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1. 发明授权

US5465151A Sensors employing interference of electromagnetic waves passing through waveguides having functionalized surfaces 失效
标题翻译：采用通过具有功能化表面的波导的电磁波干扰的传感器
公开(公告)号：US5465151A
公开(公告)日：1995-11-07
申请号：US14425
申请日：1993-02-05
申请人： Martin N. Wybourne , John F. W. Keana , Sui X. Cai , Mingdi Yan , Jong Wu
发明人： Martin N. Wybourne , John F. W. Keana , Sui X. Cai , Mingdi Yan , Jong Wu
IPC分类号： C08J7/12 , B01J19/08 , C01B31/04 , C08F8/34 , C23C16/02 , G01N21/27 , G01N21/45 , G01N21/64 , G01N21/75 , G01N21/77 , G01N33/543 , G01N33/566 , G03F7/20 , H01L21/368 , G01B9/02
CPC分类号： G01N21/7703 , C08F8/32 , G01N33/54373 , G03F7/2041 , G01N2021/7779 , G01N2201/0873
摘要： Chemical and biosensors are disclosed. An optical waveguide is used to conduct electromagnetic radiation by total internal reflection in parallel through a reference waveguide portion and at least one analyte waveguide portion. The electromagnetic radiation is then converged into an exit beam. The external surface of at least the analyte portion is covalently modified, or functionalized, relative to the reference portion. Resulting interaction of the functionalized surface with molecules comprising an analyte causes a phase change in the electromagnetic radiation passing through the analyte portion relative to the reference portion sufficient to generate a corresponding and measurable interference pattern in the exit beam. A waveguide surface is functionalized by exposure to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The resulting reaction causes the functionalizing groups to covalently bond to the surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface. Thus, the waveguide surface can be made selectively responsive to a wide variety of analytes, including cells and other biological structures.
摘要翻译：公开了化学和生物传感器。光波导用于通过参考波导部分和至少一个分析物波导部分并行地通过全内反射来传导电磁辐射。电磁辐射然后会聚到出射光束中。至少分析物部分的外表面相对于参考部分共价修饰或官能化。功能化表面与包含分析物的分子的相互作用导致相对于参考部分通过分析物部分的电磁辐射的相变足以在出射光束中产生相应和可测量的干涉图案。波导表面通过暴露于具有各自包含硝基衍生基团和官能化基团的分子的试剂而被功能化，所述分子在有电的带电粒子例如电子和离子，光子或热的情况下，其将硝化反应试剂转变为硝酸中间体。所得到的反应使官能团共价键合到表面。官能团然后可以参与下游化学，因此包括生物分子在内的各种各样的官能团中的任何一个可以共价键合到表面上。因此，波导表面可以选择性地响应于各种各样的分析物，包括细胞和其他生物结构。

2. 发明授权

US5582955A Chemical functionalization of surfaces 失效
公开(公告)号：US5582955A
公开(公告)日：1996-12-10
申请号：US495005
申请日：1995-06-26
申请人： John F. W. Keana , Martin N. Wybourne , Sui X. Cai , Mingdi Yan
发明人： John F. W. Keana , Martin N. Wybourne , Sui X. Cai , Mingdi Yan
IPC分类号： C08F8/30 , C08F8/34 , G03C5/00
CPC分类号： C08F8/30 , C08F8/34 , Y10S430/143
摘要： Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotrophic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface. Such functionalizations of the surface can be done in a single reactive step or in multiple reactive steps.

3. 发明授权

US5580697A Chemical functionalization of surfaces 失效
公开(公告)号：US5580697A
公开(公告)日：1996-12-03
申请号：US267851
申请日：1994-06-23
申请人： John F. W. Keana , Martin N. Wybourne , Sui X. Cai , Mingdi Yan
发明人： John F. W. Keana , Martin N. Wybourne , Sui X. Cai , Mingdi Yan
IPC分类号： C08J7/12 , B01J19/08 , C01B31/04 , C08F8/34 , C23C16/02 , G01N21/45 , G01N21/77 , G01N33/543 , G03F7/20 , H01L21/368 , G03C5/00
CPC分类号： G01N33/54373 , C08F8/32 , G01N21/7703 , G03F7/2041 , G01N2201/0873 , Y10S430/143
摘要： Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotrophic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface. Such functionalizations of the surface can be done in a single reactive step or in multiple reactive steps.

4. 发明授权

US5587273A Molecularly imprinted materials, method for their preparation and devices employing such materials 失效
标题翻译：分子印迹材料，其制备方法和使用这种材料的装置
公开(公告)号：US5587273A
公开(公告)日：1996-12-24
申请号：US476918
申请日：1995-06-07
申请人： Mingdi Yan , John F. W. Keana , Martin N. Wybourne , Christophe J. P. Sevrain
发明人： Mingdi Yan , John F. W. Keana , Martin N. Wybourne , Christophe J. P. Sevrain
IPC分类号： G01N21/78 , C08F8/34 , C08K5/00 , C08L101/00 , G01N27/22 , G01N33/543 , G03F7/012 , G03F7/20 , G03C5/00
CPC分类号： G01N33/54373 , C08F8/32 , G03F7/012 , G03F7/2041 , C08F2810/20 , G01N2600/00 , Y10S430/143
摘要： A molecularly imprinted substrate and sensors employing the imprinted substrate for detecting the presence or absence of analytes are described. One embodiment of the invention comprises first forming a solution comprising a solvent and (a) a polymeric material capable of undergoing an addition reaction with a nitrene, (b) a crosslinking agent (c) a functionalizing monomer and (d) an imprinting molecule. A silicon wafer is spincoated with the solution. The solvent is evaporated to form a film on the silicon wafer. The film is exposed to an energy source to crosslink the substrate, and the imprinting molecule is then extracted from the film. The invention can be used to detect an analyte by forming films which are then exposed to a reaction energy to form a crosslinked substrate. The imprinting molecules are extracted from the crosslinked substrate. The film is exposed to one or more of the imprinting molecules for a period of time sufficient to couple the imprinting molecules to the film. The presence of the molecules is then detected. The invention also provides a molecularly imprinted polymeric material and sensors employing the molecularly imprinted polymeric material.
摘要翻译：描述了分子印迹的基底和采用印迹底物检测分析物存在或不存在的传感器。本发明的一个实施方案包括首先形成包含溶剂的溶液和（a）能够与硝酸进行加成反应的聚合物，（b）交联剂（c）官能化单体和（d）压印分子。用溶液旋涂硅晶片。蒸发溶剂以在硅晶片上形成膜。该膜暴露于能量源以使基底交联，然后从膜中提取压印分子。本发明可用于通过形成膜然后暴露于反应能量以形成交联的底物来检测分析物。印记分子从交联底物中提取出来。将该膜暴露于一个或多个刻印分子一段足以使压印分子与膜结合的时间。然后检测分子的存在。本发明还提供了使用分子印迹聚合物材料的分子印迹聚合物材料和传感器。

5. 发明授权

US5830539A Methods for functionalizing and coating substrates and devices made according to the methods 失效
标题翻译：根据方法制造的基板和器件的功能化和涂覆方法
公开(公告)号：US5830539A
公开(公告)日：1998-11-03
申请号：US565199
申请日：1995-11-17
申请人： Mingdi Yan , John F. W. Keana , Goran Karapetrov , Christopher J-P Sevrain , Martin N. Wybourne
发明人： Mingdi Yan , John F. W. Keana , Goran Karapetrov , Christopher J-P Sevrain , Martin N. Wybourne
IPC分类号： A61L27/28 , A61L33/00 , B05D1/18 , B05D7/14 , B05D3/06 , B05D3/10
CPC分类号： B82Y30/00 , A61L27/28 , A61L33/0076 , B05D1/185 , B82Y40/00 , B01J2219/00497 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659
摘要： Methods for coating substrates are described. The methods comprise coating at least a portion of a substrate with particular coating materials. The coating materials can be crosslinked and coated onto a substrate. Alternatively, the coating materials may be covalently bonded to the substrates. The coating materials might themselves functionalize the substrate, or provide a biocompatible coating on the substrate. The coating materials might also include electrophilic or nucleophilic groups that allow for the subsequent reaction of the coating materials with additional reagents. The present invention also provides coated workpieces, particularly medical workpieces having a surface for contacting tissue or blood. These workpieces comprise a first layer and a second layer. The first layer comprises a molecular tether covalently bonded to the surface. The second layer is bonded to the article by the first layer and comprises a bioactive agent selected from the group consisting of biocompatible polymers, antibiotics, antimicrobials and anticoagulants.
摘要翻译：描述了涂覆基材的方法。所述方法包括用特定涂层材料涂覆至少一部分基底。涂层材料可以交联并涂覆在基材上。或者，涂层材料可以共价键合到基底上。涂层材料本身可以使基底功能化，或在基材上提供生物相容的涂层。涂层材料还可以包括允许涂层材料随后与另外的试剂反应的亲电或亲核基团。本发明还提供涂覆的工件，特别是具有用于接触组织或血液的表面的医疗工件。这些工件包括第一层和第二层。第一层包括共价结合到表面上的分子系链。第二层通过第一层结合到制品上，并且包含选自生物相容性聚合物，抗生素，抗微生物剂和抗凝剂的生物活性剂。

6. 发明申请

US20090155573A1 SCAFFOLD-ORGANIZED METAL, ALLOY, SEMICONDUCTOR AND/OR MAGNETIC CLUSTERS AND ELECTRONIC DEVICES MADE USING SUCH CLUSTERS 审中-公开
标题翻译：合金，合金，半导体和/或磁性集群和使用这种集群的电子设备
公开(公告)号：US20090155573A1
公开(公告)日：2009-06-18
申请号：US11960528
申请日：2007-12-19
申请人： Martin N. Wybourne , James E. Hutchison
发明人： Martin N. Wybourne , James E. Hutchison
IPC分类号： B32B5/16
CPC分类号： B82Y30/00 , B05D1/185 , B05D7/24 , B82B3/00 , B82Y25/00 , B82Y40/00 , C07B2200/11 , C07H21/00 , C40B40/00 , H01F1/0063 , H01L49/00 , Y10S977/705 , Y10S977/779 , Y10S977/784 , Y10T428/256
摘要： A method for forming arrays of metal, alloy, semiconductor or magnetic clusters is described. The method comprises placing a scaffold on a substrate, the scaffold comprising molecules selected from the group consisting of polynucleotides, polypeptides, and perhaps combinations thereof. Polypeptides capable of forming α helices are currently preferred for forming scaffolds. Arrays are then formed by contacting the scaffold with plural, monodispersed ligand-stabilized clusters. Each cluster, prior to contacting the scaffold, includes plural exchangeable ligands bonded thereto. If the clusters are metal clusters, then the metal preferably is selected from the group consisting of Ag, Au, Pt, Pd and mixtures thereof. A currently preferred metal is gold, and a currently preferred metal cluster is Au55 having a radius of from about 0.7 to about 1 nm. Compositions also are described, one use for which is in the formation of cluster arrays. One embodiment of the composition comprises plural monodispersed, ligand-stabilized clusters coupled to a polypeptide.
摘要翻译：描述了形成金属，合金，半导体或磁性簇的阵列的方法。该方法包括将支架置于底物上，所述支架包含选自多核苷酸，多肽及其组合的分子。能够形成α螺旋的多肽目前优选用于形成支架。然后通过使支架与多个单分散的配体稳定的簇接触而形成阵列。每个簇在接触支架之前包括与其结合的多个可交换配体。如果簇是金属簇，则金属优选选自Ag，Au，Pt，Pd及其混合物。目前优选的金属是金，并且当前优选的金属簇是具有约0.7至约1nm的半径的Au55。还描述了组合物，其中一种用于形成簇阵列。组合物的一个实施方案包括与多肽偶联的多个单分散的配体稳定的簇。

7. 发明授权

US5347141A Multiterminal lateral S-shaped negative differential conductance device 失效
标题翻译：多端侧S形负差动电导装置
公开(公告)号：US5347141A
公开(公告)日：1994-09-13
申请号：US149256
申请日：1993-11-09
申请人： Martin N. Wybourne , Doran D. Smith , Stephen M. Goodnick , Jong-Ching Wu , Chris Berven
发明人： Martin N. Wybourne , Doran D. Smith , Stephen M. Goodnick , Jong-Ching Wu , Chris Berven
IPC分类号： H01L29/76 , H01L29/772 , H01L29/80
CPC分类号： B82Y10/00 , H01L29/7613 , H01L29/772
摘要： The present invention (or multi-terminal lateral hot-electron transistor, ET) is based on a high electron mobility (hot-electron) transistor with a split-gate arrangement similar to those used in quantum wave guide devices. In the present invention, the depletion below the split gate is used to form, and control, potential barriers between the source and drain contacts. The devices, according to the present invention, exhibit pronounced SNDC which is controlled by the gate bias.
摘要翻译：本发明（或多端子横向热电子晶体管LHET）基于具有与量子波导器件中使用的类似的分离栅极布置的高电子迁移率（热电子）晶体管。在本发明中，分裂栅下方的耗尽被用于形成和控制源极和漏极接触之间的势垒。根据本发明的器件显示出由栅极偏置控制的显着的SNDC。

8. 发明授权

US07626192B2 Scaffold-organized clusters and electronic devices made using such clusters 失效
标题翻译：使用这种集群制作的脚手架组织和电子设备
公开(公告)号：US07626192B2
公开(公告)日：2009-12-01
申请号：US11120352
申请日：2005-05-02
申请人： James E. Hutchison , Martin N. Wybourne , Scott M. Reed
发明人： James E. Hutchison , Martin N. Wybourne , Scott M. Reed
IPC分类号： G01N33/553
CPC分类号： H01L51/0595 , B82Y10/00 , Y10S977/773 , Y10S977/81 , Y10S977/83
摘要： A method for forming arrays of metal, alloy, semiconductor or magnetic nanoparticles is described. An embodiment of the method comprises placing a scaffold on a substrate, the scaffold comprising, for example, polynucleotides and/or polypeptides, and coupling the nanoparticles to the scaffold. Methods of producing arrays in predetermined patterns and electronic devices that incorporate such patterned arrays are also described.
摘要翻译：描述了形成金属，合金，半导体或磁性纳米颗粒阵列的方法。该方法的一个实施方案包括将支架置于底物上，所述支架包含例如多核苷酸和/或多肽，并将纳米颗粒偶联至支架。还描述了以预定图案制造阵列的方法和结合了这种图案化阵列的电子装置。

9. 发明授权

US09034262B2 Molecularly imprinted polymer sensor systems and related methods 有权
标题翻译：分子印迹聚合物传感器系统及相关方法
公开(公告)号：US09034262B2
公开(公告)日：2015-05-19
申请号：US12304943
申请日：2007-06-14
申请人： Joseph J. Belbruno , Ursula J. Gibson , Jane E. G. Lipson , Martin N. Wybourne
发明人： Joseph J. Belbruno , Ursula J. Gibson , Jane E. G. Lipson , Martin N. Wybourne
IPC分类号： G01N15/06 , G01N33/00 , G01N27/12 , B82Y15/00
CPC分类号： G01N27/127 , B82Y15/00 , G01N27/126 , G01N2600/00 , Y10T436/11
摘要： A molecularly imprinted polymer (MIP) sensor including a substrate, two or more electrodes, a conductive layer applied to the substrate and a molecularly imprinted polymer layer applied to the conductive layer is disclosed herein The MIP sensor may form part of an MIP sensor system that can be used to detect and quantify target molecules.
摘要翻译：本文公开了一种分子印迹聚合物（MIP）传感器，其包括衬底，两个或更多个电极，施加到衬底的导电层和施加到导电层的分子印迹聚合物层.MIP传感器可以形成MIP传感器系统的一部分，可用于检测和定量靶分子。

10. 发明授权

US07326954B2 Scaffold-organized metal, alloy, semiconductor and/or magnetic clusters and electronic devices made using such clusters 失效
标题翻译：支架组织的金属，合金，半导体和/或磁簇和使用这种簇制成的电子器件
公开(公告)号：US07326954B2
公开(公告)日：2008-02-05
申请号：US10816603
申请日：2004-04-02
申请人： Martin N. Wybourne , James E. Hutchison
发明人： Martin N. Wybourne , James E. Hutchison
IPC分类号： H01L51/05
CPC分类号： B82Y30/00 , B05D1/185 , B05D7/24 , B82B3/00 , B82Y25/00 , B82Y40/00 , C07B2200/11 , C07H21/00 , C40B40/00 , H01F1/0063 , H01L49/00 , Y10S977/705 , Y10S977/779 , Y10S977/784 , Y10T428/256
摘要： A method for forming arrays of metal, alloy, semiconductor or magnetic clusters is described. The method comprises placing a scaffold on a substrate, the scaffold comprising molecules selected from the group consisting of polynucleotides, polypeptides, and perhaps combinations thereof. Polypeptides capable of forming α helices are currently preferred for forming scaffolds. Arrays are then formed by contacting the scaffold with plural, monodispersed ligand-stabilized clusters. Each cluster, prior to contacting the scaffold, includes plural exchangeable ligands bonded thereto. If the clusters are metal clusters, then the metal preferably is selected from the group consisting of Ag, Au, Pt, Pd and mixtures thereof. A currently preferred metal is gold, and a currently preferred metal cluster is Au55 having a radius of from about 0.7 to about 1 nm. Compositions also are described, one use for which is in the formation of cluster arrays. One embodiment of the composition comprises plural monodispersed, ligand-stabilized clusters coupled to a polypeptide.
摘要翻译：描述了形成金属，合金，半导体或磁性簇的阵列的方法。该方法包括将支架置于底物上，所述支架包含选自多核苷酸，多肽及其组合的分子。能够形成α螺旋的多肽目前优选用于形成支架。然后通过使支架与多个单分散的配体稳定的簇接触而形成阵列。每个簇在接触支架之前包括与其结合的多个可交换配体。如果簇是金属簇，则金属优选选自Ag，Au，Pt，Pd及其混合物。目前优选的金属是金，并且当前优选的金属簇是半径为约0.7至约1nm的Au 55。还描述了组合物，其中一种用于形成簇阵列。组合物的一个实施方案包括与多肽偶联的多个单分散的配体稳定的簇。

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