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1. 发明申请

US20070254011A1 Bone Formation Agent and Method of Production 有权
标题翻译：骨形成剂及其生产方法
公开(公告)号：US20070254011A1
公开(公告)日：2007-11-01
申请号：US10580549
申请日：2004-11-25
申请人： Matthias Schnabelrauch , Sebastian Vogt , Dieter Reif , Ute (Erbe) Reif
发明人： Matthias Schnabelrauch , Sebastian Vogt , Dieter Reif , Ute (Erbe) Reif
IPC分类号： A61L24/00 , A61L27/42 , A61L27/46
CPC分类号： A61L24/0084 , A61L24/0036 , A61L24/0042 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture. The described self-hardening, bioabsorbable composite materials can be used as bone adhesives for the fixing of bone fractures, as shaped pieces of standardised dimensions and as implants that are individual to a patient in the context of regenerative bone healing in humans and animals.
摘要翻译：描述了生产自硬化生物可吸收复合材料的方法，所生产的材料及其应用领域。该方法基于主要方法步骤（I）将聚合引发剂固定在用于生产自硬化生物可吸收复合材料的第一部分量的生物可吸收磷酸钙的微孔孔系统中，（II）固定化用于生产自硬化生物可吸收复合材料的第二部分量的生物可吸收磷酸钙的微孔孔体系中的聚合活化剂和（III）根据（I）和（II）的组分与液体或糊状的多功能单体，其能够形成生物相容的生物可吸收的聚合物网络或相应的单体混合物，并且任选地具有改变单体或单体混合物的性质的其它组分。所描述的自硬化生物可吸收复合材料可用作固定骨折的骨粘合剂，作为标准尺寸的成形件，以及在人和动物的再生骨愈合背景下对患者个体的植入物。

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