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1. 发明申请

US20070231385A1 Controlled Release Pharmaceutical Composition and a Process for Preparing the Same 审中-公开
标题翻译：控制释放药物组合物及其制备方法
公开(公告)号：US20070231385A1
公开(公告)日：2007-10-04
申请号：US10574320
申请日：2004-09-29
申请人： Himadri Sen , Suryakumar Jayanthi , Vineeth Raghavan , Ganga Arra
发明人： Himadri Sen , Suryakumar Jayanthi , Vineeth Raghavan , Ganga Arra
IPC分类号： A61K9/24 , A61K31/505 , A61K31/535 , A61K31/551 , A61K47/38
CPC分类号： A61K9/209
摘要： A three-drug antiretrovial pharmaceutical composition having a selective combination of a controlled release active formulation and an immediate release active formulation for once daily administration. The composition provides desired dosages of the actives lamivudine, zidovudine or pharmaceutically acceptable derivatives thereof, and the immediate release formulation including at least one selective Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI), preferably nevirapine or a pharmaceutically acceptable derivative thereof along with pharmaceutically acceptable excipients. The once daily composition would favour patient compliance and effective treatment. A method of reducing the pill burden in a patient suffering from HIV infection and/or Acquired Immunodeffieciency Syndrome by administering a once daily dose of the three-drug antiretroviral pharmaceutical composition.
摘要翻译：一种三药抗逆转录药物组合物，其具有控释活性制剂和立即释放活性制剂的选择性组合，每日一次给药。所述组合物提供所需剂量的拉米夫定，齐多夫定或其药学上可接受的衍生物，并且立即释放制剂包括至少一种选择性非核苷逆转录酶抑制剂（NNRTI），优选奈韦拉平或其药学上可接受的衍生物以及药学上可接受的赋形剂。每天一次的组合将有利于患者的顺应性和有效的治疗。一种通过施用一日剂量的三药抗逆转录病毒药物组合物来减少患有HIV感染和/或获得性免疫缺陷综合征的患者的药丸负担的方法。

2. 发明申请

US20070154562A1 INHALABLE BIODEGRADABLE MICROPARTICLES FOR TARGET-SPECIFIC DRUG DELIVERY IN TUBERCULOSIS AND A PROCESS THEREOF 审中-公开
标题翻译：用于靶向特异性药物输送在管腔内的可生物降解的微生物及其过程
公开(公告)号：US20070154562A1
公开(公告)日：2007-07-05
申请号：US11684562
申请日：2007-03-09
申请人： Himadri SEN , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pavan Muttil
发明人： Himadri SEN , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pavan Muttil
IPC分类号： A61K31/496 , A61K31/4965 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0053 , A61K9/1647 , A61K31/00 , A61K31/445 , A61K31/455
摘要： The present invention relates to a biodegradable microparticle composition useful for the target specific drug delivery to manage pulmonary tuberculosis, said composition comprising two anti-tuberculosis drugs, and a biodegradable polymer for drug delivery in a ratio of about 1:2 to 2: 1, wherein the anti-tubercular drugs are in the ratio of 1:2 to 2:1, also, a process for the preparation of the composition, and lastly, a method of treating pulmonary tuberculosis in a subject, said method comprising administering by inhalation alone or in combination with oral route, pharmaceutically effective amount of the composition to the subject in need thereof, wherein the dosage for inhalation is ranging between 0.5 to 10 mg/kg body weight/day and that for oral route is ranging between 4 to 32 mg/kg body weight/day.
摘要翻译：本发明涉及可用于目标特异性药物递送以管理肺结核的可生物降解的微粒组合物，所述组合物包含两种抗结核药物和用于药物递送的生物可降解聚合物，其比例为约1:2至2:1，其中抗结核药物的比例为1:2至2:1，也是制备组合物的方法，最后是治疗受试者肺结核的方法，所述方法包括单独给药或与口服途径组合的药物有效量的组合物与有需要的受试者组合，其中吸入剂量为0.5至10mg / kg体重/天，口服途径的范围为4至32mg / kg体重/天。

3. 发明申请

US20070154408A1 INHALABLE BIODEGRADABLE MICROPARTICLES FOR TARGET-SPECIFIC DRUG DELIVERY IN TUBERCULOSIS AND A PROCESS THEREOF 审中-公开
标题翻译：用于靶向特异性药物输送在管腔内的可生物降解的微生物及其过程
公开(公告)号：US20070154408A1
公开(公告)日：2007-07-05
申请号：US11684559
申请日：2007-03-09
申请人： Himadri Sen , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pavan Muttil
发明人： Himadri Sen , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pavan Muttil
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/0053 , A61K9/1647 , A61K31/00 , A61K31/445 , A61K31/455
摘要： The present invention relates to a biodegradable microparticle composition useful for the target specific drug delivery to manage pulmonary tuberculosis, said composition comprising two anti-tuberculosis drugs, and a biodegradable polymer for drug delivery in a ratio of about 1:2 to 2:1, wherein the anti-tubercular drugs are in the ratio of 1:2 to 2:1, also, a process for the preparation of the composition, and lastly, a method of treating pulmonary tuberculosis in a subject, said method comprising administering by inhalation alone or in combination with oral route, pharmaceutically effective amount of the composition to the subject in need thereof, wherein the dosage for inhalation is ranging between 0.5 to 10 mg/kg body weight/day and that for oral route is ranging between 4 to 32 mg/kg body weight/day.
摘要翻译：本发明涉及可用于目标特异性药物递送以管理肺结核的可生物降解的微粒组合物，所述组合物包含两种抗结核药物和用于药物递送的生物可降解聚合物，其比例为约1:2至2:1，其中抗结核药物的比例为1:2至2:1，也是制备组合物的方法，最后是治疗受试者肺结核的方法，所述方法包括单独给药或与口服途径组合的药物有效量的组合物与有需要的受试者组合，其中吸入剂量为0.5至10mg / kg体重/天，口服途径的范围为4至32mg / kg体重/天。

4. 发明申请

US20090208575A1 Pharmaceutical Composition Of Acid Labile Substances 审中-公开
标题翻译：酸不稳定物质的药物组成
公开(公告)号：US20090208575A1
公开(公告)日：2009-08-20
申请号：US11794748
申请日：2006-01-03
申请人： Jyothi Lakshmi Gunupati , Suryakumar Jayanthi , Himadri Sen
发明人： Jyothi Lakshmi Gunupati , Suryakumar Jayanthi , Himadri Sen
IPC分类号： A61K9/30 , A61K31/4439
CPC分类号： A61K31/133 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/4439 , A61K2300/00
摘要： A pharmaceutical composition for oral use comprising a) a core comprising an effective amount of benzimidazole and an organic stabilizing agent which is present in an amount effective to stabilize the composition, b) an intermediate layer comprising of a water insoluble polymer and an organic stabilizer, and c) an outer enteric coating layer. The organic stabilizing agent is present in the core from about 1% to about 10% by weight of the core and in the intermediate layer from about 5% to about 35% by weight of intermediate layer.
摘要翻译：一种用于口服使用的药物组合物，其包含a）包含有效量的苯并咪唑和有效稳定组合物的有机稳定剂的核心，b）包含水不溶性聚合物和有机稳定剂的中间层，和c）外肠衣层。有机稳定剂在核心中以核心的约1重量％至约10重量％存在，中间层中存在约5重量％至约35重量％的中间层。

5. 发明申请

US20050084455A1 Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof 审中-公开
标题翻译：用于结核分枝杆菌靶向特异性药物递送的可吸入的可生物降解微粒及其制备方法
公开(公告)号：US20050084455A1
公开(公告)日：2005-04-21
申请号：US10685567
申请日：2003-10-16
申请人： Himadri Sen , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pawan Muttil
发明人： Himadri Sen , Suryakumar Jayanthi , Rakesh Sinha , Rolee Sharma , Pawan Muttil
IPC分类号： A61K9/00 , A61K9/16 , A61K31/00 , A61K31/445 , A61K31/455 , A61L9/04 , A61K9/14 , A61K31/496
CPC分类号： A61K9/0075 , A61K9/0053 , A61K9/1647 , A61K31/00 , A61K31/445 , A61K31/455
摘要： The present invention relates to a biodegradable microparticle composition useful for the target specific drug delivery to manage pulmonary tuberculosis, said composition comprising two anti-tuberculosis drugs, and a biodegradable polymer for drug delivery in a ratio of about 1:2 to 2:1, wherein the anti-tubercular drugs are in the ratio of 1:2 to 2:1, also, a process for the preparation of the composition, and lastly, a method of treating pulmonary tuberculosis in a subject, said method comprising administering by inhalation alone or in combination with oral route, pharmaceutically effective amount of the composition to the subject in need thereof, wherein the dosage for inhalation is ranging between 0.5 to 10 mg/kg body weight/day and that for oral route is ranging between 4 to 32 mg/kg body weight/day.
摘要翻译：本发明涉及可用于目标特异性药物递送以管理肺结核的可生物降解的微粒组合物，所述组合物包含两种抗结核药物和用于药物递送的生物可降解聚合物，其比例为约1:2至2:1，其中抗结核药物的比例为1:2至2:1，也是制备组合物的方法，最后是治疗受试者肺结核的方法，所述方法包括单独给药或与口服途径组合的药物有效量的组合物与有需要的受试者组合，其中吸入剂量为0.5至10mg / kg体重/天，口服途径的范围为4至32mg / kg体重/天。

6. 发明申请

US20120045505A1 FIXED DOSE DRUG COMBINATION FORMULATIONS 审中-公开
标题翻译：固定剂量药物组合配方
公开(公告)号：US20120045505A1
公开(公告)日：2012-02-23
申请号：US13283747
申请日：2011-10-28
申请人： Badal Kumar Sasmal , Praveen Reddy Billa , Vijay Dinanathji Nasare , Mailatur Sivaraman Mohan , Suryakumar Jayanthi , Rajesh Dubey , Seshasayana Avvaru , Phanikumar Reddy Satti , Ranjan Mund Manas , Anitha Chidipothu , Varun Jain
发明人： Badal Kumar Sasmal , Praveen Reddy Billa , Vijay Dinanathji Nasare , Mailatur Sivaraman Mohan , Suryakumar Jayanthi , Rajesh Dubey , Seshasayana Avvaru , Phanikumar Reddy Satti , Ranjan Mund Manas , Anitha Chidipothu , Varun Jain
IPC分类号： A61K9/48 , A61P9/04 , A61P9/00 , A61P9/10 , A61K31/616 , A61P29/00
CPC分类号： A61K45/06 , A61K9/1652 , A61K9/2054 , A61K9/4808 , A61K9/5084 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/225 , A61K31/366 , A61K31/401 , A61K31/549 , A61K31/616 , A61K2300/00
摘要： Pharmaceutical formulations comprising multiple drugs, for treating or preventing cardiovascular disease. Embodiments are capsules containing individual drugs, or combinations of drugs, in the form of small tablets.
摘要翻译：包含多种药物的药物制剂，用于治疗或预防心血管疾病。实施例是包含小片形式的单独药物或药物组合的胶囊。

7. 发明申请

US20100075933A1 INJECTABLE COMPOSITIONS OF VITAMIN D COMPOUNDS 审中-公开
标题翻译：维生素D化合物的注射剂组合物
公开(公告)号：US20100075933A1
公开(公告)日：2010-03-25
申请号：US12509697
申请日：2009-07-27
申请人： Sunita Vijay Shelke , Subhasish Panda , Bikash Kumar Sahoo , Ravikumar Namballa , Hiren Patel , Suryakumar Jayanthi
发明人： Sunita Vijay Shelke , Subhasish Panda , Bikash Kumar Sahoo , Ravikumar Namballa , Hiren Patel , Suryakumar Jayanthi
IPC分类号： A61K31/59
CPC分类号： A61K31/59 , A61K9/0019 , A61K47/10
摘要： Pharmaceutical injectable compositions comprising at least one vitamin D compound as an active agent, processes for preparing such compositions, and methods of using such compositions.
摘要翻译：包含至少一种维生素D化合物作为活性剂的药物可注射组合物，制备该组合物的方法和使用该组合物的方法。

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