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1. 发明申请

WO1997044667A2 METHOD FOR USING PEPTIDE COMPLEXES/MAJOR HISTOCOMPATIBILITY COMPLEX TO OBTAIN OR PURIFY ANTIGEN-SPECIFIC T CELLS AND TO STIMULATE T CELLS 审中-公开
标题翻译：使用肽复合物/主要组氨酸复合物获得或纯化抗原特异性T细胞并刺激T细胞的方法
公开(公告)号：WO1997044667A2
公开(公告)日：1997-11-27
申请号：PCT/FR1997000892
申请日：1997-05-21
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , LANGLADE-DEMOYEN, Pierre , LONE, Yu-Chun , KOURILSKY, Philippe , ABASTADO, Jean-Pierre
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , C07K14/70539 , C12N2760/16122 , G01N33/56977 , G01N33/574
摘要： The invention features methods for using MHC/peptide complexes. The successful peptide-specific T lymphocyte purification by adsorption on a solid support coupled with a high density of MHC recombinant molecules, charged with a single peptide is disclosed. This method has enabled the isolating, purifying and quantifying of tumoral specific T lymphocytes, from peritoneal exudate and tumor-infiltrating lymphocytes. These purified T lymphocyte populations can be further multiplied in vitro. The resulting cells show a superior cytotoxic activity and an enhanced anti-tumoral action by re-injection in the tumor carrier. This novel approach is important for analysing the T lymphocytes repertoire at the peptide specificity level and to improve novel T lymphocyte adoptive immunotherapy based therapeutic treatments. Further, the MHC/peptide specific complexes can induce or stimulate peptide-specific T lymphocytes. Thus are also disclosed methods to induce cytotoxic T lymphocytes (CTL). These CTL can be used in turn to fight tumoral cell growth in vitro or in vivo. The MHC recombinant molecule charged with a single peptide can be effectively used in polymer form to stimulate specific immune response ex vivo or in vivo after being injected in man or animal.
摘要翻译：本发明的特征在于使用MHC /肽复合物的方法。公开了通过在固体支持物上吸附成功的肽特异性T淋巴细胞，其与高密度的MHC重组分子偶联，装载有单一肽。该方法能够从腹膜渗出液和肿瘤浸润淋巴细胞中分离，纯化和定量肿瘤特异性T淋巴细胞。这些纯化的T淋巴细胞群可以进一步在体外倍增。所得细胞通过在肿瘤载体中重新注射显示出优异的细胞毒性活性和增强的抗肿瘤作用。这种新方法对于分析肽特异性水平的T淋巴细胞谱和改善基于T淋巴细胞过继免疫治疗的治疗方法是重要的。此外，MHC /肽特异性复合物可以诱导或刺激肽特异性T淋巴细胞。因此，还公开了诱导细胞毒性T淋巴细胞（CTL）的方法。这些CTL可以依次用于在体外或体内抗肿瘤细胞生长。带有单个肽的MHC重组分子可以有效地以聚合物形式使用，以便在人或动物注射后离体或体内刺激特异性免疫应答。

2. 发明申请

WO1996001891A1 METHOD FOR GENERATING A POPULATION OF CELLS HAVING A HIGH SURFACE DENSITY OF A MHC MOLECULE-ASSOCIATED SPECIFIC EXOGENOUS PEPTIDE, AND CELL POPULATION 审中-公开
标题翻译：用于产生具有MHC分子相关特异性外源性细胞和细胞群体的高表面密度的细胞群体的方法
公开(公告)号：WO1996001891A1
公开(公告)日：1996-01-25
申请号：PCT/FR1995000907
申请日：1995-07-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , LANGLADE DEMOYEN, Pierre , KOURILSKY, Philippe , ABASTADO, Jean-Pierre
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR
IPC分类号： C12N05/06
CPC分类号： C07K14/70539 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , Y02A50/412
摘要： A method for generating a population of cells having a high surface density of an MHC molecule-associated specific exogenous peptide. A population of living non-tumour mammalian cells, particularly human peripheral blood lymphocyte splenic cells, ganglion cells, cord blood cells or placental cells, wherein said cells have a surface density of one MHC molecule-associated specific exogenous peptide with the same allele restriction as MHC molecules, whic h restriction is substantially higher than that of the corresponding cells that express said native MHC molecule-associated exogenous peptide.
摘要翻译：一种用于产生具有MHC分子相关特异性外源肽的高表面密度的细胞群的方法。活的非肿瘤哺乳动物细胞群，特别是人外周血淋巴细胞脾细胞，神经节细胞，脐带血细胞或胎盘细胞，其中所述细胞具有一个MHC分子相关特异性外源肽的表面密度，具有与 MHC分子的限制性明显高于表达所述天然MHC分子相关外源肽的相应细胞的限制。

3. 发明申请

WO1997018232A2 PEPTIDES DERIVED FROM THE ONCOGENE PROTEINE BCR-ABL EXPRESSED BY LEUKEMIC CELLS AND UTILISATION THEREOF FOR THE THERAPY OF HUMAN LEUKEMIAE 审中-公开
标题翻译：由白细胞表达的蛋白BCR-ABL衍生的肽和用于人类淋巴细胞的治疗的利用
公开(公告)号：WO1997018232A2
公开(公告)日：1997-05-22
申请号：PCT/FR1996001799
申请日：1996-11-14
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , LANGLADE-DEMOYEN, Pierre , ABASTADO, Jean-Pierre , KOURILSKY, Philippe
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR
IPC分类号： C07K00/00
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/82
摘要： The invention relates to peptides capable of inducing a response of human cytotoxic T lymphocytes (CTL) specifically directed against cells expressing the fusion protein BCR-ABL.
摘要翻译：本发明涉及能够诱导针对表达融合蛋白BCR-ABL的细胞的人细胞毒性T淋巴细胞（CTL）的应答的肽。

4. 发明申请

WO1994019022A1 COMPOSITION FOR USE IN THE TREATMENT OF TUMOURS AND THE IMMUNIZATION OF HUMANS AND ANIMALS 审中-公开
标题翻译：用于治疗肿瘤的组合物和人与动物的免疫
公开(公告)号：WO1994019022A1
公开(公告)日：1994-09-01
申请号：PCT/FR1994000192
申请日：1994-02-21
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE , ROTH, Claude , KOURILSKY, Philippe , MIR, Lluis , KLATZMANN, David , SALZMANN, Jean-Loup
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K35/12 , A61K35/13 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2046 , A61K38/217 , A61K38/45 , A61K38/50 , A61K2035/11 , C12N15/86 , C12N2740/13032 , C12N2740/13043 , A61K2300/00
摘要： Composition for use in the treatment of tumors and the immunization of humans or animals comprising a synergistic association of cells, viruses, or bacteria expressing, transitorily, in organisms at least one gene for producing in vivo one or more immunomodulators, and viruses, or cells producing viruses, said viruses preferably infecting dividing cells of the treated organisms and carrying within their genome at least one gene whose expression in the dividing cells will cause their destruction.
摘要翻译：用于治疗肿瘤和免疫人体或动物的组合物，包括细胞，病毒或细菌的协同关联，细胞，病毒或细菌在生物体中表达至少一种用于在体内产生一种或多种免疫调节剂和病毒或细胞的基因所述病毒优选地感染经处理的生物体的分裂细胞并在其基因组内携带至少一种在分裂细胞中表达会导致其破坏的基因。

5. 发明申请

WO1995024504A1 COMBINED USE OF GENETIC MARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE, DIAGNOSTIC KIT AND METHOD 审中-公开
标题翻译：联合使用遗传标记用于诊断阿尔茨海默病，诊断试剂盒和方法
公开(公告)号：WO1995024504A1
公开(公告)日：1995-09-14
申请号：PCT/FR1995000259
申请日：1995-03-06
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , AMOUYEL, Philippe , CHARTIER-HARLIN, Marie-Christine
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10S435/975
摘要： Combined use of at least two genetic markers selected from apolipoprotein E, D19S178 and apolipoprotein CII, for the diagnosis of Alzheimer's disease, especially apolipoprotein epsilon 4, long apolipoprotein CII (30+/-3 repeat patterns (CA) and short D19S178 (less than 167+/-4 nucleotides) alleles. The invention also concerns a method for the diagnosis of Alzheimer's disease and a kit for carrying out said method.
摘要翻译：综合使用选自载脂蛋白E，D19S178和载脂蛋白CII的至少两种遗传标记，用于诊断阿尔茨海默病，特别是载脂蛋白ε4，长载脂蛋白CII（30 +/- 3重复模式（CA）和短D19S178（小于 167 +/- 4个核苷酸）等位基因，本发明还涉及一种诊断阿尔茨海默病的方法和用于实施所述方法的试剂盒。

6. 发明申请

WO1995022961A1 LIPOSOMES AND USE THEREOF ESPECIALLY TO OBTAIN IMMUNOMODULATING COMPOSITIONS 审中-公开
标题翻译：脂质体及其特别用于获得免疫组织化学品
公开(公告)号：WO1995022961A1
公开(公告)日：1995-08-31
申请号：PCT/FR1995000215
申请日：1995-02-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , RIVEAU, Gilles , CAPRON, André , IVANOFF, Nathalie , GRZYCH, Jean-Marie , PHILLIPS, Nigel
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： A61K09/127
CPC分类号： A61K39/39 , A61K9/127 , A61K39/0003 , A61K2039/543 , A61K2039/55555 , Y02A50/423
摘要： The liposomes of the invention comprise at least one dual layer comprising a mixture formed by a phospholipid (I) with a flow temperature of 20-25 DEG C, and a phospholipid (II) with a flow temperature of 20-60 DEG C. The invention is characterized in that the molar ratio of phospholipid (I) to phospholipid (II) is 5:95 - 30:70. Said liposomes are for use in the production of vaccines.
摘要翻译：本发明的脂质体包含至少一个包含由流动温度为20-25℃的磷脂（I）和流动温度为20-60℃的磷脂（II）形成的混合物的双层。本发明的特征在于磷脂（I）与磷脂（II）的摩尔比为5:95-30:70。所述脂质体用于生产疫苗。

7. 发明申请

WO1998016553A1 BORDETELLA STRAIN EXPRESSING THE FHA HYBRID, LIPOSOMES AND VACCINES 审中-公开
标题翻译： BORDETELLA菌株表达FHA混合物，脂质体和疫苗
公开(公告)号：WO1998016553A1
公开(公告)日：1998-04-23
申请号：PCT/FR1997001802
申请日：1997-10-09
申请人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
发明人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C07K14/235
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
摘要翻译：本发明涉及一种缺乏毒素生产的博德氏菌菌株，并表达一种杂合蛋白质，其包含至少部分丝状血凝素（FHA）和至少部分与FHA异源的蛋白质。编码毒素的基因已被消除，或至少部分缺失或突变，以产生无活性毒素。该菌株可用作疫苗。本发明还涉及含有至少部分FHA蛋白质和至少一种与FHA蛋白质异源的蛋白质的脂质体，以及使用FHA来刺激免疫应答。

8. 发明申请

WO1998007847A1 M. TUBERCULOSIS COMPLEX MEMBERS MYCOBACTERIA SPECIFIC NUCLEIC ACID FRAGMENTS AND THEIR APPLICATIONS FOR THE DETECTION AND DIFFERENTIAL DIAGNOSIS OF M. TUBERCULOSIS COMPLEX MEMBERS 审中-公开
标题翻译： M. TUBERCULOSIS复合成员MYCOBACTERIA特异性核酸片段及其用于检测和差异诊断M淋巴管复合成员的应用
公开(公告)号：WO1998007847A1
公开(公告)日：1998-02-26
申请号：PCT/FR1997001483
申请日：1997-08-12
申请人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , MAGDALENA, Juana , SUPPLY, Philip , LOCHT, Camille
发明人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12N15/11
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： The invention concerns a M. tuberculosis complex mycobacteria specific fragment of nucleic acids, comprising a nucleotide chain selected among the SEQ ID NO. 1 sequence, the SEQ ID N 2 sequence, their complementary sequences or the nucleic acid sequences capable of being hybridised with one of the preceding sequences in conditions of high stringency. The invention also concerns uses of said sequences for the detection and differential diagnosis of mycobacteria members of the M. tuberculosis complex, in particular the BCG differential diagnosis of other members of the complex.
摘要翻译：本发明涉及核酸的结核分枝杆菌复合分枝杆菌特异性片段，其包含选自SEQ ID NO： 1序列，SEQ ID N 2序列，其互补序列或能够在高严格条件下与前述序列之一杂交的核酸序列。本发明还涉及所述序列用于结核分枝杆菌复合物分枝杆菌成员的检测和鉴别诊断的用途，特别是复合物其他成员的BCG鉴别诊断。

9. 发明申请

WO1995011307A1 NUCLEOTIDE VECTOR, COMPOSITION CONTAINING SUCH VECTOR AND VACCINE FOR IMMUNIZATION AGAINST HEPATITIS 审中-公开
标题翻译：核苷酸载体，含有此类载体和疫苗的组合物用于抗艾滋病毒的免疫
公开(公告)号：WO1995011307A1
公开(公告)日：1995-04-27
申请号：PCT/FR1994000483
申请日：1994-04-27
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE D'OTTAWA , DAVIS, Heather, Lynn , WHALEN, Robert, Gérald , MICHEL, Marie-Louise
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE D'OTTAWA
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , A61K48/00 , A61K2039/53 , A61K2039/57 , C12N2730/10122 , C12N2730/10134 , Y02A50/464
摘要： Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a protein of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
摘要翻译：包含编码病毒蛋白质的至少一部分的至少一个基因或一个互补DNA的核苷酸载体和提供在肌肉细胞中表达该基因的启动子。该基因可能是乙型肝炎病毒的S基因。将含有裸DNA的疫苗制剂注射到预先用能够引起肌纤维凝固性坏死的物质处理的宿主中。

10. 发明申请

WO1995007361A1 METHOD FOR THE DETECTION OF MOLECULES CONTAINING NUCLEOTIDIC MISMATCHES AND LOCATION THEREOF, AND APPLICATION TO DETECTION OF SUBSTITUTIONS OR DELETIONS OF BASES IN NUCLEOTIDIC SEQUENCES 审中-公开
标题翻译：检测包含核型错配和其位置的分子的方法，以及用于检测核酸序列中基因取代或取代的应用
公开(公告)号：WO1995007361A1
公开(公告)日：1995-03-16
申请号：PCT/FR1994001068
申请日：1994-09-09
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , MEO, Tommaso , TOSI, Mario , VERPY, Elisabeth , BIASOTTO, Michel
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6858 , C12Q1/6827
摘要： Method for the detection and/or location of mutations or deletions in nucleotidic sequences by the formation of heteroduplexes between two double strand DNA types capable of generating mismatches at the mutation or deletion sites. The heteroduplexes are revealed by marking of each type of strand using different fluorescent molecules or are screened by passing over a support which specifically retains them.
摘要翻译：通过在突变或缺失位点产生错配的两条双链DNA类型之间形成异源双链体来检测和/或定位核苷酸序列中突变或缺失的方法。异源双链体通过使用不同的荧光分子标记每种类型的链来揭示，或通过通过特异性保留它们的载体进行筛选。

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