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1. 发明申请

US20130004429A1 USE OF A NEUROFILAMENT PEPTIDE FOR THE TREATMENT OF GLIOMA 有权
标题翻译：使用神经纤维肽治疗谷氨酸
公开(公告)号：US20130004429A1
公开(公告)日：2013-01-03
申请号：US13514884
申请日：2010-12-14
申请人： Joël Eyer , Alan Peterson , Julien Balzeau , Raphaël Berges
发明人： Joël Eyer , Alan Peterson , Julien Balzeau , Raphaël Berges
IPC分类号： A61K49/00 , G01N33/574 , G01N21/64 , A61K38/16 , A61P35/00
CPC分类号： A61K38/16 , A61K49/0039 , A61K49/0056
摘要： The present invention provides a new drug to treat malignant glioma, which is the most prevalent type of primary tumor of the central nervous system (CNS). The present invention indeed shows that the isolated NFL-TBS40-63 peptide is highly specific for glioma cells, in which it triggers apoptosis. It is therefore presented here for use in a method for treating malignant glioma. The present invention further relates to the use of the NFL-TBS40-63 peptide for detecting specifically glioma cells either in vivo, or in vitro, or for addressing chemical compounds to said tumor cells.
摘要翻译：本发明提供了一种治疗恶性胶质瘤的新药，它是中枢神经系统（CNS）中最普遍的原发性肿瘤。本发明确实表明，分离的NFL-TBS40-63肽对于神经胶质瘤细胞是高度特异性的，其中它触发凋亡。因此，这里用于治疗恶性胶质瘤的方法。本发明还涉及NFL-TBS40-63肽在体内或体外特异性检测神经胶质瘤细胞或用于将化学化合物用于所述肿瘤细胞的用途。

2. 发明授权

US09446092B2 Use of a neurofilament peptide for the treatment of glioma 有权
标题翻译：使用神经丝肽治疗胶质瘤
公开(公告)号：US09446092B2
公开(公告)日：2016-09-20
申请号：US13514884
申请日：2010-12-14
申请人： Joël Eyer , Alan Peterson , Julien Balzeau , Raphaël Berges
发明人： Joël Eyer , Alan Peterson , Julien Balzeau , Raphaël Berges
IPC分类号： A61K49/00 , G01N33/574 , G01N21/64 , A61K38/16 , A61P35/00
CPC分类号： A61K38/16 , A61K49/0039 , A61K49/0056
摘要： The present invention provides a new drug to treat malignant glioma, which is the most prevalent type of primary tumor of the central nervous system (CNS). The present invention indeed shows that the isolated NFL-TBS40-63 peptide is highly specific for glioma cells, in which it triggers apoptosis. It is therefore presented here for use in a method for treating malignant glioma. The present invention further relates to the use of the NFL-TBS40-63 peptide for detecting specifically glioma cells either in vivo, or in vitro, or for addressing chemical compounds to said tumor cells.
摘要翻译：本发明提供了一种治疗恶性胶质瘤的新药，它是中枢神经系统（CNS）中最普遍的原发性肿瘤。本发明确实表明，分离的NFL-TBS40-63肽对于神经胶质瘤细胞是高度特异性的，其中它触发凋亡。因此，这里用于治疗恶性胶质瘤的方法。本发明还涉及NFL-TBS40-63肽在体内或体外特异性检测神经胶质瘤细胞或用于将化学化合物用于所述肿瘤细胞的用途。

3. 发明授权

US09023806B2 Peptide capable of altering tubulin polymerization and use thereof for inhibiting cell proliferation 有权
标题翻译：能够改变微管蛋白聚合的肽及其用于抑制细胞增殖的肽
公开(公告)号：US09023806B2
公开(公告)日：2015-05-05
申请号：US11579548
申请日：2005-04-21
申请人： Arnaud Bocquet , Joël Eyer , Alan Peterson
发明人： Arnaud Bocquet , Joël Eyer , Alan Peterson
IPC分类号： A61K38/16 , A61K38/10 , G01N33/53 , C12N5/00 , A61K38/00 , C07K14/47
CPC分类号： C07K14/4703
摘要： The invention concerns a peptide derived from intermediate filaments and an intermediate filament fragment capable of altering tubulin polymerization and used for inhibiting cell proliferation, and more particularly for obtaining medicines designed to prevent or treat diseases involving cell proliferation, such as cancers for example.
摘要翻译：本发明涉及一种衍生自中间体长丝的肽和能够改变微管蛋白聚合并用于抑制细胞增殖的中间丝状片段，更具体地涉及获得旨在预防或治疗例如癌症的疾病的药物。

4. 发明申请

US20090221476A1 Peptide Capable of Altering Tubulin Polymerization and use Thereof for Inhibiting Cell Proliferation 有权
标题翻译：能够改变微管蛋白聚合的肽和其用于抑制细胞增殖的肽
公开(公告)号：US20090221476A1
公开(公告)日：2009-09-03
申请号：US11579548
申请日：2005-04-21
申请人： Arnaud Bocquet , Joël Eyer , Alan Peterson
发明人： Arnaud Bocquet , Joël Eyer , Alan Peterson
IPC分类号： A61K38/17 , C07K4/12 , C07K7/06 , C07K14/435 , C07H21/04 , C12N15/00 , G01N33/00 , A61P35/04 , A61P31/04 , A61K38/03 , C12N5/00 , C12P21/06 , A61K38/08 , A61K38/10
CPC分类号： C07K14/4703
摘要： The invention concerns a peptide derived from intermediate filaments and an intermediate filament fragment capable of altering tubulin polymerization and used for inhibiting cell proliferation, and more particularly for obtaining medicines designed to prevent or treat diseases involving cell proliferation, such as cancers for example.
摘要翻译：本发明涉及一种衍生自中间体长丝的肽和能够改变微管蛋白聚合并用于抑制细胞增殖的中间丝状片段，更具体地涉及获得旨在预防或治疗例如癌症的疾病的药物。

5. 发明申请

US20060174360A1 Non-inbred embryonic stem cells having good developmental potential 审中-公开
标题翻译：具有良好发育潜力的非近交胚胎干细胞
公开(公告)号：US20060174360A1
公开(公告)日：2006-08-03
申请号：US10562952
申请日：2004-07-08
申请人： Alan Peterson
发明人： Alan Peterson
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： C12N15/873 , A01K67/027 , A01K67/0275 , A01K2217/05 , A01K2267/0393 , C12N2517/00 , C12N2517/02
摘要： The present invention provides non-inbred mouse embryonic stem (ES) cells comprising alleles derived from at least two different mouse strains and having high developmental potential. The ES cells optionally comprises a docking site for a transgene. Methods for production of the ES cells are also disclosed. This invention further provides chimeric and transgenic mice derived from the non-inbred ES cells and methods for deriving such mice.
摘要翻译：本发明提供了包含来自至少两种不同小鼠品系并具有高发育潜力的等位基因的非近交小鼠胚胎干细胞（ES）细胞。 ES细胞任选地包含转基因的停靠位点。还公开了ES细胞的制备方法。本发明进一步提供衍生自非近交ES细胞的嵌合和转基因小鼠以及衍生这种小鼠的方法。

6. 发明申请

US20060010420A1 Method and apparatus for storing and replaying creation history of multimedia software or other software content 有权
标题翻译：用于存储和重放多媒体软件或其他软件内容的创建历史的方法和装置
公开(公告)号：US20060010420A1
公开(公告)日：2006-01-12
申请号：US09844921
申请日：2001-04-26
申请人： Alan Peterson , James Spohrer
发明人： Alan Peterson , James Spohrer
IPC分类号： G06F9/44
CPC分类号： G11B27/034 , G06F9/453 , G11B27/105 , H04N21/854 , Y10S715/967
摘要： An authoring or other software tool is provided which allows users of the tool to review the creation and evolution of all or part of a content such as a multimedia title created using a tool incorporating the invention. According to the invention, an authoring tool comprises a recording mechanism for recording actions performed during the development or modification of software content in a manner that preserves, directly or indirectly, the relative chronological order of the actions and a playback mechanism for performing or otherwise simulating recorded actions. Preferably, the playback of an action includes annotation using text, recorded or computer-generated voice, video and/or graphic animation. Preferably, an authoring tool embodying the invention allows an author to specify criteria for which actions are to be played back, thereby providing an author with a mechanism for focusing on a particular subset of the recorded actions.
摘要翻译：提供了一种创作或其他软件工具，其允许该工具的用户审查使用包含本发明的工具创建的内容的全部或部分内容（例如多媒体标题）的创建和演变。根据本发明，创作工具包括用于记录在软件内容开发或修改期间执行的动作的记录机制，其方式是直接或间接地保留动作的相对时间顺序和用于执行或以其他方式模拟的重放机制记录的动作。优选地，动作的回放包括使用文本，记录的或计算机生成的语音，视频和/或图形动画的注释。优选地，实施本发明的创作工具允许作者指定要对其进行哪些动作的标准，从而为作者提供一种用于聚焦记录动作的特定子集的机制。

7. 外观设计

USD284359S Vase or similar article 失效
公开(公告)号：USD284359S
公开(公告)日：1986-06-24
申请号：US586695
申请日：1984-03-06
申请人： Alan Peterson
设计人： Alan Peterson

8. 发明申请

US20120234594A1 Portable Electrical Receptacle Device and Method 审中-公开
标题翻译：便携式电气插座装置及方法
公开(公告)号：US20120234594A1
公开(公告)日：2012-09-20
申请号：US13423724
申请日：2012-03-19
申请人： Alan Peterson
发明人： Alan Peterson
IPC分类号： H01R13/502
CPC分类号： H01R13/501 , H01R25/003
摘要： An electrical power distribution device and method is provided and includes a device housing, wherein the device housing is shaped to define a device cavity and includes a first housing portion and a second housing portion, wherein the first housing portion is connected to the second housing portion via a hinge member such that the first housing portion and the second housing portion rotate relative to each other between a first configuration and a second configuration, and wherein the device cavity is configured to allow the device housing to wrap around a support structure; a connecting member; a power connection cord; and at least one electrical receptacle associated with the device housing and electrically connected with the power connection cord.
摘要翻译：提供一种配电装置和方法，其包括装置壳体，其中，所述装置壳体成形为限定装置空腔并包括第一壳体部分和第二壳体部分，其中所述第一壳体部分连接到所述第二壳体部分经由铰链构件使得所述第一壳体部分和所述第二壳体部分在第一构造和第二构造之间相对于彼此旋转，并且其中所述装置空腔被配置为允许所述装置壳体围绕支撑结构包裹; 连接构件; 电源连接线; 以及与所述装置壳体相关联并与所述电源连接线电连接的至少一个电插座。

9. 发明申请

US20050090006A1 Schwann cell specific enhancers and methods of use thereof 审中-公开
标题翻译：雪旺细胞特异性增强子及其使用方法
公开(公告)号：US20050090006A1
公开(公告)日：2005-04-28
申请号：US10476389
申请日：2002-05-02
申请人： Alan Peterson , David Foran , Lorella Garofalo , Reza Forghani , Hooman Farhadi , Pierre Lepage , Thomas Hudson
发明人： Alan Peterson , David Foran , Lorella Garofalo , Reza Forghani , Hooman Farhadi , Pierre Lepage , Thomas Hudson
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： C07K14/4705 , A01K2217/05 , A61K48/00
摘要： The present invention provides isolated nucleic acid molecules which exhibit transcriptional enhancement in Schwann cells. The present invention also provides vectors comprising the subject isolated nucleic acid molecules. Methods of regulating gene expression in Schwann cells and therapeutic uses involving the isolated nucleic acids are also provided.
摘要翻译：本发明提供了在施旺细胞中显示转录增强的分离的核酸分子。本发明还提供了包含受试者分离的核酸分子的载体。还提供了调节施旺细胞中基因表达的方法和涉及分离的核酸的治疗用途。

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