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1. 发明申请

WO2009074985A2 METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT 审中-公开
标题翻译：检测预防和危及患者健康的其他条件的方法和系统
公开(公告)号：WO2009074985A2
公开(公告)日：2009-06-18
申请号：PCT/IL2008001600
申请日：2008-12-10
申请人： HADASIT MED RES SERVICE , BEN-OREN ILAN , ILAN YARON
发明人： BEN-OREN ILAN , ILAN YARON
IPC分类号： A61B5/16
CPC分类号： A61B5/024 , A61B5/01 , A61B5/021 , A61B5/026 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/4094 , A61B5/4261 , A61B5/4839 , A61B5/7275 , G16H40/63 , G16H50/20 , G16H50/50
摘要： The invention is a method and system for the detection and warning of the presence of pre-fainting and other conditions that are hazardous to the health of a patient having one or more types of disease or disorder. A wide range of physiological and physical parameters are monitored and at least two of the monitored parameters are logically and/or mathematically combining to form a function that is used to determine the value of a new parameter called the risk parameter alpha. The parameters that appear in the function are selected according to the patient's known pathological condition. An initial threshold value for alpha based on known normal values of the monitored parameters as determined by statistical studies is determined. The current value of alpha, defined as alpha(t), is determined from the function and compared to the initial value of alpha. If the comparison shows that there exists danger of the onset of a pre-fainting and/or other medically hazardous condition a warning signal is emitted. The values of alpha and the terms and parameters that comprise the function used to determine alpha(t) are continually determined and, if relevant, updated according to the history of the patient. In preferred embodiments of the invention self learning techniques are used to update the values of alpha and the function.
摘要翻译：本发明是用于检测和警告对具有一种或多种类型的疾病或病症的患者的健康有害的预晕化和其它状况的检测和警告的方法和系统。监测范围广泛的生理和物理参数，并且所监视的参数中的至少两个在逻辑上和/或数学上组合以形成用于确定称为风险参数α的新参数的值的函数。根据患者已知的病理状况选择功能中出现的参数。确定基于通过统计学研究确定的所监测参数的已知正常值的α的初始阈值。 α的当前值，定义为α（t），从该函数确定并与α的初始值进行比较。如果比较表明存在发生预晕和/或其他医疗危险状况的危险，则发出警告信号。 α和包含用于确定α（t）的函数的术语和参数的值是不断确定的，并且如果相关的话根据患者的病史更新。在本发明的优选实施例中，使用自学习技术来更新α和功能的值。

2. 发明申请

WO2007138574A3 MONITORING RESPONSIVENESS TO AND SCREENING FOR THERAPEUTIC COMPOUNDS THAT MODULAT COMPOSITION AND STRUCTURE OF CELL MEMBRANES 审中-公开
标题翻译：监测调节组合物和细胞膜结构的治疗化合物的反应和筛选
公开(公告)号：WO2007138574A3
公开(公告)日：2009-04-23
申请号：PCT/IL2007000633
申请日：2007-05-24
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A61K31/7028 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/5047
摘要： The present invention relates to modulation of structure and composition of cell membranes by a given therapeutic compound, preferably, a ß-glycolipid and thereby to modulation and treatment of pathologic disorders. More particularly, the invention relates to the use of modulation of structure and composition of immune cell membranes by a candidate therapeutic compound as a diagnostic marker for prediction and monitoring of response to treatment. The invention further provides a method of screening for substances which modulate the structure and composition of cell membranes, as well as compositions and methods using the substances identified by the screening method of the invention, for the treatment of pathologic disorders.
摘要翻译：本发明涉及通过给定的治疗化合物，优选β-糖脂调节细胞膜的结构和组成，从而调节和治疗病理性疾病。更具体地，本发明涉及通过候选治疗化合物调节免疫细胞膜的结构和组成的用途，作为对治疗反应的预测和监测的诊断标记。本发明还提供了筛选调节细胞膜的结构和组成的物质的方法，以及使用通过本发明的筛选方法鉴定的物质用于治疗病理性疾病的组合物和方法。

3. 发明申请

WO02051986A2 EDUCATED NK T CELLS AND THEIR USES IN THE TREATMENT OF IMMUNE-RELATED DISORDERS 审中-公开
标题翻译：受教育的NK T细胞及其在治疗免疫相关疾病中的用途
公开(公告)号：WO02051986A2
公开(公告)日：2002-07-04
申请号：PCT/IL0101197
申请日：2001-12-24
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A61K35/14 , A61K38/19 , C12N5/0783 , C12N5/00
CPC分类号： C12N5/0646 , A61K35/17 , A61K39/0008 , A61K2039/5158 , A61K2039/542 , A61K2039/577 , C07K16/2803 , C12N5/0087 , C12N2502/1114
摘要： The present invention relates to a method for the treatment of immune-related disorders in a mammalian subject in need of such treatment. This method comprises the step of manipulating the NK T cell population in said subject by suitable means, said manipulation of the NK T cell population resulting in modulation of the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. Manipulation of the NK T cell population may be performed either by depletion of said cells by a suitable means or alternatively by ex vivo education of the NK T cells, such that the educated NK T cells have the capability to modulate the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. The invention further relates to pharmaceutical compositions for the treatment of immune-related disorders in a mammalian subject. These compositions comprising as an effective ingredient an ex vivo educated NK T cell. The invention further provides for an ex vivo educated NK T cell and uses thereof in the treatment of immune-related disorders.
摘要翻译：本发明涉及治疗需要这种治疗的哺乳动物受试者的免疫相关病症的方法。该方法包括通过合适的手段操纵所述受试者中的NK T细胞群的步骤，所述NK T细胞群的操作导致Th1 / Th2平衡向抗炎细胞因子产生细胞的调节。 NK T细胞群的操作可以通过用合适的手段耗尽所述细胞或者通过离体培养NK T细胞来进行，使得受过教育的NK T细胞具有调节Th1 / Th2平衡的能力抗炎细胞因子产生细胞。本发明进一步涉及用于治疗哺乳动物受试者中免疫相关病症的药物组合物。这些组合物包含离体培养的NK T细胞作为有效成分。本发明进一步提供了离体培养的NK T细胞及其用于治疗免疫相关病症的用途。

4. 发明申请

WO2010125565A3 ANTI-LPS ENRICHED IMMUNOGLOBULIN PREPARATION FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF A PATHOLOGIC DISORDER 审中-公开
标题翻译：抗LPS增强的免疫球蛋白制剂用于治疗和/或预防病理学疾病的预防
公开(公告)号：WO2010125565A3
公开(公告)日：2011-01-27
申请号：PCT/IL2010000339
申请日：2010-04-27
申请人： HADASIT MED RES SERVICE , ILAN YARON , LALAZAR GADI , ADAR TOMER , MIZRAHI MEIR , BEN-YA ACOV AMI
发明人： ILAN YARON , LALAZAR GADI , ADAR TOMER , MIZRAHI MEIR , BEN-YA ACOV AMI
IPC分类号： C07K16/04 , A61K35/20 , A61K39/395 , C07K16/12 , C07K16/26 , G01N33/68
CPC分类号： A61K39/39508 , A61K2039/505 , A61K2039/507 , C07K16/04 , C07K16/1232 , C07K16/26 , C07K2317/12
摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.
摘要翻译：本发明涉及富含抗LPS抗体的制剂的使用，例如衍生自哺乳动物初乳或禽卵的那些制剂，以及任选的抗疾病相关抗原，初乳，乳或乳制品组分的任何其它抗体以及任何用于治疗，延缓或预防慢性肝病，肝硬化以及与之相关的任何并发症或紊乱等病理疾病的进展。本发明还涉及组合的组合物，其包含抗LPS富集的抗体制剂和识别至少一种对病理学病症特异的抗原的抗体的组合及其在治疗免疫相关病症中的用途。

5. 发明申请

WO2009072132A3 BETA GLYCOLIPIDS FOR THE TREATMENT OF CALCIFICATION RELATED DEGENERATIVE DISORDERS 审中-公开
标题翻译：用于治疗与钙化相关的退化性疾病的β - 甘油脂
公开(公告)号：WO2009072132A3
公开(公告)日：2009-08-13
申请号：PCT/IL2008001587
申请日：2008-12-07
申请人： HADASIT MED RES SERVICE , ILAN YARON , LOTAN HAIM , SHUVY MONY , LALAZAR GADI
发明人： ILAN YARON , LOTAN HAIM , SHUVY MONY , LALAZAR GADI
IPC分类号： A61K31/662 , A61K31/7028 , A61K31/7032 , A61K45/06 , A61P9/10
CPC分类号： A61K31/7028 , A61K31/662 , A61K31/7032 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a composition comprising a combination of at least one natural or synthetic ß-glycolipid, a mixture of at least two ß-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring ß-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof. The combined composition of the invention may be particularly used for treating calcification related degenerative disorders, specifically, vascular and valvular disorders. The invention further provides kits methods and uses thereof for treatment of calcification related disorders.
摘要翻译：本发明涉及包含至少一种天然或合成β-糖脂，至少两种β-糖脂的混合物，增加天然β-糖脂的细胞内，细胞外或血清水平的物质的组合物，或其任何组合或混合物，以及至少一种磷酸盐抑制剂或任何改变磷酸盐结合或运输进入或运出任何细胞或任何膜或其任何组合的化合物。本发明的组合组合物可特别用于治疗与钙化有关的退行性病症，特别是血管和瓣膜病症。本发明进一步提供了用于治疗钙化相关病症的试剂盒方法和用途。

6. 发明申请

WO2012017435A3 SOYBEAN EXTRACTS FOR THE TREATMENT OF HEPATIC DISORDERS 审中-公开
标题翻译：大豆提取物治疗肝脏疾病
公开(公告)号：WO2012017435A3
公开(公告)日：2016-05-19
申请号：PCT/IL2011000632
申请日：2011-08-04
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A23J1/14 , A61K36/00 , C07K1/00 , C07K14/00
CPC分类号： A61K36/48 , A61K31/167
摘要： The invention provides methods and uses of different soybean extracts, for example, enzymatic, hexane, ethanol or aqueous soybean extracts and combinations thereof for the treatment of hepatic disorders, drug induced hepatic injury, the Metabolic Syndrome or an immune-related disorder in a subject in need thereof. The invention further provides pharmaceutical compositions, kits and methods thereof for treating and preventing hepatic disorders.
摘要翻译：本发明提供不同大豆提取物的方法和用途，例如酶促，己烷，乙醇或水性大豆提取物及其组合，用于治疗受试者的肝脏疾病，药物诱导的肝损伤，代谢综合征或免疫相关疾病需要它。本发明还提供了用于治疗和预防肝脏疾病的药物组合物，试剂盒及其方法。

7. 发明申请

WO2012017435A8 SOYBEAN EXTRACTS FOR THE TREATMENT OF HEPATIC DISORDERS 审中-公开
标题翻译：大豆提取物治疗肝病
公开(公告)号：WO2012017435A8
公开(公告)日：2012-04-12
申请号：PCT/IL2011000632
申请日：2011-08-04
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A61K36/48
CPC分类号： A61K36/48 , A61K31/167
摘要： The invention provides methods and uses of different soybean extracts, for example, enzymatic, hexane, ethanol or aqueous soybean extracts and combinations thereof for the treatment of hepatic disorders, drug induced hepatic injury, the Metabolic Syndrome or an immune-related disorder in a subject in need thereof. The invention further provides pharmaceutical compositions, kits and methods thereof for treating and preventing hepatic disorders.
摘要翻译：本发明提供了不同的大豆提取物例如酶促，己烷，乙醇或含水大豆提取物及其组合用于治疗受试者的肝病，药物诱导的肝损伤，代谢综合征或免疫相关病症的方法和用途有需要的。本发明进一步提供了用于治疗和预防肝脏疾病的药物组合物，试剂盒及其方法。

8. 发明申请

WO2011027344A3 COMBINATION OF VITAMIN E AND BETA-GLYCOSPHINGOLIPIDS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING HEPATIC DISORDERS 审中-公开
标题翻译：组合物中维生素E和β-谷氨酸蛋白酶的组合以及预防和治疗肝脏疾病的方法
公开(公告)号：WO2011027344A3
公开(公告)日：2011-06-23
申请号：PCT/IL2010000713
申请日：2010-08-31
申请人： HADASIT MED RES SERVICE , ILAN YARON , MIZRAHI MEIR , BEN-YA ACOV AMI
发明人： ILAN YARON , MIZRAHI MEIR , BEN-YA ACOV AMI
IPC分类号： A61K31/355 , A61K31/7028 , A61K45/06 , A61P43/00
CPC分类号： A61K31/355 , A61K31/167 , A61K31/7028 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combined compositions comprising a combination of at least one natural or synthetic beta-glycolipid and at least one tocopherol (vitamin E). The invention further provides methods and kits using said combined compositions for treating and preventing hepatic disorders, specifically, liver insult cause by hepatotoxic drugs or caused by any one of infectious, metabolic, toxic, immune, or perfusion or blood flow related hepatic injury.
摘要翻译：本发明涉及包含至少一种天然或合成β-糖脂与至少一种生育酚（维生素E）的组合的组合组合物。本发明还提供了使用所述组合组合物治疗和预防肝脏疾病，特别是肝毒性药物引起的肝脏损伤或由感染性，代谢性，毒性，免疫或灌注或与血液相关的肝损伤中的任何一种引起的组合组合物的方法和试剂盒。

9. 发明申请

WO2009090656A3 COMBINATION THERAPY OF BETA-GLYCOLIPIDS AND ANTIBODIES FOR THE TREATMENT OF IMMUNE-RELATED DISORDERS 审中-公开
标题翻译： β-GLYCOLIPIDS与治疗免疫相关疾病的抗体的联合治疗
公开(公告)号：WO2009090656A3
公开(公告)日：2010-01-28
申请号：PCT/IL2009000072
申请日：2009-01-18
申请人： HADASIT MED RES SERVICE , BRIGHAM & WOMENS HOSPITAL , ILAN YARON , WEINER HOWARD L
发明人： ILAN YARON , WEINER HOWARD L
IPC分类号： A61K45/06 , A61K31/70 , A61K39/39 , A61P3/10 , A61P37/02 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/7028 , A61K31/7032 , A61K45/06 , C07K16/2809 , A61K2300/00
摘要： The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably, ß-glycosphingolipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immuno- modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 antibody (OKT3) is orally administered in combination with ß-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes.
摘要翻译：本发明涉及用于治疗免疫相关疾病的组合疗法。更具体地，本发明涉及将β-糖脂，优选β-糖苷脂与与来自免疫系统的组分的至少一种抗原特异性的免疫球蛋白分子，特别是抗CD3抗体组合的口服或粘膜协同组合物。本发明还提供了本发明的组合组合物用于免疫调节从而用于治疗免疫相关疾病的方法试剂盒和用途。在优选的实施方案中，在2型糖尿病的动物模型中，抗-CD3抗体（OKT3）与β葡萄糖神经酰胺（也称为糖脑啡肽）组合口服给药。

10. 发明申请

WO2008050344A3 TREATMENT OF HEPATIC ENCEPHALOPATHY AND LIVER CIRRHOSIS 审中-公开
标题翻译：治疗肝硬化和肝循环
公开(公告)号：WO2008050344A3
公开(公告)日：2008-08-28
申请号：PCT/IL2007001300
申请日：2007-10-25
申请人： YISSUM RES DEV CO , HADASIT MED RES SERVICE , ARISTOTLE UNIVERSITY OF THESSA , BERRY ELLIOT , AVRAHAM YOSEFA , MECHOULAM RAPHAEL , ILAN YARON , DAGON YOSSI , MAGEN IDDO , GRIGORIADIS NICHOLAS , POUTACHIDIS THEOFILOS
发明人： BERRY ELLIOT , AVRAHAM YOSEFA , MECHOULAM RAPHAEL , ILAN YARON , DAGON YOSSI , MAGEN IDDO , GRIGORIADIS NICHOLAS , POUTACHIDIS THEOFILOS
IPC分类号： A61K31/05 , A61K31/09 , A61K31/165 , A61K31/232 , A61K31/352 , A61P1/16
CPC分类号： A61K31/05 , A61K31/09 , A61K31/165 , A61K31/232 , A61K31/352
摘要： The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
摘要翻译：化合物D9-四氢大麻酚（THC），大麻二酚（CBD）和辣椒素可用于肝性脑病的预防，治疗或两者。化合物辣椒素，2-花生四烯酰甘油（2-AG），HU-308和大麻二醇可用于预防，治疗或两者的肝硬化。

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