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1. 发明授权

US07192750B2 Mutant Actinosynnema pretiosum strain with increased maytansinoid production 有权
标题翻译：突变型Actinosynnema前列腺炎菌株与美登木素生产增加
公开(公告)号：US07192750B2
公开(公告)日：2007-03-20
申请号：US10898169
申请日：2004-07-26
申请人： Johnson Chung , Graham S. Byng
发明人： Johnson Chung , Graham S. Byng
IPC分类号： C12P17/14 , C12P17/18 , C12N1/20
CPC分类号： C12P17/188
摘要： A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium.
摘要翻译：一种微生物，其是与以前已知的菌株相比，能够以提高的产量生产美登木素类粘虫霉素如安曲霉素P-3，称为PF4-4，（ATCC PTA-3921）的Actinosynnema preiosum种突变细菌菌株，并且能够在不同的培养条件下生长，以及通过在合适的生长培养基中培养PF4-4来生产美登木素生物素生物霉素的方法。

2. 发明授权

US06790954B2 Mutant Actinosynnema pretiosum strain with increased maytansinoid production 有权
标题翻译：突变型Actinosynnema前列腺炎菌株与美登木素生产增加
公开(公告)号：US06790954B2
公开(公告)日：2004-09-14
申请号：US10057561
申请日：2002-01-29
申请人： Johnson Chung , Graham S. Byng
发明人： Johnson Chung , Graham S. Byng
IPC分类号： C07D49816
CPC分类号： C12P17/188
摘要： A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and capable of growth under varied culture conditions, and methods of producing maytansinoid ansamitocins by culturing PF4-4 in a suitable growth medium.
摘要翻译：一种微生物，其是与以前已知的菌株相比，能够以提高的产量生产美登木素类粘虫霉素如安曲霉素P-3，称为PF4-4，（ATCC PTA-3921）的Actinosynnema preiosum种突变细菌菌株，并且能够在不同的培养条件下生长，以及通过在合适的生长培养基中培养PF4-4来生产美登木素生物素生物霉素的方法。

3. 发明授权

US4950417A Detergent formulations containing alkaline lipase derived from Pseudomonas plantarii 失效
标题翻译：含有源自植物假单胞菌（Pseudomonas plantarii）的碱性脂肪酶的洗涤剂制剂
公开(公告)号：US4950417A
公开(公告)日：1990-08-21
申请号：US346000
申请日：1989-05-01
申请人： Nancy L. Bycroft , Graham S. Byng
发明人： Nancy L. Bycroft , Graham S. Byng
IPC分类号： C11D3/386 , C12N9/20
CPC分类号： C11D3/38627 , Y10S435/874
摘要： Disclosed is a detergent formulation containing a nonionic and/or anionic detergent and the microbial lipase from a bacterium of the species Pseudomonas plantarii.
摘要翻译：公开了含有非离子和/或阴离子洗涤剂和来自植物假单胞菌（Pseudomonas plantarii）的细菌的微生物脂肪酶的洗涤剂制剂。

4. 发明授权

US07432088B2 Methods for the production of ansamitocins 有权
标题翻译：生产安曲霉素的方法
公开(公告)号：US07432088B2
公开(公告)日：2008-10-07
申请号：US11037104
申请日：2005-01-19
申请人： Cynthia Kuo , Graham S. Byng , Wayne C. Widdison
发明人： Cynthia Kuo , Graham S. Byng , Wayne C. Widdison
IPC分类号： C12P17/18 , C12P17/16 , C12N1/20
CPC分类号： C12P17/188
摘要： A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.
摘要翻译：大规模发酵生产安非他酮生产菌株的过程。一种分离粗麻黄素的方法。一种纯化沙门菌素的方法。

5. 发明授权

US5518917A Bacillus proteolyticus species which produce an alkaline protease 失效
标题翻译：产生碱性蛋白酶的蛋白水解杆菌属
公开(公告)号：US5518917A
公开(公告)日：1996-05-21
申请号：US180336
申请日：1994-01-12
申请人： Ernest W. Boyer , Graham S. Byng
发明人： Ernest W. Boyer , Graham S. Byng
IPC分类号： C11D3/386 , C12N1/20 , C12N9/54 , C12R1/07
CPC分类号： C12R1/07 , C11D3/386 , C12N9/54 , Y10S435/832 , Y10S435/839
摘要： Three strains of a species of Bacillus proteolyticus are provided. This bacterium produces an alkaline protease which is suitable for detergent formulations. The alkaline protease has the amino acid terminal sequence of Seq. ID NO.: 1 as follows: Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Arg-Gly-. In addition, the alkaline protease has a molecular weight of 28 kdaltons, an isoelectric point from 10-11.5, an optimum pH for proteolytic activity at a pH in the range of 8.5 and 11.5, and retains at least 70% of its original activity after being held at a pH of 8.0 at a temperature of 43.degree. C. for a period of 11 days.
摘要翻译：提供了三种一类Bacillus proteolyticus菌株。该细菌产生适用于洗涤剂配方的碱性蛋白酶。碱性蛋白酶具有Seq的氨基酸末端序列。 ID NO .: 1如下：Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Arg-Gly-。此外，碱性蛋白酶的分子量为28千道尔顿，等电点为10-11.5，pH在8.5和11.5范围内的蛋白水解活性的最佳pH，并保持其原始活性的至少70％在温度43℃下保持pH为8.0，持续11天。

6. 发明授权

US5328845A Fungal negative microorganism capable of producing high levels of beta-carotene 失效
标题翻译：能产生高水平β-胡萝卜素的真菌负微生物
公开(公告)号：US5328845A
公开(公告)日：1994-07-12
申请号：US858147
申请日：1992-03-27
申请人： Mark Finkelstein , Chien-Chang Huang , Graham S. Byng , Bi-Ru Tsau , Jeanette Leach
发明人： Mark Finkelstein , Chien-Chang Huang , Graham S. Byng , Bi-Ru Tsau , Jeanette Leach
IPC分类号： C12P23/00 , C12N1/14
CPC分类号： C12R1/645 , C12P23/00 , Y10S435/911
摘要： The present invention is directed toward a method for producing beta-carotene using negative (minus mating type) Mucorales fungal microorganisms. The method includes mutating and selecting negative Mucorales fungal microorganisms, culturing the selected negative microorganisms in an effective medium to produce beta-carotene, and recovering beta-carotene therefrom. The present invention provides negative microorganisms that overproduce beta-carotene, beta-carotene formulations produced by the disclosed method, and the use of such formulations to enhance pigmentation, to reduce damage caused by reactive oxygen species or phototoxic molecules, to prevent or treat cancer or cardiovascular disease, to provide a Vitamin A supplement, to enhance lactation, and to increase fertility.
摘要翻译：本发明涉及使用负（负交配型）霉菌真菌微生物生产β-胡萝卜素的方法。该方法包括突变和选择阴性霉菌真菌微生物，在有效培养基中培养所选择的阴性微生物以产生β-胡萝卜素，并从其中回收β-胡萝卜素。本发明提供了过量产生β-胡萝卜素的阴性微生物，通过所公开的方法制备的β-胡萝卜素制剂，以及使用这些制剂增强色素沉淀，减少由活性氧或光毒性分子引起的损伤，以预防或治疗癌症或心血管疾病，提供维生素A补充剂，增强哺乳期，增加生育能力。

7. 发明授权

US5250299A Synergistic antimicrobial compositions 失效
标题翻译：协同抗菌组合物
公开(公告)号：US5250299A
公开(公告)日：1993-10-05
申请号：US763899
申请日：1991-09-23
申请人： Stephen R. Good , Graham S. Byng
发明人： Stephen R. Good , Graham S. Byng
IPC分类号： A61K38/44 , A61K37/50
CPC分类号： A01N59/00 , A01N59/24 , A23L3/3481 , A23L3/358
摘要： The invention discloses an antimicrobial composition composed of a hypothiocyanate generating system adjusted to a pH between about 1.5 and about 5 with a di or tricarboxylic acid. This composition provides synergistically improved antimicrobial action. With the addition of the organic acid, the antimicrobial composition provides effective cidal activity against Gram negative microorganisms in 20 minutes or less. The composition is particularly effective against Salmonella and may be used to provide greater than 6 logs reduction in viable cell count.
摘要翻译：本发明公开了一种抗微生物组合物，其由二硫代氨基酸生成体系组成，其用二或三羧酸调节至约1.5至约5的pH。该组合物提供协同改善的抗微生物作用。随着有机酸的添加，抗微生物组合物在20分钟或更短时间内对革兰氏阴性微生物提供有效的杀螨活性。该组合物对沙门氏菌特别有效，可用于提供大于6log的活细胞计数减少。

8. 发明授权

US5565348A Alkaline protease from Bacillus proteolyticus species 失效
标题翻译：来自蛋氨酸杆菌属的碱性蛋白酶
公开(公告)号：US5565348A
公开(公告)日：1996-10-15
申请号：US390570
申请日：1995-02-17
申请人： Ernest W. Boyer , Graham S. Byng
发明人： Ernest W. Boyer , Graham S. Byng
IPC分类号： C11D3/386 , C12N1/20 , C12N9/54 , C12R1/07 , C11D7/42 , C12N9/52
CPC分类号： C12R1/07 , C11D3/386 , C12N9/54 , Y10S435/832 , Y10S435/839
摘要： An alkaline protease which is suitable for detergent formulations is produced by three strains of a species of Bacillus proteolyticus. The alkaline protease has the amino acid terminal sequence of Seq. ID NO.: 1 as follows: Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Arg-Gly-. In addition, the alkaline protease has a molecular weight of 28 kdaltons, an isoelectric point from 10-11.5, an optimum pH for proteolytic activity at a pH in the range of 8.5 and 11.5, and retains at least 70% of its original activity after being held at a pH of 8.0 at a temperature of 43.degree. C. for a period of 11 days.
摘要翻译：适用于洗涤剂配方的碱性蛋白酶由三种芽孢杆菌（Bacillus proteolyticus）菌株产生。碱性蛋白酶具有Seq的氨基酸末端序列。 ID NO .: 1如下：Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Arg-Gly-。此外，碱性蛋白酶的分子量为28千道尔顿，等电点为10-11.5，pH在8.5和11.5范围内的蛋白水解活性的最佳pH，并保持其原始活性的至少70％在温度43℃下保持pH为8.0，持续11天。

9. 发明授权

US5422247A Blakeslea trispora mated culture capable of increased beta-carotene production 失效
标题翻译：具有增加β-胡萝卜素生产能力的三孢子虫（Blakeslea trispora mated）培养物
公开(公告)号：US5422247A
公开(公告)日：1995-06-06
申请号：US155438
申请日：1993-11-19
申请人： Mark Finkelstein , Chien-Chang Huang , Graham S. Byng , Bi-Ru Tsau , Jeanette Leach
发明人： Mark Finkelstein , Chien-Chang Huang , Graham S. Byng , Bi-Ru Tsau , Jeanette Leach
IPC分类号： C12P23/00 , C12N1/14 , C12P1/02
CPC分类号： C12R1/645 , C12P23/00 , Y10S435/911
摘要： The present invention is directed toward a method for producing beta-carotene using a mated culture of Mucorales fungi. The method includes mutating and selecting negative (minus mating type) and positive (plus mating type) Mucorales fungal microorganisms, culturing the selected negative and positive microorganisms in an effective medium to form a mated culture that produces beta-carotene, and recovering beta-carotene therefrom. The present invention provides mated cultures that overproduce beta-carotene and is also directed to certain negative and positive microorganisms used to overproduce beta-carotene. The present invention also provides beta-carotene formulations produced by the claimed method, and the use of such formulations, for example, to enhance pigmentation, to reduce damage caused by reactive oxygen species or phototoxic molecules, to prevent or treat cancer or cardiovascular disease, to provide a Vitamin A supplement, to enhance lactation, and to increase fertility.
摘要翻译：本发明涉及使用Mucorales真菌的配对培养物生产β-胡萝卜素的方法。该方法包括突变和选择负（负交配型）和阳性（加交配型）霉菌真菌微生物，在有效培养基中培养所选择的阴性和阳性微生物以形成产生β-胡萝卜素的配对培养物，并回收β-胡萝卜素由此。本发明提供了过量产生β-胡萝卜素的配对培养物，并且还涉及用于过量产生β-胡萝卜素的某些阴性和阳性微生物。本发明还提供了通过所要求保护的方法制备的β-胡萝卜素制剂，并且使用这些制剂例如增强色素沉积，减少由活性氧或光毒性分子引起的损伤，以预防或治疗癌症或心血管疾病，提供维生素A补充剂，增强哺乳期和增加生育能力。

10. 发明授权

US5385837A Alkaline proteases derived from Bacillus proteolyticus 失效
标题翻译：源自蛋氨酸杆菌的碱性蛋白酶
公开(公告)号：US5385837A
公开(公告)日：1995-01-31
申请号：US181872
申请日：1994-01-13
申请人： Ernest W. Boyer , Graham S. Byng
发明人： Ernest W. Boyer , Graham S. Byng
IPC分类号： C11D3/386 , C12N1/20 , C12N9/54 , C12R1/07 , C11D7/42 , C12N9/52 , C12N9/56
CPC分类号： C12R1/07 , C11D3/386 , C12N9/54 , Y10S435/832 , Y10S435/839
摘要： Alkaline proteases derived from specific bacteria of the species Bacillus proteolyticus have enhanced stability and improved washing ability when blended in general detergents. Also disclosed are new bacteria producing these alkaline proteases. Additionally, there is also disclosed a process for the production of the alkaline proteases which comprises cultivating new bacteria and detergent compositions containing these alkaline proteases.
摘要翻译：衍生自蛋氨酸杆菌属细菌的碱性蛋白酶在一般洗涤剂中混合时具有增强的稳定性和改善的洗涤能力。还公开了产生这些碱性蛋白酶的新细菌。此外，还公开了生产碱性蛋白酶的方法，其包括培养含有这些碱性蛋白酶的新细菌和洗涤剂组合物。

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