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1. 发明授权

US08702777B2 Steep-taper flared stents and apparatus and methods for delivering them 有权
标题翻译：陡锥形支架，用于传递它们的装置和方法
公开(公告)号：US08702777B2
公开(公告)日：2014-04-22
申请号：US11466445
申请日：2006-08-22
申请人： Jeffrey A. Krolik , Eliot Kim , James H. Dreher , Farhad Khosravi
发明人： Jeffrey A. Krolik , Eliot Kim , James H. Dreher , Farhad Khosravi
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
摘要翻译：支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。当第一部分展开时，第二部分抵抗扩张。支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

2. 发明授权

US07582111B2 Steep-taper flared stents and apparatus and methods for delivering them 有权
标题翻译：陡锥形支架，用于传递它们的装置和方法
公开(公告)号：US07582111B2
公开(公告)日：2009-09-01
申请号：US11466442
申请日：2006-08-22
申请人： Jeffrey A. Krolik , Eliot Kim , James H. Dreher , Farhad Khosravi
发明人： Jeffrey A. Krolik , Eliot Kim , James H. Dreher , Farhad Khosravi
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： A stent includes a first portion including first and second bands of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second portion connected to the first portion by flexible connectors. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium and the second portion within a branch vessel extending from the ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
摘要翻译：支架包括第一部分，第一部分包括第一和第二细胞带，当支架从收缩状态扩展到扩张状态时向外张开，第二部分通过柔性连接器连接到第一部分。在使用期间，将支架以收缩状态引入主容器中，并且将第一部分定位成邻近口，第二部分位于从口部延伸的分支容器中。第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

3. 发明申请

US20070073376A1 STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 有权
标题翻译： STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELMER THEM
公开(公告)号：US20070073376A1
公开(公告)日：2007-03-29
申请号：US11466445
申请日：2006-08-22
申请人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
发明人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
IPC分类号： A61F2/84 , A61F2/90
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
摘要翻译：支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。当第一部分展开时，第二部分抵抗扩张。支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

4. 发明申请

US20070067011A1 STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 有权
标题翻译： STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELMER THEM
公开(公告)号：US20070067011A1
公开(公告)日：2007-03-22
申请号：US11466442
申请日：2006-08-22
申请人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
发明人： Jeffrey Krolik , Eliot Kim , James Dreher , Farhad Khosravi
IPC分类号： A61F2/84 , A61F2/90
CPC分类号： A61F2/958 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002
摘要： A stent includes a first portion including first and second bands of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second portion connected to the first portion by flexible connectors. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium and the second portion within a branch vessel extending from the ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
摘要翻译：支架包括第一部分，第一部分包括第一和第二细胞带，当支架从收缩状态扩展到扩张状态时向外张开，第二部分通过柔性连接器连接到第一部分。在使用期间，将支架以收缩状态引入主容器中，并且将第一部分定位成邻近口，第二部分位于从口部延伸的分支容器中。第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

5. 发明授权

US09034025B2 Balloon catheters and methods for use 有权
标题翻译：气球导管及使用方法
公开(公告)号：US09034025B2
公开(公告)日：2015-05-19
申请号：US13602074
申请日：2012-08-31
申请人： Archimedes Sanati , Farhad Khosravi
发明人： Archimedes Sanati , Farhad Khosravi
IPC分类号： A61F2/06 , A61F2/954 , A61F2/95
CPC分类号： A61F2/954 , A61F2/95 , A61F2/958 , A61F2002/30322 , A61F2002/821 , A61F2230/0071 , A61F2250/0018 , A61F2250/0026 , A61F2250/0039 , A61M25/1002 , A61M25/1011
摘要： Apparatus and methods are provided for flaring a stent deployed within a branch vessel including an ostium communicating with a main vessel, a first end of the stent extending at least partially from the branch. A catheter is provided that includes a first balloon carried on its distal end, and a second balloon that includes a distal section overlying at least a portion of the first balloon and a proximal section. The catheter distal end is introduced into the main vessel and positioned through the ostium and stent into the branch until the first balloon is disposed within the stent. The first balloon is expanded to anchor the stent, and the second balloon is expanded to flare the first end of the stent. Optionally, the first balloon is expanded further, e.g., to expand the stent within the branch body lumen and/or dilate the lesion.
摘要翻译：提供了一种装置和方法，用于扩张部署在分支容器内的支架，该支架包括与主容器连通的口，所述支架的第一端至少部分地从所述分支延伸。提供了一种导管，其包括在其远端承载的第一气囊，以及包括覆盖所述第一气囊的至少一部分的远端部分和近端部分的第二气囊。将导管远端引入主容器中并定位成通过口和支架进入分支，直到第一气囊置于支架内。将第一气囊扩张以锚固支架，并且将第二气囊膨胀以扩张支架的第一端。任选地，第一气囊进一步膨胀，例如，以使分支体腔内的支架膨胀和/或扩张病变。

6. 发明授权

US08617201B2 Vascular device for emboli, thrombus and foreign body removal and methods of use 有权
公开(公告)号：US08617201B2
公开(公告)日：2013-12-31
申请号：US13479836
申请日：2012-05-24
申请人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
发明人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/00287 , A61B2017/2212 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008 , A61M25/0069 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.

7. 发明申请

US20130267996A1 METHODS FOR SEALING A VASCULAR PUNCTURE 有权
标题翻译：用于密封血管的方法
公开(公告)号：US20130267996A1
公开(公告)日：2013-10-10
申请号：US13904994
申请日：2013-05-29
申请人： Amarpreet S. Sawhney , Farhad Khosravi , Suresh S. Pai
发明人： Amarpreet S. Sawhney , Farhad Khosravi , Suresh S. Pai
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译：提供了用于密封与血管连通的穿刺的方法，包括将由冻干的水凝胶或其它材料形成的多孔载体引入穿刺。插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子穿刺的地方

8. 发明授权

US08092514B1 Stretchable anti-buckling coiled-sheet stent 失效
标题翻译：可伸缩抗弯卷盘支架
公开(公告)号：US08092514B1
公开(公告)日：2012-01-10
申请号：US09427260
申请日：1999-10-25
申请人： Farhad Khosravi , Himanshu N. Patel , Yi Yang
发明人： Farhad Khosravi , Himanshu N. Patel , Yi Yang
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/91 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/008 , A61F2250/0018
摘要： A stent includes a coiled-up sheet having overlapping inner and outer longitudinal sections extending parallel to a longitudinal axis thereof, and defining a periphery, the coiled-up sheet being unrollable between contracted and enlarged conditions. A plurality of stretchable elements are formed in the coiled-up sheet, the stretchable elements being expandable about the periphery between an unstretched condition to facilitate placement in a delivery device in the contracted condition and a stretched condition to facilitate expansion of the coiled-up sheet to the enlarged condition upon deployment from the delivery device. Preferably, the coiled-up sheet is biased to the enlarged condition, and the stretchable elements are biased to the stretched condition. More preferably, at least one of the biases is provided by a shape memory property of the coiled-up sheet, which is activated by exposing the stent to body temperature.
摘要翻译：支架包括具有与其纵向轴线平行延伸的重叠的内部和外部纵向部分并且限定周边的盘绕的片材，所述盘绕的片材在收缩和扩大的条件之间不可展开。多个可拉伸元件形成在盘绕的片材中，可拉伸元件可以在未拉伸状态下围绕周边扩张，以便于在收缩状态下放置在输送装置中，并且拉伸条件以便于卷起片材的膨胀在从输送装置部署时变为放大状态。优选地，盘绕的片材被偏压到放大状态，并且可拉伸元件被偏压到拉伸状态。更优选地，通过将支架暴露于体温而被活化的卷曲片的形状记忆特性提供至少一个偏差。

9. 发明授权

US08092513B2 Coiled sheet graft for single and bifurcated lumens and methods of making and use 失效
标题翻译：单片和分叉腔的卷片移植物及其制作和使用方法
公开(公告)号：US08092513B2
公开(公告)日：2012-01-10
申请号：US10903804
申请日：2004-07-29
申请人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi , Michael R. Ross , Himanshu Patel
发明人： Farhad Khosravi , Michael Hogendijk , John Spiridigliozzi , Michael R. Ross , Himanshu Patel
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/07 , A61F2/93 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0075
摘要： A prosthesis is provided for treating aneurysms, occlusive disease of vessels and body organs, and arterio-venous fistulas, occurring in single and bifurcated lumens. The prosthesis comprises an expandable coiled sheet portion having a biocompatible graft, either a sheet or tube, affixed thereto along part or all of the circumference of the coiled sheet portion. The prosthesis has a small delivery profile, making it suitable for use in a variety of body vessels. Methods of making and deploying the prosthesis in single and bifurcated lumens are also provided.
摘要翻译：提供了一种假体，用于治疗动脉瘤，血管和身体器官的闭塞性疾病以及发生在单个和分叉腔内的动静脉瘘。假体包括具有生物相容性移植物（片或管）的可膨胀卷曲片部分，其沿着盘绕片部分的圆周的部分或全部固定到其上。假体具有小的输送轮廓，使其适用于各种身体血管。还提供了在单个和分叉腔内制造和部署假体的方法。

10. 发明授权

US08052713B2 Vascular filter having articulation region and methods of use in the ascending aorta 有权
标题翻译：具有关节区域的血管过滤器和在升主动脉中使用的方法
公开(公告)号：US08052713B2
公开(公告)日：2011-11-08
申请号：US11325858
申请日：2006-01-05
申请人： Farhad Khosravi , L. N. Hopkins , Amr Salahieh , Jackson F. Demond , Jeff A. Krolik
发明人： Farhad Khosravi , L. N. Hopkins , Amr Salahieh , Jackson F. Demond , Jeff A. Krolik
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel such as the ascending aorta, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of an elongated member, a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac, a guide wire, and a delivery sheath. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.
摘要翻译：提供的装置和方法用于从诸如升主动脉的血管过滤栓塞，其中血管装置包括支撑环，所述支撑环具有连接在细长构件的远端附近的关节区域，固定到支撑环的血液渗透囊使得支撑环形成可渗透囊的口，导丝和输送鞘。铰接区域包括支撑环的减小的厚度区域，当装置收缩到其输送状态时，防止在支撑环中形成扭结;以及弯曲区域，其闭合囊的口以防止材料从囊中逸出，装置被塌缩以便移除。

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