube rack in place when a gripper head picks a tube from the rack. The system also includes a push pin that pushes on the bottom of the respective tube as it is being picked from the tube rack. A one-dimensional bar code reader is included within the tube picking chamber. The gripper head is able to move vertically and rotate within the field of view of the one-dimensional bar code reader in order to facilitate identification and reading of one-dimensional bar codes located on the sidewall of picked storage tubes. The system also uses fans to facilitate efficient cooling of the tube picking chamber.
摘要翻译：管拾取机构被设计用于存储生物或化学样品的自动化，超低温（例如-80℃）的储存和检索系统。样品包含在保存在SBS足迹存储架中的储存管中，其装载到位于超低温冷冻室（-80℃）内的托盘中。管拾取机构位于邻近冷冻室的管采摘室中。当管采摘机构运行时，管采摘室保持在-20℃左右。管拾取机构包括管采摘室内的高速缓存器，以便将管架从冷冻室快速往复运动到管采集室中。梭子具有夹紧机构，用于在夹头从机架拾取管时将管架固定到位。该系统还包括一个推销，当它从管架上被拾取时，其推动相应管子的底部。管采摘室中包括一维条形码阅读器。夹持头能够在一维条形码读取器的视野内垂直移动并旋转，以便于识别和读取位于拾取的存储管的侧壁上的一维条形码。该系统还使用风扇来促进管采摘室的有效冷却。

10. 发明申请

US20090188272A1 AUTOMATED STORAGE AND RETRIEVAL SYSTEM FOR STORING BIOLOGICAL OR CHEMICAL SAMPLES AT ULTRA-LOW TEMPERATURES 有权
标题翻译：用于在超低温下存储生物或化学样品的自动存储和检索系统
公开(公告)号：US20090188272A1
公开(公告)日：2009-07-30
申请号：US12020246
申请日：2008-01-25
申请人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
发明人： Robert P. Cloutier , Julian Warhurst , Behrouz Zandi , James O'Toole , Halvard Solberg
IPC分类号： F25D25/00 , F25D13/06
CPC分类号： F25D17/06 , F25D11/04 , F25D13/04 , F25D23/025 , F25D25/04 , F25D2317/0666 , G01N1/42
摘要： An automated storage and retrieval system stores containers, typically containing biological or chemical samples, at ultra-low temperatures, i.e., from about −50° C. to about −90° C., preferably about −80° C. under normal operating conditions. Dry gas air flows are used to reduce moisture and the consequential frost within the freezer compartment. A custom insulated door is provided with an access module and a tube picking compartment as well as servo motors for controlling a robot within the ultra-low temperature freezer compartment. The robot automatically places sample storage containers in stationary storage racks within the freezer compartment. Magnetic couplings are used to transmit mechanical power from outside of the freezer compartment to the robot inside of the freezer compartment. The robot has a simplified mechanical configuration. The custom door can be readily attached to standard freezer bodies.
摘要翻译：自动存储和检索系统通常包含生物或化学样品的容器，在正常操作条件下，超低温即约-50℃至约-90℃，优选约-80℃ 。干气体气流用于减少冷冻室内的水分和结霜。定制绝缘门设有一个进出口模块和一个采摘隔间，以及用于控制超低温冷冻室内机器人的伺服电机。机器人将样品储存容器自动放置在冷冻室内的固定储物架中。磁耦合用于将冷冻室外部的机械动力传递到冷冻室内的机器人内部。机器人具有简化的机械配置。定制门可以很容易地连接到标准的冷冻机身上。

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