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1. 发明专利

JP2012255006A IgE CH3 PEPTIDE VACCINE 有权
公开(公告)号：JP2012255006A
公开(公告)日：2012-12-27
申请号：JP2012175784
申请日：2012-08-08
申请人： Pfizer Vaccines Llc , ファイザーバクシーンズエルエルシー
发明人： BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
IPC分类号： C07K16/00 , A61K39/00 , A61K39/39 , A61P11/06 , A61P37/08 , C07K19/00
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： PROBLEM TO BE SOLVED: To provide novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders.SOLUTION: The invention relates to a composition coupled to an immunogenic carrier, and optionally administered with one or more adjuvants, able to induce potent non anaphylactogenic anti-lgE antibodies in an individual capable of significantly reducing levels of circulating free IgE. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical composition thereof and their use in medicine.
摘要翻译：待解决的问题：提供包含抗原性IgE肽的新型免疫原，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。解决方案：本发明涉及与免疫原性载体偶联的组合物，并且任选地与一种或多种辅助剂一起施用，其能够在能够显着降低循环游离IgE水平的个体中诱导有效的非致敏性抗IgE抗体。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物组合物及其在药物中的用途。版权所有（C）2013，JPO＆INPIT

2. 发明申请

WO2010067286A3 IgE CH3 PEPTIDE VACCINE 审中-公开
公开(公告)号：WO2010067286A3
公开(公告)日：2010-08-05
申请号：PCT/IB2009055508
申请日：2009-12-04
申请人： PFIZER VACCINES LLC , BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
发明人： BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
IPC分类号： A61K39/00 , A61P37/08 , C07K16/00
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供免疫原，其包含优选与免疫原性载体连接的抗原性IgE肽，用于预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在医药中的应用。

3. 发明申请

WO2011027257A3 PCSK9 VACCINE 审中-公开
公开(公告)号：WO2011027257A3
公开(公告)日：2011-06-30
申请号：PCT/IB2010053784
申请日：2010-08-23
申请人： PFIZER VACCINES LLC , CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
发明人： CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
IPC分类号： C12N9/64 , A61K38/08 , A61K38/10 , A61P9/00 , A61P25/28
CPC分类号： A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供包含与免疫原性载体连接的抗原性PCSK9肽的新型免疫原，用于预防，治疗或缓解PCSK9介导的病症。本发明进一步涉及生产这些药物的方法，免疫原性组合物和其药物组合物及其在医学中的用途。

4. 发明专利

PE20161560A1 VACUNA DE PCSK9 未知
公开(公告)号：PE20161560A1
公开(公告)日：2017-01-11
申请号：PE2016002242
申请日：2010-08-23
申请人： PFIZER VACCINES LLC
发明人： WYATT DAVID MICHAEL , ULLAH JAKIR HUSSAIN , QIU XIAYANG , PIERCE BRIAN GREGORY , CHAMPION BRIAN ROBERT , HAWKINS JULIE JIA LI , FRASER JAMES DOWNEY , EISENBRAUN MICHAEL DALE , CONTILLO JR LEONARD GABRIEL , MERSON JAMES RICHARD
IPC分类号： A61K38/08 , A61K38/10 , A61P9/00 , A61P25/28 , C12N9/64
摘要： Se refiere a una composicion inmunogenica que comprende al menos dos peptidos antigenicos de PCSK9 donde: a) el primer peptido antigenico de PCSK9 consiste en una secuencia de aminoacidos de SEQ ID NO: 182 a 226, 317 y 401 a 403; y b) el segundo peptido antigenico de PCSK9 consiste en una secuencia de aminoacidos de SEQ ID NO: 46-101, 314, 318 y 319; c) un vehiculo inmunogenico tal como CRM197 o VLP de Qbeta; d) un adyuvante tal como alumbre, CpG ODN, QS21 e Iscomatrix. Dicha composicion inmunogenica es util en el tratamiento, alivio o profilaxis de enfermedades asociadas con un nivel elevado de colesterol.

5. 发明专利

AU2013273674B2 PCSK9 vaccine 未知
公开(公告)号：AU2013273674B2
公开(公告)日：2015-11-05
申请号：AU2013273674
申请日：2013-12-18
申请人： PFIZER VACCINES LLC
发明人： CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
IPC分类号： C12N9/64 , A61K38/08 , A61K38/10 , A61P9/00 , A61P25/28
摘要： R4 do-25fl /2013 The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

6. 发明专利

NZ599059A Pcsk9 vaccine 未知
公开(公告)号：NZ599059A
公开(公告)日：2014-05-30
申请号：NZ59905910
申请日：2010-08-23
申请人： PFIZER VACCINES LLC
发明人： CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
IPC分类号： C12N9/64 , A61K38/08 , A61K38/10 , A61P9/00 , A61P25/28
摘要： NZ 599059 Disclosed is an immunogen comprising at least one antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide, or a functionally active variant thereof, linked to an immunogenic carrier, wherein the antigenic PCSK9 peptide consists of an amino acid sequence selected from the group consisting of SEQ ID NOs 182-188,317, and 401-403, as defined in the complete specification.

7. 发明专利

PL2473605T3 Szczepionka PCSK9 未知
公开(公告)号：PL2473605T3
公开(公告)日：2018-08-31
申请号：PL10754583
申请日：2010-08-23
申请人： PFIZER VACCINES LLC
发明人： CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
IPC分类号： C12N9/64

8. 发明专利

MX337723B VACUNA DE PEPTIDO CH3 DE IGE. 未知
公开(公告)号：MX337723B
公开(公告)日：2016-03-15
申请号：MX2013006964
申请日：2009-12-04
申请人： PFIZER VACCINES LLC
发明人： JONES LYN HOWARD , BROWN ALAN DANIEL , ROBERTS LEE RICHARD , PRYDE DAVID CAMERON , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , KJERRSTROM ANNE MARIA KRISTINA , WYATT DAVID MICHAEL
IPC分类号： A61K38/04 , A61K39/395 , A61K47/48
摘要： La presente invención se refiere a un inmunógeno caracterizado porque comprende al menos un péptido de IgE antigéno unido a un vehículo inmunogénico, en donde dicho péptido de IgE antigénico consiste de una secuencia de aminoácidos seleccionada del grupo que consiste de las SEQ ID Nos: 311-317, 326-331, 340-344, 353-356, 365-367, 376, 377 y 386.

9. 发明专利

AU2013204233B2 IgE CH3 peptide vaccine 未知
公开(公告)号：AU2013204233B2
公开(公告)日：2015-06-25
申请号：AU2013204233
申请日：2013-04-12
申请人： PFIZER VACCINES LLC
发明人： BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
IPC分类号： C07K16/00 , A61K39/00 , A61P37/08
摘要： IgE CH3 Peptide Vaccine Abstract Novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders are disclosed. Also disclosed are methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

10. 发明专利

RU2538162C2 ВАКЦИНА ПРОТИВ PCSK9 未知
公开(公告)号：RU2538162C2
公开(公告)日：2015-01-10
申请号：RU2012107657
申请日：2010-08-23
申请人： PFIZER VACCINES LLC
发明人： CHAMPION BRIAN ROBERT , CONTILLO JR LEONARD GABRIEL , EISENBRAUN MICHAEL DALE , FRASER JAMES DOWNEY , HAWKINS JULIE JIA LI , MERSON JAMES RICHARD , PIERCE BRIAN GREGORY , QIU XIAYANG , ULLAH JAKIR HUSSAIN , WYATT DAVID MICHAEL
IPC分类号： A61K38/08 , A61K38/10 , A61P9/00
摘要： Изобретениеотноситсяк областииммунологиии биотехнологии. Представлениммуногендляиндуцированияиммунногоответапротивбелка PCSK9, содержащийантигенныйпептид PCSK9, выбранныйизгруппы, состоящейизраскрытыхв описании SEQ ID NO: 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 314, 318 и 319, содержащихаминокислотнуюпоследовательность TRFHRQ, и SEQ ID NO: 182, 183, 184, 185, 186, 187, 188, 317, 401, 402 и 403, содержащихаминокислотнуюпоследовательность SIPWNLE, гдеуказанныйантигенныйпептид PCSK9 конъюгированс иммуногеннымносителем, выбраннымиз CRM197 или Qbeta вирусоподобнойчастицы (VLP). Описанакомпозициядляиндуцированияиммунногоответапротивбелка PCSK9, содержащаяпоменьшеймередваиммуногенав иммунологическиэффективныхколичествах, гдепервыйиммуногенпредставляетсобойуказанныйиммуноген. Раскрытакомпозициядляиндуцированияиммунногоответапротивбелка PCSK9, содержащаяпоменьшеймередваиммуногенав иммунологическиэффективныхколичествах, гдепервыйиммуногенвыбранизгруппыиммуногенов, содержащихаминокислотнуюпоследовательность SIPWNLE, игдевторойиммуногенвыбранизгруппыиммуногенов, содержащихаминокислотнуюпоследовательность TRFHRQ; игдекомпозицияможетсодержатьдополнительнопоменьшеймереодинадъювант. Такжепредставленафармацевтическаякомпозициядляпредупреждения, леченияилиоблегчения PCSK9-связанныхрасстройств, содержащая: втерапевтическиэффективномколичествеуказанныйиммуноген, илиоднуизуказанныхкомпозицийи фармацевтическиприемлемыйэксципиент. Изобретениепозволяетполучитьэффективнуювакцинупротиврасстройств, связанныхс взаимодействиембелка PCSK9 сегорецепто

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