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1. 发明授权

US10023536B2 Suprametallogels and uses thereof 有权
公开(公告)号：US10023536B2
公开(公告)日：2018-07-17
申请号：US15270959
申请日：2016-09-20
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Niels Holten-Andersen , Scott Charles Grindy , Ken Kawamoto , Aleksandr V. Zhukhovitskiy
IPC分类号： A61K47/22 , C07D213/30 , C07F15/00 , C07F15/02 , C07F15/04 , C08G83/00
摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).

2. 发明申请

US20150225438A1 SUPRAMETALLOGELS AND USES THEREOF 有权
标题翻译： SUPRAMETALLOGELS及其用途
公开(公告)号：US20150225438A1
公开(公告)日：2015-08-13
申请号：US14617747
申请日：2015-02-09
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Niels Holten-Andersen , Scott Charles Grindy , Ken Kawamoto , Aleksandr V. Zhukhovitskiy
IPC分类号： C07F15/00 , A61K47/22
CPC分类号： C07D213/30 , A61K47/22 , C07F15/006 , C07F15/0066 , C07F15/02 , C07F15/04 , C08G83/008
摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).
摘要翻译：本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮）自组装本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性）肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病，或代谢紊乱）。

3. 发明授权

US09447129B2 Suprametallogels and uses thereof 有权
标题翻译： Suprametallog及其用途
公开(公告)号：US09447129B2
公开(公告)日：2016-09-20
申请号：US14617747
申请日：2015-02-09
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Niels Holten-Andersen , Scott Charles Grindy , Ken Kawamoto , Aleksandr V. Zhukhovitskiy
IPC分类号： A61K47/22 , C07F15/00 , C07F15/02 , C07F15/04
CPC分类号： C07D213/30 , A61K47/22 , C07F15/006 , C07F15/0066 , C07F15/02 , C07F15/04 , C08G83/008
摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).
摘要翻译：本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮）自组装本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性）肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病，或代谢紊乱）。

4. 发明授权

US10961338B2 Bottlebrush polymers and uses thereof 有权
公开(公告)号：US10961338B2
公开(公告)日：2021-03-30
申请号：US16080503
申请日：2017-08-25
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Ken Kawamoto , Mingjiang Zhong
IPC分类号： C08F290/06
摘要： Provided are new bottlebrush polymers and diblock bottlebrush copolymers, which can self-assemble into structures of desired morphology (e.g., hexagonal cylindrical, gyroid). The self-assembled structures of the bottlebrush polymers and copolymers provide useful materials such as photonics (e.g., photonic crystals), functional materials, chromatography media, stimuli-responsive materials, lubricants, nanolithography, films, and coatings. In certain embodiments, the backbone repeating units of the bottlebrush polymers and copolymers have two different polymeric sidechains covalently attached to the backbone repeating unit through a branched linker, wherein one of the polymeric sidechain is a polysiloxane. Also provided are methods of preparing the bottlebrush polymers and copolymers described herein.

5. 发明申请

US20170073311A1 SUPRAMETALLOGELS AND USES THEREOF 有权
标题翻译： SUPRAMETALLOGELS及其用途
公开(公告)号：US20170073311A1
公开(公告)日：2017-03-16
申请号：US15270959
申请日：2016-09-20
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Niels Holten-Andersen , Scott Charles Grindy , Ken Kawamoto , Aleksandr V. Zhukhovitskiy
IPC分类号： C07D213/30 , A61K47/22 , C07F15/00
CPC分类号： C07D213/30 , A61K47/22 , C07F15/006 , C07F15/0066 , C07F15/02 , C07F15/04 , C08G83/008
摘要： The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent. The nanostructures, supramolecular complex, and compositions may be useful in delivering an agent to a subject, tissue, or cell, as super-absorbent materials, and in treating a disease (e.g., a genetic diseases, proliferative disease (e.g., cancer or benign neoplasm), hematological disease, neurological disease, gastrointestinal disease (e.g., liver disease), spleen disease, respiratory disease (e.g., lung disease), painful condition, genitourinary disease, musculoskeletal condition, infectious disease, inflammatory disease, autoimmune disease, psychiatric disorder, or metabolic disorder).
摘要翻译：本公开提供通过过渡金属配体（例如，式（A）的Pd（II） - ，Ni（II） - 或Fe（II） - 配体）配位和结合形成的纳米结构（例如纳米球和纳米桨轮）自组装本公开还提供包括通过二价连接体Y连接的纳米结构的超分子复合物。所提供的超分子复合物能够形成凝胶（例如水凝胶）。凝胶是超标记物，表现出优异的机械性能，而不牺牲自愈，显示出高的鲁棒性和储能模量。本公开进一步提供包含纳米结构或超分子复合物和任选的试剂（例如小分子）的组合物（例如，凝胶），其中超分子复合物的纳米结构和纳米结构部分可以包封并缓慢释放试剂。纳米结构，超分子复合物和组合物可用于将药物递送至受试者，组织或细胞，作为超吸收材料，以及治疗疾病（例如，遗传性疾病，增殖性疾病（例如癌症或良性）肿瘤），血液疾病，神经系统疾病，胃肠道疾病（如肝脏疾病），脾脏疾病，呼吸系统疾病（如肺部疾病），疼痛状况，泌尿生殖器疾病，肌肉骨骼疾病，感染性疾病，炎性疾病，自身免疫性疾病，精神疾病，或代谢紊乱）。

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