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1. 发明专利

IL255446D0 Field-effect apparatus and methods for sequencing nucelic acids 未知
公开(公告)号：IL255446D0
公开(公告)日：2017-12-31
申请号：IL25544617
申请日：2017-11-05
申请人： ILLUMINA INC , BOYANOV BOYAN , GUNDERSON KEVIN L , PEISAJOVICH SERGIO , UNIV CALIFORNIA , BAI JINGWEI , CHEN CHENG YAO , MANDELL JEFFREY G , COLLINS PHILIP G , WEISS GREGORY A
发明人： BOYANOV BOYAN , GUNDERSON KEVIN L , PEISAJOVICH SERGIO , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q20060101
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

2. 发明申请

WO2012047865A3 ELECTRICALLY CONDUCTIVE POLYMER NANOWIRES WITH INCORPORATED VIRUSES 审中-公开
标题翻译：具有并发病毒的电导电聚合物纳米微粒
公开(公告)号：WO2012047865A3
公开(公告)日：2012-06-21
申请号：PCT/US2011054736
申请日：2011-10-04
申请人： UNIV CALIFORNIA , WEISS GREGORY A , PENNER REGINALD M , ARTER JESSICA A , TAGGART DAVID K , DONAVAN KEITH C
发明人： WEISS GREGORY A , PENNER REGINALD M , ARTER JESSICA A , TAGGART DAVID K , DONAVAN KEITH C
IPC分类号： G01N33/50 , C12Q1/70 , G01N27/26
CPC分类号： C12Q1/70 , C12Q1/6825 , C12Q1/701 , G01N27/127 , C12Q2563/116 , C12Q2563/137 , C12Q2563/157
摘要： Grafting M13 bacteriophage into an array of poly (3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.
摘要翻译：将M13噬菌体接枝到聚（3,4-乙烯二氧噻吩）（PEDOT）（PEDOT）纳米线的阵列中，产生导电聚合物和可复制遗传包装（rgps）如病毒的杂交体。通过光刻图案化的纳米线电沉积（LPNE）在电聚合过程中将rgps掺入PEDOT的聚合物骨架中。所得到的rgps-PEDOT纳米线阵列使生物相关缓冲液中分析物的实时，无试剂电化学生物传感。

3. 发明申请

WO2012047865A2 ELECTRICALLY CONDUCTIVE POLYMER NANOWIRES WITH INCORPORATED VIRUSES 审中-公开
公开(公告)号：WO2012047865A2
公开(公告)日：2012-04-12
申请号：PCT/US2011054736
申请日：2011-10-04
申请人： UNIV CALIFORNIA , WEISS GREGORY A , PENNER REGINALD M , ARTER JESSICA A , TAGGART DAVID K , DONAVAN KEITH C
发明人： WEISS GREGORY A , PENNER REGINALD M , ARTER JESSICA A , TAGGART DAVID K , DONAVAN KEITH C
IPC分类号： G01N33/50 , C12Q1/70 , G01N27/26
CPC分类号： C12Q1/70 , C12Q1/6825 , C12Q1/701 , G01N27/127 , C12Q2563/116 , C12Q2563/137 , C12Q2563/157
摘要： Grafting M13 bacteriophage into an array of poly (3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.

4. 发明申请

WO2007104058A2 METHOD AND APPARATUS FOR TARGET DETECTION USING ELECTRODE-BOUND VIRUSES 审中-公开
标题翻译：使用电极病毒检测目标的方法和装置
公开(公告)号：WO2007104058A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063723
申请日：2007-03-09
申请人： UNIV CALIFORNIA , WEISS GREGORY A , PENNER REGINALD M , TAM PHILLIP Y , YANG LI-MEI , BRIGHAM TYLER
发明人： WEISS GREGORY A , PENNER REGINALD M , TAM PHILLIP Y , YANG LI-MEI , BRIGHAM TYLER
IPC分类号： C12Q1/70
CPC分类号： G01N27/327 , G01N27/3277
摘要： A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.
摘要翻译：能够检测分析物或生物标志物的存在和/或浓度的生物传感器包括可操作地耦合到阻抗分析器的至少一个导电电极，用于响应于多个施加的交流电流来测量电极的电阻阻抗的变化的频率。在一个实施方案中，至少一个电极被化学键合到表面的自组装单层覆盖。多个病毒颗粒如噬菌体病毒固定在自组装单层上，并可暴露于测试或样品溶液中。病毒颗粒可以从噬菌体展示的文库中获得，以检测多种靶，包括例如DNA，RNA，小分子和蛋白质或多肽。在另一个实施方案中，病毒颗粒在布置在基底上的一对细长电极之间静电结合到基底上。

5. 发明申请

WO2010135431A3 COMPOSITIONS, DEVICES, AND METHODS RELATED TO PROSTATE-SPECIFIC MEMBRANE ANTIGEN 审中-公开
标题翻译：与前列腺特异性膜抗原相关的组合物，装置和方法
公开(公告)号：WO2010135431A3
公开(公告)日：2011-01-13
申请号：PCT/US2010035410
申请日：2010-05-19
申请人： WEISS GREGORY A , ARTER JESSICA , DIAZ JUAN E , UNIV CALIFORNIA
发明人： WEISS GREGORY A , ARTER JESSICA , DIAZ JUAN E
IPC分类号： C07K4/00 , A61K49/00 , A61K51/00
CPC分类号： G01N33/57434 , C12N9/6445
摘要： PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.
摘要翻译：因此公开了PSMA配体，组合物和方法，其中配体是具有序列X1X2CVEVX3QNSCX4X5的肽，其中X1-X5独立地是天然或非天然氨基酸或具有序列CALCEFLG [SEQ ID NO：1]的肽。特别优选的方面包括用于样品中PSMA的检测和/或定量的诊断试剂，治疗试剂和诊断成像试剂。

6. 发明专利

AU2016261850A1 Field-effect apparatus and methods for sequencing nucelic acids 未知
公开(公告)号：AU2016261850A1
公开(公告)日：2017-11-16
申请号：AU2016261850
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/68
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

7. 发明专利

CA2984112A1 FIELD-EFFECT APPARATUS AND METHODS FOR SEQUENCING NUCELIC ACIDS 未知
公开(公告)号：CA2984112A1
公开(公告)日：2016-11-17
申请号：CA2984112
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12M1/34
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

8. 发明专利

AU2016261850B2 Field-effect apparatus and methods for sequencing nucelic acids 未知
公开(公告)号：AU2016261850B2
公开(公告)日：2022-02-24
申请号：AU2016261850
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/68
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

9. 发明专利

CA2984112C FIELD-EFFECT APPARATUS AND METHODS FOR SEQUENCING NUCELIC ACIDS 未知
公开(公告)号：CA2984112C
公开(公告)日：2021-07-06
申请号：CA2984112
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/6869 , C12M1/34
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

10. 发明专利

SG11201708854PA FIELD-EFFECT APPARATUS AND METHODS FOR SEQUENCING NUCELIC ACIDS 未知
公开(公告)号：SG11201708854PA
公开(公告)日：2017-11-29
申请号：SG11201708854P
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/68
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

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