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1. 发明授权

EP1532168B1 METHOD FOR REFOLDING NEISSERIAL NSPA PROTEIN 有权
标题翻译：方法折叠蛋白NSPA淋球菌作者：
公开(公告)号：EP1532168B1
公开(公告)日：2014-07-23
申请号：EP03757819.2
申请日：2003-08-28
申请人： GlaxoSmithKline Biologicals s.a. , Utrecht University
发明人： Biemans, Ralph , Bos, Martine , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Tommassen, Jan , Weynants, Vincent
IPC分类号： C07K14/22 , A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , C07K14/22
摘要： The present invention provides an isolated refolded NspA protein, and a method of preparing it.

2. 发明公开

EP2481419A2 NEISSERIAL VACCINES 审中-公开
标题翻译：奈瑟-IMPFSTOFF
公开(公告)号：EP2481419A2
公开(公告)日：2012-08-01
申请号：EP12157807.4
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer-membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines which have been rendered safer and/or more effective for use in human subjects. In particular combinations of gene downregulations are described such as PorA & OpA, PorA and OpC, OpA and OpC, and PorA and OpA and OpC. The FrpB downregulation is also described. Alternatively, or in addition, IgtB - is shown to be an optimal mutation for effectively and safely using L3 and/or L2 LOS in Neisseria vaccine compositions. Bleb vaccines derived from IgtB - and capsular polysaccharide deficient meningococcal mutants are further described; as are advantageous methods of making bleb preparations where LOS is to be retained as an important antigen.
摘要翻译：本发明涉及奈瑟氏球菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的应用。更具体地说，涉及制备新型工程化脑膜炎球菌菌株的方法，这些菌株更适合于产生奈司菌素，特别是脑膜炎球菌，外膜囊泡（或气泡）疫苗。还基于使用已经变得更安全和/或更有效地用于人类受试者的新型LOS亚单位或脑膜炎球菌外膜囊泡（或泡沫）疫苗来描述有利的方法和疫苗产品。描述了基因下调的组合，例如PorA和OpA，PorA和OpC，OpA和OpC，以及PorA和OpA和OpC。还描述了FrpB下调。或者或另外，IgtB-被证明是在奈瑟氏球菌疫苗组合物中有效和安全地使用L3和/或L2 LOS的最佳突变。衍生自IgtB-和荚膜多糖缺乏型脑膜炎球菌突变体的Bleb疫苗进一步描述; 制备其中保留LOS作为重要抗原的泡制剂的有利方法也是如此。

3. 发明公开

EP2258386A3 Neisseria Vaccine composition 审中-公开
公开(公告)号：EP2258386A3
公开(公告)日：2011-11-02
申请号：EP10177891.8
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095 , C07K14/22 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.

4. 发明公开

EP2255826A3 NEISSERIAL VACCINE COMPOSITIONS COMPRISING A COMBINATION OF ANTIGENS 有权
标题翻译：奈瑟疫苗组合抗原的组合CONTAIN
公开(公告)号：EP2255826A3
公开(公告)日：2012-03-28
申请号：EP10177890.0
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.

5. 发明公开

EP2258386A2 Neisseria Vaccine composition 审中-公开
标题翻译：奈瑟菌疫苗组合物
公开(公告)号：EP2258386A2
公开(公告)日：2010-12-08
申请号：EP10177891.8
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译：本发明涉及用于治疗和预防奈瑟球菌病的免疫原性组合物和疫苗。本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原组合，所述抗原包括粘附素，自转运蛋白，毒素，铁获取蛋白和膜结合蛋白（优选整体外膜蛋白）。抗原的这种组合能够靶向针对奈瑟氏菌生命周期的不同方面的免疫应答，导致更有效的免疫应答。

6. 发明公开

EP2258384A3 Neisseria vaccine composition 无效
标题翻译：奈瑟菌疫苗组合物
公开(公告)号：EP2258384A3
公开(公告)日：2011-12-28
申请号：EP10177881.9
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.

7. 发明公开

EP2255826A2 NEISSERIAL VACCINE COMPOSITIONS COMPRISING A COMBINATION OF ANTIGENS 有权
标题翻译： NEISSERIA IMPFSTOFFZUSAMMENSETZUNGEN DIE EINE KOMBINATION VON ANTIGENEN ENTHALTEN
公开(公告)号：EP2255826A2
公开(公告)日：2010-12-01
申请号：EP10177890.0
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译：本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自体转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。

8. 发明授权

EP2255826B1 NEISSERIAL VACCINE COMPOSITIONS COMPRISING A COMBINATION OF ANTIGENS 有权
标题翻译：奈瑟疫苗组合抗原的组合CONTAIN
公开(公告)号：EP2255826B1
公开(公告)日：2016-04-13
申请号：EP10177890.0
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.

9. 发明公开

EP2258387A3 Neisseria vaccine composition 审中-公开
标题翻译：奈瑟菌疫苗组合物
公开(公告)号：EP2258387A3
公开(公告)日：2011-10-19
申请号：EP10177892.6
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095 , C07K14/22 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.

10. 发明公开

EP2258387A2 Neisseria vaccine composition 审中-公开
标题翻译： Neisseria Impfstoffzusammensetzung
公开(公告)号：EP2258387A2
公开(公告)日：2010-12-08
申请号：EP10177892.6
申请日：2003-07-31
申请人： GlaxoSmithKline Biologicals S.A.
发明人： Berthet, Francois-Xavier Jacques , Biemans, Ralph , Denoel, Philippe , Feron, Christiane , Goraj, Carine , Poolman, Jan , Weynants, Vincent
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译：本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自体转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。

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