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1. 发明申请

WO2012125955A2 METHODS AND MATERIALS FOR PROLONGING USEFUL STORAGE OF RED BLOOD CELL PREPARATIONS AND PLATELET PREPARATIONS 审中-公开
标题翻译：有助于红血球细胞制备和制备的有效储存的方法和材料
公开(公告)号：WO2012125955A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029510
申请日：2012-03-16
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , DYNASIL BIOMEDICAL CORPORATION , JOYNER, Michael J. , ERICSON, Daniel Grant
发明人： JOYNER, Michael J. , ERICSON, Daniel Grant
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
CPC分类号： C12N5/0644 , A01N1/0226 , A01N1/0263
摘要： This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO 2 to store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production by a red blood cell preparation, (b) reduces the level of lactate formation by a red blood cell preparation, and/or (c) reduces the pH level of a red blood cell preparation are provided. Such methods and materials can result in prolonging the useful lifespan of the red blood cells of the red blood cell preparation. This document also provides methods and materials involved in prolonging useful storage of platelet preparations. For example, methods and materials for storing platelets in a manner that reduces platelet metabolism, that preserves platelet function, and/or that reduces the risk of bacterial contamination are provided.
摘要翻译：本文件提供了增强红细胞制剂储存能力的方法和材料。例如，使用二氧化碳来存储红细胞的方法和材料，其方法是：（a）降低红细胞的葡萄糖水平或2,3-DPG消耗或降低2,3-DPG产生的水平制剂，（b）通过红细胞制剂降低乳酸盐形成的水平，和/或（c）降低红细胞制剂的pH值。这样的方法和材料可以延长红细胞制剂的红细胞的使用寿命。本文件还提供延长血小板制剂有用储存的方法和材料。例如，提供了以减少血小板代谢，保留血小板功能和/或降低细菌污染风险的方式存储血小板的方法和材料。

2. 发明公开

EP2685815A2 METHODS AND MATERIALS FOR PROLONGING USEFUL STORAGE OF RED BLOOD CELL PREPARATIONS AND PLATELET PREPARATIONS 审中-公开
标题翻译：方法和材料续期存储的红细胞，血小板的制剂的使用
公开(公告)号：EP2685815A2
公开(公告)日：2014-01-22
申请号：EP12757403.6
申请日：2012-03-16
申请人： Mayo Foundation For Medical Education And Research , Dynasil Biomedical Corporation
发明人： JOYNER, Michael J. , ERICSON, Daniel Grant
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
CPC分类号： C12N5/0644 , A01N1/0226 , A01N1/0263
摘要： This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO2 to store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production by a red blood cell preparation, (b) reduces the level of lactate formation by a red blood cell preparation, and/or (c) reduces the pH level of a red blood cell preparation are provided. Such methods and materials can result in prolonging the useful lifespan of the red blood cells of the red blood cell preparation. This document also provides methods and materials involved in prolonging useful storage of platelet preparations. For example, methods and materials for storing platelets in a manner that reduces platelet metabolism, that preserves platelet function, and/or that reduces the risk of bacterial contamination are provided.

3. 发明申请

WO2017210267A3 PLASMA-BASED FILMS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2017210267A3
公开(公告)日：2017-12-07
申请号：PCT/US2017/035159
申请日：2017-05-31
申请人： ERICSON, Daniel Grant
发明人： ERICSON, Daniel Grant
IPC分类号： A61L27/22 , A61L27/58 , A61L15/32
摘要： The present invention relates to plasma-based films and in particular to flexible plasma-based films. The invention further relates to and to methods of making and using the flexible plasma-based films. Embodiments of the invention have been particularly developed for making flexible plasma-based films useful as a hemostat in the treatment and/or prevention of mild to severe as well as arterial bleedings, as an anti-adhesive sheet to reduce or prevent development of surgery-induced adhesions, as a wound healing patch, as a wound dressing, or as a film useful in hernia repair. Embodiments of the invention will be described hereinafter with reference to these applications. However, it will be appreciated that the invention is not limited to this particular field of use.

4. 发明申请

WO2017210267A2 PLASMA-BASED FILMS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：基于等离子体的膜及其制备和使用方法
公开(公告)号：WO2017210267A2
公开(公告)日：2017-12-07
申请号：PCT/US2017/035159
申请日：2017-05-31
申请人： ERICSON, Daniel Grant
发明人： ERICSON, Daniel Grant
IPC分类号： A61L27/22 , A61L27/58 , A61L15/32
摘要： The present invention relates to plasma-based films and in particular to flexible plasma-based films. The invention further relates to and to methods of making and using the flexible plasma-based films. Embodiments of the invention have been particularly developed for making flexible plasma-based films useful as a hemostat in the treatment and/or prevention of mild to severe as well as arterial bleedings, as an anti-adhesive sheet to reduce or prevent development of surgery-induced adhesions, as a wound healing patch, as a wound dressing, or as a film useful in hernia repair. Embodiments of the invention will be described hereinafter with reference to these applications. However, it will be appreciated that the invention is not limited to this particular field of use.
摘要翻译：本发明涉及基于等离子体的膜，并且特别涉及基于柔性等离子体的膜。本发明还涉及制造和使用柔性等离子体基薄膜的方法。本发明的实施方式已经被特别开发用于制造柔性等离子体基膜，作为用于治疗和/或预防轻度至重度以及动脉出血的止血剂，作为减少或防止外科手术的发展的抗粘连片，诱导的粘连，伤口愈合贴片，伤口敷料或用于疝修复的薄膜。以下将参照这些应用描述本发明的实施例。然而，应该理解，本发明不限于这个特定的使用领域。

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