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1. 发明申请

US20060018997A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20060018997A1
公开(公告)日：2006-01-26
申请号：US10886527
申请日：2004-07-07
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： A21D8/02 , C12N1/21
CPC分类号： C12N9/2417 , A21D8/042
摘要： We describe a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid substitution at position 161 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. The PS4 variant polypeptide may further comprise one or more further mutations at a position selected from the group consisting of: 121 and 223, preferably 121F, 121Y, 121W, 223E and 223K, more preferably G121F, G121Y, G121W, G223E and/or G223K, or the group consisting of: 134, 141, 157, 223, 307, 334, 33 and 34, preferably G134R, A141P, I157L, G223A, H307L, S334P, N33Y and D34N. In preferred embodiments, the PS4 variant polypeptide further comprises a mutation at position 87, preferably G87S, a mutation at position 178, preferably L178F, and/or a mutation at position 179, preferably A179T.
摘要翻译：我们描述了一种包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含参考位置编号在161位置的氨基酸取代的SEQ ID NO：1所示的假单胞菌糖酵母外切酶序列.PS4变体多肽可以在选自121和223，优选121F，121Y，121W，223E和223K的位置进一步包含一个或多个另外的突变，更优选G121F，G121Y，G121W，G223E和/或G223K，或由134,141,157,223,307,334,33和34，优选G134R，A141P，I157L，G223A，H307L，S334P， N33Y和D34N。在优选的实施方案中，PS4变体多肽还包含位置87，优选G87S，178位突变，优选L178F和/或179位突变，优选A179T的突变。

2. 发明申请

US20070141693A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20070141693A1
公开(公告)日：2007-06-21
申请号：US11483220
申请日：2006-07-07
申请人： Casper Berg , Patrick Maria Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Kellet-Smith , Karsten Kragh , Wei Liu , Andrew Shaw , Bo Sorensen , Charlotte Thoudahl
发明人： Casper Berg , Patrick Maria Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Kellet-Smith , Karsten Kragh , Wei Liu , Andrew Shaw , Bo Sorensen , Charlotte Thoudahl
IPC分类号： C12N9/32 , C12N1/21
CPC分类号： A21D8/042 , A23L33/18 , C12N9/2411 , C12N9/2414 , C12N9/2417 , C12N9/2425 , C12N9/2428
摘要： The invention provides for a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity which may be selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1, uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.
摘要翻译：本发明提供可衍生自具有淀粉酶活性的亲本多肽的PS4变体多肽，其可以选自： 146，157，161，178，179，223，229，272，303，307，309和334; （b）包含位置33,34,121,134,141,145,146,157,178,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 参考如SEQ ID NO：1所示的假单胞菌属酵母内切酶序列的位置编号，这种多肽作为食品或饲料添加剂的使用，以及编码其的核酸。

3. 发明申请

US20080107773A1 Polypeptide 有权
标题翻译：多肽
公开(公告)号：US20080107773A1
公开(公告)日：2008-05-08
申请号：US11857691
申请日：2007-09-19
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： A23L1/105 , A23J1/18 , A23L1/03
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: 6121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
摘要翻译：我们公开了包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含以下位置的取代：6121D，134,141,157 ，223,307和334，参照SEQ ID NO：1所示的假单胞菌糖酵母外切酶序列的位置编号。

4. 发明申请

US20060008890A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20060008890A1
公开(公告)日：2006-01-12
申请号：US10886505
申请日：2004-07-07
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： C12N9/26 , C07H21/04 , C12P21/06 , C12N1/21
CPC分类号： A21D8/042 , A23L33/18
摘要： We describe a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid substitution at position 121 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. The PS4 variant polypeptide may further comprise one or more further mutations at a position selected from the group consisting of: 161 and 223, preferably 161A, 223E and 223K, more preferably S161A, G223E and/or G223K, or the group consisting of: 134, 141, 157, 223, 307, 334, 33 and 34, preferably G134R, A141P, I157L, G223A, H307L, S334P, N33Y and D34N. In preferred embodiments, the PS4 variant polypeptide further comprises a mutation at position 87, preferably G87S, a mutation at position 178, preferably L178F, and/or a mutation at position 179, preferably A179T.
摘要翻译：我们描述了一种包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非产麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含参考位置编号在121位的氨基酸取代的SEQ ID NO：1所示的假单胞菌糖酵母外切酶序列.PS4变体多肽可以在选自161和223，优选161A，223E和223K，更优选S161A的位置进一步包含一个或多个另外的突变，G223E和/或G223K，或由134,141,157,223,307,334,33和34，优选G134R，A141P，I157L，G223A，H307L，S334P，N33Y和D34N组成的组。在优选的实施方案中，PS4变体多肽还包含位置87，优选G87S，178位突变，优选L178F和/或179位突变，优选A179T的突变。

5. 发明申请

US20060073583A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20060073583A1
公开(公告)日：2006-04-06
申请号：US10947612
申请日：2004-09-22
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： A21D8/02 , C12N9/26 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12N9/2411 , A21D2/267 , A21D8/042 , C12N9/2414 , C12N9/2417
摘要： We describe a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid mutation at one or more positions selected from the group consisting of: 146, 157, 158, 198, 229, 303, 306, 309, 316 and 353, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. Preferably, the PS4 variant polypeptide comprises an amino acid mutation selected from the group consisting of: 146G, 146M, 157M, 158T, 158A, 158S, 198W, 198F, 229P, 303E, 303D, 306T, 306G, 309P, 316S, 316P, 316K, 316Q and 353T, preferably 146G, 157M, 158T, 198W, 229P, 303E, 303D, 306T, 306G, 309P, 316S, 316P or 353T. in highly preferred embodiments, the PS4 variant polypeptide has a sequence selected from SEQ ID NO: 15 to 28.
摘要翻译：我们描述了一种包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含一个或多个选自下组的位置的氨基酸突变包括：146,157,158,198,29,303,306,309,316和353，其参考如SEQ ID NO：1所示的假单胞菌属的嗜酸性粒细胞淀粉酶序列的位置编号。优选地，PS4变体多肽包含选自146G，146M，157M，158T，158A，158S，198W，198F，229P，303E，303D，306T，306G，309P，316S，316P，316K，316Q和353T的氨基酸突变，优选 146G，157M，158T，198W，229P，303E，303D，306T，306G，309P，316S，316P或353T。在非常优选的实施方案中，PS4变体多肽具有选自SEQ ID NO：15至28的序列。

6. 发明申请

US20060008888A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20060008888A1
公开(公告)日：2006-01-12
申请号：US10886504
申请日：2004-07-07
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： C12N9/00 , C07H21/04 , C12P21/06
CPC分类号： A21D8/042 , A23L33/18 , C12N9/2417 , C12P19/14
摘要： We describe a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid substitution at position 223 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. The PS4 variant polypeptide may further comprise one or more further mutations at a position selected from the group consisting of: 121 and 161, preferably 121F, 121Y, 121W and 161A, more preferably G121F, G121Y, G121W and/or S161A, or the group consisting of: 134, 141, 157, 223, 307, 334, 33 and 34, preferably G134R, A141P, I157L, G223A, H307L, S334P, N33Y and D34N. In preferred embodiments, the PS4 variant polypeptide further comprises a mutation at position 87, preferably G87S, a mutation at position 178, preferably L178F, and/or a mutation at position 179, preferably A179T.
摘要翻译：我们描述了包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含参考位置编号在223位置的氨基酸取代如SEQ ID NO：1所示的假单胞菌糖酵母外切酶序列.PS4变体多肽还可以在选自121和161，优选121F，121Y，121W和161A的位置进一步包含一个或多个另外的突变，更多优选G121F，G121Y，G121W和/或S161A，或由134,141,157,223,307,334,33和34，优选G134R，A141P，I157L，G223A，H307L，S334P，N33Y和D34N组成的组。在优选的实施方案中，PS4变体多肽还包含位置87，优选G87S，178位突变，优选L178F和/或179位突变，优选A179T的突变。

7. 发明申请

US20050112237A1 Polypeptide 失效
标题翻译：多肽
公开(公告)号：US20050112237A1
公开(公告)日：2005-05-26
申请号：US10886023
申请日：2004-07-07
申请人： Karsten Kragh , Bo Sorensen
发明人： Karsten Kragh , Bo Sorensen
IPC分类号： A21D8/02 , A21D8/04 , A23L1/03 , A23L1/09 , A23L1/305 , C07H21/04 , C11D3/386 , C12N1/21 , C12N9/28 , C12N9/32 , C12N15/74
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: G121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
摘要翻译：我们公开了包含PS4变体多肽的食品添加剂，其中PS4变体多肽可衍生自具有非麦芽糖外切酶活性的亲本多肽，其中PS4变体多肽包含以下位置的取代：G121D，134,141,157 ，223,307和334，参照SEQ ID NO：1所示的假单胞菌糖酵母外切酶序列的位置编号。

8. 发明申请

US20070072270A1 Polypeptide 有权
公开(公告)号：US20070072270A1
公开(公告)日：2007-03-29
申请号：US11635511
申请日：2006-12-08
申请人： Karsten Kragh , Harm Mulder , Steffen Petersen , Helle Fomsgaard , Oene Veltman
发明人： Karsten Kragh , Harm Mulder , Steffen Petersen , Helle Fomsgaard , Oene Veltman
IPC分类号： C12N9/24 , C12P21/06 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： A21D8/042 , A23K20/189 , A23L29/35 , C12N9/2417 , C12Y302/0106
摘要： We disclose a PS4 variant polypeptide derivable from a parent polypeptide, the parent polypeptide having non-maltogenic exoamylase activity, which PS4 variant polypeptide comprises one or more of the following substitutions: G69P, A141P, G223A, A268P, G313P, S399P and G400P, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1. Such PS4 variant polypeptides may be used as exo-amylases, particularly as non-maltogenic exoamylases. Combinations of such PS4 variant polypeptides together with Novamyl are disclosed.

9. 发明授权

US6013504A .alpha.-1,4-glucan lyase from a fungus infected algae, its purification, gene cloning and expression in microorganisms 失效
标题翻译：来自真菌感染藻类的α-1,4-葡聚糖裂解酶，其纯化，基因克隆和在微生物中的表达
公开(公告)号：US6013504A
公开(公告)日：2000-01-11
申请号：US633768
申请日：1996-07-02
申请人： Shukun Yu , Kirsten Bojsen , Karsten Kragh , Maja Bojko , John Nielsen , Jan Marcussen
发明人： Shukun Yu , Kirsten Bojsen , Karsten Kragh , Maja Bojko , John Nielsen , Jan Marcussen
IPC分类号： C12N15/09 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/88 , C12N15/60 , C12P19/02 , C12R1/19 , C12R1/685 , C12R1/84 , C12R1/89 , C12R1/90
CPC分类号： C12P19/02 , C12N9/00 , C12N9/88
摘要： A method of preparing .alpha.-1,4-glucan lyase enzymes is described. The method comprises isolating the enzymes from a fungally infected algae. The amino acid sequences of the enzymes have been determined. The nucleic acid sequences coding for the enzymes have also been determined.
摘要翻译： PCT No.PCT / EP94 / 03399 Sec。 371日期：1996年7月2日 102（e）日期1996年7月2日PCT 1994年10月15日PCT PCT。公开号WO95 / 10618 日期1996年4月20日描述了制备α-1,4-葡聚糖裂解酶的方法。该方法包括从真菌感染的藻类中分离酶。已经确定了酶的氨基酸序列。也已经确定了编码酶的核酸序列。

10. 发明申请

US20070020731A1 Thermostable amylase polypeptides, nucliec acids encoding those polypeptides and uses thereof 有权
标题翻译：热稳定淀粉酶多肽，编码这些多肽的核酸及其用途
公开(公告)号：US20070020731A1
公开(公告)日：2007-01-25
申请号：US11528999
申请日：2006-09-27
申请人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Gijsbert Gerritse , Wei Liu , Andrew Shaw
发明人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Gijsbert Gerritse , Wei Liu , Andrew Shaw
IPC分类号： C12P21/06 , C07H21/04 , C12N9/32 , C12N15/74 , C12N1/21
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This is invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶显示出改变的热稳定性。

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