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1. 发明申请

WO2011079446A1 METHOD AND APPARATUS FOR PASSCODE ENTRY 审中-公开
标题翻译：用于进食的方法和装置
公开(公告)号：WO2011079446A1
公开(公告)日：2011-07-07
申请号：PCT/CN2009/076249
申请日：2009-12-30
申请人： NOKIA CORPORATION , ZOU, Yanming , XIE, Xiaohui , LIU, Changsong , CHEN, Yan
发明人： ZOU, Yanming , XIE, Xiaohui , LIU, Changsong , CHEN, Yan
IPC分类号： G06F17/21
CPC分类号： G06F21/31 , G06K9/50 , G06K2209/01
摘要： An apparatus and method for receiving a first user input comprising a first set of strokes; causing a representation of the first set of strokes to be displayed; whilst the representation of the first set of strokes is displayed, receiving a second user input comprising a second set of strokes; causing a representation of each of the second set of strokes to be displayed as it is received, the representation of the second set of strokes at least partially overlapping the representation of the first set of strokes; resolving the first user input into a first character; and resolving the second user input into a second character.
摘要翻译：一种用于接收包括第一组笔划的第一用户输入的装置和方法; 导致要显示的第一组笔画的表示; 同时显示第一组笔画的表示，接收包括第二组笔画的第二用户输入; 使得所述第二组笔画中的每一个的表示在其被接收时被显示，所述第二组笔画的表示至少部分地与所述第一组笔画的表示重叠; 将所述第一用户输入解析为第一字符; 并将第二用户输入解析为第二个字符。

2. 发明申请

WO2022187303A1 A METHOD FOR TREATING A DISEASE OR CONDITION USING A PYRAZOLE COMPOUND OR FORMULATION THEREOF 审中-公开
公开(公告)号：WO2022187303A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018432
申请日：2022-03-02
申请人： RIGEL PHARMACEUTICALS, INC. , CHOU, Lu , DUAN, Matt , DARWISH, Ihab , SHAW, Simon , BHAMIDIPATI, Somasekhar , TAYLOR, Vanessa , CHEN, Yan , FAN, Dazhong , LUO, Zhushou
发明人： CHOU, Lu , DUAN, Matt , DARWISH, Ihab , SHAW, Simon , BHAMIDIPATI, Somasekhar , TAYLOR, Vanessa , CHEN, Yan , FAN, Dazhong , LUO, Zhushou
IPC分类号： A61K31/4439 , A61P35/00 , A61P43/00
摘要： Disclosed herein are embodiments of a method for treating a disease or condition in a subject, comprising administering to the subject, a pyrazole compound according to formula (I). The compound may be administered as a composition, such as a spray-dried formulation. The disease or condition may be hidradenitis suppurativa, or a lymphoid neoplasm, and may be chronic myeloid leukemia or chronic myelomonocytic leukemia.

3. 发明申请

WO2019006126A1 KINASE INHIBITORS AND METHODS FOR MAKING AND USING 审中-公开
公开(公告)号：WO2019006126A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040021
申请日：2018-06-28
申请人： RIGEL PHARMACEUTICALS, INC. , TAYLOR, Vanessa , CHEN, Yan , YEN, Rose
发明人： TAYLOR, Vanessa , CHEN, Yan , YEN, Rose
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D405/04 , C07D417/04 , C07D417/14 , A61P29/00 , A61K31/496 , A61K31/5377
摘要： Disclosed embodiments concern kinase inhibitors, such as interleukin receptor associated kinases (IRAK) inhibitors, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent a kinase-associated disease or condition, particularly an IRAK- associated disease or condition.

4. 发明申请

WO2012047775A1 PHARMACEUTICAL COMBINATIONS 审中-公开
标题翻译：药物组合
公开(公告)号：WO2012047775A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054536
申请日：2011-10-03
申请人： NOVARTIS AG , CHEN, Yan , HUANG, Xizhong , MURPHY, Leon , NYFELER, Beat
发明人： CHEN, Yan , HUANG, Xizhong , MURPHY, Leon , NYFELER, Beat
IPC分类号： A61K31/4188 , A61K31/4745 , A61P35/00
CPC分类号： A61K31/436 , A61K31/4188 , A61K31/4745 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which comprises (a) an mTOR catalytic inhibitor, such as a catalytic phosphatidylinositol- 3-kinase (PI3K) and mTOR inhibitor compound which is an imidazoquinoline derivative and (b) at least one allosteric mTOR inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of an mammalian target of rapamycin (mTOR) kinase dependent proliferative diseases; and the uses of such a combination in the treatment of mTOR kinase dependent proliferative diseases; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
摘要翻译：本发明涉及药物组合，其包含（a）mTOR催化抑制剂，例如催化磷脂酰肌醇-3-激酶（PI3K）和作为咪唑并喹啉衍生物的mTOR抑制剂化合物和（b）至少一种变构mTOR抑制剂化合物和任选的至少一种用于同时，分别或顺序使用的药学上可接受的载体，特别是用于治疗雷帕霉素（mTOR）激酶依赖性增殖性疾病的哺乳动物靶标; 以及这种组合在治疗mTOR激酶依赖性增殖性疾病中的应用; 包含这种组合的药物组合物; 使用这种组合来制备用于治疗增殖性疾病的药物; 商业包装或产品，其包含作为同时，分开或顺序使用的组合制剂的组合; 以及治疗温血动物，特别是人的方法。

5. 发明申请

WO2011146928A2 METHODS FOR CALIBRATING PROTEIN LEVELS IN CELLS AND TISSUE SPECIMENS 审中-公开
标题翻译：用于校准细胞和组织样本中的蛋白质水平的方法
公开(公告)号：WO2011146928A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037574
申请日：2011-05-23
申请人： ON-Q-ITY , WARD, Brian , PIERCEALL, William, E. , QUAN, Stella , CHEN, Yan , WANG, XiaoZhe , ALAPARTHI, Lakshmi, P. , SPROTT, Kam, Marie , CHANG, Hua , WEAVER, David, T.
发明人： WARD, Brian , PIERCEALL, William, E. , QUAN, Stella , CHEN, Yan , WANG, XiaoZhe , ALAPARTHI, Lakshmi, P. , SPROTT, Kam, Marie , CHANG, Hua , WEAVER, David, T.
CPC分类号： G01N33/57492 , G01N33/6803
摘要： A method is described for the use of an internal calibrator marker for normalization of quantifiable protein detection in cells. This internal calibrator will ostensibly serve as an enumerator of epitope immune-integrity. Optimally, it will be a robust biomarker analyte of the same class (i.e protein) to that for which it is being held as a control, with consistent levels of expression across tissues but with a dynamic range commensurate with assay and treatment conditions. While stable expression in a biological context is a requirement, it will exhibit a suitable dynamic level of expression due to technical variation relative to a test marker to which it will serve as a surrogate.
摘要翻译：描述了使用内部校准器标记物来对细胞中的可量化蛋白质检测进行归一化的方法。该内部校准器将表面上用作表位免疫完整性的计数器。最佳地，它将是与其作为对照保持相同类别（即蛋白质）的健康的生物标志物分析物，具有在组织之间具有一致水平的表达，但具有与测定和治疗条件相当的动态范围。虽然在生物学语境中稳定表达是一个要求，但是由于相对于其将用作替代物的测试标记的技术变化，它将表现出合适的动态表达水平。

6. 发明申请

WO2010085684A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 审中-公开
标题翻译：用于抑制JAK路径的组合物和方法
公开(公告)号：WO2010085684A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021856
申请日：2010-01-22
申请人： RIGEL PHARMACEUTICALS, INC. , LI, Hui , HECKRODT, Thilo, J. , CHEN, Yan , MCMURTRIE, Darren, John , TAYLOR, Vanessa , SINGH, Rajinder , DING, Pingyu , THOTA, Sambaiah , YEN, Rose
发明人： LI, Hui , HECKRODT, Thilo, J. , CHEN, Yan , MCMURTRIE, Darren, John , TAYLOR, Vanessa , SINGH, Rajinder , DING, Pingyu , THOTA, Sambaiah , YEN, Rose
IPC分类号： C07D401/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D491/08 , C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54
CPC分类号： C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
摘要翻译：公开了式I化合物，含有它们的组合物，以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶，特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。

7. 发明申请

WO2009035919A1 RATE DISTORTION OPTIMIZATION FOR INTER MODE GENERATION FOR ERROR RESILIENT VIDEO CODING 审中-公开
标题翻译：用于错误恢复视频编码的帧间生成的速率失真优化
公开(公告)号：WO2009035919A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075397
申请日：2008-09-05
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY , AU, Oscar Chi Lim , CHEN, Yan
发明人： AU, Oscar Chi Lim , CHEN, Yan
IPC分类号： G06K9/36
CPC分类号： H04N19/109 , H04N19/147 , H04N19/166 , H04N19/172 , H04N19/176 , H04N19/19 , H04N19/61
摘要： Optimal selection of an inter mode is provided for video data being encoded to achieve enhanced error resilience when the video data is decoded. End to end distortion cost from encoder to decoder for inter mode selection is determined based on residue energy and quantization error. Using the distortion cost function based on residue energy and quantization error, and an optimal Lagrangian parameter, the optimal inter mode is selected for use during encoding for maximum error resilience. The optimal Lagrangian parameter can be set to be proportional to an error-free Lagrangian parameter with a scale factor determined by packet loss rate.
摘要翻译：为视频数据进行编码以提供对视频数据进行解码时增强的错误恢复能力的最佳选择。基于残余能量和量化误差确定帧间模式选择的编码器到解码器的端对端失真成本。使用基于残余能量和量化误差的失真成本函数，以及最优拉格朗日参数，选择最佳互模式以在编码期间使用最大误差弹性。可以将最优拉格朗日参数设置为与无丢失的拉格朗日参数成比例，其中缩放因子由分组丢失率确定。

8. 发明申请

WO2009032560A1 OXYGEN SCAVENGING PLASTIC COMPOSITIONS 审中-公开
标题翻译：氧气扫描塑料组合物
公开(公告)号：WO2009032560A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/074029
申请日：2008-08-22
申请人： INVISTA TECHNOLOGIES S.AR.L. , CHEN, Yan , SUN, Qun , DRBOHLAV, Joseph
发明人： CHEN, Yan , SUN, Qun , DRBOHLAV, Joseph
IPC分类号： C08L67/02
CPC分类号： C08L67/02 , C08L67/025 , Y10T428/1334 , Y10T428/139 , C08L2666/18
摘要： The present invention relates to a composition comprising a polyester, a copolyester ether and an oxidation catalyst, wherein the copolyester ether comprises a polyether segment comprising poly(tetramethylene-co-alkylene ether). The composition has oxygen scavenging properties and produces articles having low haze. Other embodiments of the present invention disclosed herein are articles made from the composition and methods to make such articles.
摘要翻译：本发明涉及包含聚酯，共聚酯醚和氧化催化剂的组合物，其中共聚酯醚包括聚（四亚甲基 - 共 - 亚烷基醚）的聚醚链段。该组合物具有除氧性能并且产生具有低雾度的物品。本文公开的本发明的其它实施方案是由制备这种制品的组合物和方法制成的制品。

9. 发明申请

WO2007041569A1 METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL 审中-公开
标题翻译：从牛奶的胃肠道动物中选择性去除钾离子的方法和组合物
公开(公告)号：WO2007041569A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/038602
申请日：2006-10-02
申请人： ILYPSA, INC. , COPE, Michael J. , MANSKY, Paul , LIU, Futian , CHANG, Han-Ting , CHARMOT, Dominique , CONNOR, Eric , BIYANI, Kalpesh , LIU, Mingjun , MONG, Tony Kwok-Kong , CHEN, Yan
发明人： COPE, Michael J. , MANSKY, Paul , LIU, Futian , CHANG, Han-Ting , CHARMOT, Dominique , CONNOR, Eric , BIYANI, Kalpesh , LIU, Mingjun , MONG, Tony Kwok-Kong , CHEN, Yan
IPC分类号： A61K31/75 , A61K31/785 , A61K9/16 , A61K9/50 , A61P3/12
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译：本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

10. 发明申请

WO2005047724A2 SYSTEM AND METHOD FOR DAMPING VIBRATIONS IN ELEVATOR CABLES 审中-公开
标题翻译：用于在电梯电缆中阻尼振动的系统和方法
公开(公告)号：WO2005047724A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/035523
申请日：2004-11-15
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY , ZHU, Weidong , CHEN, Yan
发明人： ZHU, Weidong , CHEN, Yan
IPC分类号： F16F
CPC分类号： B66B11/028
摘要： A vibration damped elevator system is provided that includes a damper or dampers attached to the elevator cable. The damping coefficients of the damper or dampers are chosen to provide optimum dissipation of the vibratory energy in the elevator cable. A method of determining the optimum placement of the damper or dampers and their respective damping coefficients is also provided.
摘要翻译：提供了一种减震电梯系统，其包括附接到电梯电缆的阻尼器或阻尼器。选择阻尼器或阻尼器的阻尼系数以提供电梯电缆中的振动能量的最佳耗散。还提供了一种确定阻尼器或阻尼器的最佳位置及其各自阻尼系数的方法。

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