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1. 发明授权

US5693753A Method of isolating .beta.A4 peptide species ending at carboxy-terminals residue 42 using monoclonal antibody 369.2B 失效
标题翻译：使用单克隆抗体369.2B分离终止于羧基末端残基42的β4A肽物质的方法
公开(公告)号：US5693753A
公开(公告)日：1997-12-02
申请号：US472627
申请日：1995-06-07
申请人： Gerhard Konig , Paul Graham
发明人： Gerhard Konig , Paul Graham
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P25/28 , C07K1/14 , C07K1/22 , C07K7/08 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , C07K14/4711 , A61K2039/505 , A61K38/00
摘要： The instant invention provides for monoclonal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
摘要翻译：本发明提供对βA4肽特异的单克隆抗体369.2B，特别是βA4“1-42”的游离C-末端但不是“1-43”，并且染色扩散和纤维状淀粉样蛋白，血管淀粉样蛋白和神经原纤维缠结。本发明进一步提供具有相同结合特异性的抗体片段及其构建体。本发明还提供了使用本发明的抗体治疗独特形式的β-A4肽的诊断，筛选和治疗方法。

2. 发明授权

US5679531A Methods of detecting .beta.A4 peptide species ending at carboxy-terminus residue 42 using monoclonal antibody 369.2B 失效
标题翻译：使用单克隆抗体369.2B检测以羧基末端残基42结束的β4A肽物质的方法
公开(公告)号：US5679531A
公开(公告)日：1997-10-21
申请号：US484969
申请日：1995-06-07
申请人： Gerhard Konig , Paul Graham
发明人： Gerhard Konig , Paul Graham
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P25/28 , C07K1/14 , C07K1/22 , C07K7/08 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , C07K14/4711 , A61K2039/505 , A61K38/00
摘要： The instant invention provides for monoclomal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
摘要翻译：本发明提供对βA4肽特异性的单体抗体369.2B，特别是βA4“1-42”的游离C-末端而不是“1-43”，并且染色扩散和纤维状淀粉样蛋白，血管淀粉样蛋白和神经原纤维缠结。本发明进一步提供具有相同结合特异性的抗体片段及其构建体。本发明还提供了使用本发明的抗体治疗独特形式的β-A4肽的诊断，筛选和治疗方法。

3. 发明授权

US5786180A Monoclonal antibody 369.2B specific for .beta. A4 peptide 失效
标题翻译：单克隆抗体369.2B特异于βA4肽
公开(公告)号：US5786180A
公开(公告)日：1998-07-28
申请号：US388463
申请日：1995-02-14
申请人： Gerhard Konig , Paul Graham
发明人： Gerhard Konig , Paul Graham
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P25/28 , C07K1/14 , C07K1/22 , C07K7/08 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/18 , C07K14/4711 , A61K2039/505 , A61K38/00
摘要： The instant invention provides for monoclonal antibody which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
摘要翻译：本发明提供对βA4肽特异性的单克隆抗体，特别是βA4“1-42”但不是“1-43”的游离C末端，并且染色扩散和纤维状淀粉样蛋白，血管淀粉样蛋白，和神经原纤维缠结。本发明进一步提供具有相同结合特异性的抗体片段及其构建体。本发明还提供了使用本发明的抗体治疗独特形式的β-A4肽的诊断，筛选和治疗方法。

4. 发明申请

US20060278601A1 Plastic closure, closure and container package, and method of manufacture 审中-公开
标题翻译：塑料封闭，容器包装及其制造方法
公开(公告)号：US20060278601A1
公开(公告)日：2006-12-14
申请号：US11150738
申请日：2005-06-10
申请人： Kenneth Bloom , Paul Graham
发明人： Kenneth Bloom , Paul Graham
IPC分类号： B65D45/00 , B65D45/32 , B65D53/00
CPC分类号： B65D51/145 , B29C45/1615 , B29C45/1635 , B29L2031/265 , B29L2031/56 , B29L2031/565 , B65D41/045
摘要： A method of making a closure having an end panel and a sealing liner on one face of the end panel includes providing an injection mold having at least first and second mold elements, at least one of which is movable with respect to the other. The first and second mold elements are positioned to form a first mold cavity, and the end panel is injection molded within the first mold cavity. At least one of the first and second mold elements then is moved to form a second mold cavity in which a face of the end panel forms at least one mold cavity wall, and the sealing liner is injection molded onto the face of the end panel. The end panel and liner are then removed from the second mold cavity. The liner/disk subassembly thus is provided more easily and economically than if the liner were compression molded in situ onto the undersurface of a separately formed disk. The closure preferably is a two-piece closure, and the method preferably includes the step of assembling the end panel to a separately formed closure shell.
摘要翻译：在端板的一个面上制造具有端板和密封衬套的封闭件的方法包括提供具有至少第一和第二模具元件的注塑模具，其中至少一个模具元件可相对于另一个元件移动。第一和第二模具元件被定位成形成第一模具腔，并且端板在第一模腔内被注射模制。然后第一和第二模具元件中的至少一个被移动以形成第二模腔，其中端板的表面形成至少一个模腔壁，并且将密封衬套注塑到端板的表面上。然后将端板和衬套从第二模腔中取出。因此，如果衬垫在原位压缩成型到单独形成的盘的下表面上，则衬垫/盘子组件被更容易和经济地提供。封闭件优选地是两件式封闭件，并且该方法优选地包括将端板组装到单独形成的封闭壳体的步骤。

5. 发明申请

US20050038893A1 Determining the relevance of offers 有权
标题翻译：确定报价的相关性
公开(公告)号：US20050038893A1
公开(公告)日：2005-02-17
申请号：US10639811
申请日：2003-08-11
申请人： Paul Graham
发明人： Paul Graham
IPC分类号： G06F15/16 , G06Q30/00
CPC分类号： G06Q30/0269 , G06Q30/02
摘要： Offers are targeted to consumers by comparing offer profiles and consumer profiles. Offer profiles are created by analyzing the cumulative content of communications associated with consumers who respond to the offers. Consumer profiles are created by analyzing the cumulative content of communications associated with a user of an electronic communications system. An offer may be selected to be sent to a user based on the relative similarity between the user's consumer profile and the offer profile.
摘要翻译：通过比较优惠资料和消费者资料，优惠针对消费者。通过分析与响应优惠的消费者相关联的通信的累积内容来创建优惠资料。通过分析与电子通信系统的用户相关联的通信的累积内容来创建消费者简档。可以基于用户的消费者简档和报价简档之间的相对相似度来选择向用户发送报价。

6. 发明申请

US20090285358A1 Battery 有权
公开(公告)号：US20090285358A1
公开(公告)日：2009-11-19
申请号：US12464483
申请日：2009-05-12
申请人： Erin L. Ballard , Craig Buckland , Yang Cao , Javit A. Drake , Thomas Dufresne , Richard E. Durkot , Paul Graham , Joseph H. Nurre , Philip Trainer , Darren Trokhan , Jonathan Tse
发明人： Erin L. Ballard , Craig Buckland , Yang Cao , Javit A. Drake , Thomas Dufresne , Richard E. Durkot , Paul Graham , Joseph H. Nurre , Philip Trainer , Darren Trokhan , Jonathan Tse
IPC分类号： G01N23/06 , G01F17/00
CPC分类号： G01N23/046 , G01N2223/419 , G01N2223/639 , H01M6/5083 , H01M10/4285
摘要： A non-invasive multi-step process that includes tomography is applied to determine features of a battery.

7. 发明申请

US20070087294A1 Imaged anti-copy film 有权
标题翻译：成像反复制影片
公开(公告)号：US20070087294A1
公开(公告)日：2007-04-19
申请号：US11251166
申请日：2005-10-14
申请人： Paul Graham , Jonathan Kitchin
发明人： Paul Graham , Jonathan Kitchin
IPC分类号： G03C1/42
CPC分类号： B41M5/52 , B41M3/148 , B41M5/5218 , G03G7/00 , G03G7/0026 , G03G7/006 , Y10S283/902 , Y10S428/915
摘要： An anti-copy film is disclosed. The film has a light transmissive imageable substrate having opposing first and second surfaces. Each surface has an image receptive coating. Complementary positive and negative images are disposed on the first and second surfaces such that an imaged area on the first surface is in registration with a non-imaged area on the second surface. The anti-copy film appears substantially opaque when viewed orthogonally to and appears partially transparent when viewed obliquely to either the first or second surfaces.
摘要翻译：公开了一种防复印膜。该膜具有具有相对的第一和第二表面的透光可成像基底。每个表面都有一个图像接受涂层。补充的正和负图像设置在第一和第二表面上，使得第一表面上的成像区域与第二表面上的非成像区域对准。当与第一表面或第二表面倾斜地观察时，防复制膜在与正交方向观察时显示为基本不透明，并且当部分透明时呈现部分透明。

8. 发明申请

US20070087186A1 Privacy film 有权
标题翻译：隐私电影
公开(公告)号：US20070087186A1
公开(公告)日：2007-04-19
申请号：US11250676
申请日：2005-10-14
申请人： Graham Clarke , Paul Graham , Brent Hansen , Travis Hoium , David Slama
发明人： Graham Clarke , Paul Graham , Brent Hansen , Travis Hoium , David Slama
IPC分类号： B32B33/00
CPC分类号： B29C33/424 , B29C59/022 , B29C2059/023 , G02B5/00 , Y10S283/901 , Y10S283/902 , Y10S428/916 , Y10T428/14 , Y10T428/24372 , Y10T428/2457 , Y10T428/25
摘要： The present invention pertains to privacy film that can be used with documents. The privacy film has a light transmissive, polymeric base sheet that has opposing first and second surfaces. A plurality of light directing elements protrudes from the first surface of the base sheet. The base sheet can be constructed of a first polymeric material. The light directing elements can be constructed of a second polymeric material. The first and second polymeric material may be the same material. The light directing elements are substantially constant in its cross-section dimension and disposed substantially parallel to each other.
摘要翻译：本发明涉及可与文件一起使用的隐私电影。该隐私膜具有透光的聚合物基片，其具有相对的第一和第二表面。多个导光元件从基片的第一表面突出。基片可以由第一聚合物材料构成。光引导元件可以由第二聚合物材料构成。第一和第二聚合物材料可以是相同的材料。导光元件在其横截面尺寸上基本上恒定并且基本上彼此平行地设置。

9. 发明授权

US06581061B2 Remote web site authoring system and method 有权
公开(公告)号：US06581061B2
公开(公告)日：2003-06-17
申请号：US10038285
申请日：2002-01-02
申请人： Paul Graham
发明人： Paul Graham
IPC分类号： G06F1730
CPC分类号： G06F17/3089
摘要： A remote web site authoring system is located on a server in communication with one or more clients via a network with in a distributed computing environment. The system provides a what-you-see-is-what-you-get (WYSIWYG) interface program that enables the client to edit a web page of within a web site maintained on the remote server while concurrently viewing a replica of that web page. The system dynamically generates the replica of the web page while the client is editing the web page. The system combines the two elements of remote authoring, i.e., editing the web site and viewing the web site, enabling the user to view a replica of the web site during the editing process.

10. 发明授权

US06205469B1 Method for client-server communications through a minimal interface 失效
标题翻译：通过最小接口进行客户端 - 服务器通信的方法
公开(公告)号：US06205469B1
公开(公告)日：2001-03-20
申请号：US08863874
申请日：1997-05-27
申请人： Paul Graham
发明人： Paul Graham
IPC分类号： G06F1582
CPC分类号： G06F9/54 , G06F9/4486
摘要： The concept of a subroutine call is one of the basic ideas in computer science. The invention relates to a technique for achieving the effect of subroutine calls in certain situations where they would not otherwise be possible. The invention allows for the simulation of subroutine calls in applications where the interaction with a client is reduced to successive iterations in which the application sends the client a set of keys, and the client chooses one of the keys and sends it back to the application (i.e., a minimal interface). In one implementation, the invention is used to simulate subroutine calls in an application running on a Web server and communicating with the client through successive Web pages.
摘要翻译：子程序调用的概念是计算机科学的基本思想之一。本发明涉及一种用于在某些情况下实现子程序调用的效果的技术，否则这些情况将不可能。本发明允许在与客户端的交互减少到应用向客户端发送一组密钥的连续迭代的应用中的子程序调用的模拟，并且客户端选择一个密钥并将其发送回应用（即最小接口）。在一个实现中，本发明用于模拟在Web服务器上运行的应用程序中的子程序调用，并通过连续的网页与客户端进行通信。

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