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1. 发明申请

WO2010040261A1 PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS 审中-公开
标题翻译：制备2-烷基-3-硝基-5-硝基苯并呋喃的方法
公开(公告)号：WO2010040261A1
公开(公告)日：2010-04-15
申请号：PCT/CN2008/072644
申请日：2008-10-10
申请人： LONZA LTD , WELLIG, Alain , RODUIT, Jean-Paul , DAI, Danmei , CHEN, Rongmin
发明人： WELLIG, Alain , RODUIT, Jean-Paul , DAI, Danmei , CHEN, Rongmin
IPC分类号： C07D307/80 , C07C49/76
CPC分类号： C07C45/673 , C07C45/455 , C07C45/71 , C07C251/52 , C07D307/80 , C07C49/84 , C07C49/825
摘要： The present invention relates to a process for the preparation of a compound of formula (I), wherein R 1 is selected from C 1-6 -alkyl, C 3-6 -cycloalkyl and aralkyl, and wherein R 2 at each occurrence independently is halogen or C 1-6 -alkyl, and m is an integer from 0 to 4, Q is selected from halogen, -NO 2 and -NR 3 R 4 , wherein R 3 and R 4 are independently selected from hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R 3 and R 4 together form a C 4-6 -alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1选自C 1-6 - 烷基，C 3-6 - 环烷基和芳烷基，并且其中R 2在每次出现时独立地为卤素或C1- 并且m是0至4的整数，Q选自卤素，-NO 2和-NR 3 R 4，其中R 3和R 4独立地选自氢，C 1-6 - 烷基，C 3-6 - 环烷基，芳基，芳烷基，甲磺酰基和甲苯磺酰基，或其中R3和R4一起形成C4-6亚烷基，Y在每次出现时为氢或可在酸性条件下水解切割的羟基保护基W，n为1〜 3，n为1〜3的整数，条件是n和m不大于5。

2. 发明公开

EP2344467A1 PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS 审中-公开
标题翻译：制备2-烷基-3-芳酰基-5-硝基苯并呋喃的方法
公开(公告)号：EP2344467A1
公开(公告)日：2011-07-20
申请号：EP08877230.6
申请日：2008-10-10
申请人： Lonza Ltd.
发明人： WELLIG, Alain , RODUIT, Jean-Paul , DAI, Danmei , CHEN, Rongmin
IPC分类号： C07D307/80 , C07C49/76
CPC分类号： C07C45/673 , C07C45/455 , C07C45/71 , C07C251/52 , C07D307/80 , C07C49/84 , C07C49/825
摘要： The present invention relates to a process for the preparation of a compound of formula (I), wherein R
1 is selected from C
1-6 -alkyl, C
3-6 -cycloalkyl and aralkyl, and wherein R
2 at each occurrence independently is halogen or C
1-6 -alkyl, and m is an integer from 0 to 4, Q is selected from halogen, -NO
2 and -NR
3 R
4 , wherein R
3 and R
4 are independently selected from hydrogen, C
1-6 -alkyl, C
3-6 -cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R
3 and R
4 together form a C
4-6 -alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1选自C 1-6 - 烷基，C 3-6 - 环烷基和芳烷基，并且其中R 2在每次出现时独立地为卤素或C 1-6 - 烷基，并且m是0至4的整数，Q选自卤素，-NO 2和-NR 3 R 4，其中R 3和R 4独立地选自氢，C 1-6 - 烷基，C 3-6 - 环烷基，芳基，芳烷基，甲磺酰基和甲苯磺酰基，或者其中R 3和R 4一起形成C 4-6 - 亚烷基，Y在每次出现时为氢或羟基保护基W，在酸性条件下被水解裂解，并且n是1至3的整数，且n是1至3的整数，条件是n和m一起不大于5。

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