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1. 发明申请

WO0052155A3 RECOMBINATION OF INSERTION MODIFIED NUCLEIC ACIDS 审中-公开
标题翻译：插入改性核酸的重组
公开(公告)号：WO0052155A3
公开(公告)日：2001-07-26
申请号：PCT/US0005573
申请日：2000-03-03
申请人： MAXYGEN INC , PATTEN PHILLIP A , HEINRICHS VOLKER , STEMMER WILLEM P C
发明人： PATTEN PHILLIP A , HEINRICHS VOLKER , STEMMER WILLEM P C
IPC分类号： C12N15/10 , C12N15/82 , C12P21/04 , C12N15/11 , C12N9/00 , C12N9/14 , C12N15/62
CPC分类号： C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
摘要翻译：调节，调节和改进用于核酸洗牌过程的分子的杂交性质和重组性质的方法涉及重组混合物，并且提供调节，调节，改进和进化的RNA和蛋白质剪接的方法。

2. 发明申请

WO0125438A3 IFN-ALPHA HOMOLOGUES 审中-公开
公开(公告)号：WO0125438A3
公开(公告)日：2002-07-11
申请号：PCT/US0027781
申请日：2000-10-06
申请人： MAXYGEN INC , HEINRICHS VOLKER , CHEN TEDDY , PATTEN PHILLIP A
发明人： HEINRICHS VOLKER , CHEN TEDDY , PATTEN PHILLIP A
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/56 , C12N1/21 , C12N15/21 , A61K31/70 , A61K38/21 , C07K16/24 , C12N5/10 , C12N15/62 , G06F19/00
CPC分类号： C07K14/56 , A61K38/00 , Y02A90/26
摘要： Alpha interferon homologues (both nucleic acids and polypeptides) are provided. Compositions including these interferon homologue polypeptides and nucleic acids, recombinant cells comprising said homologue polypeptides and nucleic acids, methods of making the new homologues, antibodies to the new homologues, and methods of using the homologues are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are also provided.
摘要翻译：提供α干扰素同源物（核酸和多肽）。提供包括这些干扰素同系物多肽和核酸的组合物，包含所述同源多肽和核酸的重组细胞，制备新同系物的方法，对新同系物的抗体以及使用同源物的方法。还提供了包含核酸或多肽的序列的整合系统。

3. 发明申请

WO2007146975A3 METHODS FOR GENERATING GENETIC DIVERSITY BY PERMUTATIONAL MUTAGENESIS 审中-公开
标题翻译：用于通过生物转化产生遗传多样性的方法
公开(公告)号：WO2007146975A3
公开(公告)日：2008-01-31
申请号：PCT/US2007071070
申请日：2007-06-13
申请人： ATHENIX CORP , HEINRICHS VOLKER
发明人： HEINRICHS VOLKER
IPC分类号： C12N15/10
CPC分类号： C12N15/1058
摘要： Methods for generating genetic diversity in a polynucleotide or polypeptide sequence are included. The methods include permutational mutagenesis strategies for introducing genetic diversity to alter or improve the function of the polynucleotide or polypeptide. The methods include aligning a set of homologous sequences and generating a consensus translation or a consensus sequence that encompasses the full diversity of the aligned sequences, and then incorporating that consensus translation or consensus sequence into a functional polypeptide or polynucleotide to test for altered or improved function.
摘要翻译：包括在多核苷酸或多肽序列中产生遗传多样性的方法。所述方法包括用于引入遗传多样性以改变或改善多核苷酸或多肽的功能的置换诱变策略。所述方法包括对齐一组同源序列并产生包含比对序列的完全多样性的共有翻译或共有序列，然后将该共有翻译或共有序列并入功能性多肽或多核苷酸以测试改变或改善的功能。

4. 发明申请

WO2010075498A2 AXMI-150 DELTA-ENDOTOXIN GENE AND METHODS FOR ITS USE 审中-公开
标题翻译： AXMI-150 DELTA-ENDOTOXIN基因及其使用方法
公开(公告)号：WO2010075498A2
公开(公告)日：2010-07-01
申请号：PCT/US2009069381
申请日：2009-12-23
申请人： ATHENIX CORP , SAMPSON KIMBERLY S , TOMSO DANIEL J , HEINRICHS VOLKER
发明人： SAMPSON KIMBERLY S , TOMSO DANIEL J , HEINRICHS VOLKER
IPC分类号： C12N15/82 , C07K14/325
CPC分类号： C12N15/8286 , C07K14/325 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules having nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, the nucleotide sequence set forth in SEQ ID NO: 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包括杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包括对应于多核苷酸的氨基酸序列。具体而言，本发明提供了具有编码SEQ ID NO：2所示氨基酸序列的核苷酸序列的分离的核酸分子，即SEQ ID NO：1,3,4,5,6,7， 8，9，10，11或12，以及其变体和片段。

5. 发明申请

WO2007146980A2 IMPROVED EPSP SYNTHASES: COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：改进的EPSP合成：组合物和使用方法
公开(公告)号：WO2007146980A2
公开(公告)日：2007-12-21
申请号：PCT/US2007071076
申请日：2007-06-13
申请人： ATHENIX CORP , HEINRICHS VOLKER
发明人： HEINRICHS VOLKER
IPC分类号： C07K14/43
CPC分类号： C12N9/1092 , C12N15/8275
摘要： Compositions and methods for conferring tolerance to glyphosate in bacteria, plants, plant cells, tissues and seeds are provided. Compositions include novel EPSP synthase enzymes and nucleic acid molecules encoding such enzymes, vectors comprising those nucleic acid molecules, and host cells comprising the vectors.
摘要翻译：提供了在细菌，植物，植物细胞，组织和种子中赋予草甘膦耐受性的组合物和方法。组合物包括新型EPSP合成酶和编码这种酶的核酸分子，包含那些核酸分子的载体和包含载体的宿主细胞。

6. 发明申请

WO2010003065A3 AXMI-IL 5, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184 : VIP3A INSECTICIDAL PROTEINS FROM BACILLUS THURINGIENSIS AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-IL 5，AXMI-113，AXMI-005，AXMI-163和AXMI-184：来自BACILLUS THURINGIENSIS的VIP3A杀虫蛋白及其使用方法
公开(公告)号：WO2010003065A3
公开(公告)日：2010-05-20
申请号：PCT/US2009049527
申请日：2009-07-02
申请人： ATHENIX CORP , SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
发明人： SAMPSON KIMBERLY S , AGARWAL SHRUTI , CAMPBELL CHRIS , MCNULTY BRIAN , TOMSO DANIEL J , CAROZZI NADINE , HARGISS TRACY , KOZIEL MICHAEL G , DUCK NICHOLAS B , HEINRICHS VOLKER
IPC分类号： C07K14/325 , A01H5/00 , C12N15/82
CPC分类号： C07K14/325 , A01N37/18 , C07K14/32 , C07K16/1278 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in host cells. Compositions also comprise transformed host cells. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 6, 13, or 14, or the nucleotide sequence set forth in SEQ ID NO: 1, 2, 3, 11, or 12, as well as variants and fragments thereof.
摘要翻译：提供了赋予宿主细胞杀虫活性的组合物和方法。提供了包含δ-内毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在宿主细胞中转化和表达。组合物还包含转化的宿主细胞。特别地，提供了分离的δ-内毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：4,5,6,13或14所示氨基酸序列的核苷酸序列或SEQ ID NO：1所示的核苷酸序列， 2,3,11或12，以及其变体和片段。

7. 发明申请

WO2009099906A3 DIRECTED EVOLUTION OF GRG31 AND GRG36 EPSP SYNTHASE ENZYMES 审中-公开
标题翻译： GRG31和GRG36 EPSP合成酶的定向演化
公开(公告)号：WO2009099906A3
公开(公告)日：2009-11-05
申请号：PCT/US2009032515
申请日：2009-01-30
申请人： ATHENIX CORP , HEINRICHS VOLKER , SCHOUTEN LAURA COOPER , VANDE BERG BRIAN
发明人： HEINRICHS VOLKER , SCHOUTEN LAURA COOPER , VANDE BERG BRIAN
IPC分类号： C12N9/10 , C12N15/82
CPC分类号： C12N15/8275 , C12N9/1092
摘要： Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding glyphosate resistance or tolerance polypeptides are provided, particularly polypeptide variants of SEQ ID NO:2 and 4. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides containing nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:7-28, or the nucleotide sequence set forth in SEQ ID NO:29 or 30.
摘要翻译：提供了赋予除草剂对细菌，植物，植物细胞，组织和种子的抗性或耐受性的组合物和方法。组合物包括编码除草剂抗性或耐受性多肽的多核苷酸，包含那些多核苷酸的载体和包含该载体的宿主细胞。本发明的核苷酸序列可用于DNA构建体或表达盒中，用于在生物体（包括微生物和植物）中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。具体而言，提供了编码草甘膦抗性或耐受性多肽的分离的多核苷酸，特别是SEQ ID NO：2和4的多肽变体。另外，包含对应于多核苷酸的氨基酸序列。具体而言，本发明提供了分离的多核苷酸，其含有编码SEQ ID NO：7-28所示氨基酸序列或SEQ ID NO：29或30所示核苷酸序列的核苷酸序列。

8. 发明申请

WO2009052242A3 AXMI-066 AND AXMI-076: DELTA-ENDOTOXIN PROTEINS AND METHODS FOR THEIR USE 审中-公开
标题翻译： AXMI-066和AXMI-076：DELTA-内毒素蛋白及其使用方法
公开(公告)号：WO2009052242A3
公开(公告)日：2009-08-06
申请号：PCT/US2008080090
申请日：2008-10-16
申请人： ATHENIX CORP , TOMSO DANIEL J , SAMPSON KIMBERLY S , AGARWAL SHRUTI , VOLRATH SANDRA , DESAI NALINI , HEINRICHS VOLKER
发明人： TOMSO DANIEL J , SAMPSON KIMBERLY S , AGARWAL SHRUTI , VOLRATH SANDRA , DESAI NALINI , HEINRICHS VOLKER
IPC分类号： C07K14/325 , C12N15/82
CPC分类号： C07K14/325 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:5, 2, or 10, the nucleotide sequence set forth in SEQ ID NO:4, 1, 3, 4, 6, 9, or 11, or the nucleotide sequence deposited in a bacterial host as Accession No. B-50045, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：5,2或10所示氨基酸序列的核苷酸序列，SEQ ID NO：4,1,3,4 ，6,9或11个核苷酸序列，或以细菌宿主保藏号B-50045以及其变体和片段沉积的核苷酸序列。

9. 发明专利

CA2385045A1 IFN-ALPHA HOMOLOGUES 未知
公开(公告)号：CA2385045A1
公开(公告)日：2001-04-12
申请号：CA2385045
申请日：2000-10-06
申请人： MAXYGEN INC
发明人： PATTEN PHILLIP A , CHEN TEDDY , HEINRICHS VOLKER
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/56 , C12N1/21 , C12N15/21 , A61K31/70 , A61K38/21 , C07K16/24 , C12N5/10 , C12N15/62 , G06F19/00
摘要： Alpha interferon homologues (both nucleic acids and polypeptides) are provided. Compositions including these interferon homologue polypeptides and nucleic acids, recombinant cells comprising said homologue polypeptides and nucleic acids, methods of making the new homologues, antibodies to the new homologues, and methods of using the homologues are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are al so provided.

10. 发明专利

AU3719500A Recombination of insertion modified nucleic acids 未知
公开(公告)号：AU3719500A
公开(公告)日：2000-09-21
申请号：AU3719500
申请日：2000-03-03
申请人： MAXYGEN INC
发明人： PATTEN PHILLIP A , HEINRICHS VOLKER , STEMMER WILLEM P C
IPC分类号： C12N15/10 , C12N15/82 , C12P21/04 , C12N15/11 , C12N9/00 , C12N9/14 , C12N15/62
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.

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