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1. 发明授权

US06476207B1 Genes and gene expression products that are differentially regulated in prostate cancer 失效
标题翻译：在前列腺癌中差异调控的基因和基因表达产物
公开(公告)号：US06476207B1
公开(公告)日：2002-11-05
申请号：US09328475
申请日：1999-06-09
申请人： Jimmy Zhang , Jon H. Astle , Eddie Carroll, III , Wilson O. Endege , Donna M. Ford , John E. Monahan , Robert Schlegel , Kathleen E. Steinmann
发明人： Jimmy Zhang , Jon H. Astle , Eddie Carroll, III , Wilson O. Endege , Donna M. Ford , John E. Monahan , Robert Schlegel , Kathleen E. Steinmann
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57434 , G01N33/57488
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断和治疗剂，包括探针，反义构建体和抗体。本发明还涉及在前列腺癌中差异表达的多核苷酸。

2. 发明授权

US06262333B1 Human genes and gene expression products 失效
标题翻译：人类基因和基因表达产物
公开(公告)号：US06262333B1
公开(公告)日：2001-07-17
申请号：US09328111
申请日：1999-06-08
申请人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Steven E. Bushnell , Eddie Carroll, III , Theodore J. Catino , Adnan Derti , Donna M. Ford , Marcia E. Lewis , John E. Monahan , Robert Schlegel
发明人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Steven E. Bushnell , Eddie Carroll, III , Theodore J. Catino , Adnan Derti , Donna M. Ford , Marcia E. Lewis , John E. Monahan , Robert Schlegel
IPC分类号： A01K6700
CPC分类号： C07K14/47 , A61K38/00
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs. and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly colon cancer cell lines and/or tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体。和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌细胞系和/或组织中是差异调节的。

3. 发明授权

US06262334B1 Human genes and expression products: II 失效
标题翻译：人类基因和表达产物：II
公开(公告)号：US06262334B1
公开(公告)日：2001-07-17
申请号：US09385982
申请日：1999-08-30
申请人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Eddie Carroll, III , Theodore J. Catino , Poornima Dwivedi , Donna M. Ford , Marcia E. Lewis , Gary A. Molino , John E. Monahan , Robert Schlegel
发明人： Wilson O. Endege , Kathleen E. Steinmann , Jon H. Astle , Christopher C. Burgess , Eddie Carroll, III , Theodore J. Catino , Poornima Dwivedi , Donna M. Ford , Marcia E. Lewis , Gary A. Molino , John E. Monahan , Robert Schlegel
IPC分类号： A01K6700
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.
摘要翻译：本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

4. 发明授权

US06504019B2 Nucleic acid probes having highly hydrophilic non-nucleosidic tags with multiple labels, and uses thereof 失效
公开(公告)号：US06504019B2
公开(公告)日：2003-01-07
申请号：US09813644
申请日：2001-03-21
申请人： Guohan Yang , Donna M. Ford , Say-Jong Law , John E. Monahan , Todd B. Sells
发明人： Guohan Yang , Donna M. Ford , Say-Jong Law , John E. Monahan , Todd B. Sells
IPC分类号： C07H2104
CPC分类号： C07H21/04 , C07H21/00
摘要： Highly hydrophilic non-nucleosidic tags with multiple labels are provided for use in nucleic acid probes. The tags are branched structures having a phosphodiester backbone, which have the advantages of a small dimensional size and high hydrophilicity. After the tag is labeled, its high negative charge and minimal size help to keep the carriers away from DNA or RNA molecules, due to repulsion between negative charges. Non-specific intercalation and steric hindrance are therefore minimized, and the hydrophobicity, if any of reporter molecules is reduced. The probes are used in place of conventionally labeled oligonucleotides for a variety of hybridization reactions.

5. 发明授权

US5571039A Abdominal support 失效
标题翻译：腹部支持
公开(公告)号：US5571039A
公开(公告)日：1996-11-05
申请号：US330789
申请日：1994-10-28
申请人： Donna M. Ford
发明人： Donna M. Ford
IPC分类号： A41C1/10 , A41C1/08
CPC分类号： A41C1/10
摘要： This invention pertains to an abdominal support for the extended abdomen of a person who is pregnant or has a large abdomen due to obesity. The abdominal support comprises: (a) girdle for fitting about at least a portion of the abdomen, hips and buttocks of a person, said girdle comprising: (i) a first web having therein elastic fibres, said web forming the girdle which fits about at least a portion of the abdomen, hips and the buttocks of the person; (ii) a second web over one side of the abdomen having therein a set of generally parallel elastic fibres inclined at an angle upwardly from the rear base of the left side of the abdomen of the person towards its front and attaching at a frontal midline; and (iii) a third web over the other side of the abdomen having therein a set of generally parallel elastic fibres inclined at an angle upwardly from the rear base of the right side of the abdomen of the person towards its front and attaching at a frontal midline; and (b) adjustable length suspenders detachably secured to the upper region of the girdle for fitting over the shoulders of the person and assisting in uplifting the weight of the abdominal area of the person and distributing the weight to the shoulders of person.
摘要翻译：本发明涉及由于肥胖而怀孕或腹部大腹部的延长腹部的腹部支撑。腹部支撑件包括：（a）用于装配人的腹部，臀部和臀部的至少一部分的腰带，所述腰带包括：（i）具有弹性纤维的第一腹板，所述腹板形成围绕该人的至少一部分腹部，臀部和臀部; （ii）位于腹部一侧的第二腹板，其中具有一组大体上平行的弹性纤维，该组弹性纤维从人的腹部的左侧的后方向上向前倾斜并且在前侧中线附近; 和（iii）在腹部的另一侧上的第三腹板，其中具有一组大体上平行的弹性纤维，该组弹性纤维从人的腹部的右侧的后底部朝向前方向上倾斜一定角度，中线及（b）可调节长度的吊带可拆卸地固定在腰带的上部区域，以装配在该人的肩上，并协助提升该人的腹部区域的重量，并将重量分配给人的肩膀。

6. 发明授权

US4899556A Jewelry with interchangeable ornamentation 失效
标题翻译：珠宝与可互换的装饰
公开(公告)号：US4899556A
公开(公告)日：1990-02-13
申请号：US252588
申请日：1988-10-03
申请人： Donna M. Ford
发明人： Donna M. Ford
IPC分类号： A44B1/12 , A44C7/00 , A44C17/02
CPC分类号： A44C7/002 , A44B1/123 , A44C17/0208 , A44C17/0216 , Y10T24/3651 , Y10T24/367
摘要： A removable member, having a front surface for receiving a flexible sheet of ornamental material thereover, is attachably engageable with a backing member. A peripheral edge of the sheet is gripped and held between the engaged members. The backing member carries a post, clip, pin or other device for attachment to a selected substrate such as the human body or the clothing. The movable member is held in snap engagement with the backing member for convenient separation and changeability of the ornamental sheet material.

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