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1. 发明授权

US06759227B2 Caspase homologue 失效
标题翻译：半胱天冬酶同源物
公开(公告)号：US06759227B2
公开(公告)日：2004-07-06
申请号：US09764803
申请日：2001-01-17
申请人： Marc van de Craen , Wim Declercq , Peter Vandenabeele , Walter Fiers
发明人： Marc van de Craen , Wim Declercq , Peter Vandenabeele , Walter Fiers
IPC分类号： C12N950
CPC分类号： C12N9/6475 , A01K2217/05 , A61K38/00
摘要： Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue. The new molecules are most related to human/murine caspase-2 and human caspase-9 and possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a very short prodomain. Northern blot analysis revealed that mRNA expression of the new caspase is predominant in skin.
摘要翻译：胱天蛋白酶是半胱氨酰天冬氨酸特异性蛋白酶，其中许多蛋白酶在细胞凋亡中起核心作用。本发明涉及鉴定新的鼠半胱天冬酶及其人类同源物。新分子与人/鼠半胱天冬酶-2和人类半胱天冬酶-9最相关，并且具有催化涉及的胱天蛋白酶的所有典型氨基酸残基，包括QACRG盒，并且不包含或仅仅是非常短的前结构域。 Northern印迹分析显示，新的胱天蛋白酶的mRNA表达在皮肤中占主导地位。

2. 发明申请

US20070036826A1 Influenza immunogen and vaccine 失效
标题翻译：流感免疫原和疫苗
公开(公告)号：US20070036826A1
公开(公告)日：2007-02-15
申请号：US11509382
申请日：2006-08-24
申请人： Ashley Birkett , Walter Fiers
发明人： Ashley Birkett , Walter Fiers
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K39/292 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
摘要翻译：公开了一种嵌合的羧基末端截短的乙型肝炎病毒核衣壳蛋白（HBc），其包含用于诱导产生针对流感M2蛋白的抗体的免疫原。 2至4个拷贝中的免疫原性流感病毒序列优选在N末端或HBc免疫原性环序列中或附近表达。 HBc嵌合体优选含有流感特异性T细胞表位，并且优选地被设计用于增强自组装颗粒的稳定性和提高那些嵌合颗粒的产量。还公开了制造和使用这种开发者的方法。

3. 发明申请

US20060115489A1 Influenza immunogen and vaccine 失效
标题翻译：流感免疫原和疫苗
公开(公告)号：US20060115489A1
公开(公告)日：2006-06-01
申请号：US10787734
申请日：2004-02-26
申请人： Ashley Birkett , Walter Fiers
发明人： Ashley Birkett , Walter Fiers
IPC分类号： A61K39/29 , C12N7/00 , C07K14/02 , C12N7/01
CPC分类号： A61K39/145 , A61K39/12 , A61K39/292 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
摘要翻译：公开了一种嵌合的羧基末端截短的乙型肝炎病毒核衣壳蛋白（HBc），其包含用于诱导产生针对流感M2蛋白的抗体的免疫原。 2至4个拷贝中的免疫原性流感病毒序列优选在N末端或HBc免疫原性环序列中或附近表达。 HBc嵌合体优选含有流感特异性T细胞表位，并且优选地被设计用于增强自组装颗粒的稳定性和提高那些嵌合颗粒的产量。还公开了制造和使用这种开发者的方法。

4. 发明授权

US6093554A Genetics manipulations with recombinant DNA virus comprising sequences derived from RNA virus 失效
标题翻译：用包含源自RNA病毒的序列的重组DNA病毒的遗传操作
公开(公告)号：US6093554A
公开(公告)日：2000-07-25
申请号：US234163
申请日：1999-01-21
申请人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
发明人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
IPC分类号： C07K14/08 , C07K14/48 , C12N9/12 , C12N15/82 , C12P21/06 , C07G17/00 , C12N5/02 , C12N5/04 , C12P21/04
CPC分类号： C07K14/005 , C07K14/48 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8283 , C12N9/127 , C12N2770/38022
摘要： The invention relates to genetic manipulations of eukaryotic organisms, with recombinant DNA comprising RNA virus derived sequences for protecting such organisms against RNA viruses or enabling inducible or tissue-specific production of foreign proteins/peptides or RNAs. One embodiment of the recombinant DNA according to the invention comprises recombinant DNA, comprising two, 12-250 base pair long, inverted repeat nucleotide sequences with therebetween at least one nucleotide sequence which is derived from RNA virus which for its replication is dependent upon a viral RNA/RNA polymerase, said RNA virus derived sequence comprising at least cis elements for replication but no gene that codes for viral RNA/RNA polymerase and no gene that codes for viral coat protein. The invention also relates to eukaryotic or prokaryotic cells or organisms which incorporate the recombinant DNA according to the invention. Further, the invention relates to a method of protecting such cells or organisms by genetically incorporating recombinant DNA according to the invention.
摘要翻译：本发明涉及真核生物的遗传操作，其中重组DNA包含RNA病毒衍生的序列，用于保护这些生物体免受RNA病毒的侵袭或使得诱导或组织特异性产生外源蛋白/肽或RNA。根据本发明的重组DNA的一个实施方案包含重组DNA，其包含两个12-250碱基对长的反向重复核苷酸序列，其间具有至少一个核苷酸序列，其衍生自RNA病毒，其复制依赖于病毒 RNA / RNA聚合酶，所述RNA病毒衍生序列至少包含用于复制的顺式元件，但没有编码病毒RNA / RNA聚合酶的基因，并且没有编码病毒外壳蛋白的基因。本发明还涉及掺入根据本发明的重组DNA的真核或原核细胞或生物体。此外，本发明涉及通过遗传掺入根据本发明的重组DNA来保护这些细胞或生物体的方法。

5. 发明授权

US07449188B2 Recombinant oligometric protein complexes with enhanced immunogenic potential 有权
标题翻译：具有增强的免疫原性潜能的重组寡聚蛋白复合物
公开(公告)号：US07449188B2
公开(公告)日：2008-11-11
申请号：US10466655
申请日：2002-01-18
申请人： Marina De Filette , Tom Maria Deroo , Walter Fiers , Marleen Maras , Willy Alfons Min Jou
发明人： Marina De Filette , Tom Maria Deroo , Walter Fiers , Marleen Maras , Willy Alfons Min Jou
IPC分类号： A61K39/145 , A61K39/385 , C07K19/00 , C07K14/11 , C12N15/62 , C12N15/44 , C12N15/63 , C12N1/21 , C12N5/10
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/40 , C07K2319/70 , C07K2319/73 , C12N2760/16122 , C12N2760/16222
摘要： The present invention relates to a chimeric protein comprising an antigen and an oligomerisation domain. The present invention relates further to recombinant oligomeric protein complexes comprising said chimeric protein and the use thereof for the manufacture of a vaccine.
摘要翻译：本发明涉及包含抗原和寡聚化结构域的嵌合蛋白。本发明进一步涉及包含所述嵌合蛋白的重组寡聚蛋白复合物及其用于制造疫苗的用途。

6. 发明授权

US06746671B2 Use of a cytokine-producing lactococcus strain to treat colitis 有权
标题翻译：使用产生细胞因子的乳球菌菌株治疗结肠炎
公开(公告)号：US06746671B2
公开(公告)日：2004-06-08
申请号：US09838718
申请日：2001-04-19
申请人： Lothar Steidler , Erik R. Remaut , Walter Fiers
发明人： Lothar Steidler , Erik R. Remaut , Walter Fiers
IPC分类号： A01N6300
CPC分类号： A61K38/2066 , A61K38/00 , A61K38/162 , A61K38/208 , C07K14/52 , C07K14/5428 , C07K14/715 , C12N15/746
摘要： An administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, for example, IL10 and/or soluble TNF receptor via the oral route. Preferably, inoculation occurs along with a suspension of recombinant Lactococcus lactis cells, which had been engineered to produce the respective proteins.
摘要翻译：用于在肠粘膜上递送细胞因子或细胞因子拮抗剂，优选通过口服途径优选酸敏抗炎药，例如IL10和/或可溶性TNF受体的施用策略。优选地，接种与重组乳酸乳球菌细胞的悬浮液一起发生，其已被工程化以产生相应的蛋白质。

7. 发明授权

US06197542B1 Genetic manipulations with recombinant DNA comprising sequences derived from RNA virus 失效
标题翻译：使用包含衍生自RNA病毒的序列的重组DNA的遗传操作
公开(公告)号：US06197542B1
公开(公告)日：2001-03-06
申请号：US08901379
申请日：1997-07-28
申请人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
发明人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
IPC分类号： C12P2106
CPC分类号： C12N9/127 , C07K14/005 , C07K14/48 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8283 , C12N2770/38022
摘要： The invention relates to genetic manipulations of eukaryotic organisms, with recombinant DNA comprising RNA virus derived sequences for protecting such organisms against RNA viruses or enabling inducible or tissue-specific production of foreign proteins/peptides or RNAs. One embodiment of the recombinant DNA according to the invention comprises recombinant DNA, comprising two, 12-1250 base pair long, inverted repeat nucleotide sequences with therebetween at least one nucleotide sequence which is derived from RNA virus which for its replication is dependent upon a viral RNA/RNA polymerase, said RNA virus derived sequence comprising at least cis elements for replication but no gene that codes for viral RNA/RNA polymerase and no gene that codes for viral coat protein. The invention also relates to eukaryotic or prokaryotic cells or organisms which incorporate the recombinant DNA according to the invention. Further the invention relates to a method of protecting such cells or organisms by genetically incorporating recombinant DNA according to the invention.
摘要翻译：本发明涉及真核生物的遗传操作，其中重组DNA包含RNA病毒衍生的序列，用于保护这些生物体免受RNA病毒的侵袭或使得诱导或组织特异性产生外源蛋白/肽或RNA。根据本发明的重组DNA的一个实施方案包含重组DNA，其包含两个12-1250碱基对长的反向重复核苷酸序列，其间具有至少一个核苷酸序列，其衍生自RNA病毒，其复制依赖于病毒 RNA / RNA聚合酶，所述RNA病毒衍生序列至少包含用于复制的顺式元件，但没有编码病毒RNA / RNA聚合酶的基因，并且没有编码病毒外壳蛋白的基因。本发明还涉及掺入根据本发明的重组DNA的真核或原核细胞或生物体。此外，本发明涉及通过遗传掺入根据本发明的重组DNA来保护此类细胞或生物体的方法。

8. 发明授权

US5668256A Chimeric interleukin 5-receptor/immunoglobulin polypeptides 失效
标题翻译：嵌合白介素5受体/免疫球蛋白多肽
公开(公告)号：US5668256A
公开(公告)日：1997-09-16
申请号：US421822
申请日：1995-04-13
申请人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
发明人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
IPC分类号： A61K38/00 , A61P11/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C07K16/46
CPC分类号： C07K14/7155 , C07K16/2866 , C07K19/00 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
摘要翻译：由具有编码人白细胞介素-5受体的α和/或β链中的至少一个的片段的第一DNA亚序列的DNA序列编码的嵌合多肽和编码人白细胞介素-5受体的恒定结构域的第二DNA亚序列人免疫球蛋白的重链或轻链或其片段可用于治疗伴有嗜酸性粒细胞增多症的疾病。

9. 发明授权

US5455337A DNA encoding chimeric polypeptides comprising the interleukin-5 receptor .alpha.-chain fused to immunoglobulin heavy chain constant regions 失效
标题翻译：编码包含与免疫球蛋白重链恒定区融合的白细胞介素-5受体α-链的嵌合多肽的DNA
公开(公告)号：US5455337A
公开(公告)日：1995-10-03
申请号：US947130
申请日：1992-09-16
申请人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
发明人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
IPC分类号： A61K38/00 , A61P11/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C07H21/04 , C12N1/21 , C12N15/11
CPC分类号： C07K14/7155 , C07K16/2866 , C07K19/00 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
摘要翻译：由具有编码人白细胞介素-5受体的α和/或β链中的至少一个的片段的第一DNA亚序列的DNA序列编码的嵌合多肽和编码人白细胞介素-5受体的恒定结构域的第二DNA亚序列人免疫球蛋白的重链或轻链或其片段可用于治疗伴有嗜酸性粒细胞增多症的疾病。

10. 发明授权

US07993652B2 Immunoprotective influenza antigen and its use in vaccination 有权
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：US07993652B2
公开(公告)日：2011-08-09
申请号：US12795506
申请日：2010-06-07
申请人： Sabine Neirynck , Willy Min Jou , Walter Fiers
发明人： Sabine Neirynck , Willy Min Jou , Walter Fiers
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/55566 , A61K2039/55572 , C07K2319/00 , C12N2710/14143 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
摘要翻译：本发明涉及流感抗原，其包含至少保守的流感病毒膜蛋白的细胞外部分或其功能片段和呈递载体的融合产物，其可以是呈递（多）肽或非肽结构，如聚糖，肽模拟物，合成聚合物。本发明进一步涉及抗流感疫苗，其中至少包含本发明的抗原，任选地在一种或多种赋形剂的存在下。本发明还涉及抗原的用途，制备抗原的方法和表达抗原的受体细胞。

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