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1. 发明申请

WO2007050493A1 SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可移植医疗设备中AV间隔选择的系统和方法
公开(公告)号：WO2007050493A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041247
申请日：2006-10-19
申请人： MEDTRONIC, INC. , CHIRIFE, Raul , COMBS, William J. , LUNDSTROM, Russell L. Jr.
发明人： COMBS, William J. , LUNDSTROM, Russell L. Jr.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译：可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。

2. 发明申请

WO2007101013A2 SYSTEM AND METHOD FOR DELIVERY OF CARDIAC PACING IN A MEDICAL DEVICE IN RESPONSE TO ISCHEMIA 审中-公开
标题翻译：在医疗器械中输送心肌梗塞的系统和方法对ISCHEMIA的反应
公开(公告)号：WO2007101013A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062427
申请日：2007-02-20
申请人： MEDTRONIC, INC. , SHELDON, Todd J. , COMBS, William J. , STYLOS, Lee , LU, Steven Ning , NEHLS, Robert J.
发明人： SHELDON, Todd J. , COMBS, William J. , STYLOS, Lee , LU, Steven Ning , NEHLS, Robert J.
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/3627
摘要： An implantable medical device system and method in which the implantable device is adapted to operate in a minimum ventricular pacing mode. The device delivers cardiac pacing pulses in a first pacing mode during a normal mode of operation and upon detecting myocardial ischemia alters the first pacing mode in response to the myocardial ischemia detection.
摘要翻译：一种植入式医疗装置系统和方法，其中所述可植入装置适于以最小心室起搏模式操作。该装置在正常操作模式期间以第一起搏模式递送心脏起搏脉冲，并且在检测心肌缺血时，响应于心肌缺血检测改变第一起搏模式。

3. 发明公开

EP1988962A2 SYSTEM AND METHOD FOR DELIVERY OF CARDIAC PACING IN A MEDICAL DEVICE IN RESPONSE TO ISCHEMIA 审中-公开
标题翻译：体系，提供医疗设备中心脏STEP的响应缺血
公开(公告)号：EP1988962A2
公开(公告)日：2008-11-12
申请号：EP07757216.2
申请日：2007-02-20
申请人： Medtronic, Inc.
发明人： SHELDON, Todd J. , COMBS, William J. , STYLOS, Lee , LU, Steven Ning , NEHLS, Robert J.
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/3627
摘要： An implantable medical device system and method in which the implantable device is adapted to operate in a minimum ventricular pacing mode. The device delivers cardiac pacing pulses in a first pacing mode during a normal mode of operation and upon detecting myocardial ischemia alters the first pacing mode in response to the myocardial ischemia detection.

4. 发明申请

WO2008112375A2 HEART MONITORING SYSTEMS, APPARATUS AND METHODS ADAPTED TO DETECT MYOCARDIAL ISCHEMIA 审中-公开
标题翻译：心脏监测系统，适用于检测心肌缺血的装置和方法
公开(公告)号：WO2008112375A2
公开(公告)日：2008-09-18
申请号：PCT/US2008/053770
申请日：2008-02-13
申请人： MEDTRONIC, INC. , COMBS, William J. , AUDET, Sarah A. , CARNEY, James K.
发明人： COMBS, William J. , AUDET, Sarah A. , CARNEY, James K.
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0402 , A61B5/721 , A61B5/7475
摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.
摘要翻译：实施例包括适于检测心肌缺血的心脏监测系统，装置和方法。一种设备包括适于感测与心脏功能相关的第一输入并且当第一输入指示心肌缺血时产生第一层触发信号的至少一个第一层传感器/分析器。在一个实施例中，第一层传感器/分析仪包括ECG传感器/分析仪。在另一个实施例中，第一层传感器/分析仪包括患者激励器。一种装置还包括至少一个第二层传感器/分析器，其适于感测与心脏功能有关的第二输入，并且当第二输入指示心肌缺血时产生第二层触发信号。在一个实施例中，第二层传感器分析仪包括心音传感器/分析仪。触发元件适于响应于第一层触发信号和第二层触发信号而产生响应调用信号。响应调用信号可以调用患者警报，到外部系统的消息和/或心脏刺激。

5. 发明申请

WO2007124238A1 IMPLANTABLE MEDICAL DEVICE WITH AUTOMATIC ISCHEMIA THRESHOLD DETERMINATION 审中-公开
标题翻译：具有自动ISCHEMIA阈值确定的可植入医疗设备
公开(公告)号：WO2007124238A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/065733
申请日：2007-03-31
申请人： MEDTRONIC, INC. , STYLOS, Lee , SHELDON, Todd J. , LU, Steven Ning , COMBS, William J. , NEHLS, Robert J.
发明人： STYLOS, Lee , SHELDON, Todd J. , LU, Steven Ning , COMBS, William J. , NEHLS, Robert J.
IPC分类号： A61N1/365 , A61N1/37 , A61N1/372
CPC分类号： A61N1/3702 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/37252
摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.
摘要翻译：可植入医疗装置（IMD）执行患者的周期性测试以确定缺血阈值信息。在患者静止时的选定时间，IMD随着时间的推移增加起搏速率，直到其从患者或缺血传感器接收到反馈。 IMD根据接收到反馈时的起搏速率来确定阈值。阈值信息可以用于调整速率自适应起搏期间可以使用的上起搏速率，以确定药物治疗的效果，并提供患者冠状动脉疾病状态的一般指示。对缺血区的起搏速率的周期性增加也提供心肌的预处理，以允许患者在没有心绞痛的情况下更大的运动益处。

6. 发明授权

EP1945300B1 SYSTEM FOR AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE 有权转让
标题翻译： SYSTEM FOR AV间隔选择在植入式医疗设备
公开(公告)号：EP1945300B1
公开(公告)日：2009-09-30
申请号：EP06817275.8
申请日：2006-10-19
申请人： MEDTRONIC, INC.
发明人： COMBS, William J. , LUNDSTROM, Russell L. Jr. , CHIRIFE, Raul
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

7. 发明公开

EP1945300A1 SYSTEM AND METHOD OF AV INTERVAL SELECTION IN AN IMPLANTABLE MEDICAL DEVICE 有权转让
标题翻译： SYSTEM FOR AV间隔选择在植入式医疗设备
公开(公告)号：EP1945300A1
公开(公告)日：2008-07-23
申请号：EP06817275.8
申请日：2006-10-19
申请人： MEDTRONIC, INC. , Chirife, Raul
发明人： COMBS, William J. , LUNDSTROM, Russell L. Jr.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.

8. 发明公开

EP2136704A2 HEART MONITORING SYSTEMS, APPARATUS AND METHODS ADAPTED TO DETECT MYOCARDIAL ISCHEMIA 审中-公开
标题翻译：心脏监测系统，心肌缺血的检测仪器和方法
公开(公告)号：EP2136704A2
公开(公告)日：2009-12-30
申请号：EP08729694.3
申请日：2008-02-13
申请人： MEDTRONIC, INC.
发明人： COMBS, William J. , AUDET, Sarah A. , CARNEY, James K.
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0402 , A61B5/721 , A61B5/7475
摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.

9. 发明公开

EP2012875A1 IMPLANTABLE MEDICAL DEVICE WITH AUTOMATIC ISCHEMIA THRESHOLD DETERMINATION 审中-公开
标题翻译：具有自动ISCHÄMIEGRENZWERTBESTIMMUNG植入式医疗设备
公开(公告)号：EP2012875A1
公开(公告)日：2009-01-14
申请号：EP07759911.6
申请日：2007-03-31
申请人： Medtronic, Inc.
发明人： STYLOS, Lee , SHELDON, Todd J. , LU, Steven Ning , COMBS, William J. , NEHLS, Robert J.
IPC分类号： A61N1/365 , A61N1/37 , A61N1/372
CPC分类号： A61N1/3702 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/37252
摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.

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