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1. 发明申请

WO2010010178A1 THE TUBERCULOSIS RV2707C PROTEIN, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： TUBERCULOSIS RV2707C蛋白，组合物及其用途
公开(公告)号：WO2010010178A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059583
申请日：2009-07-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A , GLAXO GROUP LIMITED , BROWN, James , METTENS, Pascal , MURPHY, Dennis
发明人： BROWN, James , METTENS, Pascal , MURPHY, Dennis
IPC分类号： C07K14/35 , C12N5/10 , C12N15/62 , C12N15/63 , C12N1/19 , C12N1/21 , C07K16/12 , A61K39/04 , A61K31/711 , A61K31/713 , C12P21/02
CPC分类号： C07K14/35 , A61K39/04 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv2707c protein sequence; (ii) a variant of an Rv2707c protein sequence; or (iii) an immunogenic fragment of an Rv2707c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译：本发明涉及一种多肽，其包含：（i）Rv2707c蛋白质序列; （ii）Rv2707c蛋白序列的变体; 或（iii）Rv2707c蛋白序列的免疫原性片段。在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。

2. 发明申请

WO2010010179A1 THE TUBERCULOSIS RV2386C PROTEIN, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： TUBERCULOSIS RV2386C蛋白，组合物及其用途
公开(公告)号：WO2010010179A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059585
申请日：2009-07-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , BROWN, James , METTENS, Pascal , MURPHY, Dennis
发明人： BROWN, James , METTENS, Pascal , MURPHY, Dennis
IPC分类号： C12N15/60 , C12N15/61 , C12N9/88 , C12N9/90 , C07K14/35 , A61K38/51 , A61K38/52 , A61K39/04
CPC分类号： A61K39/04 , A61K38/00 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07K14/35 , C12N9/88 , C12N9/90
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译：本发明涉及一种多肽，其包含：（i）Rv2386c蛋白质序列; （ii）Rv2386c蛋白序列的变体; 或（iii）Rv2386c蛋白序列的免疫原性片段。在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。

3. 发明申请

WO2011092253A1 MODIFIED TUBERCULOSIS ANTIGENS 审中-公开
标题翻译：改良的TUBCCOSOSIS抗原
公开(公告)号：WO2011092253A1
公开(公告)日：2011-08-04
申请号：PCT/EP2011/051158
申请日：2011-01-27
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , BLAIS, Normand , BROWN, James , GELINAS, Anne-Marie , METTENS, Pascal , MURPHY, Dennis
发明人： BLAIS, Normand , BROWN, James , GELINAS, Anne-Marie , METTENS, Pascal , MURPHY, Dennis
IPC分类号： A61K39/04
CPC分类号： C07K14/35 , A61K39/04 , C07K2319/00
摘要： Modified Rv3616c proteins and their use as medicaments, particularly for the prevention of reactivation of tuberculosis.
摘要翻译：改良的Rv3616c蛋白及其用作药物，特别是用于预防结核病的再活化。

4. 发明申请

WO2010010180A1 NOVEL COMPOSITIONS AND METHODS 审中-公开
标题翻译：新型组合物和方法
公开(公告)号：WO2010010180A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059586
申请日：2009-07-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , BROWN, James , METTENS, Pascal , MURPHY, Dennis
发明人： BROWN, James , METTENS, Pascal , MURPHY, Dennis
IPC分类号： A61K39/04 , C07K14/35 , G01N33/569
CPC分类号： A61K39/04 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , C07H21/04 , C07K14/35 , G01N2333/35 , G01N2800/12
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
摘要翻译：本发明涉及一种多肽，其包含：（i）Rv1753c蛋白序列; （ii）Rv1753c蛋白序列的变体; 或（iii）Rv1753c蛋白序列的免疫原性片段。在其它方面，本发明涉及用于治疗或预防结核病的相关多核苷酸，融合蛋白和方法。

5. 发明申请

WO2010010177A1 NOVEL COMPOSITIONS AND METHODS 审中-公开
标题翻译：新型组合物和方法
公开(公告)号：WO2010010177A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059580
申请日：2009-07-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , BROWN, James , METTENS, Pascal , MURPHY, Dennis
发明人： BROWN, James , METTENS, Pascal , MURPHY, Dennis
IPC分类号： C07K14/35 , A61K39/04
CPC分类号： A61K39/04 , A61K49/00 , C07K14/35
摘要： The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c protein sequence for use in the treatment or prevention of latent TB. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of latent tuberculosis.
摘要翻译：本发明涉及一种多肽，其包含：（i）Rv3616c蛋白序列; （ii）Rv3616c蛋白序列的变体; 或（iii）用于治疗或预防潜伏性TB的Rv3616c蛋白序列的免疫原性片段。在其它方面，本发明涉及相关的多核苷酸，融合蛋白和用于治疗或预防潜伏性结核病的方法。

6. 发明申请

WO2008040757A1 VACCINES AGAINST CHLAMYDIAL INFECTION 审中-公开
标题翻译：杀虫剂感染疫苗
公开(公告)号：WO2008040757A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060500
申请日：2007-10-03
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , CORIXA CORPORATION , ALDERSON, Mark , COLER, Rhea , LOBET, Yves , MAISONNEUVE, Jean-Francois L , METTENS, Pascal , PROBST, Peter , REED, Steven
发明人： ALDERSON, Mark , COLER, Rhea , LOBET, Yves , MAISONNEUVE, Jean-Francois L , METTENS, Pascal , PROBST, Peter , REED, Steven
IPC分类号： A61K39/118 , A61P31/04
CPC分类号： A61K39/118 , A61K2039/53 , A61K2039/54 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
摘要： A method for the treatment or prevention of ocular Chlamydia trachomatis infection by the administration of a safe and effective amount of an immunogenic composition comprising one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding said proteins or fragments, selected from the list consisting of Swib, Momp, Ct-858, Ct-875, Ct-622, Ct-089, passenger domain of PmpG (PmpGpd) and passenger domain of PmpD (PmpDpd).
摘要翻译：一种通过施用安全有效量的免疫原性组合物治疗或预防眼沙眼衣原体感染的方法，所述组合物包含一种或多种沙眼衣原体沙眼衣原体蛋白，其免疫原性片段或编码所述蛋白质或片段的多核苷酸，其选自西班牙，Momp，Ct-858，Ct-875，Ct-622，Ct-089，PmpG（PmpGpd）的乘客域和PmpD（PmpDpd）的乘客域。

7. 发明申请

WO2004080375A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2004080375A2
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002643
申请日：2004-03-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , MEYKENS, Rene , METTENS, Pascal , MONTEYNE, Philippe
发明人： MEYKENS, Rene , METTENS, Pascal , MONTEYNE, Philippe
IPC分类号： A61K
CPC分类号： A61K39/0012 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/775 , C07K16/18
摘要： The present invention relates to novel vaccine therapies, and prophylactic treatments of atherosclerotic diseases. Accordingly there is provided, immunogens comprising specific fragments or derivatives of Apolipoprotein C-III (ApoCIII). The vaccines of the present invention, comprising said immunogens, are potent in the prevention, or reduction, of atherosclerotic plaque formation over prolonged periods of time, thereby reducing the potential of atherosclerosis leading to coronary or cerebrovascular disease. Also provided are methods of treating or preventing atherosclerosis by active vaccination, or passive vaccination through administration to a patient of an antibody that is capable of binding to the specific fragments of ApoCIII. Specific monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the immunogens of the present invention in medicine, and methods of their production. The fragments of ApoCIII which form the basis of the immunogens of the present invention, and also the targets for passive immunotherapy, are encompassed within the regions between amino acid numbers 45-76 and, particularly, 12-35 of the mature form of human ApoCIII.
摘要翻译：本发明涉及新型疫苗疗法和动脉粥样硬化疾病的预防性治疗。因此，提供了包含载脂蛋白C-III（ApoCIII）的特异性片段或衍生物的免疫原。包含所述免疫原的本发明的疫苗在延长的时间段内有效预防或减少动脉粥样硬化斑块的形成，从而降低导致冠状动脉或脑血管疾病的动脉粥样硬化的可能性。还提供了通过主动接种治疗或预防动脉粥样硬化的方法，或通过向患者施用能够结合到ApoCIII的特异性片段的抗体的被动接种。提供特异性单克隆抗体及其在治疗动脉粥样硬化中的应用。还提供了本发明的免疫原在医药中的用途及其制备方法。形成本发明的免疫原的基础的ApoCIII的片段以及被动免疫治疗的靶标包含在成熟形式的人ApoCIII的氨基酸数45-76之间，特别是12-35的区域内。

8. 发明申请

WO2004081046A2 NOVEL COMPOSITION 审中-公开
标题翻译：新组合
公开(公告)号：WO2004081046A2
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002640
申请日：2004-03-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BIOINVENT INTERNATIONAL A.B. , METTENS, Pascal , MEYKENS, Rene , MONTEYNE, Philippe , SCHIÖTT, Torbjörn , STRANDBERG, Leif
发明人： METTENS, Pascal , MEYKENS, Rene , MONTEYNE, Philippe , SCHIÖTT, Torbjörn , STRANDBERG, Leif
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/565
摘要： The present invention relates to novel therapies and treatments of atherosclerotic diseases. Accordingly there is provided, methods of treating or preventing atherosclerosis by passive vaccination through administration to a patient of a human antibody that is capable of binding to the specific fragments of ApoCIII. Specific human monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the antibodies of the present invention in medicine.
摘要翻译：本发明涉及动脉粥样硬化疾病的新疗法和治疗。因此，提供了通过向能够结合到ApoCIII的特异性片段的人抗体的患者施用被动接种来治疗或预防动脉粥样硬化的方法。提供特异性人单克隆抗体及其在治疗动脉粥样硬化中的应用。还提供了本发明的抗体在医药中的用途。

9. 发明申请

WO2004081045A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2004081045A2
公开(公告)日：2004-09-23
申请号：PCT/EP2004/002642
申请日：2004-03-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , METTENS, Pascal , MONTEYNE, Philippe
发明人： METTENS, Pascal , MONTEYNE, Philippe
IPC分类号： C07K14/775
CPC分类号： C07K14/775 , A61K39/0012
摘要： The present invention relates to novel vaccine therapies, and prophylactic treatments of atherosclerotic diseases. Accordingly there is provided, immunogens comprising specific fragments or derivatives of oxidised Apolipoprotein C-III (ApoCIII). The vaccines of the present invention, comprising said immunogens, are potent in the prevention, or reduction, of atherosclerotic plaque formation over prolonged periods of time, thereby reducing the potential of atherosclerosis leading to coronary or cerebrovascular disease. Also provided are methods of treating or preventing atherosclerosis by active vaccination, or passive vaccination through administration to a patient of an antibody that is capable of binding to the specific fragments of ApoCIII. Specific monoclonal antibodies and their use in therapy of atherosclerosis is provided. There is further provided the use of the immunogens of the present invention in medicine, and methods of their production. The fragments of ApoCIII which form the basis of the immunogens of the present invention, and also the targets for passive immunotherapy, are encompassed within the regions between amino acid numbers 45-76 and, particularly, 12-35 of the mature form of human ApoCIII.
摘要翻译：本发明涉及新型疫苗疗法和动脉粥样硬化疾病的预防性治疗。因此，提供了包含氧化的载脂蛋白C-III（ApoCIII）的特异性片段或衍生物的免疫原。包含所述免疫原的本发明的疫苗有效地预防或减少长时间的动脉粥样硬化斑块形成，从而降低导致冠状动脉或脑血管疾病的动脉粥样硬化的可能性。还提供了通过主动接种治疗或预防动脉粥样硬化的方法，或通过向患者施用能够结合到ApoCIII的特异性片段的抗体的被动接种。提供特异性单克隆抗体及其在治疗动脉粥样硬化中的应用。还提供了本发明的免疫原在医药中的用途及其制备方法。形成本发明免疫原的基础的ApoCIII片段以及被动免疫治疗的靶标包含在成熟形式的人ApoCIII的氨基酸数45-76之间，特别是12-35的区域内。

10. 发明申请

WO2005058349A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2005058349A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014379
申请日：2004-12-14
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , LUDWIG INSTITUTE FOR CANCER RESEARCH , METTENS, Pascal , UYTTENHOVE, Catherine , VAN SNICK, Jacques
发明人： METTENS, Pascal , UYTTENHOVE, Catherine , VAN SNICK, Jacques
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577
摘要： The present invention relates to improved vaccines and immunogenic compositions, and processes for the preparation of such vaccines and immunogenic compositions. In particular, the present invention relates to vaccines and immunogenic compositions capable of generating an immune response against IL-12 or IL-23, or a subunit or component thereof, for the treatment of a disease, in particular an autoimmune-implicated disease.
摘要翻译：本发明涉及改进的疫苗和免疫原性组合物，以及制备这种疫苗和免疫原性组合物的方法。特别地，本发明涉及能够产生针对IL-12或IL-23或其亚基或其组分的免疫应答的疫苗和免疫原性组合物，用于治疗疾病，特别是自身免疫性牵连疾病。

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