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1. 发明授权

US09673031B2 Conversion of ion arrival times or ion intensities into multiple intensities or arrival times in a mass spectrometer 有权
公开(公告)号：US09673031B2
公开(公告)日：2017-06-06
申请号：US12302177
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyzer comprising an ion detector comprising an Analog to Digital Converter. Signals from the Analog to Digital Converter are digitized and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighboring time bins T(n), T(n+1).

2. 发明授权

US08519331B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08519331B2
公开(公告)日：2013-08-27
申请号：US12528173
申请日：2008-02-21
申请人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/0095 , H01J49/423 , H01J49/424
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
摘要翻译：公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极杆组离子阱，其中在每个棒中设置有槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。

3. 发明申请

US20100252730A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100252730A1
公开(公告)日：2010-10-07
申请号：US12668813
申请日：2008-07-14
申请人： Martin Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
发明人： Martin Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/02 , H01J49/26
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).
摘要翻译：公开了一种质谱仪，其包括四极杆组离子阱（2,3），其中在离子阱（4,5）的出口产生一个电势场，该离子阱在一个径向方向上随着半径的增加而减小。离子阱（2,3）内的离子质量选择性地沿径向激发。已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱（2,3）轴向地排出，。

4. 发明申请

US20100148056A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100148056A1
公开(公告)日：2010-06-17
申请号：US12516610
申请日：2007-12-14
申请人： Daniel James Kenny , Jason Lee Wildgoose , Martin Green
发明人： Daniel James Kenny , Jason Lee Wildgoose , Martin Green
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap (7) or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode (2) which forms part of the Time of Flight mass analyser. Ions in the pulse or packet of ions which is released become temporally dispersed and the orthogonal acceleration electrode (2) is energised multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译：公开了一种质谱仪，其包括正交加速时间飞行质量分析器。从离子阱（7）或替代地从布置在作为飞行时间质量分析器的一部分的正交加速电极（2）的上游的行波离子导向器释放脉冲或包离子。释放的脉冲或离子束中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极（2）被多次通电。

5. 发明申请

US20100038530A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100038530A1
公开(公告)日：2010-02-18
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱（1），其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子在径向上被限制在离子导向器或离子阱（1）内。沿离子导向器或离子阱（1）的轴向长度的至少一部分保持静电势阱。沿离子导向器或离子阱（1）的轴向长度的至少一部分施加时变均匀电场。静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱（1）喷出。

6. 发明申请

US20140005970A1 Method Of Deadtime Correction in Mass Spectrometry 审中-公开
标题翻译：质谱法死亡时间校正方法
公开(公告)号：US20140005970A1
公开(公告)日：2014-01-02
申请号：US13977863
申请日：2012-01-09
申请人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
发明人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent and/or intensity measurements for a species of interest in an analyte to correct for hardware limitations within a mass spectrometer, which method comprises the steps of acquiring raw data produced by a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent and/or intensity measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent and/or intensity measurements with associated uncertainties.
摘要翻译：一种提高分析物感兴趣的物种的m / z依赖和/或强度测量的保真度以校正质谱仪内的硬件限制的方法，该方法包括以下步骤：获取由质谱仪产生的原始数据，识别原始数据中与感兴趣物种相关的区域，形成数学模型以计算影响m / z依赖和/或强度测量的参数的联合概率分布，从联合概率分布中分析获取样本以产生校正的或精确的m / z依赖和/或强度测量与相关的不确定性。

7. 发明申请

US20130317756A1 Method Of Deadtime Correction In Mass Spectrometry 审中-公开
标题翻译：质谱中死时间校正方法
公开(公告)号：US20130317756A1
公开(公告)日：2013-11-28
申请号：US13977861
申请日：2012-01-09
申请人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
发明人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent measurements for a species of interest in an analyte in a mass spectrometer, which method comprises the steps of acquiring raw data produced in a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent measurements with associated uncertainties.
摘要翻译：一种提高质谱仪中分析物中感兴趣的物种的m / z依赖性测量的保真度的方法，该方法包括以下步骤：获取在质谱仪中产生的原始数据，识别与原始数据相关的原始数据中的区域形成感兴趣的物种，形成一个数学模型，以计算影响m / z依赖性测量的参数的联合概率分布，从联合概率分布中分析获得样本，以产生具有相关不确定性的校正或精确的m / z相关度量。

8. 发明授权

US08519328B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08519328B2
公开(公告)日：2013-08-27
申请号：US13435877
申请日：2012-03-30
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyzer.
摘要翻译：公开了一种具有入口电极和出射电极的离子导向器或离子阱。出口电极的电位周期性地下降相当短的时间段，允许一些离子通过出射电极的孔离开离子导向器或离子阱。出口电极的电位下降的时间段逐渐增加，并且离子导向器或离子阱以质荷比依赖的方式出现离子。离子导向器或离子阱可以作为质量分离器或低分辨率质量分析器来操作。

9. 发明申请

US20100001180A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20100001180A1
公开(公告)日：2010-01-07
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/40 , H01J49/26
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

10. 发明申请

US20090121123A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090121123A1
公开(公告)日：2009-05-14
申请号：US11916438
申请日：2006-06-05
申请人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译：公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

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