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1. 发明申请

US20110166151A1 GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVES CONTAINING PHENYL GROUP HAVING SULFONIC ACID ESTER STRUCTURE INTRODUCED THEREIN AS SUBSTITUENT 失效
标题翻译：包含具有作为替代物引入的磺酸酯结构的苯基的1,2,3,4-四氢喹啉衍生物的GLUCOCORTICOID受体激动剂
公开(公告)号：US20110166151A1
公开(公告)日：2011-07-07
申请号：US13063186
申请日：2009-09-11
申请人： Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
发明人： Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
IPC分类号： A61K31/498 , C07D241/38 , A61P37/02
CPC分类号： C07D295/135 , A61K31/498 , A61K31/5377 , C07D241/44 , C07D409/12
摘要： The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R1 represents a group represented by general formula (2a), (3a), (4a) or (5a); R2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like; R3 represents a lower alkyl group; R4, R5, R6 or R7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; and m, n, p or q represents a number of 0, 1 or 2.
摘要翻译：本发明的目的在于找到引入其中具有磺酸酯结构的苯基作为取代基的新的1,2,3,4-四氢喹喔啉衍生物的新药理活性。由通式（1）表示的化合物或其盐可用作糖皮质激素受体激动剂，特别是作为糖皮质激素受体激动剂（例如类固醇）被认为有效的疾病的治疗剂，例如炎性骨 /关节疾病，炎症性眼部疾病（眼睛前部或后部的炎症性眼部疾病）。 R1表示通式（2a），（3a），（4a）或（5a）表示的基团。 R 2表示可以具有取代基的低级烷基，可以具有取代基的低级环烷基等。 R3表示低级烷基; R4，R5，R6或R7表示卤素原子，可以具有取代基的低级烷基，羟基，可以具有取代基的低级烷氧基等; m，n，p或q表示0,1或2的数。

2. 发明授权

US08664221B2 Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent 失效
标题翻译：通过给予含有其中引入了磺酸酯结构的苯基的1,2,3,4-四氢喹喔啉化合物作为取代基来治疗炎性疾病的方法
公开(公告)号：US08664221B2
公开(公告)日：2014-03-04
申请号：US13063186
申请日：2009-09-11
申请人： Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
发明人： Masatomo Kato , Miwa Takai , Takahiro Matsuyama , Tatsuji Kurose , Yumi Hagiwara , Kenji Oki , Mamoru Matsuda , Toshiyuki Mori
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50 , C07D241/36
CPC分类号： C07D295/135 , A61K31/498 , A61K31/5377 , C07D241/44 , C07D409/12
摘要： The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R1 represents a group represented by general formula (2a), (3a), (4a) or (5a); R2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like; R3 represents a lower alkyl group; R4, R5, R6 or R7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; and m, n, p or q represents a number of 0, 1 or 2.
摘要翻译：本发明的目的在于找到引入其中具有磺酸酯结构的苯基作为取代基的新的1,2,3,4-四氢喹喔啉衍生物的新药理活性。由通式（1）表示的化合物或其盐可用作糖皮质激素受体激动剂，特别是作为糖皮质激素受体激动剂（例如类固醇）被认为有效的疾病的治疗剂，例如炎性骨 /关节疾病，炎症性眼部疾病（眼睛前部或后部的炎症性眼部疾病）。 R1表示通式（2a），（3a），（4a）或（5a）表示的基团。 R 2表示可以具有取代基的低级烷基，可以具有取代基的低级环烷基等。 R3表示低级烷基; R4，R5，R6或R7表示卤素原子，可以具有取代基的低级烷基，羟基，可以具有取代基的低级烷氧基等; m，n，p或q表示0,1或2的数。

3. 发明申请

US20120028330A1 POLYPEPTIDE HAVING ACTIVITY OF AMINOACYL-tRNA SYNTHETASE AND USE THEREOF 有权
标题翻译：具有氨基酸-TRNA合成酶活性的多肽及其用途
公开(公告)号：US20120028330A1
公开(公告)日：2012-02-02
申请号：US13180209
申请日：2011-07-11
申请人： Shigeyuki Yokoyama , Kensaku Sakamoto , Kenji Oki , Takahito Mukai
发明人： Shigeyuki Yokoyama , Kensaku Sakamoto , Kenji Oki , Takahito Mukai
IPC分类号： C12N9/00 , C07H21/04
CPC分类号： C12N9/93
摘要： A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an IleRS, a ValRS, an AlaRS, a ProRS, or a ThrRS, the editing polypeptide having been either inserted between a Rossman-fold N domain and a Rossman-fold C domain that exist in the altered polypeptide, or bound to an N terminal of the altered polypeptide. Thus provided are a new aaRS that exhibits high substrate specificity to an unnatural amino acid and a technique that involves the use of such an aaRS.
摘要翻译：根据本发明的多肽包括：通过改变ArgRS，CysRS，MetRS，GlnRS，GluRS，LysRS，TyrRS或TrpRS获得的改变的多肽，使得识别出非天然氨基酸; 和衍生自PheRS，LeuRS，IleRS，ValRS，AlaRS，ProRS或ThrRS的编辑多肽，所述编辑多肽已插入Rossman折叠N结构域和Rossman折叠C结构域之间，存在于改变的多肽中，或者与改变的多肽的N末端结合。因此提供了对非天然氨基酸表现出高底物特异性的新aaRS和涉及使用这种aaRS的技术。

4. 发明申请

US20100261911A1 THERAPEUTIC AGENT FOR TRPV1-MEDIATED DISEASE 审中-公开
标题翻译： TRPV1介导性疾病治疗药物
公开(公告)号：US20100261911A1
公开(公告)日：2010-10-14
申请号：US12682090
申请日：2008-10-16
申请人： Kenji Oki , Fumio Tsuji , Chikako Setoguchi , Iwao Seki , Masaaki Murai , Minoru Sasano
发明人： Kenji Oki , Fumio Tsuji , Chikako Setoguchi , Iwao Seki , Masaaki Murai , Minoru Sasano
IPC分类号： C07D213/40
CPC分类号： A61K31/4409 , A61K31/44 , C07D213/36
摘要： An object of the present invention is to find a novel pharmacological action of a urea compound having a structure represented by the general formula [I]. The urea compound having a structure represented by the general formula [I] or a salt thereof has an excellent therapeutic effect on a TRPV1-mediated disease. In the formula, A represents a lower alkylene group or a lower alkenylene group; R1 represents a hydrogen atom, an alkyl group which may have a substituent or an alkenyl group which may have a substituent; and R2 and R3 are the same or different and represent a hydrogen atom or a lower alkyl group which may be substituted by a monocyclic cycloalkyl group, a polycyclic cycloalkyl group, or an aryl group.
摘要翻译：本发明的目的是找到具有由通式[I]表示的结构的尿素化合物的新药理作用。具有由通式[I]表示的结构的脲化合物或其盐对TRPV1介导的疾病具有优异的治疗作用。在该式中，A表示低级亚烷基或低级亚烯基; R1表示氢原子，可以具有取代基的烷基或可具有取代基的烯基; R2和R3相同或不同，表示氢原子或可被单环环烷基，多环环烷基或芳基取代的低级烷基。

5. 发明申请

US20090089757A1 Configurable Web Services System and a Method to Detect Defects in Software Applications 审中-公开
标题翻译：可配置的Web服务系统和检测软件应用程序缺陷的方法
公开(公告)号：US20090089757A1
公开(公告)日：2009-04-02
申请号：US11865610
申请日：2007-10-01
申请人： Sreeranga P. Rajan , Oksana I. Tkachuk , Indradeep Ghosh , Mukul R. Prasad , Tadahiro Uehara , Kazuki Munakata , Kenji Oki
发明人： Sreeranga P. Rajan , Oksana I. Tkachuk , Indradeep Ghosh , Mukul R. Prasad , Tadahiro Uehara , Kazuki Munakata , Kenji Oki
IPC分类号： G06F9/44
CPC分类号： G06F11/3684 , G06F8/10
摘要： In accordance with a particular embodiment of the present invention, a method is offered that includes detecting one or more defects in a software application composed of heterogeneous languages using a configurable web services architecture. The detecting step further includes: capturing use cases associated with the software application and checking their validity; providing an automatic invocation of property monitors for model checking; and visualizing one or more defects in the software application for diagnosis. The detecting can further include transforming a heterogeneous software application into a homogeneous application. In more specific embodiments, the detecting further includes providing an automatic test generation for a presentation layer associated with the software application. The configuration associated with the software application can be a simple properties file. The detecting further includes simulating user behavior and generating drivers to test business logic from the use cases or scenarios.
摘要翻译：根据本发明的特定实施例，提供了一种方法，其包括使用可配置的web服务架构检测由异构语言组成的软件应用中的一个或多个缺陷。所述检测步骤还包括：捕获与所述软件应用相关联的使用情况并检查其有效性; 提供模型检查的属性监视器的自动调用; 并可视化软件应用程序中的一个或多个缺陷进行诊断。该检测还可以包括将异构软件应用程序转换为同构应用程序。在更具体的实施例中，检测还包括提供与软件应用相关联的表示层的自动测试生成。与软件应用程序相关的配置可以是一个简单的属性文件。该检测还包括模拟用户行为并生成驱动程序以从用例或场景测试业务逻辑。

6. 发明授权

US07421996B2 Lubricating device for engine 失效
标题翻译：发动机润滑装置
公开(公告)号：US07421996B2
公开(公告)日：2008-09-09
申请号：US11539375
申请日：2006-10-06
申请人： Kenji Oki
发明人： Kenji Oki
IPC分类号： F02F7/00 , F01M11/03 , F01M1/02 , F01M11/02
CPC分类号： F01M11/0004 , F01M1/02 , F01M11/02 , F01M2001/0269 , F01M2001/0284 , F01M2011/0066
摘要： An lubrication device for an engine includes: a crank case which freely rotatably supports a crank shaft and also which stores oil at its lower part; an oil strainer which is so arranged as to be fixed in the crank case; and an oil pump which suctions the oil at the lower part in the crank case via the oil strainer. In the lubricating device, the machining efficiency can be improved by reducing the time of machining to a crank case to thereby decentralize machining processes, and also the oil temperature can be reduced. A crank case cover covering part of a crank case and coupled with the crank case is provided with an oil suction passage which leads to an oil pump, and an oil strainer communicates with the oil suction passage via a connecting pipe which is a member different from the crank case.
摘要翻译：一种用于发动机的润滑装置，包括：曲轴箱，其可自由旋转地支撑曲轴，并且在其下部存储油; 油过滤器，被布置成固定在曲轴箱中; 以及通过油过滤器吸入曲轴箱下部的油的油泵。在润滑装置中，通过减少对曲轴箱的加工时间从而分散加工过程，可以提高加工效率，并且还可以降低油温。曲轴箱盖覆盖曲轴箱的一部分并与曲轴箱连接，设有一个通向油泵的吸油通道，油滤网通过与不同于曲轴箱。

7. 发明申请

US20050158787A1 Base sequence detection apparatus and base sequence automatic analyzing apparatus 有权
标题翻译：基序检测装置和基序自动分析装置
公开(公告)号：US20050158787A1
公开(公告)日：2005-07-21
申请号：US11045646
申请日：2005-01-31
申请人： Sadato Hongo , Minoru Ishikawa , Takiji Ishimura , Shigeru Wakayama , Shinji Yanaga , Kenji Oki , Jun Okada
发明人： Sadato Hongo , Minoru Ishikawa , Takiji Ishimura , Shigeru Wakayama , Shinji Yanaga , Kenji Oki , Jun Okada
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/5438
摘要： A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.
摘要翻译：碱基序列检测装置具有形成在基序列检测芯片上的信道。沿通道形成工作电极，并且包括固定在其上的探针，在通道的内表面上形成相对电极，并且在通道的内表面上形成参考电极。引入端口从通道的上游侧引入溶液或空气，输送口将溶液或空气输送到通道中，并且样品通过样品注入口注入通道。

8. 发明申请

US20090297751A1 Fluoropolymer Blends with Inorganic Layered Compounds 有权
标题翻译：含氟聚合物与无机分层化合物混合
公开(公告)号：US20090297751A1
公开(公告)日：2009-12-03
申请号：US12482633
申请日：2009-06-11
申请人： Pham Hoai Nam , Jeong Chang Lee , Kenji Oki , Hajime Sato
发明人： Pham Hoai Nam , Jeong Chang Lee , Kenji Oki , Hajime Sato
IPC分类号： B32B1/08 , B32B5/00 , B32B5/16 , C08L27/12
CPC分类号： C08F214/262 , B29K2027/12 , C08K3/34 , C08L27/12 , Y10T428/139 , Y10T428/265 , Y10T428/269 , Y10T428/2982
摘要： Perfluoropolymer composites are provided which are obtained by dispersing layered-silicates having properties of swelling or cleaving in dispersion media in perfluoropolymers and having the ratio of the viscosity, V0.1, at 0.1 rad/sec by a parallel plate mode of a dynamic rheometer to the viscosity, V1, measured at 1 rad/sec is 1.5 or greater, viscosity being measured at 340° C. A method for making the perfluoropolymer composites is provided, and molded articles therefrom. And additionally, perfluoropolymer composites, where layered-silicates having properties of swelling or cleaving in dispersion media are dispersed in perfluoropolymers, with the storage elasticity of 2 times or higher than that of fluoropolymers, at temperatures greater than the glass transition temperature of perfluoropolymers.
摘要翻译：提供了全氟聚合物复合材料，其通过在分散介质中分散具有膨胀或裂解性能的层状硅酸盐在全氟聚合物中并通过动态流变仪的平行板模式将粘度V 0.1与0.1rad / sec的比例分散到以1rad / sec测量的粘度V1为1.5或更大，粘度在340℃下测量。提供了制备全氟聚合物复合材料的方法及其模塑制品。此外，在具有大于全氟聚合物的玻璃化转变温度的温度下，在分散介质中具有膨胀或裂解性质的分层硅酸盐分散在全氟聚合物中的全氟聚合物复合材料，其储存弹性是含氟聚合物的储存弹性的2倍或更高。

9. 发明申请

US20090226966A1 Polypeptide having activity of aminoacyl-tRNA synthetase and use thereof 审中-公开
标题翻译：具有氨基-tRNA合成酶活性的多肽及其用途
公开(公告)号：US20090226966A1
公开(公告)日：2009-09-10
申请号：US12322782
申请日：2009-02-05
申请人： Shigeyuki Yokoyama , Kensaku Sakamoto , Kenji Oki , Takahito Mukai
发明人： Shigeyuki Yokoyama , Kensaku Sakamoto , Kenji Oki , Takahito Mukai
IPC分类号： C12N9/00 , C12N15/52 , C12P21/02
CPC分类号： C12N9/93
摘要： A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an IleRS, a ValRS, an AlaRS, a ProRS, or a ThrRS, the editing polypeptide having been either inserted between a Rossman-fold N domain and a Rossman-fold C domain that exist in the altered polypeptide, or bound to an N terminal of the altered polypeptide. Thus provided are a new aaRS that exhibits high substrate specificity to an unnatural amino acid and a technique that involves the use of such an aaRS.
摘要翻译：根据本发明的多肽包括：通过改变ArgRS，CysRS，MetRS，GlnRS，GluRS，LysRS，TyrRS或TrpRS获得的改变的多肽，使得识别出非天然氨基酸; 和衍生自PheRS，LeuRS，IleRS，ValRS，AlaRS，ProRS或ThrRS的编辑多肽，所述编辑多肽已插入Rossman折叠N结构域和Rossman折叠C结构域之间，存在于改变的多肽中，或者与改变的多肽的N末端结合。因此提供了对非天然氨基酸表现出高底物特异性的新aaRS和涉及使用这种aaRS的技术。

10. 发明授权

US06708652B2 Engine valve timing apparatus 失效
标题翻译：发动机气门正时装置
公开(公告)号：US06708652B2
公开(公告)日：2004-03-23
申请号：US10024173
申请日：2001-12-21
申请人： Kenji Oki
发明人： Kenji Oki
IPC分类号： F16H708
CPC分类号： F01L1/022 , F01L1/02 , F01L1/024 , F01L1/053
摘要： A valve timing transmission apparatus is disclosed that increases the freedom of attachment positions for a pivot pin supporting a one end of timing chain and enables arrangement of a chain tensioner in an optimum position for tensioning of the timing chain. An opening having a diameter greater than a sprocket is provided on the drive sprocket side of an outer side wall of a timing chamber which is formed in one side wall of an engine main body and which accommodates the timing chain. A lid plate is removably secured to the engine main body so as to close the opening. Support bosses supporting both ends of the pivot pin are formed in opposite walls of the engine main body and the lid plate.
摘要翻译：公开了一种气门正时传动装置，其增加了支撑正时链的一端的枢轴销的安装位置的自由度，并且能够将链条张紧器布置在用于张紧正时链条的最佳位置。具有大于链轮直径的开口设置在形成在发动机主体的一个侧壁中并且容纳正时链的正时室的外侧壁的驱动链轮侧。盖板可拆卸地固定到发动机主体上以封闭开口。支撑枢轴销的两端形成在发动机主体和盖板的相对壁上。

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