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1. 发明授权

US4745186A 2,3,4-triacylhexoses and mixtures thereof 失效
标题翻译： 2,3,4-三酰基己糖及其混合物
公开(公告)号：US4745186A
公开(公告)日：1988-05-17
申请号：US828108
申请日：1986-02-10
申请人： John B. Mudd , Basil A. Burke , Jon F. Fobes , Muraleedharan G. Nair
发明人： John B. Mudd , Basil A. Burke , Jon F. Fobes , Muraleedharan G. Nair
IPC分类号： A21D2/08 , A21D10/04 , A23D7/015 , A23L1/24 , A23L1/305 , A61K8/60 , A61K8/97 , A61Q1/06 , A61Q3/02 , A61Q5/06 , A61Q9/02 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C07H13/06 , C07H13/02 , C07H11/00
CPC分类号： A61Q19/00 , A21D10/04 , A21D2/08 , A23D7/015 , A23L27/60 , A23L33/17 , A61K8/60 , A61K8/97 , C07H13/06 , A61Q1/06 , A61Q15/00 , A61Q17/04 , A61Q19/001 , A61Q19/002 , A61Q19/10 , A61Q3/02 , A61Q5/06 , A61Q9/02 , Y10S514/846 , Y10S514/847
摘要： The present invention comprises a new class of 2,3,4-tri-O-acylhexoses and mixtures thereof. Members of the new class of compounds are comprised of a hexose sugar having fatty acids attached at the 2, 3 and 4 positions of the hexose moiety. The fatty acids can be saturated or unsaturated, and can have a relative molecular size of up to C.sub.30. When at least one of the acylating fatty acid groups on the hexose molecule contains more than 7 carbons, the resulting 2,3,4-tri-O-acylhexoses (or mixtures thereof) have a non-bitter taste. On the other hand, when none of the acylating fatty acids have more than 7 carbons, the resulting 2,3,4-tri-O-acylhexoses (and mixtures that contain them) are bitter when tasted.The new 2,3,4-tri-O-acylhexoses can be synthesized using known chemical methods. Alternatively, the new compounds, and especially mixtures thereof, are obtained as the result of selective extraction and purification of the epicuticular exudate from Lycopersicon pennellii plant parts. Mixtures of 2,3,4-tri-O-acylhexoses, especially as found in the Lycopersicon pennellii natural plant extract, or the glucolipid fraction thereof, are useful as evaporation suppressants, antitranspirants and antidesiccants. The Lycopersicon pennellii natural plant extract is also useful as an ingredient in cosmetic and toiletry formulations, while the non-bitter glucolipid subfraction is especially useful as a "low calorie" substitute for fats in foods.
摘要翻译：本发明包括一类新的2,3,4-三-O-酰基己糖及其混合物。新类化合物的成员由在己糖部分的2,3和4位上连接有脂肪酸的己糖组成。脂肪酸可以是饱和的或不饱和的，并且可以具有高达C30的相对分子大小。当己糖分子上的至少一个酰化脂肪酸基团含有多于7个碳时，得到的2,3,4-三-O-酰基己糖（或其混合物）具有非苦味。另一方面，当酰化脂肪酸不超过7个碳时，得到的2,3,4-三-O-酰基己糖（和含有它们的混合物）在品尝时是苦的。新的2,3,4-三-O-酰基己糖可以使用已知的化学方法合成。或者，作为从番茄植物部分选择性提取和纯化表皮渗出物的结果，获得新化合物，特别是其混合物。 2,3,4-三-O-酰基己糖的混合物，特别是在番茄番茄植物提取物中发现的，或其糖脂部分，可用作蒸发抑制剂，防转铁剂和防腐剂。番茄番茄天然植物提取物也可用作化妆品和化妆品配方中的成分，而非苦味的葡萄糖脂亚类特别可用作食品中脂肪的“低热量”替代物。

2. 发明授权

US4876277A Antimicrobial/antifungal compositions 失效
标题翻译：抗微生物/抗真菌组合物
公开(公告)号：US4876277A
公开(公告)日：1989-10-24
申请号：US55737
申请日：1987-05-29
申请人： Basil A. Burke , Muraleedharan G. Nair
发明人： Basil A. Burke , Muraleedharan G. Nair
IPC分类号： A01N43/30 , C07D317/64
CPC分类号： A01N43/30 , C07D317/64
摘要： Substituted olefinic (allyl) benzene compounds which exhibit important antimicrobial (antibacterial and antifungal) activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antifungal composition active ingredient is one or more 4,5-substituted 2,3-alkylidenedioxy-1-olefinic benzenes of the formula: ##STR1## where R.sub.1 and R.sub.2 may be the same or different, and are selected from OH, and C.sub.1 -C.sub.5 alkoxy (--OR) or thioalkyl (--SR) groups. R.sub.3 and R.sub.4 are selected from H and C.sub.1 -C.sub.5 alkyl, alkenyl and alkynyl groups, and R.sub.5 is selected from C.sub.3 -C.sub.7 alkyl, alkenyl and alkynyl groups. The preferred compounds are 4,5-substituted-2,3-methylenedioxy-1-allyl benzenes. Where R.sub.1 =OCH.sub.3, R.sub.2 =OH, R.sub.3 and R.sub.4 =H and R.sub.5 =allyl (2',3' propenyl) the compound may be called nor methyl-pseudo-dillapiole. Where R.sub.1 =R.sub.2 =OCH.sub.3, R.sub.3 and R.sub.4 are again H, and R.sub.5 =allyl, the compound may be called pseudo-dillapiole. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g., antifungal activity against wheat powdery mildew, but do not affect seed germination or have herbicidal or insecticial activity. Methods and compositions for delivery of these agents against such pathogens, and methods of chemical synthesis of the compounds are disclosed.
摘要翻译：显示出重要的抗微生物（抗菌和抗真菌）活性，组合物和递送针对病原体和病原体的方法的取代的烯丙基（烯丙基）苯化合物，以及通常可得的反应物的合成方法。抗真菌组合物活性成分是一种或多种下式的4,5-取代的2,3-亚烷基二氧基-1-烯烃苯：其中R 1和R 2可以相同或不同，并且选自OH，和C 1 -C 5烷氧基（-OR）或硫代烷基（-SR）基团。 R3和R4选自H和C1-C5烷基，烯基和炔基，R5选自C3-C7烷基，烯基和炔基。优选的化合物是4,5-取代-2,3-亚甲二氧基-1-烯丙基苯。其中R1 = OCH3，R2 = OH，R3和R4 = H，R5 =烯丙基（2'，3'丙烯基），化合物可称为甲基假鞭毛虫。当R 1 = R 2 = OCH 3时，R 3和R 4再次为H，R 5为烯丙基，该化合物可称为伪鞭毛虫。包括这些化合物的组合物对各种病原体和病原体表现出抗菌活性，例如野油菜黄单胞菌（Xanthomonas campestris spp。）细菌，针对各种真菌和细菌的抗真菌活性，并且是高度特异性的，例如抗小麦白粉病的抗真菌活性，但不影响种子发芽或具有除草或昆虫活性。公开了用于递送这些试剂以抵抗这种病原体的方法和组合物，以及化合物的化学合成方法。

3. 发明申请

US20180192648A1 COMPOUNDS FOR INHIBITION OF FUNGAL MYCOTOXIN AND SPORULATION 审中-公开
公开(公告)号：US20180192648A1
公开(公告)日：2018-07-12
申请号：US15864696
申请日：2018-01-08
申请人： Gale M. Strasburg , Juma A. Mmongoyo , John E. Linz , Felicia Wu , Jovin K. Mugula , Amila A. Dissanayake , Chuan-Rui Zhang , Josephine M. Wee , Muraleedharan G. Nair , Devin M. Day
发明人： Gale M. Strasburg , Juma A. Mmongoyo , John E. Linz , Felicia Wu , Jovin K. Mugula , Amila A. Dissanayake , Chuan-Rui Zhang , Josephine M. Wee , Muraleedharan G. Nair , Devin M. Day
IPC分类号： A01N43/20 , A01N25/02
CPC分类号： A01N43/20 , A01N25/02
摘要： Compounds and compositions are described herein that inhibit the biosynthesis of mycotoxins and fungal sporulation. Such compounds and compositions are useful for inhibiting mold. Methods of using such compounds and compositions are also described herein that involve applying the compositions to plants, plant parts, structures, containers, and other surfaces.

4. 发明授权

US08337914B2 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US08337914B2
公开(公告)日：2012-12-25
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
发明人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
IPC分类号： A61K36/04 , A61K36/736 , A61K36/00
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

5. 发明申请

US20090018211A1 Method for inhibiting of COX2 and inflammation with phenolic aldehydes 审中-公开
标题翻译：用酚醛抑制COX2和炎症的方法
公开(公告)号：US20090018211A1
公开(公告)日：2009-01-15
申请号：US11825748
申请日：2007-07-09
申请人： Muraleedharan G. Nair , Mulabagal Vanisree , Ruby L. Alexander-Lindo , David L. DeWitt
发明人： Muraleedharan G. Nair , Mulabagal Vanisree , Ruby L. Alexander-Lindo , David L. DeWitt
IPC分类号： A61K31/11 , A61P29/00
CPC分类号： A61K31/11
摘要： A method for inhibiting of COX2 and inflammation by administering a hydroxybenzaldehyde.
摘要翻译：通过施用羟基苯甲醛来抑制COX2和炎症的方法。

6. 发明授权

US5981775A Process for the preparation of isoflavones 有权
标题翻译：异黄酮制备方法
公开(公告)号：US5981775A
公开(公告)日：1999-11-09
申请号：US154230
申请日：1998-09-16
申请人： Balasubramanian Sreenivasan , Muraleedharan G. Nair
发明人： Balasubramanian Sreenivasan , Muraleedharan G. Nair
IPC分类号： C07D311/36 , C07D311/04
CPC分类号： C07D311/36
摘要： A process for the preparation of an isoflavone from a 2'-hydroxydeoxybenzoin(I) is described. The process uses prepared N,N'-dimethyl(chloromethylene) ammonium chloride as a reactant with (I) in borontrifluoride etherate or other Lewis acid as a solvent. The isoflavones are known biologically active compounds.
摘要翻译：描述了从2'-羟基脱氧苯偶姻（I）制备异黄酮的方法。该方法使用制备的N，N'-二甲基（氯亚甲基）氯化铵作为反应物与（I）在三氟化硼醚合物或其它路易斯酸作为溶剂中。异黄酮是已知的生物活性化合物。

7. 发明授权

US5009698A Method for stimulating plant growth using synthetically produced 9-beta-1(+) adenosine 失效
标题翻译：使用合成产生的9-β-1（+）腺苷刺激植物生长的方法
公开(公告)号：US5009698A
公开(公告)日：1991-04-23
申请号：US345217
申请日：1989-04-28
申请人： Stanley K. Ries , Violet F. Wert , Muraleedharan G. Nair
发明人： Stanley K. Ries , Violet F. Wert , Muraleedharan G. Nair
IPC分类号： A01N43/90
CPC分类号： A01N43/90
摘要： A method for stimulating plant growth using synthetically produced 9-beta-L(+) adenosine is described. The method uses the synthetically produced compound instead of a naturally occurring material which occurs in only minute amounts and is difficult to isolate.
摘要翻译：描述了使用合成产生的9-β-L（+）腺苷刺激植物生长的方法。该方法使用合成产生的化合物代替仅以微量发生且难以分离的天然存在的材料。

8. 发明授权

US07341747B2 Carrier-free composition for the treatment of onychomycosis 有权
标题翻译：用于治疗甲真菌病的无载体组合物
公开(公告)号：US07341747B2
公开(公告)日：2008-03-11
申请号：US10949681
申请日：2004-09-24
申请人： Muraleedharan G. Nair
发明人： Muraleedharan G. Nair
IPC分类号： A61K36/00 , A61K36/53
CPC分类号： A61K31/05 , A61K31/045 , A61K31/125 , A61K36/61 , A61K2300/00
摘要： A composition for the treatment of onychomycosis (fungal nail disease) is described. The composition consists essentially of thymol, camphor, menthol and Eucalyptus citridiora as a colorless liquid oil without any carrier or solvent for these ingredients.
摘要翻译：描述了用于治疗甲真菌病（真菌性指甲疾病）的组合物。该组合物基本上由麝香草酚，樟脑，薄荷醇和柠檬酸桉树作为无色液体油组成，没有任何载体或溶剂用于这些成分。

9. 发明授权

US07195784B2 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
公开(公告)号：US07195784B2
公开(公告)日：2007-03-27
申请号：US10294106
申请日：2002-11-14
申请人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.

10. 发明授权

US06875746B1 Anticancer anthraquinones and method of use thereof 失效
标题翻译：抗癌蒽醌类及其使用方法
公开(公告)号：US06875746B1
公开(公告)日：2005-04-05
申请号：US10355483
申请日：2003-01-31
申请人： Muraleedharan G. Nair , Robert H. Cichewicz , Navindra P. Seeram , Yanjun Zhang
发明人： Muraleedharan G. Nair , Robert H. Cichewicz , Navindra P. Seeram , Yanjun Zhang
IPC分类号： C07H15/244 , A61K31/122 , A61K31/21 , A61K31/70 , A61K31/704 , A61P33/10 , A61P33/12 , C07C50/34 , C07C50/38 , C07C66/02 , C07C69/157 , A01N43/04 , A01N37/00
CPC分类号： A61K31/70 , A61K31/21 , C07C50/38 , Y02A50/423
摘要： Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: wherein R1 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R2 is a group containing 1-12 carbons selected from the group consisting of alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate and combinations thereof; and R3 is a group containing 1 to 12 carbons selected from the group consisting of methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, and combinations thereof. The preferred anthraquinones are 1-hydroxy-2-acetyl-3,6-methyl anthraquinone, 2-acetyl-3,6-methyl anthraquinone monoacetate, 1-hydroxy-2-acetyl-3,7-methyl anthraquinone, 2-acetyl-3,7-methyl anthraquinone monoacetate, 1,2,8-trihydroxy-3-methyl anthraquinone, 1,8-dihydroxy-2-O-β-D-glucopyranoside anthraquinone, 1,2,8-trihydroxy-3-hydroxymethyl anthraquinone, and 1,8-dihydroxy-3-carboxy anthraquinone.
摘要翻译：描述了具有抗癌或抗肿瘤活性的蒽醌，其可用于在体外或体内抑制癌细胞和包含肿瘤的细胞。优选地，蒽醌具有以下化学式：其中R 1选自氢，烷基和取代的烷基; R2是含有选自烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物及其组合的1-12个碳的基团; 并且R 3是选自甲基，烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物及其组合中的1至12个碳的基团。优选的蒽醌是1-羟基-2-乙酰基-3,6-甲基蒽醌，2-乙酰基-3,6-甲基蒽醌单乙酸酯，1-羟基-2-乙酰基-3,7-甲基蒽醌，2-乙酰基 - 3,7-甲基蒽醌单乙酸酯，1,2,8-三羟基-3-甲基蒽醌，1,8-二羟基-2-O-β-D-吡喃葡萄糖苷蒽醌，1,2,8-三羟基-3-羟甲基蒽醌，和1,8-二羟基-3-羧基蒽醌。

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