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1. 发明申请

WO1991018005A1 CLONED GENES ENCODING THE D1 DOPAMINE RECEPTOR 审中-公开
标题翻译：克隆D1多巴胺受体的克隆基因
公开(公告)号：WO1991018005A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003308
申请日：1991-05-13
申请人： DUKE UNIVERSITY , OREGON HEALTH SCIENCES UNIVERSITY
发明人： DUKE UNIVERSITY , OREGON HEALTH SCIENCES UNIVERSITY , BUNZOW, James, Robert , CIVELLI, Olivier , GRANDY, David, K. , ZHOU, Qun, Yong , CARON, Marc, G. , DEARRY, Allen , FALARDEAU, Pierre , GINGRICH, Jay, A.
IPC分类号： C07H21/04
CPC分类号： C07H21/00 , C07K14/70571 , C12Q1/6876 , C12Q2600/158
摘要： Cloned genes which code for the D1 dopamine receptor are disclosed. The receptors coded for by these clones bind dopamine ligands with the proper pharmacological profile and, when expressed in the cell membrane of a suitable host and so bound, stimulate adenylyl cyclase. Also disclosed are vectors comprising a cloned gene encoding a D1-dopamine receptor, cells transformed with such vectors, and oligonucleotide probes capable of selectively hybridizing to DNA comprising a portion of a gene coding for a D1-dopamine receptor. The cloned genes are useful for making proteins and cell membrane preparations which can be used to screen compounds for D1-dopamine receptor binding activity, are useful in molecular biology, and are useful as diagnostic probes.
摘要翻译：公开了编码D1多巴胺受体的克隆基因。由这些克隆编码的受体结合具有适当药理学特征的多巴胺配体，并且当在合适的宿主的细胞膜中表达并如此结合时，刺激腺苷酸环化酶。还公开了包含编码D1-多巴胺受体的克隆基因，用这些载体转化的细胞和能够与包含编码D1-多巴胺受体的基因的一部分的DNA选择性杂交的寡核苷酸探针的载体。克隆的基因可用于制备可用于筛选化合物的多巴胺受体结合活性的蛋白质和细胞膜制剂，可用于分子生物学，并且可用作诊断探针。

2. 发明申请

WO1998003204A1 COVALENT POLAR LIPID CONJUGATES WITH BIOLOGICALLY-ACTIVE COMPOUNDS FOR USE IN SALVES 审中-公开
标题翻译：具有生物活性化合物的共价极性脂质与SALVES一起使用
公开(公告)号：WO1998003204A1
公开(公告)日：1998-01-29
申请号：PCT/US1996012124
申请日：1996-07-23
申请人： OREGON HEALTH SCIENCES UNIVERSITY
发明人： OREGON HEALTH SCIENCES UNIVERSITY , YATVIN, Milton, B. , STOWELL, Michael, H., B.
IPC分类号： A61K47/48
CPC分类号： A61K47/62 , A61K47/544
摘要： This invention herein describes a method of facilitating the entry of drugs into cells and tissues at pharmokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This polar lipid/drug conjugate targeting invention embodies an advance over other drug targeting methods because through this method, intracellular drug concentrations may reach levels which are orders of magnitude higher than those achieved otherwise. Furthermore, it refines the drug delivery process by allowing therapeutic agents to be directed to certain intracellular structures. This technology is appropriate for use with antiproliferative, antibiotic, antimycotic, antiviral and antineoplastic drugs, in particular in combination with a multiplicity of other emollients and agents to make up topically-active substances such as salves, for rapid and efficient introduction of such agents through the epidermis for treatment of skin diseases and other disorders.
摘要翻译：本发明在此描述了一种促进药物进入细胞和组织的药学上有用水平的方法，还涉及将药物靶向细胞内的特定细胞器的方法。这种极性脂质/药物共轭靶向发明体现了其他药物靶向方法的进步，因为通过该方法，细胞内药物浓度可达到比其它药物浓度高数量级的水平。此外，它通过使治疗剂被引导到某些细胞内结构来改善药物递送过程。该技术适用于抗增生，抗生素，抗真菌，抗病毒和抗肿瘤药物，特别是与多种其他润肤剂和药剂组合以组合局部活性物质如药膏，以快速有效地引入这些药剂通过用于治疗皮肤病和其他疾病的表皮。

3. 发明申请

WO1996012020A3 HEMOGLOBIN RECEPTORS FROM NEISSERIAE 审中-公开
公开(公告)号：WO1996012020A3
公开(公告)日：1996-04-25
申请号：PCT/US1995013623
申请日：1995-10-17
申请人： OREGON HEALTH SCIENCES UNIVERSITY , STOJILJKOVIC, Igor , SO, Magdalene , HWA, Vivian , HEFFRON, Fred , NASSIF, Xavier
发明人： OREGON HEALTH SCIENCES UNIVERSITY
IPC分类号： C12N15/12

4. 发明申请

WO1995016793A1 COMPOSITIONS AND METHODS RELATING TO DNA MISMATCH REPAIR GENES 审中-公开
标题翻译：与DNA错配修复基因相关的组合物和方法
公开(公告)号：WO1995016793A1
公开(公告)日：1995-06-22
申请号：PCT/US1994014746
申请日：1994-12-16
申请人： OREGON HEALTH SCIENCES UNIVERSITY , DANA-FARBER CANCER INSTITUTE , BAKER, Sean, M. , BOLLAG, Roni, J. , KOLODNER, Richard, D. , BRONNER, C., Eric , LISKAY, Robert, M.
发明人： OREGON HEALTH SCIENCES UNIVERSITY , DANA-FARBER CANCER INSTITUTE
IPC分类号： C12Q01/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156 , C12Q2600/16
摘要： Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
摘要翻译：描述人错配修复基因的基因组序列，以及检测那些基因中的突变和/或多态性的方法。还描述了诊断受试者的癌症易感性的方法，以及鉴定和分类错配修复缺陷型肿瘤的方法。特别地，提供了与人类mutL同系物，hMLH1和hPMS1基因相关的序列和方法。

5. 发明申请

WO1998018004A1 GROWTH OF B CELL LYMPHOMAS ON HIV-INFECTED ENDOTHELIAL CELLS 审中-公开
标题翻译： B细胞淋巴瘤对HIV感染性内皮细胞的生长
公开(公告)号：WO1998018004A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019323
申请日：1997-10-23
申请人： OREGON HEALTH SCIENCES UNIVERSITY , NELSON, Jay , MOSES, Ashlee , BAGBY, Grover
发明人： OREGON HEALTH SCIENCES UNIVERSITY
IPC分类号： G01N33/53
CPC分类号： C12N5/0694 , C12N2501/115 , C12N2501/165 , C12N2501/23 , C12N2502/28 , C12N2502/99 , C12N2503/02
摘要： The present invention provides methods of stimulating proliferation of neoplastic B cells, methods of screening for inhibitors of neoplastic B cells, and co-cultures of neoplastic B cells and endothelial cells transduced with a viral nucleic acid.
摘要翻译：本发明提供刺激肿瘤B细胞增殖的方法，筛选肿瘤B细胞抑制剂的方法，以及用病毒核酸转导的肿瘤B细胞和内皮细胞的共培养。

6. 发明申请

WO1998011139A1 SMALL AND INTERMEDIATE CONDUCTANCE, CALCIUM-ACTIVATED POTASSIUM CHANNELS AND USES THEREOF 审中-公开
标题翻译：小型和中间性导管，钙激活钾通道及其用途
公开(公告)号：WO1998011139A1
公开(公告)日：1998-03-19
申请号：PCT/US1997016033
申请日：1997-09-10
申请人： OREGON HEALTH SCIENCES UNIVERSITY , ICAgen, INC. , ADELMAN, John, P. , MAYLIE, James , BOND, Chris, T. , SILVIA, Christopher, P.
发明人： OREGON HEALTH SCIENCES UNIVERSITY , ICAgen, INC.
IPC分类号： C07K14/705
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/705 , C07K2299/00 , G01N2500/04
摘要： This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositons for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
摘要翻译：本发明涉及小和中等电导，钙激活的钾通道蛋白。更具体地，本发明涉及用于制备和检测钙激活的钾通道蛋白的组合物和方法以及编码钙激活的钾通道蛋白的核酸。本发明还提供了用于测定通过钙激活的钾通道增加或减少钾离子通量的化合物的方法和组合物。

7. 发明申请

WO1997002360A1 ASSAYS TO EVALUATE CHEMOTHERAPEUTIC EFFECTIVENESS OF DRUGS 审中-公开
标题翻译：评估药物的化学疗效
公开(公告)号：WO1997002360A1
公开(公告)日：1997-01-23
申请号：PCT/US1996011330
申请日：1996-07-03
申请人： OREGON HEALTH SCIENCES UNIVERSITY
发明人： OREGON HEALTH SCIENCES UNIVERSITY , RODLAND, Karin, D. , MCNEIL, Scott , MAGUN, Bruce
IPC分类号： C12Q01/00
CPC分类号： C12Q1/48 , C12Q1/6897 , G01N33/573 , G01N2800/52
摘要： In vitro assays which respond to signal pathway modulating compounds in transformed cells are described. By measuring the effect of candidate drugs on specific kinase targets, successful candidates can be screened. Tumor biopsies can be assayed for susceptibility to treatment with a particular drug using similar assays. The VL30 controlled expression of a reporter gene can also be used in screening assays for both inhibitors and stimulators of cell proliferation.
摘要翻译：描述了响应转化细胞中信号通路调节化合物的体外测定。通过测量候选药物对特定激酶靶标的影响，可以筛选成功的候选者。可以使用类似的测定法来测定肿瘤活组织检查对于用特定药物治疗的易感性。报道基因的VL30受控表达也可用于抑制剂和细胞增殖刺激物的筛选测定。

8. 发明申请

WO1992017568A1 A cDNA CLONE ENCODING A HUMAN NOREPINEPRHINE TRANSPORTER 审中-公开
标题翻译： A cDNA克隆编码人类肾上腺素转运蛋白
公开(公告)号：WO1992017568A1
公开(公告)日：1992-10-15
申请号：PCT/US1992001376
申请日：1992-02-20
申请人： OREGON HEALTH SCIENCES UNIVERSITY
发明人： OREGON HEALTH SCIENCES UNIVERSITY , AMARA, Susan, G. , PACHOLCZYK, Tadeusz , BLAKELY, Randy, D.
IPC分类号： C12N05/10
CPC分类号： C07K14/70571
摘要： A cDNA encoding human norepinephrine transporter isolated from human neuroblastoma cells is disclosed. Determination of the nucleotide sequence thereof permitted a putative amino-acid sequence of the transporter protein to be determined. Mammalian cells transfected with the cDNA produced an mRNA species similar in size to that produced by norepinephrine-producing neurons. Such transfected cells also became capable of norepinephrine uptake. The uptake was inhibitable by various uptake-inhibiting drugs, including cocaine, to a degree similar to the effect of such drugs on noradrenergic neurons. The cloned cDNA makes possible well-controlled studies of transporter function in non-neuronal cells without the obfuscating influence of other transporters in the same cells. Such studies include the relative effects of various drugs such as antidepressants.
摘要翻译：公开了编码从人神经母细胞瘤细胞分离的人去甲肾上腺素转运蛋白的cDNA。其核苷酸序列的确定允许确定转运蛋白的推定氨基酸序列。用cDNA转染的哺乳动物细胞产生与去甲肾上腺素产生的神经元产生的大小相似的mRNA。这样的转染细胞也能够去甲肾上腺素摄取。各种吸收抑制药物（包括可卡因）的吸收可以与类似药物对去甲肾上腺素能神经元的作用类似。克隆的cDNA使得在非神经元细胞中转运蛋白功能的良好控制研究成为可能，而没有其他转运蛋白在相同细胞中的混淆影响。这些研究包括各种药物如抗抑郁药的相对作用。

9. 发明申请

WO1998017325A2 COVALENT POLAR LIPID CONJUGATES FOR TARGETING 审中-公开
标题翻译：有价值的极乐团队
公开(公告)号：WO1998017325A2
公开(公告)日：1998-04-30
申请号：PCT/US1997019486
申请日：1997-10-27
申请人： OREGON HEALTH SCIENCES UNIVERSITY , YATVIN, Milton, B. , STOWELL, Michael, H., B. , MEREDITH, Michael, J.
发明人： OREGON HEALTH SCIENCES UNIVERSITY
IPC分类号： A61K97/48
CPC分类号： C07H19/06 , A61K31/00 , A61K47/543 , A61K47/544 , B82Y5/00 , C07H19/10
摘要： This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This polar lipid/drug conjugate targeting invention embodies an advance over other drug targeting methods known in the prior art, because the invention provides drug concentrations in such physiologically protected sites that can reach therapeutically-effective levels after administration of systemic levels much lower than are currently administered to achieve a therapeutic dose. This technology is appropriate for use with psychotropic, neurotropic and neurological drugs, agents and compounds, for rapid and efficient introduction of such agents across the blood-brain barrier. Further, the invention provides means for retention and prolonged enzymatic release of psychotropic, neurotropic and neurological drugs, agents and compounds comprising the conjugates of the invention, in the brain and central nervous system.
摘要翻译：本发明在此描述了一种促进药物进入生理学保护部位的细胞和组织的药学上有用水平的方法，以及将药物靶向细胞内的特定细胞器的方法。这种极性脂质/药物共轭靶向发明体现了先前技术中已知的其它药物靶向方法的进步，因为本发明提供了在这样的生理保护部位中的药物浓度，其在施用远低于目前的系统水平后达到治疗有效水平施用以达到治疗剂量。该技术适用于精神药物，神经营养因子和神经药物，药剂和化合物，用于快速有效地将这些药物引入血脑屏障。此外，本发明提供了在脑和中枢神经系统中保留和延长酶促释放精神药物，神经营养因子和神经药物，包含本发明缀合物的药剂和化合物的方法。

10. 发明申请

WO1998010068A2 METHODS AND REAGENTS FOR DISCOVERING AND USING MAMMALIAN MELANOCORTIN RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE FEEDING BEHAVIOR IN ANIMALS 审中-公开
标题翻译：发现和使用MAMMALIAN MELANOCORTIN受体激动剂和拮抗剂以调节动物饲养行为的方法和试剂
公开(公告)号：WO1998010068A2
公开(公告)日：1998-03-12
申请号：PCT/US1997015565
申请日：1997-09-04
申请人： OREGON HEALTH SCIENCES UNIVERSITY , CONE, Roger, D. , FAN, Wei , BOSTON, Bruce, A. , KESTERTON, Robert, A. , LU, Dongsi , CHEN, Wenbiao
发明人： OREGON HEALTH SCIENCES UNIVERSITY
IPC分类号： C12N15/12
CPC分类号： C07K14/72 , A61K38/00 , C07K7/56 , C07K14/723 , C12Q1/6876 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , G01N33/74 , G01N2333/68 , G01N2333/695 , G01N2333/72 , G01N2333/726 , G01N2500/00
摘要： The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and mammalian cells into which said recombinant expression constructs have been introduced that express functional mammalian melanocortin receptors. The invention provides a panel of such transformed mammalian cells expressing melanocortin receptors for screening compounds for receptor agonist and antagonist activity. The invention also provides methods for using such panels of melanocortin receptor-expressing mammalian cells to specifically detect and identify agonists and antagonists for each melanocortin receptor, as well as patterns of agonist and antagonist activity of said compounds for the class of melanocortin receptors. Such screening methods provide a means for identifying compounds with patterns of melanocortin agonist and antagonist activity which is associated with the capacity to influence or modify metabolism and behavior, particularly feeding behavior.
摘要翻译：本发明提供了包含编码哺乳动物黑皮质素受体的核酸的重组表达构建体和已经引入表达功能性哺乳动物黑皮质素受体的所述重组表达构建体的哺乳动物细胞。本发明提供了一组这样的转化的哺乳动物细胞，其表达用于筛选受体激动剂和拮抗剂活性的化合物的黑皮质素受体。本发明还提供了使用这样的黑皮质素受体表达哺乳动物细胞的这种面板来特异性检测和鉴定每种黑皮质素受体的激动剂和拮抗剂的方法，以及所述化合物对黑皮质素受体类的激动剂和拮抗剂活性的模式。这种筛选方法提供用于鉴定与影响或改变代谢和行为，特别是进食行为的能力相关的黑皮质素激动剂和拮抗剂活性的化合物的方法。

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