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1. 发明授权

US07410987B2 Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative 有权
标题翻译：通过施用包含2-苯基苯并噻唑啉衍生物的卡帕阿片受体激动剂来治疗疼痛或瘙痒的方法
公开(公告)号：US07410987B2
公开(公告)日：2008-08-12
申请号：US11434028
申请日：2006-05-15
申请人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi Kohno
发明人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi Kohno
IPC分类号： A61K31/428 , A61P29/00
CPC分类号： C07D417/12 , A61K31/428 , C07D277/66
摘要： A method of treating pain or pruritis comprising administering to a patient in need thereof a pharmaceutically effective amount of a κ opioid receptor agonist of the formula wherein R is an alkyl having an amino group as a substituent; and R1 is acyl.
摘要翻译：一种治疗疼痛或瘙痒症的方法，包括向有需要的患者施用药学有效量的下式的κ阿片受体激动剂其中R是具有氨基作为取代基的烷基; R 1是酰基。

2. 发明申请

US20060205796A1 Method for treating pain or pruritis by administering opinoid receptor agonist comprising 2-phenylbenzothiazoling derivative 有权
标题翻译：通过施用包含2-苯基苯并噻唑啉衍生物的阿片样物质受体激动剂治疗疼痛或瘙痒的方法
公开(公告)号：US20060205796A1
公开(公告)日：2006-09-14
申请号：US11434028
申请日：2006-05-15
申请人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi kohno
发明人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi kohno
IPC分类号： A61K31/428
CPC分类号： C07D417/12 , A61K31/428 , C07D277/66
摘要： A method of treating pain or pruritis comprising administering to a patient in need thereof a pharmaceutically effective amount of a κ opioid receptor agonist of the formula wherein R is an alkyl having an amino group as a substituent; and R1 is acyl.
摘要翻译：一种治疗疼痛或瘙痒症的方法，包括向有需要的患者施用药学有效量的下式的κ阿片受体激动剂其中R是具有氨基作为取代基的烷基; R 1是酰基。

3. 发明授权

US07112598B2 κ opioid receptor agonist comprising 2-phenylbenzothiazoline derivative 有权
标题翻译： κ阿片受体激动剂，其包含2-苯基苯并噻唑啉衍生物
公开(公告)号：US07112598B2
公开(公告)日：2006-09-26
申请号：US10509549
申请日：2003-03-28
申请人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi Kohno
发明人： Maki Tokai , Takahiro Honda , Masashi Niwa , Yaeko Osumi , Ken-ichi Fujimura , Shin-ichi Kohno
IPC分类号： C07D277/66 , C07D417/12 , A61K31/428 , A61P29/00 , A61P25/04
CPC分类号： C07D417/12 , A61K31/428 , C07D277/66
摘要： A compound or a salt thereof having the following formula wherein R1 is acyl, R2 is hydrogen, halogen, unsubstituted alkyl or alkyl substituted by halogen; R3 is halogen or alkoxy; R4 is cycloalkyl, unsubstituted alkyl or alkyl substituted by cycloalkyl, aryl or hydroxyl or an ester thereof or alkoxy; R5 is hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; or R4 and R5 are bonded with each other to form a pyrrolidine ring substituted by hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; R6 is hydroxyl or an ester thereof, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkoxy, mercapto or alkylthio; and A1 and A2, are the same or different, and are alkylene, provided that (i) when R4 and R5 are bonded to each other to form the pyrrolidine ring substituted by hydroxyl or an ester thereof, R2 is halogen; (ii) when R4 and R5 are bonded to each other to form the pyrrolidine ring substituted by alkoxyalkyl, R2 is hydrogen; (iii) when R6 is hydroxyl or an ester thereof, R4 is isopropyl.
摘要翻译：具有下式的化合物或其盐，其中R 1是酰基，R 2是氢，卤素，未取代的烷基或被卤素取代的烷基; R 3是卤素或烷氧基; R 4是环烷基，未取代的烷基或被环烷基，芳基或羟基或其酯或烷氧基取代的烷基; R 5是羟基或其酯，烷氧基或烷氧基烷基; 或R 4和R 5彼此键合以形成被羟基或其酯取代的吡咯烷环，烷氧基或烷氧基烷基; R 6是羟基或其酯，烷氧基，烷氧基烷氧基，烷氧基烷氧基烷氧基，巯基或烷硫基; 和A 1和A 2各自相同或不同，并且是亚烷基，条件是（i）当R 4和R 0 > 5个彼此键合以形成被羟基或其酯取代的吡咯烷环，R 2是卤素; （ii）当R 4和R 5彼此键合以形成被烷氧基烷基取代的吡咯烷环时，R 2是氢; （iii）当R 6为羟基或其酯时，R 4为异丙基。

4. 发明申请

US20050113430A1 Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative 有权
标题翻译：卡帕阿片受体激动剂包含2-苯基苯并噻唑啉衍生物
公开(公告)号：US20050113430A1
公开(公告)日：2005-05-26
申请号：US10509549
申请日：2003-03-28
申请人： Maki Tokai , Takahiro Honda , Yaeko Osumi , Ken-ichi Fujimura
发明人： Maki Tokai , Takahiro Honda , Yaeko Osumi , Ken-ichi Fujimura
IPC分类号： A61K31/428 , A61P19/02 , A61P19/06 , A61P25/04 , A61P29/00 , A61P43/00 , C07D277/66 , C07D417/12
CPC分类号： C07D417/12 , A61K31/428 , C07D277/66
摘要： The present invention provides κ opioid receptor agonists comprising 2-phenylbenzothiazoline derivatives. The present invention relates to κ opioid receptor agonists comprising compounds or salts thereof having the chemical structure represented by the general formula [I]. Namely, it is important for exhibition of the κ opioid receptor agonist actions to have an alkyl group having an amino group at a phenyl group of 2-phenylbenzothiazoline as a substituent and to have an acyl group at a nitrogen atom of 2-phenylbenzothiazoline, wherein R is alkyl having the amino group as the substituent; and R1 is acyl.
摘要翻译：本发明提供包含2-苯基苯并噻唑啉衍生物的κ阿片受体激动剂。本发明涉及具有由通式[I]表示的化学结构的化合物或其盐的κ阿片受体激动剂。即，对于具有2-苯基苯并噻唑啉的苯基具有氨基的烷基作为取代基并且在2-苯基苯并噻唑啉的氮原子上具有酰基，对于κ阿片受体激动剂作用的展示是重要的，其中 R是具有氨基作为取代基的烷基; R 1是酰基。

5. 发明授权

US09023572B2 Method for producing toner for developing electrostatic image and apparatus for producing resin particles 有权
标题翻译：用于生产静电图像显影用调色剂的方法和用于制备树脂颗粒的装置
公开(公告)号：US09023572B2
公开(公告)日：2015-05-05
申请号：US12784906
申请日：2010-05-21
申请人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
发明人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
IPC分类号： G03G9/08 , B01J19/06 , B01J4/00 , C08J3/12 , G03G9/16 , G03G9/18
CPC分类号： B01J19/06 , B01J4/002 , B01J4/007 , B01J2219/00123 , C08J3/122 , G03G9/0804 , G03G9/16 , G03G9/18
摘要： A method for producing resin particles, including ejecting a liquid containing at least a resin in the form of droplets from a droplet ejecting unit having a plurality of holes provided in a part of a flow channel for feeding the liquid containing at least a resin, and drying and solidifying the ejected droplets so as to obtain the resin particles, while the ejected droplets are transported by a primary transport air flow flowing in the direction in which the droplets are ejected, wherein the ejected droplets are further transported by a secondary transport air flow which transports the ejected droplets in a different direction from a direction in which the primary transport air flow flows, and wherein a smaller angle of angles formed between a velocity vector of the primary transport air flow and a velocity vector of the secondary transport air flow is less than 120 degrees.
摘要翻译：一种树脂颗粒的制造方法，其特征在于，包括从具有设置在至少含有树脂的液体的流路的一部分的具有多个孔的液滴喷射单元的液滴喷射单元喷出至少含有液滴形式的液体的液体，干燥并固化喷出的液滴，以便获得树脂颗粒，同时喷射的液滴通过沿着喷射液滴的方向流动的初级输送空气流输送，其中喷射的液滴通过二次输送空气流进一步输送其沿着与一次输送空气流动的方向不同的方向输送喷射的液滴，并且其中在一次输送空气流的速度矢量与二次输送空气流的速度矢量之间形成的较小的角度角为小于120度。

6. 发明申请

US20150104739A1 TONER, DEVELOPER, AND IMAGE FORMING APPARATUS 审中-公开
标题翻译：调色剂，开发商和图像形成装置
公开(公告)号：US20150104739A1
公开(公告)日：2015-04-16
申请号：US14384490
申请日：2013-03-07
申请人： Tsuneyasu Nagatomo , Satoshi Kojima , Syouko Satoh , Kiwako Hirohara , Osamu Uchinokura , Junichi Awamura , Satoshi Ogawa , Takahiro Honda
发明人： Tsuneyasu Nagatomo , Satoshi Kojima , Syouko Satoh , Kiwako Hirohara , Osamu Uchinokura , Junichi Awamura , Satoshi Ogawa , Takahiro Honda
IPC分类号： G03G9/00
CPC分类号： G03G9/08755 , G03G9/0804 , G03G9/0819 , G03G9/08797 , G03G9/09716 , G03G9/09725
摘要： A toner, containing: toner base particles; and an external additive, the toner base particles each including a binder resin and a releasing agent, wherein the external additive includes non-spherical coalesced particles in each of which primary particles are coalesced together, and wherein the coalesced particles satisfy the following formula (1): Nx/1,000×100≦30% where Nx is a number of the primary particles present alone relative to 1,000 of the coalesced particles, as observed under a scanning electron microscope after stirring 0.5 g of the coalesced particles and 49.5 g of a carrier placed in a 50 mL bottle for 10 minutes by means of a mixing and stirring device at 67 Hz.
摘要翻译：调色剂，含有：调色剂基础颗粒; 和外部添加剂，所述调色剂基础颗粒各自包含粘合剂树脂和脱模剂，其中所述外部添加剂包括其中一次颗粒聚结在一起的非球形聚结颗粒，并且其中所述聚结颗粒满足下式（1 ）：Nx / 1,000×100＆nlE; 30％其中Nx是相对于1000个聚结颗粒单独存在的一次颗粒数，如在扫描电子显微镜下观察到的，搅拌0.5g聚结颗粒和49.5g载体通过67Hz的混合搅拌装置置于50mL瓶中10分钟。

7. 发明授权

US08948631B2 Image forming apparatus and density adjusting method 有权
标题翻译：图像形成装置和密度调节方法
公开(公告)号：US08948631B2
公开(公告)日：2015-02-03
申请号：US13091188
申请日：2011-04-21
申请人： Takahiro Honda
发明人： Takahiro Honda
IPC分类号： G03G15/00 , G03G15/01
CPC分类号： G03G15/0178 , G03G15/0131 , G03G15/0194 , G03G15/5058 , G03G2215/00059
摘要： An image forming apparatus has a memory, an image forming unit, an intermediate transfer member, a density detector, a background density measurer, a test patch controlling unit and a density correcting unit. The density detector detects the density of the intermediate transfer member. The background density measurer stores background density, in the memory in correspondence with position information on the intermediate transfer member at a predetermined timing before a calibration for adjusting image formation density. The test patch controlling unit causes the image forming unit to form a test patch, on the intermediate transfer member while the intermediate transfer member is driven at a predetermined speed. The density correcting unit executes the calibration to adjust image formation density according to a difference between the background density stored in the memory when executing the calibration and corresponding to the position and density of the test patch.
摘要翻译：图像形成装置具有存储器，图像形成单元，中间转印构件，浓度检测器，背景浓度测量器，测试块控制单元和浓度校正单元。密度检测器检测中间转印部件的密度。背景浓度测量器在调整图像形成密度的校准之前的预定定时将与中间转印部件上的位置信息相对应的记录体中的背景浓度存储。测试片控制单元使图像形成单元在中间转印构件上以预定速度驱动中间转印构件时形成测试片。密度校正单元执行校准，以在执行校准时根据存储在存储器中的背景浓度之间的差异来调整图像形成密度，并且与测试贴片的位置和密度相对应。

8. 发明授权

US08318400B2 Method of preparing toner and the toner, and developer and image forming method using the toner 有权
标题翻译：调色剂和调色剂的制备方法以及使用调色剂的显影剂和成像方法
公开(公告)号：US08318400B2
公开(公告)日：2012-11-27
申请号：US12264299
申请日：2008-11-04
申请人： Yohichiroh Watanabe , Kazumi Suzuki , Takahiro Honda , Shinji Ohtani , Yoshihiro Norikane
发明人： Yohichiroh Watanabe , Kazumi Suzuki , Takahiro Honda , Shinji Ohtani , Yoshihiro Norikane
IPC分类号： G03G9/087
CPC分类号： G03G9/0806 , G03G9/0804 , G03G9/0819 , G03G9/0821 , G03G9/08795 , G03G9/08797 , G03G2215/0602
摘要： A method of preparing a toner, including periodically discharging a toner constituent liquid from plural nozzles having the same aperture diameter with a mechanical oscillator, wherein the toner constituent liquid includes: a binder resin, a colorant, and an organic solvent, wherein the binder resin and the colorant are dissolved or dispersed in the organic solvent; forming a droplet of the toner constituent liquid in a gas phase; and solidifying the droplet, wherein the aperture diameter is from 3 to 30 μm, and the binder resin has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) of THF (tetrahydrofuran)-soluble components therein of from 1.5 to 15 in a molecular weight distribution measured by GPC (gel permeation chromatography), and a ½ flow temperature (Tm) of from 114 to 149° C.
摘要翻译：一种制备调色剂的方法，包括用机械振荡器从具有相同孔径的多个喷嘴周期性地排出调色剂组分液体，其中调色剂构成液体包括：粘合剂树脂，着色剂和有机溶剂，其中粘合剂树脂并且着色剂溶解或分散在有机溶剂中; 在气相中形成调色剂组分液滴; 并使所述液滴固化，其中所述孔径为3〜30μm，所述粘结剂树脂的重均分子量（Mw）与THF的数均分子量（Mn）的比（Mw / Mn）（四氢呋喃） - 可溶成分为1.5〜15，分子量分布为GPC（凝胶渗透色谱法），½流动温度（Tm）为114〜149℃。

9. 发明申请

US20100297548A1 METHOD FOR PRODUCING TONER FOR DEVELOPING ELECTROSTATIC IMAGE AND APPARATUS FOR PRODUCING RESIN PARTICLES 有权
标题翻译：用于生产用于制造静电图像的调色剂的方法和用于生产树脂颗粒的装置
公开(公告)号：US20100297548A1
公开(公告)日：2010-11-25
申请号：US12784906
申请日：2010-05-21
申请人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
发明人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
IPC分类号： G03G9/08 , C08F6/00
CPC分类号： B01J19/06 , B01J4/002 , B01J4/007 , B01J2219/00123 , C08J3/122 , G03G9/0804 , G03G9/16 , G03G9/18
摘要： A method for producing resin particles, including ejecting a liquid containing at least a resin in the form of droplets from a droplet ejecting unit having a plurality of holes provided in a part of a flow channel for feeding the liquid containing at least a resin, and drying and solidifying the ejected droplets so as to obtain the resin particles, while the ejected droplets are transported by a primary transport air flow flowing in the direction in which the droplets are ejected, wherein the ejected droplets are further transported by a secondary transport air flow which transports the ejected droplets in a different direction from a direction in which the primary transport air flow flows, and wherein a smaller angle of angles formed between a velocity vector of the primary transport air flow and a velocity vector of the secondary transport air flow is less than 120 degrees.
摘要翻译：一种树脂颗粒的制造方法，其特征在于，包括从具有设置在至少含有树脂的液体的流路的一部分的具有多个孔的液滴喷射单元的液滴喷射单元喷出至少含有液滴形式的液体的液体，干燥并固化喷出的液滴，以便获得树脂颗粒，同时喷射的液滴通过沿着喷射液滴的方向流动的初级输送空气流输送，其中喷射的液滴通过二次输送空气流进一步输送其沿着与一次输送空气流动的方向不同的方向输送喷射的液滴，并且其中在一次输送空气流的速度矢量与二次输送空气流的速度矢量之间形成的较小的角度角为小于120度。

10. 发明授权

US07736826B2 Toner, developer and image forming apparatus 有权
标题翻译：调色剂，显影剂和成像装置
公开(公告)号：US07736826B2
公开(公告)日：2010-06-15
申请号：US12212235
申请日：2008-09-17
申请人： Hiroto Higuchi , Fumihiro Sasaki , Shinichiro Yagi , Shigeru Emoto , Junichi Awamura , Naohito Shimota , Masami Tomita , Toshiki Nanya , Takahiro Honda , Maiko Kondo
发明人： Hiroto Higuchi , Fumihiro Sasaki , Shinichiro Yagi , Shigeru Emoto , Junichi Awamura , Naohito Shimota , Masami Tomita , Toshiki Nanya , Takahiro Honda , Maiko Kondo
IPC分类号： G03G9/087
CPC分类号： G03G9/0827 , G03G9/0819
摘要： A toner composition including toner particles including at least a binder resin; and a colorant, wherein the toner composition satisfies at least one of the following relationships (1) and (2): B≦14 when 155
摘要翻译：一种调色剂组合物，其包含至少包含粘合剂树脂的调色剂颗粒; 和着色剂，其中调色剂组合物满足以下关系（1）和（2）中的至少一个：当155 n1; 180时，B＆和149;当145和nlE时为0.6A-79; A＆lt; 155;（1）其中A表示调色剂组合物的形状因子SF-1，B表示粒径不大于3μm的调色剂颗粒的含量; 和B＆nlE; 14当0.920＆nlE; A'＆nlE; 0.950; 和B＆lt; ll; 394-400A'当0.950

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