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1. 发明申请

US20060154862A1 Processes for preparing a polypeptide 审中-公开
标题翻译：制备多肽的方法
公开(公告)号：US20060154862A1
公开(公告)日：2006-07-13
申请号：US11262122
申请日：2005-10-28
申请人： Anup Ray , Hiren Kumar Patel , Johannes Ludescher , Mariappan Anbazhagan , Mahendra Patel , Ingolf Macher
发明人： Anup Ray , Hiren Kumar Patel , Johannes Ludescher , Mariappan Anbazhagan , Mahendra Patel , Ingolf Macher
IPC分类号： A61K38/16 , C07K1/02
CPC分类号： C08G69/10 , A61K38/00 , C07K14/001
摘要： The present invention relates to processes for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate.
摘要翻译：本发明涉及制备包含L-酪氨酸，L-丙氨酸，L-谷氨酸和L-赖氨酸的多肽或其药学上可接受的盐的方法。多肽或其药学上可接受的盐优选为醋酸格拉司他。

2. 发明申请

US20050249814A1 Solubility of hydrophobic drugs with a compound having a carboxylic acid moiety 失效
标题翻译：疏水性药物与具有羧酸部分的化合物的溶解度
公开(公告)号：US20050249814A1
公开(公告)日：2005-11-10
申请号：US11124343
申请日：2005-05-06
申请人： Gary Barbera , Chetan Doshi , Mahendra Patel , Pablo Davila , Satishkumar Patel
发明人： Gary Barbera , Chetan Doshi , Mahendra Patel , Pablo Davila , Satishkumar Patel
IPC分类号： A61K9/48 , A61K31/205 , A61K31/496 , A61K31/519 , A61K31/5513 , A61K31/56 , A61K31/704 , A61K47/12
CPC分类号： A61K9/4858 , A61K31/205 , A61K31/519 , A61K31/5513 , A61K31/56 , A61K31/704 , A61K31/7048 , A61K47/12 , A61K2300/00
摘要： A pharmaceutical composition having improved solubility comprising a hydrophobic drug or pharmaceutically acceptable salt thereof and a compound having at least one carboxylic acid moiety, wherein the molar ratio of the compound having at least one carboxylic acid moiety to the hydrophobic drug or pharmaceutically acceptable salt thereof is from about 0.1:1 to about 25:1. The pharmaceutical composition exhibits rapid dissolution upon contact with physiological solvents, such as water, saliva or gastrointestinal fluids.
摘要翻译：具有改善的溶解度的药物组合物，其包含疏水性药物或其药学上可接受的盐和具有至少一个羧酸部分的化合物，其中具有至少一个羧酸部分的化合物与疏水性药物或其药学上可接受的盐的摩尔比为约0.1:1至约25:1。药物组合物在与生理溶剂如水，唾液或胃肠液接触时表现出快速溶解。

3. 发明授权

US5450438A Fallback method to 1200 bits per second for use in mobile radio 失效
标题翻译：后备方法，以每秒1200位的速度在移动无线电中使用
公开(公告)号：US5450438A
公开(公告)日：1995-09-12
申请号：US96541
申请日：1993-07-26
申请人： Joan E. Landry , Mahendra Patel , Robert E. Scott
发明人： Joan E. Landry , Mahendra Patel , Robert E. Scott
IPC分类号： H04L27/00 , H04L1/00 , H04L1/18 , H04L1/20 , H04M11/06 , H04W28/22
CPC分类号： H04M11/06 , H04L1/20 , H04W28/22 , H04L1/1803 , H04L1/188
摘要： In a mobile data communications system, a near-end modem initiates a data connection to a far-end modem at the highest permissible data rate, e.g., at 9600 bits per second (bps). If the communications channel subsequently degrades, either the near-end modem, or the far-end modem, initiates an autorate, or fallback sequence, e.g., to 4800 bps. However, if channel performance is still poor at 4800 bps, then one, or both, of the modems initiate a fallback to 1200 bps--skipping over the data rate of 2400 bps, which is not included within the fallback sequence.
摘要翻译：在移动数据通信系统中，近端调制解调器以最高允许数据速率（例如，以每秒9600比特（bps））发起到远端调制解调器的数据连接。如果通信信道随后降级，则近端调制解调器或远端调制解调器启动自动或回退序列，例如至4800bps。然而，如果信道性能在4800bps仍然很差，那么调制解调器中的一个或两者将启动后退到1200bps，跳过2400bps的数据速率，这不包括在回退序列中。

4. 发明申请

US20050095287A1 Fosinopril composition 审中-公开
标题翻译：福斯普利组合物
公开(公告)号：US20050095287A1
公开(公告)日：2005-05-05
申请号：US10915507
申请日：2004-08-10
申请人： Amol Matharu , Mahendra Patel
发明人： Amol Matharu , Mahendra Patel
IPC分类号： A61K9/20 , A61K31/675 , A61K31/66
CPC分类号： A61K31/675 , A61K9/2027
摘要： This disclosure relates to stable pharmaceutical formulations of the drug fosinopril sodium comprising a lubricant which is sodium stearate or a mixture composed of stearic acid esters, propylene glycol monoesters, distilled monoglycerides, sodium stearoyl lactylate, and silicon dioxide.
摘要翻译：本公开涉及药物福辛普利钠的稳定药物制剂，其包含润滑剂，其为硬脂酸钠或由硬脂酸酯，丙二醇单酯，蒸馏单酸甘油酯，硬脂酰乳酸钠和二氧化硅组成的混合物。

5. 发明授权

US5071643A Solvent system enhancing the solubility of pharmaceuticals for encapsulation 失效
标题翻译：溶剂系统提高药物的溶解度
公开(公告)号：US5071643A
公开(公告)日：1991-12-10
申请号：US104911
申请日：1987-10-09
申请人： Man S. Yu , Foo S. Hom , Sibaprasanna Chakrabarti , Chong-Heng Huang , Mahendra Patel
发明人： Man S. Yu , Foo S. Hom , Sibaprasanna Chakrabarti , Chong-Heng Huang , Mahendra Patel
IPC分类号： A61K9/08 , A61K9/00 , A61K9/20 , A61K9/48 , A61K9/66 , A61K45/00 , A61K47/00 , A61K47/04 , A61K47/32 , A61K47/34
CPC分类号： A61K9/2009 , A61K9/2031 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species. For amphoteric pharmaceutical agents, either hydroxide ion or hydrogen ion sources may be utilized to effect partial ionization.The disclosed solvent system is useful because it not only provides for the enhancement or improvement of bioavailability of acidic, basic and amphoteric pharmaceutical agents by delivering them already in solution, but it also provides for a highly concentrated solution capable of encapsulation in a small enough vessel to permit easy swallowing.The highly concentrated solid solutions of the present invention are also useful for conversion into tablets and as veterinary spot and pour on preparations.
摘要翻译：本发明涉及一种用于增强酸性，碱性或两性药剂在产生适于软胶囊填充或两片封装的高度浓缩溶液中的溶解度的溶剂体系。溶剂系统包含每摩尔当量药剂和1-20％水含有0.2-1.0摩尔当量离子化剂的聚乙二醇。可以加入甘油或聚乙烯吡咯烷酮以进一步提高某些药物的溶解度。所公开的溶剂系统能够提高40-400％的药剂的溶解度。电离剂通过引起游离药剂的部分电离（中和）起作用。当药剂为酸性时，电离剂优选为氢氧根离子，而当药剂为碱性时，电离剂优选为氢离子。对于两性药剂，可以使用氢氧根离子或氢离子源来实现部分电离。所公开的溶剂系统是有用的，因为它不仅通过将其输送到溶液中来提供酸性，碱性和两性药物的生物利用度的增强或改善，而且还提供能够在足够小的容器中包封的高度浓缩的溶液容易吞咽。本发明的高度浓缩的固体溶液也可用于转化成片剂和兽药斑点并倒入制剂上。

6. 发明申请

US20050136107A1 Extended release antibiotic composition 有权
标题翻译：延长释放抗生素组成
公开(公告)号：US20050136107A1
公开(公告)日：2005-06-23
申请号：US10743367
申请日：2003-12-22
申请人： Mahendra Patel , Bhaskarbhai Patel , Amol Matharu
发明人： Mahendra Patel , Bhaskarbhai Patel , Amol Matharu
IPC分类号： A61K9/20 , A61K9/24 , A61K9/28 , A61K31/7048 , A61K9/22
CPC分类号： A61K9/2866 , A61K9/2054 , A61K9/209 , A61K31/7048
摘要： An extended-release antibiotic composition comprising at least one antibiotic, and greater than 50 weight percent, based on the total weight of the composition, of a polymer component, wherein said polymer component comprises at least one pharmaceutically acceptable hydrophilic polymer, and said polymer component has a viscosity of less than about 50 cps.
摘要翻译：基于组合物的总重量，包含至少一种抗生素和大于50重量％的延长释放抗生素组合物，其中所述聚合物组分包含至少一种药学上可接受的亲水性聚合物，并且所述聚合物组分具有小于约50cps的粘度。

7. 发明授权

US5872128A Stabilized composition of ticlopidine hydrochloride 失效
标题翻译：盐酸噻氯匹定的稳定组合物
公开(公告)号：US5872128A
公开(公告)日：1999-02-16
申请号：US950822
申请日：1997-10-15
申请人： Mahendra Patel , Mukteeshwar Gande , Pankaj Dave , Madhava Reddy Uppugalla
发明人： Mahendra Patel , Mukteeshwar Gande , Pankaj Dave , Madhava Reddy Uppugalla
IPC分类号： A61K31/4365 , C07D513/04 , A61K31/435
CPC分类号： A61K31/4365
摘要： A novel pharmaceutical composition including thieno-pyridine derivatives, primarily ticlopidine hydrochloride, having no other organic or inorganic acid stabilizing agents or metal stearates. The stable pharmaceutical composition also includes hydrogenated vegetable oil as lubricant and other suitable non-ionic inert pharmaceutical excipients.
摘要翻译：一种新型药物组合物，包括噻吩并吡啶衍生物，主要是噻氯匹定盐酸盐，不含其它有机或无机酸稳定剂或金属硬脂酸盐。稳定的药物组合物还包括氢化植物油作为润滑剂和其它合适的非离子惰性药物赋形剂。

8. 发明授权

US5479650A Method and apparatus for switching communications from a secondary channel to a primary channel 失效
标题翻译：用于从第二信道切换到主信道的通信的方法和装置
公开(公告)号：US5479650A
公开(公告)日：1995-12-26
申请号：US996434
申请日：1992-12-24
申请人： James L. Archibald , Mahendra Patel
发明人： James L. Archibald , Mahendra Patel
IPC分类号： G06F11/20 , G06F11/267 , H04L12/26 , H04L29/14 , H04M11/06 , G06F11/00
CPC分类号： H04M11/06 , G06F11/221 , H04L69/40 , G06F11/2007 , H04L12/2697 , H04L43/50
摘要： Some data communications networks employ the use of both a leased line and a dial-up line between two modems. Typically, the dial-up line provides a backup capability when the leased line causes a degradation in the signal quality of the data signal. This degradation of the signal quality of the data signal is detected by one of the two modems, which then automatically establishes a data connection over the dial-up line. However, it is preferable to switch back to the leased line as soon as possible since the leased line usually costs less than the dial-up line. Therefore, in order to test the leased line, the entire data signal is simultaneously transmitted on both the dial-up line and the leased line. The use of the existing data signal to test the leased line's effect on signal quality allows the modem to perform a more complete analysis of the returned data signal so that a premature transition back to the leased line does not occur.
摘要翻译：一些数据通信网络使用两个调制解调器之间的租用线路和拨号线路。通常，当租用线路导致数据信号的信号质量下降时，拨号线路提供备用功能。数据信号的信号质量的这种下降由两个调制解调器之一检测，然后两个调制解调器通过拨号线自动建立数据连接。然而，由于租用线路通常成本低于拨号线路，因此最好尽快切换回租用线路。因此，为了测试专线，在拨号线和租用线路上同时发送整个数据信号。使用现有的数据信号来测试租用线路对信号质量的影响，使得调制解调器能够对返回的数据信号执行更完整的分析，从而不会发生回到租用线路的过早转换。

9. 发明授权

US5360615A Solvent system enhancing the solubility of pharmaceuticals for encapsulation 失效
标题翻译：溶剂体系提高药物的包封溶解度
公开(公告)号：US5360615A
公开(公告)日：1994-11-01
申请号：US890285
申请日：1992-05-26
申请人： Man S. Yu , Foo S. Hom , Sibaprasanna Chakrabarti , Chong-Heng Huang , Mahendra Patel
发明人： Man S. Yu , Foo S. Hom , Sibaprasanna Chakrabarti , Chong-Heng Huang , Mahendra Patel
IPC分类号： A61K9/08 , A61K9/00 , A61K9/20 , A61K9/48 , A61K9/66 , A61K45/00 , A61K47/00 , A61K47/04 , A61K47/32 , A61K47/34
CPC分类号： A61K9/2009 , A61K9/2031 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species. For amphoteric pharmaceutical agents, either hydroxide ion or hydrogen ion sources may be utilized to effect partial ionization.The disclosed solvent system is useful because it not only provides for the enhancement or improvement of bioavailability of acidic, basic and amphoteric pharmaceutical agents by delivering them already in solution, but it also provides for a highly concentrated solution capable of encapsulation in a small enough vessel to permit easy swallowing.The highly concentrated solid solutions of the present invention are also useful for conversion into tablets and as veterinary spot and pour on preparations.
摘要翻译：本发明涉及一种用于增强酸性，碱性或两性药剂在产生适于软胶囊填充或两片封装的高度浓缩溶液中的溶解度的溶剂体系。溶剂系统包含每摩尔当量药剂和1-20％水含有0.2-1.0摩尔当量离子化剂的聚乙二醇。可以加入甘油或聚乙烯吡咯烷酮以进一步提高某些药物的溶解度。所公开的溶剂系统能够提高40-400％的药剂的溶解度。电离剂通过引起游离药剂的部分电离（中和）起作用。当药剂为酸性时，电离剂优选为氢氧根离子，而当药剂为碱性时，电离剂优选为氢离子。对于两性药剂，可以使用氢氧根离子或氢离子源来实现部分电离。所公开的溶剂系统是有用的，因为它不仅通过将其输送到溶液中来提供酸性，碱性和两性药物的生物利用度的增强或改善，而且还提供能够在足够小的容器中包封的高度浓缩的溶液容易吞咽。本发明的高度浓缩的固体溶液也可用于转化成片剂和兽药斑点并倒入制剂上。

10. 外观设计

USD689982S1 Reclining pool mister 有权
标题翻译：斜倚泳池先生
公开(公告)号：USD689982S1
公开(公告)日：2013-09-17
申请号：US29430181
申请日：2012-08-22
申请人： Mahendra Patel
设计人： Mahendra Patel

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