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1. 发明授权

US3969418A (4-Biphenylyl)-butenols 失效
标题翻译：（4-联苯基） - 丁烯醇
公开(公告)号：US3969418A
公开(公告)日：1976-07-13
申请号：US485574
申请日：1974-07-03
申请人： Helmut Teufel , Wolfhard Engel , Ernst Seeger
发明人： Helmut Teufel , Wolfhard Engel , Ernst Seeger
IPC分类号： C07C31/34 , C07C31/14
摘要： Compounds of the formula ##SPC1##Wherein A is ##EQU1## or WHERE Z is hydrogen or methyl, andR.sub.1 is halogen or, when A is ##EQU2## also hydrogen, THE COMPOUNDS ARE USEFUL AS ANTIPHLOGISTICS.
摘要翻译：式WHEREIN A的化合物是Z CH 3 | | C = CH-CH 2 - 或-C = CH-或者其中Z是氢或甲基，并且R 1是卤素，或者当A是Z | -C = CH-CH 2 - ，也是氢，化合物作为抗肿瘤药物有用。

2. 发明授权

US4021479A Derivatives of 4-(4-biphenylyl)-butyric acid 失效
标题翻译： 4-（4-联苯基） - 丁酸的衍生物
公开(公告)号：US4021479A
公开(公告)日：1977-05-03
申请号：US406196
申请日：1973-10-15
申请人： Ernst Seeger , Wolfhard Engel , Josef Nickl , Helmut Teufel
发明人： Ernst Seeger , Wolfhard Engel , Josef Nickl , Helmut Teufel
IPC分类号： C07C57/58 , C07C63/333 , C07C65/14
CPC分类号： C07C205/56 , C07C57/58 , Y10S514/916
摘要： Compounds of the formulas ##STR1## and ##STR2## wherein A is --CH.sub.2 -- or --CH(OH)--,R.sub.1 is hydrogen, halogen or, when R.sub.2 and R.sub.3 are other than both hydrogen, also methyl,R.sub.2 is hydrogen, halogen, cyano, nitro, amino or (alkanoyl of 1 to 4 carbon atoms)-amino,R.sub.3 is hydrogen or halogen,Provided, however, that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, andR.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and non-toxic salts of the free acids (R.sub.4 = H) formed with inorganic or organic bases; the compounds as well as their salts are useful as antiphlogistics and antiproliferatives.
摘要翻译：其中A是-CH 2 - 或-CH（OH） - ，R 1是氢，卤素，或者当R 2和R 3不同于氢时，也是甲基，R 2是氢，卤素，氰基，硝基，氨基或（1至4个碳原子的烷酰基） - 氨基，R3是氢或卤素，提供，然而，至少一个R 1，R 2和R 3不是氢，并且R 4是氢或烷基 1至4个碳原子的无毒盐和无机或有机碱形成的游离酸（R4 = H）的无毒盐; 化合物及其盐可用作消炎剂和抗增殖剂。

3. 发明授权

US3992535A 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US3992535A
公开(公告)日：1976-11-16
申请号：US626623
申请日：1975-10-29
申请人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/04 , A61K31/54
CPC分类号： C07D275/06 , C07D279/02
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.
摘要翻译：式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基，噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

4. 发明授权

US3987197A 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof 失效
标题翻译： 3-（2'-氟-4-二苯基） - 丁酸及其盐
公开(公告)号：US3987197A
公开(公告)日：1976-10-19
申请号：US577170
申请日：1975-05-14
申请人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Josef Nickl , Gunther Engelhardt
发明人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Josef Nickl , Gunther Engelhardt
IPC分类号： C07C45/46 , C07C57/58 , C07C57/76 , C07C63/333 , C07C245/14 , C07F9/54
CPC分类号： C07C245/14 , C07C255/00 , C07C45/46 , C07C57/58 , C07C57/76 , C07F9/5407
摘要： 3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof formed with inorganic or organic bases; the compound as well as its salts are useful as antiphlogistics and antirheumatics.

5. 发明授权

US3997589A 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof 失效
标题翻译： 4-（2 {40-氟-4-联苯基] -4-氧代 - 丁酸及其酯及其盐
公开(公告)号：US3997589A
公开(公告)日：1976-12-14
申请号：US543266
申请日：1975-01-23
申请人： Ernst Seeger , Wolfhard Engel , Josef Nickl , Helmut Teufel
发明人： Ernst Seeger , Wolfhard Engel , Josef Nickl , Helmut Teufel
IPC分类号： C07C57/58 , C07C65/20 , C07C69/76
CPC分类号： C07C57/58
摘要： Compounds of the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 4 carbon atoms, and, when R is hydrogen, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antiphlogistics and antiproliferatives.
摘要翻译：其中R是氢或1至4个碳原子的烷基，当R是氢时，其无机盐与无机或有机碱形成; 化合物以及盐可用作消炎剂和抗增殖剂。

6. 发明授权

US3969419A 3-(2-Halo-4-biphenylyl)-1-butanols and derivatives thereof 失效
标题翻译： 3-（2-卤代-4-联苯基）-1-丁醇及其衍生物
公开(公告)号：US3969419A
公开(公告)日：1976-07-13
申请号：US497716
申请日：1974-08-15
申请人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Gunther Engelhardt
发明人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Gunther Engelhardt
IPC分类号： C07C69/007 , C07C27/00 , C07C29/147 , C07C33/46 , C07C43/178 , C07C45/71 , C07C51/41 , C07C67/00 , C07C69/12 , C07C69/22 , C07C69/76 , C07C69/773 , C07D213/55 , C07D213/79 , C07C31/14 , C07C69/14 , C07C69/24 , C07C69/78
CPC分类号： C07D213/79 , C07C43/1786 , C07C45/71
摘要： Compounds of the formula formula ##EQU1## wherein R.sub.1 is chlorine or fluorine, and R.sub.2 is hydrogen, alkanoyl of 1 to 10 carbon atoms, benzoyl, nicotinoyl or isonicotinoyl,Or, when R.sub.2 contains a basic nitrogen atom, a non-toxic, pharmacologically acceptable salt thereof formed with an inorganic or organic acid; the compounds as well as the salts are useful as antiphlogistics.
摘要翻译：化学式为CH 3 | CH-CH 2 -CH 2 -OR 2的化合物，其中R 1是氯或氟，R 2是氢，1-10个碳原子的烷酰基，苯甲酰基，烟酰基或异烟酰基，OR，当R 2含有碱性氮原子时，由无机或有机酸形成的无毒的药学上可接受的盐; 化合物以及盐可用作消炎剂。

7. 发明授权

US3969523A Antiphlogistic pharmaceutical compositions containing a 1-(nicotinoyl or isonicotinoyl)-3-biphenylyl-alkanone-(2) 失效
标题翻译：含有1-（烟酰基或异烟酰基）-3-联苯基 - 烷酮（2）的消炎药物组合物
公开(公告)号：US3969523A
公开(公告)日：1976-07-13
申请号：US607667
申请日：1975-08-25
申请人： Josef Nickl , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
发明人： Josef Nickl , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
IPC分类号： C07D307/85 , A61K31/455
CPC分类号： C07D307/85 , C07C45/64 , Y10S514/87
摘要： Pharmaceutical compositions containing a compound of the formula ##SPC1##WhereinR.sub.1 is hydrogen, fluoro or chloro,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, andR.sub.3 is nicotinoyl or isonicotinoyl, or an optically active antipode thereof; and a method of using the same as antiphlogistics.
摘要翻译：含有下式化合物的药物组合物，其中R 1为氢，氟或氯，R 2为氢或1至3个碳原子的烷基，R 3为烟酰基或异烟酰基或其光学活性对映体; 以及将其用作消炎药的方法。

8. 发明授权

US3950427A Araliphatic ketones and carbinols 失效
标题翻译：脂肪族酮和甲醇
公开(公告)号：US3950427A
公开(公告)日：1976-04-13
申请号：US532174
申请日：1974-12-12
申请人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
发明人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
IPC分类号： C07C49/20 , C07C27/00 , C07C29/136 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/40 , C07C33/18 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/40 , C07C33/46 , C07C33/48 , C07C33/50 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/62 , C07C45/67 , C07C49/233 , C07C49/235 , C07C49/237 , C07C67/00 , C25B3/04 , C07C49/76 , C07C49/80
CPC分类号： C25B3/04 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/175 , C07C29/40 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/46 , C07C33/483 , C07C33/486 , C07C33/50 , C07C45/004 , C07C45/29 , C07C45/513 , C07C45/62 , C07C45/74 , C07C49/215 , C07C49/217 , C07C49/225 , C07C49/233 , C07C49/235 , C07C49/237 , C07B2200/09 , C07C2101/14 , C07C2101/18
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is isobutyl, phenyl, o-fluoro-phenyl, o-chloro-phenyl, cyclopentyl, cyclohexyl, methyl-cyclo-hexyl or cycloheptyl,R.sub.2 is hydrogen, fluorine, chlorine or bromine,R.sub.3 is methyl, ethyl or, when R.sub.1 is phenyl, fluoro-phenyl or chloro-phenyl, or R.sub.1 is cyclohexyl and R.sub.2 is halogen, also hydrogen,Z.sub.1 and Z.sub.2 are hydrogen or together form an additional carbon-to-carbon bond,A is ##EQU1## or ##EQU2## and M IS 2, 4, 6, 8 OR WHEN R.sub.1 is halo-phenyl, isobutyl, cyclohexyl, methyl-cyclohexyl, cyclopentyl or cycloheptyl and/or R.sub.2 is halogen and/or R.sub.3 is methyl or ethyl and/or A is --CH(OH)--, also O; the compounds are useful as antiphlogistics.
摘要翻译：式WHERE R1的化合物是异丁基，苯基，邻 - 氟 - 苯基，邻 - 氯 - 苯基，环戊基，环己基，甲基 - 环己基或环庚基，R2是氢，氟，氯或溴，R3是甲基，乙基或者当R 1为苯基，氟代苯基或氯代苯基或R 1为环己基且R 2为卤素时，氢，Z 1和Z 2为氢或一起形成另外的碳 - 碳键，A为O并原-C - 或HOH ANGLE -C-和M为2,4,6,8或当R 1为卤代苯基，异丁基，环己基，甲基 - 环己基，环戊基或环庚基和/或R 2为卤素和/或R 3为甲基或乙基和/或A是-CH（OH） - ，也是O; 该化合物可用作消炎药。

9. 发明授权

US4137313A 2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 2,5-二氢-1,2-噻嗪（5,6-b）吲哚-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4137313A
公开(公告)日：1979-01-30
申请号：US872889
申请日：1978-01-27
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： A61K31/54 , A61P7/02 , A61P29/00 , C07D209/42 , C07D513/04 , C07D513/14 , A61K31/38
CPC分类号： C07D513/04 , C07D209/42 , C07D513/14 , Y10S514/822
摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.
摘要翻译：式中的化合物，其中R1是氢，甲基或乙基; R2是甲基或乙基; Y是氢，氟，氯，溴，甲氧基，甲基，乙基或三氟甲基; 并且Ar是可以具有一个或两个连接到其上的甲基或乙基取代基的2-噻唑基; 5,6-二氢-4H-环戊基噻唑-2-基; 4,5,6,7-四氢-2-苯并噻唑基; 2-苯并噻唑基可具有与其连接的甲基取代基的3-异噻唑基; 可以具有连接到其上的甲基或羟基取代基的2-吡啶基; 3-吡啶基; 4-吡啶基; 4-嘧啶基; 吡嗪基 2-苯并咪唑基; 可具有与其连接的甲基取代基的2-恶唑基; 2-苯并恶唑基; 或可具有与其连接的氟，氯，溴，甲基，乙基，三氟甲基或甲氧基取代基的苯基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂和血小板聚集抑制剂。

10. 发明授权

US4328235A Suppressing pain with benzothiazol-2(3H)-ones 失效
标题翻译：用苯并噻唑-2（3H）酮抑制疼痛
公开(公告)号：US4328235A
公开(公告)日：1982-05-04
申请号：US163965
申请日：1980-06-30
申请人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
发明人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , A61K31/428 , A61P25/04 , A61P29/00 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425
摘要： There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.
摘要翻译：描述了含有作为活性物质的通式为“IMAGE”的苯并噻唑-2（3H） - 酮的药物组合物，其中R表示氢原子或甲基，甲氧基或乙氧基。药物组合物用作止痛剂和解热药，并且几乎没有或没有高铁血红蛋白形成活性。

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