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1. 发明申请

US20140170645A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：US20140170645A1
公开(公告)日：2014-06-19
申请号：US13967957
申请日：2013-08-15
申请人： IntegenX Inc.
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

2. 发明申请

US20140065628A1 Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis 审中-公开
标题翻译：电泳中多色，异相检测的方法和装置
公开(公告)号：US20140065628A1
公开(公告)日：2014-03-06
申请号：US13966252
申请日：2013-08-13
申请人： IntegenX Inc.
发明人： Ezra Van Gelder , Stephen J. Williams
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44726 , G01N27/44791
摘要： The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g., analysis of a plurality of STR markers utilized in a forensic database (e.g., CODIS) to identify humans.
摘要翻译：本公开提供了用于使用单个光源或多个光源分离和检测用多个可光谱可分辨染料标记的核酸片段的方法和装置。使用更多数量的光源可增加可询问的光谱可分辨染料的数量。具有更多数量的光谱可分辨染料的标记片段允许具有片段分化的片段更多的重叠，因此可以在更小的片段大小/长度范围上进行分离。为了提高使用多个光源的检测系统的检测灵敏度，光源发射的光可以在空间上彼此分离和/或可以调制每个光源的强度。一个或多个光源中的每一个可以是例如激光器或发光二极管。本公开的方法和装置可用于进行遗传分析，例如分析在法医数据库（例如，CODIS）中使用的多个STR标记以鉴定人。

3. 发明申请

US20130074944A1 Methods and Apparatuses for Releasably Fastening Pins 审中-公开
标题翻译：可释放紧固销的方法和装置
公开(公告)号：US20130074944A1
公开(公告)日：2013-03-28
申请号：US13626765
申请日：2012-09-25
申请人： IntegenX Inc.
发明人： Ezra Van Gelder
IPC分类号： F16L55/00
CPC分类号： B01L9/547 , B01L3/0279 , B01L2200/025 , B01L2200/148 , B01L2300/0838 , G01N35/1009 , G01N35/1065 , G01N2035/1037 , G01N2035/1076 , Y10T137/0402 , Y10T137/598
摘要： The present technology relates to pins that are used for moving liquid samples from source wells into target wells. A releasable fastening mechanism simplifies calibration of positions (e.g., vertical positions) of the pins relative to a frame releasably holding the pins.
摘要翻译：本技术涉及用于将液体样品从源阱移动到目标井中的引脚。可释放的紧固机构简化了相对于可释放地保持销的框架的销的位置（例如，垂直位置）的校准。

4. 发明申请

US20170197213A1 SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS 审中-公开
公开(公告)号：US20170197213A1
公开(公告)日：2017-07-13
申请号：US15342914
申请日：2016-11-03
申请人： IntegenX Inc.
发明人： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar EL-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
IPC分类号： B01L3/00 , G01N27/447 , B01L7/00
CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/0818 , B01L3/5029 , B01L3/527 , B01L7/52 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/0421 , B01L2400/043 , B01L2400/0478 , B01L2400/0487 , B01L2400/0616 , B01L2400/0638 , G01N27/44743 , G01N27/44791 , G01N2035/00158 , G01N2035/0091
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

5. 发明申请

US20130115607A1 Sample Preparation, Processing and Analysis Systems 有权
标题翻译：样品制备，加工和分析系统
公开(公告)号：US20130115607A1
公开(公告)日：2013-05-09
申请号：US13656503
申请日：2012-10-19
申请人： IntegenX Inc.
发明人： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar El-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , B01L3/502715 , B01L3/5029 , B01L3/527 , B01L7/52 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0616 , G01N27/44704 , G01N2035/00158
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
摘要翻译：本公开提供了一种综合和自动化的样本回答系统，其从包含生物材料的样品开始，在少于两小时内产生遗传图谱。在某些实施方案中，生物材料是DNA，并且遗传图谱涉及确定受试者的一个或多个位点（例如，遗传基因座）等位基因，例如STR（短串联重复）分布，例如如 CODIS系统。该系统可以执行若干操作，包括（a）提取和分离核酸; （b）在选择的位点（例如遗传基因座）扩增核苷酸序列; 和（c）扩增产物的检测和分析。这些操作可以在包括多个集成模块的系统中进行，包括分析物准备模块; 检测和分析模块和控制模块。

6. 发明申请

US20210277445A1 Sample Preparation, Processing and Analysis Systems 有权
公开(公告)号：US20210277445A1
公开(公告)日：2021-09-09
申请号：US17119874
申请日：2020-12-11
申请人： Integenx Inc.
发明人： David Eberhart , Yuan Li , James Ogg , Ezra Van Gelder , Stephen J. Williams , Timothy Woudenberg , Dean S. Burgi , William D. Nielsen
IPC分类号： C12Q1/686 , B01L3/00 , B01L7/00
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

7. 发明授权

US10865440B2 Sample preparation, processing and analysis systems 有权
公开(公告)号：US10865440B2
公开(公告)日：2020-12-15
申请号：US14381179
申请日：2013-02-28
申请人： INTEGENX INC.
发明人： David Eberhart , Yuan Li , James Ogg , Ezra Van Gelder , Stephen J. Williams , Timothy Woudenberg , Dean S. Burgi , William D. Nielsen
IPC分类号： C12Q1/68 , C12Q1/686 , B01L3/00 , B01L7/00 , G01N27/447 , G01N35/00
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/527 , B01L7/52 , B01L3/5029 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/0684 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/043 , B01L2400/0421 , B01L2400/0478 , B01L2400/0616 , G01N27/44704 , G01N2035/00158 , C12Q1/686 , C12Q2565/629
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

8. 发明授权

US10525467B2 Sample preparation, processing and analysis systems 有权
公开(公告)号：US10525467B2
公开(公告)日：2020-01-07
申请号：US15342914
申请日：2016-11-03
申请人： IntegenX Inc.
发明人： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar EL-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
IPC分类号： B01L3/00 , B01L7/00 , G01N27/447 , B01F13/00 , B01F13/08 , G01N35/00
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

9. 发明授权

US08894946B2 Sample preparation, processing and analysis systems 有权
标题翻译：样品制备，加工和分析系统
公开(公告)号：US08894946B2
公开(公告)日：2014-11-25
申请号：US13656503
申请日：2012-10-19
申请人： IntegenX Inc.
发明人： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar El-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
IPC分类号： G01N21/75 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/68 , B01L3/502715 , B01L3/5029 , B01L3/527 , B01L7/52 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0616 , G01N27/44704 , G01N2035/00158
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
摘要翻译：本公开提供了一种综合和自动化的样本回答系统，其从包含生物材料的样品开始，在少于两小时内产生遗传图谱。在某些实施方案中，生物材料是DNA，并且遗传图谱涉及确定受试者的一个或多个位点（例如，遗传基因座）等位基因，例如STR（短串联重复）分布，例如如 CODIS系统。该系统可以执行多个操作，包括（a）提取和分离核酸; （b）在选择的位点（例如遗传基因座）扩增核苷酸序列; 和（c）扩增产物的检测和分析。这些操作可以在包括多个集成模块的系统中进行，包括分析物准备模块; 检测和分析模块和控制模块。

10. 发明公开

US20230405589A1 SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS 审中-公开
公开(公告)号：US20230405589A1
公开(公告)日：2023-12-21
申请号：US18336352
申请日：2023-09-11
申请人： IntegenX, Inc.
发明人： William D. Nielsen , Richard J. Belcinski , Gregory Bogdan , David Eberhart , Omar El-Sissi , Stevan B. Jovanovich , Michael Recknor , Ezra Van Gelder , David W. Wyrick
IPC分类号： B01L3/00 , G01N27/447 , B01L7/00 , B01F33/30 , B01F33/452
CPC分类号： B01L3/502715 , G01N27/44743 , G01N27/44791 , B01L3/5029 , B01L3/527 , B01L7/52 , B01F33/30 , B01F33/452 , B01L2400/0421 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/143 , B01L2300/023 , B01L2300/027 , B01L2300/0672 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , G01N2035/0091
摘要： A system for controlling custody of a sample can include a cartridge comprising a sample receptacle configured to receive an article configured to deliver a sample to the cartridge, a cartridge module having a cartridge receptacle configured to receive the cartridge; a housing enclosing the cartridge module and the cartridge. The housing can include a closable door; at least one sensor configured to produce a signal indicating: insertion or removal of an article into or from the sample receptacle; whether the cartridge is inserted into the cartridge receptacle; or whether the door is open or closed. The system can further include a computer programmed to record a signal from the at least one sensor for a recording period of time and to display a signal history to a user.

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