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1. 发明申请

WO2008135879A1 ACCELERATED T2-MAPPING IN MRI THROUGH UNDERSAMPLING AND K-T RECONSTRUCTION 审中-公开
标题翻译：通过下颌和K-T重建加速磁共振成像
公开(公告)号：WO2008135879A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051574
申请日：2008-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SENEGAS, Julien , DAHNKE, Hannes , STEHNING, Christian , WINKELMANN, Stefanie
发明人： SENEGAS, Julien , DAHNKE, Hannes , STEHNING, Christian , WINKELMANN, Stefanie
IPC分类号： G01R33/50
CPC分类号： G01R33/50
摘要： The invention relates to a device for MR imaging of a body (7) placed in an examination volume. The device (1) is arranged to:a) generate a series of MR echo signals for multiple echo time values (TE 1 , TE 2 , TE 3 , TE 4 ) by subjecting at least a portion of said body (7) to an MR imaging sequence of at least one RF pulse and switched magnetic field gradients, b) acquire MR signal data from a set of k- space positions with sub-sampling in the phase-encoding direction, c) estimate MR signal data for skipped k-space positions by combining MR signal data from acquired k-space positions, so as to complete the MR signal data set, d) reconstruct an MR image for each echo time value (TE 1 , TE 2 , TE 3 , TE 4 ) from the completed MR signal data set, and e) compute a relaxation time map from the set of reconstructed MR images.
摘要翻译：本发明涉及放置在检查体积中的身体（7）的MR成像装置。设备（1）被布置成：a）产生用于多个回波时间值（TE 1 SUB，TE 2，TE 3）的一系列MR回波信号，通过对所述主体（7）的至少一部分进行至少一个RF脉冲和切换的磁场梯度的MR成像序列的影响，b）获取MR信号数据一组在相位编码方向上具有子采样的k空间位置，c）通过组合来自所获取的k空间位置的MR信号数据来估计用于跳过的k空间位置的MR信号数据，以便完成MR信号数据设置，d）为每个回波时间值（TE 1，TE 2，TE 3，TE 4， / SUB>），e）从重建的MR图像的集合计算弛豫时间图。

2. 发明申请

WO2006018780A1 MR METHOD FOR THE QUANTITATIVE DETERMINATION OF LOCAL RELAXATION TIME VALUES 审中-公开
标题翻译：用于定量确定局部放松时间值的方法
公开(公告)号：WO2006018780A1
公开(公告)日：2006-02-23
申请号：PCT/IB2005/052625
申请日：2005-08-08
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , DAHNKE, Hannes , SCHAEFFTER, Tobias
发明人： DAHNKE, Hannes , SCHAEFFTER, Tobias
IPC分类号： G01R33/50 , G01R33/565
CPC分类号： G01R33/50 , G01R33/281 , G01R33/56536 , G01R33/56563
摘要： The invention relates to an MR method for the quantitative determination of local relaxation time values in an examination volume. Firstly, a plurality of echo signals (1, 2, 3) with different echo time values (t 1 , t 2 , t 3 ) are recorded in a phase-sensitive manner. From these echo signals (1, 2, 3), complex MR images (4, 5, 6) are then reconstructed for the different echo time values (t 1 , t 2 , t 3 ). Next, local resonant frequency values (7) are calculated for each image point from the echo-time-dependent change in the phases of the complex image values, and then preliminary local magnetic field inhomogeneity values (8) are calculated from the local resonant frequency values (7). The invention proposes that the local relaxation time values (10) be determined from the echo-time-dependent change in the amplitudes of the image values and correction of the local relaxation time values (10) be carried out taking account of final local magnetic field inhomogeneity values. The preliminary magnetic field inhomogeneity values (8) are used as start values for an iterative optimization procedure (19) for determining the final local magnetic field inhomogeneity values.
摘要翻译：本发明涉及用于定量测定检查体积中局部弛豫时间值的MR方法。首先，具有不同回波时间值（t 1，t 2，t 3 3）的多个回波信号（1,2,3）以相敏的方式记录。根据这些回波信号（1,2,3），然后针对不同的回波时间值（t 1，...，T 2）重建复数MR图像（4,5,6） >，t 3 3）。接下来，从复图像值的相位的回波 - 时间相关的变化中，针对每个图像点计算局部谐振频率值（7），然后从局部谐振频率计算初步局部磁场不均匀性值（8）值（7）。本发明提出，根据图像值幅度的回波 - 时间相关的变化确定局部弛豫时间值（10），并且考虑到最终局部磁场来执行局部弛豫时间值（10）的校正不均匀性值。将初步磁场不均匀性值（8）用作用于确定最终局部磁场不均匀性值的迭代优化程序（19）的起始值。

3. 发明申请

WO2008087586A1 DETERMINATION OF SUSCEPTIBILITY-INDUCED MAGNETIC FIELD GRADIENTS BY MAGNETIC RESONANCE 审中-公开
标题翻译：通过磁共振测定可触发感应磁场梯度
公开(公告)号：WO2008087586A1
公开(公告)日：2008-07-24
申请号：PCT/IB2008/050126
申请日：2008-01-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DAHNKE, Hannes , SCHAEFFTER, Tobias , VAN DER MEULEN, Peter
发明人： DAHNKE, Hannes , SCHAEFFTER, Tobias , VAN DER MEULEN, Peter
IPC分类号： G01R33/28 , G01R33/48 , G01R33/3875
CPC分类号： G01R33/56536 , G01R33/243 , G01R33/281 , G01R33/286 , G01R33/3875 , G01R33/48 , G01R33/5601
摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by co mput ing echo shift parameters (SP x , SP y , SP z ) from subsets of the MR image data set, the echo shift parameters (SP x , SP y , SP z ) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number ( n ) of spatially adjacent pixel or voxel values of the MR image data set (21).
摘要翻译：本发明涉及一种用于身体（7）的磁共振成像的装置。装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6）朝向身体（7）的RF脉冲，用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10），以及用于形成MR图像的重建装置（14）从信号样本。根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲的MR成像序列和切换的磁场梯度来生成一系列MR回波信号（20），b ）获取用于重建MR图像数据集（21）的MR回波信号，c）通过输入回波移位参数（SP SP x S，SP SP）计算梯度图（22） MR图像数据组的子集，回波移位参数（SP ，SP＆gt; Z＆lt; / SUB＆gt; 指示磁场梯度引起k空间中的回波位置的移位，其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

4. 发明申请

WO2008132686A1 QUANTIFICATION FOR MR PARAMETERS SUCH AS T1 OR T2 IN A SUB-REGION OF A SUBJECT 审中-公开
标题翻译： MR参数的数量，例如T1或T2在一个子区域的子区域
公开(公告)号：WO2008132686A1
公开(公告)日：2008-11-06
申请号：PCT/IB2008/051622
申请日：2008-04-28
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , STEHNING, Christian , DAHNKE, Hannes
发明人： STEHNING, Christian , DAHNKE, Hannes
IPC分类号： G01R33/483 , G01R33/50
CPC分类号： G01R33/50 , G01R33/481 , G01R33/4812 , G01R33/4833
摘要： The practical use of existing techniques for measuring characteristic magnetic resonance (MR) parameters such as spin-lattice relaxation time ( T1 ), spin-spin relaxation time ( T2 ), proton density ( p ), T2*, etc., is limited by the extended periods of time required for the measurement. It is thus desirable to have a method of measuring or quantifying characteristic MR parameters in a shorter period of time. Accordingly, a method of quantifying at least one characteristic MR parameter in a subject is hereby disclosed. The method comprises identifying (103) a region to be scanned in the subject, defining (105) a sub-region within the identified region, acquiring (107) MR data from the defined sub-region, and processing (109) the acquired MR data to quantify the at least one characteristic parameter in the defined sub-region.
摘要翻译：用于测量自旋晶格弛豫时间（T1），自旋 - 自旋弛豫时间（T2），质子密度（p），T2 *等特征磁共振（MR）参数的现有技术的实际应用受到测量所需的延长时间。因此，期望具有在更短的时间段内测量或量化特征MR参数的方法。因此，公开了一种定量对象中的至少一个特征MR参数的方法。该方法包括：识别（103）被摄体中要扫描的区域，定义（105）识别区域内的子区域，从所定义的子区域获取（107）MR数据，以及处理（109）所获取的MR 数据以量化所定义的子区域中的至少一个特征参数。

5. 发明申请

WO2007122553A3 PASSIVE MR VISUALISATION OF INTEVENTIONAL INSTRUMENTS 审中-公开
公开(公告)号：WO2007122553A3
公开(公告)日：2007-11-01
申请号：PCT/IB2007/051376
申请日：2007-04-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KRUEGER, Sascha , WEISS, Steffen , DAHNKE, Hannes , SCHAEFFTER, Tobias, R.
发明人： KRUEGER, Sascha , WEISS, Steffen , DAHNKE, Hannes , SCHAEFFTER, Tobias, R.
IPC分类号： G01R33/28
摘要： The invention relates to a device for magnetic resonance imaging of a body (7), wherein the device (1) is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence comprising RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image (21) therefrom, c) calculate a susceptibility gradient map (22) from the MR echo signals or from the MR image (21), the susceptibility gradient map (22) indicating local susceptibility induced magnetic field gradients, d) determine the position of an interventional instrument (16) having paramagnetic or ferromagnetic properties from the susceptibility gradient map (22).

6. 发明申请

WO2012007871A1 SYSTEM AND METHOD FOR GENERATING A SYSTEM FUNCTION FOR USE IN THE RECONSTRUCTION OF IMAGES 审中-公开
标题翻译：用于生成用于重建图像的系统功能的系统和方法
公开(公告)号：WO2012007871A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/052969
申请日：2011-07-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmbH , BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
发明人： BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
IPC分类号： G06T1/00 , A61B5/05
CPC分类号： G06T1/0007 , A61B5/0515
摘要： The present invention relates to a system and a corresponding method for generating a system function for use in the reconstruction of images in an imaging device for imaging the distribution of a tracer material in an object, wherein the system function describes the mapping between tracer distribution and imaging signals acquired by the imaging device. The proposed system comprises an acquisition means (220) for acquiring a first portion (SF Tr ) of the system function, said first portion describing dynamics of the tracer material, an imaging device (210) for acquiring a second portion (SF Sc ) of the system function, said second portion (SF Sc ) describing characteristics of the imaging device, and combination means (230) for combining said first and second portions to generate said system function.
摘要翻译：本发明涉及一种用于生成系统功能的系统和相应方法，所述系统功能用于成像设备中的图像的重构，用于对对象中的示踪材料的分布进行成像，其中所述系统功能描述了示踪剂分布与由成像装置获取的成像信号。所提出的系统包括用于获取系统功能的第一部分（SF Tr）的获取装置（220），所述第一部分描述示踪材料的动力学，用于获取第二部分（SF Sc）的成像装置（210）所述系统功能，描述所述成像装置的特征的所述第二部分（SF Sc）以及用于组合所述第一和第二部分以产生所述系统功能的组合装置（230）。

7. 发明申请

WO2007122527A2 MAGNETIC RESONANCE DEVICE AND METHOD 审中-公开
标题翻译：磁共振装置及方法
公开(公告)号：WO2007122527A2
公开(公告)日：2007-11-01
申请号：PCT/IB2007/051176
申请日：2007-04-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V., , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DAHNKE, Hannes , SCHAEFFTER, Tobias
发明人： DAHNKE, Hannes , SCHAEFFTER, Tobias
IPC分类号： G01R33/28 , G01R33/48 , G01R33/3875
CPC分类号： G01R33/286 , G01R33/3875 , G01R33/48 , G01R33/56536
摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SP x , SP y , SP z ) from subsets of the MR image data set, the echo shift parameters (SP x , SP y , SP z ) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).
摘要翻译：本发明涉及一种用于身体（7）的磁共振成像的装置。装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6）朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14）从信号样本。根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重构MR图像数据集（21）的MR回波信号，c）通过计算回波移位参数（SP＆lt; x＆gt;，SP＆gt; 回波移位参数（SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt; 指示磁场梯度引起k空间中的回波位置的移位，其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

8. 发明公开

EP1926425A2 MULTIPLE CONTRAST AGENT INJECTION FOR IMAGING 有权
标题翻译：多次造影剂注射IMAGING
公开(公告)号：EP1926425A2
公开(公告)日：2008-06-04
申请号：EP06795935.3
申请日：2006-09-07
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips Electronics N.V.
发明人： DAHNKE, Hannes , SCHAEFFTER, Tobias
IPC分类号： A61B5/055 , A61B6/00 , A61K49/00 , G01R33/28 , G01R33/56
CPC分类号： A61B5/055 , A61B6/481 , A61K49/1818 , B82Y5/00 , G01R33/50 , G01R33/5601 , G01R33/56366
摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.

9. 发明公开

EP2004242A2 SYSTEMS AND METHODS FOR CELL MEASUREMENT UTILIZING ULTRASHORT T2* RELAXOMETRY 审中-公开
标题翻译：系统和方法小区测量采用超短T2 *弛豫
公开(公告)号：EP2004242A2
公开(公告)日：2008-12-24
申请号：EP07735226.8
申请日：2007-03-22
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： LIU, Wei , DAHNKE, Hannes , SCHAEFFTER, Tobias
IPC分类号： A61K49/06
CPC分类号： A61K49/1896 , A61K49/1866 , B82Y5/00
摘要： The present disclosure is directed to a new technique for MR measurement of ultrashort T2* relaxation utilizing spin-echo acquisition. The ultrashort T2* relaxometry can be used for the quantification of highly concentrated iron labeled cells in cell trafficking and therapy. In an exemplary embodiment, a signal is induced by a low flip angle RF pulse. Following excitation pulse, a gradient readout is applied to form an echo. The time between the RF pulse and the center of the gradient readout is defined as TE. In tissues with highly concentrated iron labeled cells, T2* could be below 1 millisecond. Therefore, the signal can be decayed to a noise level with an echo time of a couple milliseconds. Because T2* is much longer in SPIO labeled cells, the signal acquired by spin echo is much bigger than that from the gradient echo, thus avoiding the negative effects associated with the massive signal loss in the image. The ultrashort T2* relaxation map can then by overlaid on the regular T2* map to generate the final T2* map of the field of view.

10. 发明公开

EP2106556A1 DETERMINATION OF SUSCEPTIBILITY-INDUCED MAGNETIC FIELD GRADIENTS BY MAGNETIC RESONANCE 审中-公开
标题翻译：用磁共振法测定磁化率引起的磁场梯度
公开(公告)号：EP2106556A1
公开(公告)日：2009-10-07
申请号：EP08702424.6
申请日：2008-01-15
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： DAHNKE, Hannes , SCHAEFFTER, Tobias , VAN DER MEULEN, Peter
IPC分类号： G01R33/28 , G01R33/48 , G01R33/3875
CPC分类号： G01R33/56536 , G01R33/243 , G01R33/281 , G01R33/286 , G01R33/3875 , G01R33/48 , G01R33/5601
摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by co mput ing echo shift parameters (SPx, SPy, SPz) from subsets of the MR image data set, the echo shift parameters (SPx, SPy, SPz) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).
摘要翻译：本发明涉及用于身体（7）的磁共振成像的装置。装置（1）包括用于在检查体积中建立基本上均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6）（7）的RF脉冲，用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10），以及用于形成MR图像的重建装置（14）来自信号样本。根据本发明，该装置被配置为：a）通过使主体（7）的至少一部分经历RF脉冲和切换磁场梯度的MR成像序列来产生一系列MR回波信号（20），b ）从中获取用于重建MR图像数据集（21）的MR回波信号，c）通过从MR图像数据集的子集中输入回波偏移参数（SPx，SPy，SPz）来计算梯度图（22）指示k空间中回波位置的磁场梯度引起的移位的回波移位参数（SPx，SPy，SPz），其中每个子集包括MR图像数据集（21）的空间相邻像素或体素值的数量（n））。

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