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1. 发明申请

US20060217614A1 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US20060217614A1
公开(公告)日：2006-09-28
申请号：US11089528
申请日：2005-03-24
申请人： Panu Takala , Matti Huiku
发明人： Panu Takala , Matti Huiku
IPC分类号： A61B5/02
CPC分类号： A61B5/4821 , A61B5/02 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/0402 , A61B5/0816 , A61B5/4824
摘要： The invention relates to the determination of the clinical state of a subject. In order to bring about an uncomplicated method for monitoring the clinical state of a subject and for accomplishing a diagnostic scale, such as a nociception scale, on which a certain reading corresponds to the same level for all patients, a normalization transform is applied to a measurement signal containing physiological data obtained from a patient, whereby a normalized measurement signal having a predetermined value range is obtained. The normalization transform is dependent on predetermined history data, such as previous signal data of said measurement signal. A diagnostic index dependent on the normalized measurement signal is then formed, the diagnostic index serving as a measure of the clinical state of the patient. The diagnostic index may be formed based on one or more normalized measurement signals.
摘要翻译：本发明涉及确定受试者的临床状态。为了实现用于监测受试者的临床状态和完成诊断量表（例如伤害感受量表）的简单方法，其中某一读数对应于所有患者的相同水平，归一化变换被应用于测量信号，其包含从患者获得的生理数据，由此获得具有预定值范围的归一化测量信号。归一化变换取决于预定历史数据，例如所述测量信号的先前信号数据。然后形成依赖于归一化测量信号的诊断指标，诊断指标用作患者临床状态的量度。诊断指标可以基于一个或多个归一化的测量信号形成。

2. 发明授权

US08715193B2 Determination of the clinical state of a subject 有权
标题翻译：确定受试者的临床状态
公开(公告)号：US08715193B2
公开(公告)日：2014-05-06
申请号：US11089528
申请日：2005-03-24
申请人： Panu Takala , Matti Huiku
发明人： Panu Takala , Matti Huiku
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/4821 , A61B5/02 , A61B5/021 , A61B5/02416 , A61B5/0261 , A61B5/0402 , A61B5/0816 , A61B5/4824
摘要： The invention relates to the determination of the clinical state of a subject. In order to bring about an uncomplicated method for monitoring the clinical state of a subject and for accomplishing a diagnostic scale, such as a nociception scale, on which a certain reading corresponds to the same level for all patients, a normalization transform is applied to a measurement signal containing physiological data obtained from a patient, whereby a normalized measurement signal having a predetermined value range is obtained. The normalization transform is dependent on predetermined history data, such as previous signal data of said measurement signal. A diagnostic index dependent on the normalized measurement signal is then formed, the diagnostic index serving as a measure of the clinical state of the patient. The diagnostic index may be formed based on one or more normalized measurement signals.
摘要翻译：本发明涉及确定受试者的临床状态。为了实现用于监测受试者的临床状态和完成诊断量表（例如伤害感受量表）的简单方法，其中某个读数对应于所有患者的相同水平，归一化变换被应用于测量信号，其包含从患者获得的生理数据，由此获得具有预定值范围的归一化测量信号。归一化变换取决于预定历史数据，例如所述测量信号的先前信号数据。然后形成依赖于归一化测量信号的诊断指标，诊断指标用作患者临床状态的量度。诊断指标可以基于一个或多个归一化的测量信号形成。

3. 发明授权

US07635337B2 Determination of clinical stress of a subject in pulse oximetry 失效
标题翻译：脉搏血氧饱和度测定受试者的临床应激
公开(公告)号：US07635337B2
公开(公告)日：2009-12-22
申请号：US11089548
申请日：2005-03-24
申请人： Matti Huiku , Panu Takala
发明人： Matti Huiku , Panu Takala
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/14551 , A61B5/08 , A61B5/4821 , A61B5/4824
摘要： The invention relates to the determination of the clinical stress of a subject. In order to bring about an uncomplicated and cost-effective method for monitoring the stress status of a subject, plethysmographic signal data is acquired from the subject and a first measurement signal is derived, which is indicative of a predetemined feature of the respiration modulation appearing in the said signal data. An index signal is then formed based on the first measurement signal and the index signal is employed as an index indicative of the clinical stress of the subject.
摘要翻译：本发明涉及确定受试者的临床压力。为了实现用于监测受试者的应激状态的简单且成本有效的方法，从受试者获取体积描记信号数据，并且导出第一测量信号，其表示出现在呼吸调节中的预调节特征所述信号数据。然后基于第一测量信号形成索引信号，并且使用索引信号作为指示对象的临床压力的指标。

4. 发明申请

US20060217615A1 Determination of clinical stress of a subject in pulse oximetry 失效
公开(公告)号：US20060217615A1
公开(公告)日：2006-09-28
申请号：US11089548
申请日：2005-03-24
申请人： Matti Huiku , Panu Takala
发明人： Matti Huiku , Panu Takala
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/14551 , A61B5/08 , A61B5/4821 , A61B5/4824
摘要： The invention relates to the determination of the clinical stress of a subject. In order to bring about an uncomplicated and cost-effective method for monitoring the stress status of a subject, plethysmographic signal data is acquired from the subject and a first measurement signal is derived, which is indicative of a predetemined feature of the respiration modulation appearing in the said signal data. An index signal is then formed based on the first measurement signal and the index signal is employed as an index indicative of the clinical stress of the subject.

5. 发明授权

US07549959B2 Stimulation arrangement for measurement of physiological signal reactivity 有权
标题翻译：用于测量生理信号反应性的刺激方案
公开(公告)号：US07549959B2
公开(公告)日：2009-06-23
申请号：US11743834
申请日：2007-05-03
申请人： Panu Takala , Juha Virtanen
发明人： Panu Takala , Juha Virtanen
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/0484 , A61B5/0205 , A61B5/0402 , A61B5/7285
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a subject. In order to obtain a compact measurement arrangement that enables reliable assessment of changes in the reactivity of the subject even during a long time period, a conventional monitoring device is provided with a stimulation module configured to supply stimuli to the subject through a measurement probe that the device uses to receive physiological signal data from the subject. The measurement probe may comprise, for example, an arm cuff through which the device monitors the blood pressure of the subject.
摘要翻译：本发明涉及一种用于评估受试者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了获得紧凑的测量装置，即使在长时间段内也能够可靠地评估对象的反应性变化，常规的监视装置设置有刺激模块，该刺激模块被配置为通过测量探针向受试者提供刺激，设备用于从受试者接收生理信号数据。测量探针可以包括例如臂套，该装置通过该袖带监测受试者的血压。

6. 发明申请

US20080275347A1 Stimulation Arrangement For Measurement Of Physiological Signal Reactivity 有权
标题翻译：用于测量生理信号反应性的刺激方案
公开(公告)号：US20080275347A1
公开(公告)日：2008-11-06
申请号：US11743834
申请日：2007-05-03
申请人： Panu Takala , Juha Virtanen
发明人： Panu Takala , Juha Virtanen
IPC分类号： A61B5/02 , A61B5/0476
CPC分类号： A61B5/0484 , A61B5/0205 , A61B5/0402 , A61B5/7285
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a subject. In order to obtain a compact measurement arrangement that enables reliable assessment of changes in the reactivity of the subject even during a long time period, a conventional monitoring device is provided with a stimulation module configured to supply stimuli to the subject through a measurement probe that the device uses to receive physiological signal data from the subject. The measurement probe may comprise, for example, an arm cuff through which the device monitors the blood pressure of the subject.
摘要翻译：本发明涉及一种用于评估受试者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了获得紧凑的测量装置，即使在长时间段内也能够可靠地评估对象的反应性变化，常规的监视装置设置有刺激模块，该刺激模块被配置为通过测量探针向受试者提供刺激，设备用于从受试者接收生理信号数据。测量探针可以包括例如臂套，该装置通过该袖带监测受试者的血压。

7. 发明授权

US07330750B2 Estimation of cardiac death risk 有权
标题翻译：心脏死亡风险的估计
公开(公告)号：US07330750B2
公开(公告)日：2008-02-12
申请号：US10423474
申请日：2003-04-25
申请人： Jouni Erkkilä , Mikko Kaski , Panu Takala
发明人： Jouni Erkkilä , Mikko Kaski , Panu Takala
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7275 , G06F19/00
摘要： The invention relates to a method and apparatus for predicting a sudden heart abnormality for an individual patient. In order to provide a prediction mechanism that is suitable for acute care, three sub-indices are determined based on medical data obtained from the patient. The first sub-index indicates the level of deterministic chaos in the heart rate variability of the patient, the second sub-index indicates the energy level in the myocardium of the patient, and the third sub-index indicates the degree of ventricular arrhythmia of the patient. Based on the first, second, and third sub-indices, at least one overall risk index is then determined, the overall risk index indicating the risk level of a sudden heart abnormality for the patient.
摘要翻译：本发明涉及一种用于预测个体患者的突发性心脏异常的方法和装置。为了提供适用于急性护理的预测机制，基于从患者获得的医学数据确定三个子指标。第一子指标表示患者心率变异性的确定性混沌水平，第二子指标表示患者心肌的能量水平，第三子指标表示患者的心律失常程度患者。根据第一，第二和第三子指数，确定至少一个总体风险指数，总体风险指数表示患者突然心脏异常的风险水平。

8. 发明申请

US20080167541A1 Interference Suppression in Spectral Plethysmography 审中-公开
标题翻译：光谱体积描记中的干扰抑制
公开(公告)号：US20080167541A1
公开(公告)日：2008-07-10
申请号：US11621203
申请日：2007-01-09
申请人： Panu Takala , Borje Rantala
发明人： Panu Takala , Borje Rantala
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/7207
摘要： The invention relates to a patient monitoring device, especially to a pulse oximeter. For suppressing the effects of an interference source causing adverse modulation in one or more blood related signals input to the device, a power spectrum is derived for each blood related signal and the frequency of an interference source causing unwanted modulation in the blood related signal(s) is identified. A weight function is determined, in which the relative weight of at least one frequency is dampened, the at least one frequency depending on the identified frequency. The weight function is applied to the power spectrum(s), thereby to obtain at least one weighted power spectrum. A blood related parameter of the subject is defined based on the at least one weighted power spectrum.
摘要翻译：本发明涉及一种患者监测装置，特别涉及一种脉搏血氧计。为了抑制在输入到装置的一个或多个血液相关信号中引起不利调制的干扰源的影响，导出针对每个血液相关信号的功率谱和在血液相关信号（s）中造成不需要的调制的干扰源的频率）。确定加权函数，其中至少一个频率的相对权重被抑制，所述至少一个频率取决于所识别的频率。权重函数被应用于功率谱，从而获得至少一个加权的功率谱。基于至少一个加权功率谱定义对象的与血液相关的参数。

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