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1. 发明申请

WO2011066320A2 OPTICAL STIMULATION THERAPY 审中-公开
标题翻译：光刺激治疗
公开(公告)号：WO2011066320A2
公开(公告)日：2011-06-03
申请号：PCT/US2010/057878
申请日：2010-11-23
申请人： MEDTRONIC, INC. , DENISON, Timothy, J. , KUNAL, Paralikar , MUNNS, Gordon, O. , SANTA, Wesley, A. , CONG, Peng , NIELSEN, Christian, S. , NORTON, John, D. , KEIMEL, John, G.
发明人： DENISON, Timothy, J. , KUNAL, Paralikar , MUNNS, Gordon, O. , SANTA, Wesley, A. , CONG, Peng , NIELSEN, Christian, S. , NORTON, John, D. , KEIMEL, John, G.
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： An implantable medical system comprises a therapy delivery module comprising a light source that generates light and a controller that controls the output of the light source, an optical light guide configured to deliver the light from the light source to a target tissue, a lead with a sense electrode for sensing bioelectric signals, and a sensing module configured to determine a patient therapeutic state based on the sensed bioelectric signals substantially simultaneously with the delivery of light from the light source, wherein the controller is configured to adjust the delivery of light to the target tissue based on the sensed patient therapeutic state.
摘要翻译：可植入医疗系统包括治疗传递模块，该治疗传递模块包括产生光的光源和控制光源输出的控制器，光学光导构造成将光从光源传递到目标组织，具有用于感测生物电信号的感测电极的导线以及感测模块，所述感测模块被配置成基于所感测的生物电信号基本与从所述光源输送的光基本同时地确定患者治疗状态，其中所述控制器被配置为基于感测到的患者治疗状态调整光向目标组织的传递。

2. 发明申请

WO2016077295A3 IMPLANTABLE MEDICAL DEVICES WITH ELECTRICALLY ISOLATED BATTERIES IN A SEPARATE ENCLOSURE 审中-公开
公开(公告)号：WO2016077295A3
公开(公告)日：2016-05-19
申请号：PCT/US2015/059868
申请日：2015-11-10
申请人： MEDTRONIC, INC.
发明人： HOVLAND, Erik, J. , IYER, Rajesh, V. , MAY, Steven, J. , MUNNS, Gordon, O. , SANTA, Wesley, A.
IPC分类号： A61N1/375 , A61N1/378
摘要： Medical devices include a separate enclosure that houses a battery and electrically isolates the battery from external conditions such as any metal enclosures and ultimately isolates the battery from body fluids. Thus, the separate enclosure attaches to a housing of a medical device and provides for modularity of the battery which allows, for instance, different size batteries to be used with the same medical device design. The separate enclosure further prevents stimulation current from leaking back to the battery housing by providing the electrical isolation.

3. 发明申请

WO2010062451A1 DETERMINING INTERCARDIAC IMPEDANCE 审中-公开
标题翻译：确定心血管阻抗
公开(公告)号：WO2010062451A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/058127
申请日：2009-09-24
申请人： MEDTRONIC, INC. , WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
发明人： WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
IPC分类号： A61B5/053 , G01R27/02 , H03F3/00 , A61B5/026 , A61N1/372 , A61N1/39 , A61N1/365
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译：公开了一种用于确定复杂心脏间阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调直流信号的信号发生器装置，用于调制可调直流信号以产生调制至少一个用于在心肌上传播调制信号的电极，至少一个用于检测来自心肌的输出调制信号的传感器，以及至少一个用于减少输出的调制信号中的过程噪声（攻击者）的影响的电路。该至少一个电路包括放大器，解调器和积分器。最终输出的调制信号的幅度和相位指示心肌的复阻抗。心肌复杂阻抗模式的变化提供了向心肌减少的氧气和血流量的指示。该装置可用于植入式装置，包括心脏起搏器和植入式心脏复律除颤器。

4. 发明授权

EP2200692B1 FREQUENCY SELECTIVE MONITORING OF PHYSIOLOGICAL SIGNALS 有权
标题翻译：生理信号频率的选择性监控
公开(公告)号：EP2200692B1
公开(公告)日：2016-11-09
申请号：EP08832864.6
申请日：2008-09-25
申请人： Medtronic, Inc.
发明人： DENISON, Timothy, J. , JENSEN, Randy, M. , SANTA, Wesley, A.
IPC分类号： A61N1/00 , A61B5/0452 , A61B5/048 , A61B5/021
CPC分类号： A61B5/04004 , A61B5/04018 , A61B5/048 , A61B5/4082 , A61B5/4094

5. 发明申请

WO2010051153A1 DETERMINING INTERCARDIAC IMPEDANCE 审中-公开
标题翻译：确定干扰素阻力
公开(公告)号：WO2010051153A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/060314
申请日：2009-10-12
申请人： MEDTRONIC, INC. , WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
发明人： WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/6846 , A61B5/7217
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译：公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调直流电信号的信号发生器装置，用于调制可调直流电信号以产生调制信号的调制器，用于传播的至少一个电极跨越心肌的调制信号，用于检测来自心肌的输出调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。所述至少一个电路包括放大器，解调器和积分器。最终输出的调制信号的振幅和相位表示心肌的复阻抗。心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。

6. 发明申请

WO2009042172A2 FREQUENCY SELECTIVE MONITORING OF PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：频率选择性监测生理信号
公开(公告)号：WO2009042172A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/011110
申请日：2008-09-25
申请人： MEDTRONIC, INC. , DENISON, Timothy, J. , JENSEN, Randy, M. , SANTA, Wesley, A.
发明人： DENISON, Timothy, J. , JENSEN, Randy, M. , SANTA, Wesley, A.
IPC分类号： A61N1/00 , A61B5/0452
CPC分类号： A61B5/04004 , A61B5/04018 , A61B5/048 , A61B5/4082 , A61B5/4094
摘要： In general, the disclosure is directed to a frequency selective monitor and methods for monitoring physiological signals in one or more selected frequency bands. A frequency selective monitor may utilize a heterodyning, chopper- stabilized amplifier architecture to convert a selected frequency band to a baseband for analysis. The frequency selective monitor may be useful in a variety of therapeutic and/or diagnostic applications. As examples, a frequency selective signal monitor may be provided within a medical device or within a sensor coupled to a medical device. The physiological signal may be analyzed in one or more selected frequency bands to trigger delivery of patient therapy and/or recording of diagnostic information.
摘要翻译：通常，本发明涉及一种频率选择性监测器和用于监测一个或多个所选频带中的生理信号的方法。频率选择性监视器可以利用外差斩波稳定的放大器架构将选定的频带转换为基带用于分析。频率选择性监测器可用于各种治疗和/或诊断应用。作为示例，可以在医疗装置内或耦合到医疗装置的传感器内提供频率选择信号监视器。可以在一个或多个所选频带中分析生理信号以触发患者治疗的传递和/或记录诊断信息。

7. 发明申请

WO2016182743A1 METHODS AND DEVICES THAT UTILIZE HARDWARE TO MOVE BLOCKS OF OPERATING PARAMETER DATA FROM MEMORY TO A REGISTER SET 审中-公开
标题翻译：使用硬件将操作参数数据块从存储器移动到寄存器集的方法和设备
公开(公告)号：WO2016182743A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/029626
申请日：2016-04-27
申请人： MEDTRONIC, INC.
发明人： HOCKEN, Robert , SANTA, Wesley, A. , ARNETT, Christopher, M. , SHAH, Jalpa, S. , SIVULA, Joel, E.
IPC分类号： G06F13/28 , A61N1/00
CPC分类号： G06F13/28 , A61N1/36146 , A61N1/37235 , G11C16/12 , H03K3/64
摘要： A hardware based block moving controller of an active device such as an implantable medical device that provides electrical stimulation reads a parameter data from a block of memory and then writes the parameter data to a designated register set of a component that performs an active function. The block of memory may include data that specifies a size of the block of memory to be moved to the register set. The block of memory may also include data that indicates a number of triggers to skip before moving a next block of memory to the register set. A trigger that causes the block moving controller to move the data from the block of memory to the register set may be generated in various ways such as through operation of the component having the register set or by a separate timer.
摘要翻译：有源器件（例如提供电刺激的可植入医疗器械）的基于硬件的块移动控制器从存储器块读取参数数据，然后将参数数据写入执行有效功能的组件的指定寄存器组。存储器块可以包括指定要移动到寄存器组的存储器块的大小的数据。存储器块还可以包括指示在将下一个存储块移动到寄存器组之前跳过的触发数的数据。导致块移动控制器将数据从存储器块移动到寄存器组的触发器可以以各种方式生成，例如通过具有寄存器组的组件的操作或通过单独的定时器的操作。

8. 发明申请

WO2008133626A1 SEIZURE PREDICTION 审中-公开
标题翻译：检测预测
公开(公告)号：WO2008133626A1
公开(公告)日：2008-11-06
申请号：PCT/US2007/010393
申请日：2007-04-30
申请人： MEDTRONIC, INC. , DENISON, Timothy, J. , SANTA, Wesley, A.
发明人： DENISON, Timothy, J. , SANTA, Wesley, A.
IPC分类号： A61B5/0476
CPC分类号： A61B5/053 , A61B5/04004 , A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7228 , A61B5/7275 , A61N1/08 , A61N1/36082 , G06F19/00
摘要： Seizure prediction systems and methods include measuring impedance within a brain of a patient to determine whether the brain is in a state indicative of a possibility of an onset of a seizure. In some embodiments, the measured impedance is compared to a predetermined threshold in order to determine whether the brain is in a state indicative of a possibility of a seizure. In other embodiments, a trend of the impedance measurements is correlated to a template. In other embodiments, a frequency component of a waveform of the impedance measurement amplitudes over time is correlated to frequency components of a template waveform. Upon detecting a state in which a seizure is likely to occur, a seizure indicator may be generated, which, in some embodiments, may be used to activate therapy delivery to the patient or, in other embodiments, activate an alarm.
摘要翻译：癫痫发作预测系统和方法包括测量患者脑内的阻抗，以确定大脑是否处于指示癫痫发作可能性的状态。在一些实施例中，将测量的阻抗与预定阈值进行比较，以便确定大脑是否处于指示癫痫发作的可能性的状态。在其他实施例中，阻抗测量的趋势与模板相关。在其他实施例中，随时间的阻抗测量幅度的波形的频率分量与模板波形的频率分量相关。在检测到可能发生癫痫发作的状态时，可以产生咬合指示器，在一些实施例中，可以使用缉获指示器来激活对患者的治疗递送，或者在其他实施例中激活警报。

9. 发明申请

WO2008133625A1 SEIZURE PREDICTION 审中-公开
标题翻译：检测预测
公开(公告)号：WO2008133625A1
公开(公告)日：2008-11-06
申请号：PCT/US2007/010390
申请日：2007-04-30
申请人： MEDTRONIC, INC. , DENISON, Timothy, J. , SANTA, Wesley, A.
发明人： DENISON, Timothy, J. , SANTA, Wesley, A.
IPC分类号： A61B5/048 , A61N1/36
CPC分类号： A61B5/053 , A61B5/4094 , A61N1/36082
摘要： Seizure prediction systems and methods include measuring impedance and a potential within a brain of a patient to determine whether the brain is in a state indicative of a possibility of seizure. In some embodiments, at least one of the measured impedance or the measured potential may be used as a primary indication of the brain state indicative of a possibility of seizure. In one embodiment, if one of the measured impedance or the measured potential indicates a seizure, the other measurement (impedance or potential) may be used to validate whether the brain is in the state indicative of the possibility of seizure.
摘要翻译：缉获预测系统和方法包括测量患者的脑中的阻抗和潜力，以确定大脑是否处于指示癫痫发作可能性的状态。在一些实施例中，测量的阻抗或测量电位中的至少一个可以被用作指示发作可能性的脑状态的主要指示。在一个实施例中，如果所测量的阻抗或测量的电位之一表示发作，则可以使用另一测量（阻抗或电位）来验证大脑是否处于表示发作可能性的状态。

10. 发明公开

EP2200692A2 FREQUENCY SELECTIVE MONITORING OF PHYSIOLOGICAL SIGNALS 有权
标题翻译：生理信号频率的选择性监控
公开(公告)号：EP2200692A2
公开(公告)日：2010-06-30
申请号：EP08832864.6
申请日：2008-09-25
申请人： Medtronic, Inc.
发明人： DENISON, Timothy, J. , JENSEN, Randy, M. , SANTA, Wesley, A.
IPC分类号： A61N1/00 , A61B5/0452 , A61B5/048 , A61B5/021
CPC分类号： A61B5/04004 , A61B5/04018 , A61B5/048 , A61B5/4082 , A61B5/4094
摘要： The disclosure is directed to a frequency selective monitor (6) and methods for monitoring physiological signals in one or more selected frequency bands. A frequency selective monitor may utilize a heterodyning, chopper-stabilized amplifier architecture (30) to convert a selected frequency band to a baseband for analysis. The frequency selective monitor may be useful in a variety of therapeutic and/or diagnostic applications. As examples, a frequency selective signal monitor may be provided within a medical device (20) or within a sensor (14) coupled to a medical device. The physiological signal may be analyzed in one or more selected frequency bands to trigger delivery of patient therapy and/or recording of diagnostic information.

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