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1. 发明申请

WO2010117543A1 PACKAGING SYSTEMS FOR PERCUTANEOUSLY DELIVERABLE BIOPROSTHETIC VALVES 审中-公开
标题翻译：可递送生物渗透阀的包装系统
公开(公告)号：WO2010117543A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/026946
申请日：2010-03-11
申请人： MEDTRONIC VASCULAR INC. , TRAN, Don , RYAN, Timothy , ALLEN, Jeffrey , DENTON, Melissa , PODBELSKI, Adam
发明人： TRAN, Don , RYAN, Timothy , ALLEN, Jeffrey , DENTON, Melissa , PODBELSKI, Adam
IPC分类号： A61F2/00 , A61F2/24
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping
摘要翻译：公开了一种用于在存储溶液中运送假体组织瓣膜并且将生物假体瓣膜准备和装载到基于导管的输送系统上的包装系统。包装系统包括填充有附着到输送导管的储存溶液的流体密封容器，其中容器围绕在装运和储存期间处于输送导管的预加载位置的假肢组织瓣膜。假体组织瓣膜可以包括附接到输送导管以将组织瓣膜正确定位以装载在输送导管内的附接机构。在另一个实施例中，假体组织瓣膜在运输期间未附接到输送导管时，附接机构可与假体组织瓣膜运输

2. 发明申请

WO2010117541A1 PACKAGING SYSTEMS FOR PERCUTANEOUSLY DELIVERABLE BIOPROSTHETIC VALVES 审中-公开
标题翻译：可递送生物渗透阀的包装系统
公开(公告)号：WO2010117541A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/026942
申请日：2010-03-11
申请人： MEDTRONIC VASCULAR INC. , RYAN, Timothy , TRAN, Don , ALLEN, Jeffrey , DENTON, Melissa , PODBELSKI, Adam
发明人： RYAN, Timothy , TRAN, Don , ALLEN, Jeffrey , DENTON, Melissa , PODBELSKI, Adam
IPC分类号： A61F2/00 , A61F2/24
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.
摘要翻译：公开了一种用于在存储溶液中运送假体组织瓣膜并且将生物假体瓣膜准备和装载到基于导管的输送系统上的包装系统。包装系统包括填充有附着到输送导管的储存溶液的流体密封容器，其中容器围绕在装运和储存期间处于输送导管的预加载位置的假肢组织瓣膜。假体组织瓣膜可以包括附接到输送导管以将组织瓣膜正确定位以装载在输送导管内的附接机构。在假体组织瓣膜在运输期间未附着到输送导管的另一实施例中，附接机构可与假体组织瓣膜运输容器相互作用，以防止生物假体瓣膜在运输期间移动。

3. 发明申请

WO2010056518A2 CATHETER INNER MEMBER 审中-公开
标题翻译：导管内部会员
公开(公告)号：WO2010056518A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/062305
申请日：2009-10-28
申请人： MEDTRONIC VASCULAR, INC. , COLLINS, Chris , TRAN, Don , NAFEA, Bijan , BERTHIAUME, William , KINKADE, Jeremy
发明人： COLLINS, Chris , TRAN, Don , NAFEA, Bijan , BERTHIAUME, William , KINKADE, Jeremy
IPC分类号： A61M5/00 , A61M25/00
CPC分类号： A61M25/007 , A61F2/95 , A61F2002/9517 , A61M25/0029 , A61M2025/0004 , A61M2025/0019 , A61M2025/0037 , A61M2025/0183
摘要： A catheter inner member includes an inner member body, including a first side and a second side, the second side opposing the first side. The inner member body includes an inner surface defining an inner member inner lumen and an outer surface defining a surrounding environment. The inner member further includes at least a first flush port and a second flush port in the inner member body. The first flush port and second flush port provide fluid communication between the inner lumen and a surrounding environment. The first flush port disposed on the first side and the second flush port disposed on the second side, wherein the first flush port is axially displaced from the second flush port.
摘要翻译：导管内部构件包括内部构件主体，其包括第一侧和第二侧，第二侧与第一侧相对。内部构件主体包括限定内部构件内腔的内表面和限定周围环境的外表面。内部构件还包括内部构件主体中的至少第一冲洗口和第二冲洗口。第一冲洗口和第二冲洗口提供内腔和周围环境之间的流体连通。设置在第一侧的第一冲洗口和设置在第二侧的第二冲洗口，其中第一冲洗口从第二冲洗口轴向移位。

4. 发明申请

WO2017200671A1 TOOL AND METHOD FOR COMPRESSING A STENTED PROSTHESIS 审中-公开
标题翻译：用于压缩假体的工具和方法
公开(公告)号：WO2017200671A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/027712
申请日：2017-04-14
申请人： MEDTRONIC VASCULAR INC.
发明人： ORTH, Geoffrey , BRUNER, Kenny , TRAN, Don , MEDELSON, Jill , KEOGH, James, R.
IPC分类号： A61F2/95
摘要： A tool for compressing a stented prosthesis. The tool includes first and second sets of rollers. The first set includes a plurality of rollers arranged to define a first working region having a first working diameter. The second set includes a plurality of rollers arranged to define a second working region having a second working diameter. The sets of rollers are arranged such that the working regions are axially aligned. The first working diameter is greater than the second working diameter. A stented prosthesis traversing the first working region and then the second working region is forced to a compressed state. In some embodiments, the tool includes one or more intermediate sets of rollers between the first and second sets of rollers, with each of the intermediate sets of rollers defining a working region having a working diameter. The respective working diameters progressively decrease in a downstream direction.
摘要翻译：
用于压缩支架假体的工具。该工具包括第一和第二组辊子。第一组包括布置成限定具有第一工作直径的第一工作区域的多个辊子。第二组包括布置成限定具有第二工作直径的第二工作区域的多个辊子。这些辊组布置成使得工作区域轴向对齐。第一工作直径大于第二工作直径。穿过第一工作区域然后第二工作区域的支架假体被强制成压缩状态。在一些实施例中，工具包括在第一组辊和第二组辊之间的一个或多个中间辊组，其中每个中间辊组限定具有工作直径的工作区域。各工作直径在下游方向上逐渐减小。

5. 发明申请

WO2017152097A1 STENTED PROSTHESIS DELIVERY SYSTEM HAVING A BUMPER 审中-公开
标题翻译：专用假体送货系统，具有保险杠
公开(公告)号：WO2017152097A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020738
申请日：2017-03-03
申请人： MEDTRONIC VASCULAR INC.
发明人： TRAN, Don , BARAJAS-TORRES, Martha , LALLY, Marian , GLOSS, Michael , GROEN, Timothy , MENDOZA, Leonel , SOM, Siyan , SILVER, Michele , BROWN, Nathan , MENDELSON, Jill
IPC分类号： A61F2/24 , A61F2/966
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/966 , A61F2002/9665 , A61F2230/0067 , A61F2250/0039
摘要： Numerous delivery devices for delivery of a stented prosthesis, such as a stented prosthetic heart valve. Various delivery devices include a capsule that is advanced proximally to retain the stented prosthesis, which is secured over an inner shaft assembly of the delivery device. The delivery device further includes a bumper or bumper assembly to provide a smooth transition of the capsule over the stented prosthesis. In some alternate disclosed embodiments, the bumper further serves to connect various elements of the inner shaft assembly. Additional embodiments include a bumper assembly arranged and configured to longitudinally expand and contract to substantially fill any open space as the capsule is retracted from the stented prosthesis, which prevents kinking in the capsule. Additional embodiments include proximal and/or distal bumpers for temporarily covering and smoothing the ends of the stented prosthesis as part of a delivery device that does not include a capsule.
摘要翻译：许多用于输送支架假体的输送装置，例如带支架假体心脏瓣膜。各种输送装置包括向近侧推进以保持支架假体的胶囊，其被固定在输送装置的内轴组件上。输送装置还包括保险杠或保险杠组件，以提供胶囊在支架假体上的平滑过渡。在一些替代公开的实施例中，缓冲器还用于连接内轴组件的各种元件。另外的实施例包括缓冲器组件，该缓冲器组件被布置和构造成当胶囊从带支架的假体缩回时纵向膨胀和收缩以基本上填充任何开放空间，这防止了胶囊中的扭结。另外的实施例包括近端和/或远端缓冲器，用于暂时覆盖并平滑支架假体的端部，作为不包括胶囊的输送装置的一部分。

6. 发明申请

WO2017106161A3 DEVICES AND METHODS FOR TRANSCATHETER VALVE LOADING AND IMPLANTATION 审中-公开
公开(公告)号：WO2017106161A3
公开(公告)日：2017-06-22
申请号：PCT/US2016/066323
申请日：2016-12-13
申请人： MEDTRONIC VASCULAR INC.
发明人： BARAJAS-TORRES, Martha , MAUCH, Kevin , SANDSTROM, Jeffrey , MENDELSON, Jill , TRAN, Don
IPC分类号： A61F2/24
摘要： The present disclosure relates to numerous devices and methods for transcatheter stented prosthetic heart valve loading and delivery. Such devices and methods reduce suture tangling and also provide the ability to adjust the stented prosthetic heart valve expansion and contraction prior to the final release of the stented prosthetic heart valve (100) from the delivery device (200).

7. 发明申请

WO2017106161A2 DEVICES AND METHODS FOR TRANSCATHETER VALVE LOADING AND IMPLANTATION 审中-公开
标题翻译：装置和方法传输线阀加载和植入
公开(公告)号：WO2017106161A2
公开(公告)日：2017-06-22
申请号：PCT/US2016/066323
申请日：2016-12-13
申请人： MEDTRONIC VASCULAR INC.
发明人： ROTHSTEIN, Paul , BARAJAS-TORRES, Martha , MAUCH, Kevin , SANDSTROM, Jeffrey , MENDELSON, Jill , TRAN, Don
CPC分类号： A61F2/2439 , A61F2/2415 , A61F2/2418
摘要： The present disclosure relates to numerous devices and methods for transcatheter stented prosthetic heart valve loading and delivery. Such devices and methods reduce suture tangling and also provide the ability to adjust the stented prosthetic heart valve expansion and contraction prior to the final release of the stented prosthetic heart valve from the delivery device.
摘要翻译：本公开涉及用于经导管支架假体心脏瓣膜装载和输送的多种装置和方法。这种装置和方法减少了缝合线缠结，并且还提供了在支架假体心脏瓣膜从输送装置最终释放之前调整支架假体心脏瓣膜扩张和收缩的能力。

8. 发明申请

WO2009131750A1 CATHETER FLUSHING MANDREL 审中-公开
标题翻译：导管冲洗机
公开(公告)号：WO2009131750A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/035967
申请日：2009-03-04
申请人： MEDTRONIC VASCULAR INC. , BERTHIAUME, William , TRAN, Don , COLLINS, Chris
发明人： BERTHIAUME, William , TRAN, Don , COLLINS, Chris
IPC分类号： A61M39/16
CPC分类号： A61M25/00 , A61F2/95 , A61M25/0017 , A61M25/01 , A61M25/0102 , A61M2025/0079 , A61M2025/0183
摘要： A mandrel includes a mandrel body with a proximal major diameter barrel section, a diameter reducing/tapered portion and a distal minor diameter barrel section. The tapered portion connects the proximal major diameter barrel section and distal minor diameter barrel section. The proximal major diameter barrel section has a major diameter, the distal minor diameter barrel section has a minor diameter, the minor diameter less than the major diameter. The minor diameter is less than a diameter of an inner lumen of a coaxial catheter, and the major diameter exceeds the inner diameter of the outer lumen guidewire exit port of the coaxial catheter, and the tapered portion is sized to form a fluid seal the inner diameter of the outer lumen guidewire exit port. The distal minor diameter barrel section of the mandrel occupies and substantially seals and prevent flow through it to the catheter distal end guidewire entry port.
摘要翻译：心轴包括具有近端大直径圆筒部分，直径减小/锥形部分和远端小直径圆筒部分的心轴本体。锥形部分连接近端大直径筒部和远端小直径筒部。近端大直径筒部分具有大直径，远端较小直径筒部分具有小直径，小直径小于大直径。小直径小于同轴导管的内腔的直径，并且大直径超过同轴导管的外腔导丝出口的内径，并且锥形部分的尺寸设定成形成流体密封内外腔导丝出口的直径。心轴的远端较小直径的筒部分占据并基本上密封并防止流过其到导管远端导丝入口。

9. 发明申请

WO2018071115A1 STENTED PROSTHETIC HEART VALVE DELIVERY SYSTEM HAVING AN EXPANDABLE BUMPER 审中-公开
标题翻译：具有可膨胀保险装置的人造心脏瓣膜输送系统
公开(公告)号：WO2018071115A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/050339
申请日：2017-09-06
申请人： MEDTRONIC VASCULAR INC.
发明人： TRAN, Don , BARAJAS-TORRES, Martha , MITCHELL, James , MENDOZA, Leonel , SOM, Siyan , MENDELSON, Jill , GROSSMAN, David
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2418
摘要： Delivery devices for delivery of a stented prosthetic heart valve. Various delivery devices include an outer sheath assembly including an outer sheath connected to a capsule that is advanced proximally to retain the prosthetic valve, which is secured over an inner shaft assembly of the delivery device. The delivery device further includes a bumper to provide a smooth transition of the capsule over the prosthetic valve during loading and recapture procedures. The bumper is expandable from a first position to a second position in which a distal end of the bumper is expanded to increase its diameter. The bumper can be biased in the second, expanded position so that the bumper automatically transitions to the expanded position upon retraction of the outer sheath.
摘要翻译：用于递送支架假体心脏瓣膜的递送装置。各种递送装置包括外护套组件，所述外护套组件包括连接到胶囊的外护套，所述胶囊向近侧推进以保持假体瓣膜，所述假体瓣膜固定在递送装置的内轴组件上。输送装置还包括缓冲器，以在装载和重新捕获程序期间提供胶囊在假体瓣膜上的平滑过渡。保险杠可从第一位置扩张到第二位置，在第二位置中，保险杠的远端被扩张以增大其直径。保险杠可以偏置在第二扩展位置，以便在外护套缩回时保险杠自动转换到扩展位置。

10. 发明申请

WO2017214094A3 TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM WITH PROTECTIVE FEATURE 审中-公开
公开(公告)号：WO2017214094A3
公开(公告)日：2017-12-14
申请号：PCT/US2017/036077
申请日：2017-06-06
申请人： MEDTRONIC VASCULAR INC.
发明人： VAUGHAN, Brendan , BRITTON, Maeve , BARAJAS-TORRES, Martha , DESHMUKH, Susheel , MENDOZA, Leonal , SOM, Siyan , SILVER, Michele , TRAN, Don , BROWN, Nathan , MENDELSON, Jill
IPC分类号： A61F2/24 , A61F2/95
摘要： Delivery devices for a stented prosthetic heart valve. The delivery device includes a spindle, at least one cord, and a covering feature associated with the spindle for selectively covering at least a portion of a stented prosthetic heart valve tethered to the spindle in a delivery state. In some embodiments, the covering feature includes a tip mounted to the spindle. The tip can include an overhang region for selectively covering a portion of the stented prosthetic heart valve. In other embodiments, the tip can include a tip body and a compressible foam bumper. In yet other embodiments, the covering feature includes an outer sheath arranged to selectively cover the stented prosthetic heart valve. The outer sheath can be elastic and stretchable for recapturing a partially expanded prosthesis, for example by including one or more windows covered by a stretchable covering layer.

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