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1. 发明申请

US20060014135A1 Assay for distinguishing live and dead cells 失效
标题翻译：用于区分活细胞和死细胞的分析
公开(公告)号：US20060014135A1
公开(公告)日：2006-01-19
申请号：US11082241
申请日：2005-03-15
申请人： Jinhong Fan , Vadim Kutsyy , Eugeni Vaisberg
发明人： Jinhong Fan , Vadim Kutsyy , Eugeni Vaisberg
IPC分类号： C12Q1/00 , G06F19/00 , G01N33/48
CPC分类号： G06K9/00147 , G06T7/0012
摘要： Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is a cytoskeletal component such as tubulin. Prior to producing an image for analysis, cells may be treated with a marker that highlights the live-dead indicator in the image. In the case of tubulin, the marker will co-locate with tubulin and provide a signal that is captured in the image (e.g., a fluorescent emission).
摘要翻译：图像分析方法和装置用于区分活细胞和死细胞。所述方法可以包括分割图像以识别由一个或多个单元占用的区域，并且确定该区域内特定的活死人指示器特征的存在。在某些实施方案中，指示剂特征是细胞骨架成分如微管蛋白。在生成用于分析的图像之前，可以使用突出显示图像中活死人指示符的标记来处理细胞。在微管蛋白的情况下，标记物将与微管蛋白共同定位，并提供在图像中捕获的信号（例如，荧光发射）。

2. 发明申请

US20070031818A1 Assay for distinguishing live and dead cells 审中-公开
标题翻译：用于区分活细胞和死细胞的分析
公开(公告)号：US20070031818A1
公开(公告)日：2007-02-08
申请号：US11355258
申请日：2006-02-14
申请人： Vadim Kutsyy , Jinhong Fan , Eugeni Vaisberg
发明人： Vadim Kutsyy , Jinhong Fan , Eugeni Vaisberg
IPC分类号： C12Q1/00 , C12Q1/68 , G06K9/00
CPC分类号： G06T7/0012 , G06K9/00147 , G06T2207/10056 , G06T2207/20081 , G06T2207/30024
摘要： Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is a cytoskeletal component such as tubulin. In certain embodiments, the methods may involve determining the value of an indicator expression that is based on cellular components such as DNA and/or cellular protein. Prior to producing an image for analysis, cells may be treated with a marker that highlights the live-dead indicator in the image.
摘要翻译：图像分析方法和装置用于区分活细胞和死细胞。所述方法可以包括分割图像以识别由一个或多个单元占用的区域，并确定该区域内特定的活死人指示器特征的存在。在某些实施方案中，指示剂特征是细胞骨架成分如微管蛋白。在某些实施方案中，所述方法可以涉及确定基于诸如DNA和/或细胞蛋白质的细胞组分的指示物表达的值。在生成用于分析的图像之前，可以使用突出显示图像中活死人指示符的标记来处理细胞。

3. 发明授权

US07817840B2 Predicting hepatotoxicity using cell based assays 失效
标题翻译：使用基于细胞的测定预测肝毒性
公开(公告)号：US07817840B2
公开(公告)日：2010-10-19
申请号：US11375541
申请日：2006-03-13
申请人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
发明人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
IPC分类号： G06K9/00 , G06K9/36 , G01N1/30 , C12Q1/44
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067 , G06K9/00147 , G06T7/12 , G06T7/41 , G06T2207/10056 , G06T2207/10064 , G06T2207/20152 , G06T2207/30024
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译：基于细胞的测定用于评估刺激的肝毒性。成像技术用于分析刺激对肝细胞的影响。图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。

4. 发明申请

US20060228695A1 Predicting hepatotoxicity using cell based assays 审中-公开
公开(公告)号：US20060228695A1
公开(公告)日：2006-10-12
申请号：US11375597
申请日：2006-03-13
申请人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
发明人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067 , G06K9/00147 , G06T7/12 , G06T7/41 , G06T2207/10056 , G06T2207/10064 , G06T2207/20152 , G06T2207/30024
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

5. 发明申请

US20060234332A1 Predicting hepatotoxicity using cell based assays 失效
标题翻译：使用基于细胞的测定预测肝毒性
公开(公告)号：US20060234332A1
公开(公告)日：2006-10-19
申请号：US11375541
申请日：2006-03-13
申请人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
发明人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
IPC分类号： G01N1/30
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067 , G06K9/00147 , G06T7/12 , G06T7/41 , G06T2207/10056 , G06T2207/10064 , G06T2207/20152 , G06T2207/30024
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译：基于细胞的测定用于评估刺激的肝毒性。成像技术用于分析刺激对肝细胞的影响。图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。

6. 发明授权

US07235353B2 Predicting hepatotoxicity using cell based assays 失效
标题翻译：使用基于细胞的测定预测肝毒性
公开(公告)号：US07235353B2
公开(公告)日：2007-06-26
申请号：US10623486
申请日：2003-07-18
申请人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
发明人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
IPC分类号： C12Q3/00 , C12Q1/68 , C12Q1/26 , C12Q1/04 , C12N5/00
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译：基于细胞的测定用于评估刺激的肝毒性。成像技术用于分析刺激对肝细胞的影响。图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。

7. 发明申请

US20050014216A1 Predicting hepatotoxicity using cell based assays 失效
标题翻译：使用基于细胞的测定预测肝毒性
公开(公告)号：US20050014216A1
公开(公告)日：2005-01-20
申请号：US10623486
申请日：2003-07-18
申请人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
发明人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
IPC分类号： G01N1/30 , G01N33/50 , G06T7/00 , G01N33/48
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译：基于细胞的测定用于评估刺激的肝毒性。成像技术用于分析刺激对肝细胞的影响。图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。

8. 发明申请

US20050014217A1 Predicting hepatotoxicity using cell based assays 审中-公开
公开(公告)号：US20050014217A1
公开(公告)日：2005-01-20
申请号：US10719988
申请日：2003-11-20
申请人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
发明人： Larry Mattheakis , Jay Trautman , Gregg Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Adams , Aibing Rao
IPC分类号： G01N1/30 , G01N33/50 , G06K9/46 , G06T5/00 , G06T7/00 , G06T7/40 , G01N33/48
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067 , G06K9/00147 , G06T7/12 , G06T7/41 , G06T2207/10056 , G06T2207/10064 , G06T2207/20152 , G06T2207/30024
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

9. 发明授权

US07323318B2 Assay for distinguishing live and dead cells 失效
标题翻译：用于区分活细胞和死细胞的分析
公开(公告)号：US07323318B2
公开(公告)日：2008-01-29
申请号：US11082241
申请日：2005-03-15
申请人： Jinhong Fan , Vadim Kutsyy , Eugeni A. Vaisberg
发明人： Jinhong Fan , Vadim Kutsyy , Eugeni A. Vaisberg
IPC分类号： C12Q1/02
CPC分类号： G06K9/00147 , G06T7/0012
摘要： Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and determining the presence of a particular live-dead indicator feature within the region(s). In certain embodiments, the indicator feature is a cytoskeletal component such as tubulin. Prior to producing an image for analysis, cells may be treated with a marker that highlights the live-dead indicator in the image. In the case of tubulin, the marker will co-locate with tubulin and provide a signal that is captured in the image (e.g., a fluorescent emission).
摘要翻译：图像分析方法和装置用于区分活细胞和死细胞。所述方法可以包括分割图像以识别由一个或多个单元占用的区域，并确定该区域内特定的活死人指示器特征的存在。在某些实施方案中，指示剂特征是细胞骨架成分如微管蛋白。在生成用于分析的图像之前，可以使用突出显示图像中活死人指示符的标记来处理细胞。在微管蛋白的情况下，标记物将与微管蛋白共同定位，并提供在图像中捕获的信号（例如，荧光发射）。

10. 发明申请

US20070202487A1 Assay for phospholipidosis 审中-公开
标题翻译：磷脂测定
公开(公告)号：US20070202487A1
公开(公告)日：2007-08-30
申请号：US11653096
申请日：2007-01-12
申请人： Jinhong Fan
发明人： Jinhong Fan
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G01N33/5076 , G01N33/5026 , G01N33/5067 , G01N33/56966 , G01N2800/044 , G01N2800/085 , G01N2800/40 , G06T7/0012 , G06T2207/30024
摘要： Cell based assays for phospholipidosis are provided. The assays employ image and data analysis technology to provide an indication of whether a population of cells exhibits phospholipidosis. Methods to assess the effect of a stimulus on inducing phospholipidosis in a population of cells are also provided.
摘要翻译：提供了基于细胞的磷脂测定法。该测定采用图像和数据分析技术来提供细胞群是否表现出磷脂病。还提供了评估刺激对细胞群中诱导磷脂病的作用的方法。

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