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1. 发明申请

WO0058508A2 BIALLELIC MARKERS RELATED TO GENES INVOLVED IN DRUG METABOLISM 审中-公开
标题翻译：与药物代谢相关的基因相关的二元标记
公开(公告)号：WO0058508A2
公开(公告)日：2000-10-05
申请号：PCT/IB0000403
申请日：2000-03-24
申请人： GENSET SA , BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN AKENINE ANNICK
发明人： BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN-AKENINE ANNICK
IPC分类号： C12Q1/68 , A01K67/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/11 , G06F19/00
CPC分类号： C12Q1/6827 , C12Q1/6876 , C12Q2600/142 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
摘要翻译：本发明提供了多核苷酸，其包括衍生自涉及异种生物如药物的生物转化的基因和来自这些基因侧翼的基因组区域的双重标记。还提供了与这些双重标记物侧翼的区域杂交的引物。本发明还提供了适用于对本发明的一种或多种双重标记物的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。

2. 发明申请

WO0056924A3 GENOMIC SEQUENCE OF THE PURH GENE AND PURH-RELATED BIALLELIC MARKERS 审中-公开
标题翻译：嘌呤基因和与之相关的BIALLELIC标记的基因组序列
公开(公告)号：WO0056924A3
公开(公告)日：2001-08-09
申请号：PCT/IB0000404
申请日：2000-03-22
申请人： GENSET SA , BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN AKENINE ANNICK
发明人： BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN-AKENINE ANNICK
IPC分类号： A61K38/00 , A61K48/00 , C12N9/10 , C12Q1/68 , C07K14/00 , C12N15/52
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the PURH gene. The invention also concerns biallelic markers of a PURH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.
摘要翻译：本发明涉及PURH基因的基因组序列。本发明还涉及PURH基因的双重标记和这些标记与癌症之间建立的关联，特别是前列腺癌。本发明提供了确定个体对癌症的易感性以及用于诊断癌症的手段以及用于对作用于癌症的药剂的最终治疗反应的预后/检测的手段。

3. 发明申请

WO0058509A3 PROSTATE CANCER ASSOCIATED HUMAN FIBRONECTIN GENE AND BIALLELIC MARKERS 审中-公开
标题翻译：前列腺癌相关人类纤维蛋白基因和双标记
公开(公告)号：WO0058509A3
公开(公告)日：2002-09-12
申请号：PCT/IB0000431
申请日：2000-03-28
申请人： GENSET SA , BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN-AKENINE ANNICK
发明人： BLUMENFELD MARTA , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN-AKENINE ANNICK
IPC分类号： C12N15/12 , C12Q1/68 , C12N5/16 , G06F17/30
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The invention concerns the genomic sequence of the Fibronectin gene. The invention also concerns biallelic markers of a Fibronectin gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.
摘要翻译：本发明涉及纤连蛋白基因的基因组序列。本发明还涉及纤连蛋白基因的双重标记和这些标记与癌症之间建立的关联，特别是前列腺癌。本发明提供了确定个体对癌症的易感性以及用于诊断癌症的手段以及用于对作用于癌症的药剂的最终治疗反应的预后/检测的手段。

4. 发明申请

WO0100669A3 A BAP28 GENE AND PROTEIN 审中-公开
标题翻译： BAP28基因和蛋白质
公开(公告)号：WO0100669A3
公开(公告)日：2002-01-17
申请号：PCT/IB0001183
申请日：2000-06-23
申请人： GENSET SA , BARRY CAROLINE , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN AKENINE ANNICK
发明人： BARRY CAROLINE , BOUGUELERET LYDIE , CHUMAKOV ILYA , COHEN-AKENINE ANNICK
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , A01K67/027 , C12N5/10 , C12N15/63 , G01N33/50 , G01N33/68
CPC分类号： C07K14/4702 , A01K2217/075 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is directed to BAP28 polypeptides, BAP28 cDNA sequences encoding BAP28 polypeptides, to the genomic DNA sequence of the BAP28 gene as well as to regulatory regions located at the 5'- and 3'-ends of the BAP28 coding region. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the BAP28 gene useful in genetic analysis. The invention concerns an association of the BAP28 -related biallelic markers with prostate cancer. Therefore, the invention contemplates the diagnostic and treatment methods of prostate cancer.
摘要翻译：本发明针对BAP28多肽，编码BAP28多肽的BAP28 cDNA序列与BAP28基因的基因组DNA序列以及位于BAP28编码区的5'和3'端的调节区。本发明还涉及针对可用作诊断试剂的这种多肽的抗体。本发明还包括可用于遗传分析的BAP28基因的双重标记。本发明涉及BAP28相关双标记与前列腺癌的关联。因此，本发明考虑了前列腺癌的诊断和治疗方法。

5. 发明申请

WO0028080A3 METHODS, SOFTWARE AND APPARATI FOR IDENTIFYING GENOMIC REGIONS HARBORING A GENE ASSOCIATED WITH A DETECTABLE TRAIT 审中-公开
标题翻译：用于鉴定与可检测特征相关的基因的基因组区域的方法，软件和装置
公开(公告)号：WO0028080A3
公开(公告)日：2000-08-17
申请号：PCT/IB9901846
申请日：1999-11-10
申请人： GENSET SA , SCHORK J NICHOLAS , ESSIOUX LAURENT , COHEN AKENINE ANNICK , BLUMENFELD MARTA , COHEN DANIEL
发明人： SCHORK J NICHOLAS , ESSIOUX LAURENT , COHEN-AKENINE ANNICK , BLUMENFELD MARTA , COHEN DANIEL
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F17/30 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/00
CPC分类号： G06F19/18 , C12Q1/6827 , G06F19/22 , G06F19/24
摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.
摘要翻译：本发明涉及用于确定基因组区域是否具有与可检测性状相关的基因的方法，软件和装置。在一个实施方案中，本发明涉及确认基因组区域具有与可检测性状相关的基因的方法，包括以下步骤：鉴定怀疑携带与可检测性状相关的基因的候选基因组区域，构建与性状相关的使用候选基因组区域中的双等位基因标记分布关联值，在随机基因组区域中鉴定多个双等位基因标记，所述多个双等位标记不怀疑携带与可检测性状相关的基因，使用双等位基因标记构建随机分布的关联值随机基因组区域，将关联值的性状关联分布与关联值的随机分布进行比较，并确定关联值的性状关联分布和关联值的随机分布是否彼此显着不同。在其他实施例中，本发明包括用于以可检索的形式执行包括该软件的上述方法和设备的软件。

6. 发明专利

CA2368672A1 GENOMIC SEQUENCE OF THE PURH GENE AND PURH-RELATED BIALLELICMARKERS 未知
公开(公告)号：CA2368672A1
公开(公告)日：2000-09-28
申请号：CA2368672
申请日：2000-03-22
申请人： GENSET SA
发明人： COHEN-AKENINE ANNICK , CHUMAKOV ILYA , BLUMENFELD MARTA , BOUGUELERET LYDIE
IPC分类号： A61K38/00 , A61K48/00 , C12N9/10 , C12Q1/68 , C12Q1/6883 , C12Q1/6886 , C07K14/00 , C12N15/52
摘要： The invention concerns the genomic sequence of the PURH gene. The invention also concerns biallelic markers of a PURH gene and the association establish ed between these markers and cancer, particularly prostate cancer. The inventio n provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.

7. 发明专利

CA2363551A1 BIALLELIC MARKERS RELATED TO GENES INVOLVED IN DRUG METABOLISM 未知
公开(公告)号：CA2363551A1
公开(公告)日：2000-10-05
申请号：CA2363551
申请日：2000-03-24
申请人： GENSET SA
发明人： COHEN-AKENINE ANNICK , CHUMAKOV ILYA , BOUGUELERET LYDIE , BLUMENFELD MARTA
IPC分类号： C12Q1/68 , A01K67/00 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/11 , G06F19/00
摘要： The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs an d from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Furthe r, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.

8. 发明专利

ES2229781T3 METODOS PROGRAMAS Y APARATOS PARA IDENTIFICAR REGIONES GENOMICAS QUE ALBERGAN UN GEN ASOCIADO CON UN RASGO DETECTABLE. 未知
公开(公告)号：ES2229781T3
公开(公告)日：2005-04-16
申请号：ES99954287
申请日：1999-11-10
申请人： GENSET SA
发明人： SCHORK J NICHOLAS , ESSIOUX LAURENT , COHEN-AKENINE ANNICK , BLUMENFELD MARTA , COHEN DANIEL
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F17/30 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/00
摘要： Un método para confirmar o determinar si una región genómica candidata alberga un gen asociado con un rasgo detectable, que comprende las etapas de: construir una distribución de una región candidata de los valores de ensayo utilizando una pluralidad de marcadores bialélicos en una región genómica candidata sospechosa de albergar dicho gen asociado a dicho rasgo detectable, siendo dicha distribución de la región candidata de los valores de ensayo indicativa de la diferencia en las frecuencias de dicha pluralidad de marcadores bialélicos en dicha región candidata en individuos no emparentados que poseen dicho rasgo detectable y en individuos control que no poseen dicho rasgo detectable; construir una distribución de una región aleatoria de los valores de ensayo utilizando una pluralidad de marcadores bialélicos en regiones genómicas aleatorias que no son sospechosas de albergar dicho gen asociado a dicho rasgo detectable, siendo dicha distribución de la región aleatoria de los valores de ensayo indicativa de la diferencia en las frecuencias de dicha pluralidad de marcadores bialélicos en dichas regiones genómicas aleatorias en individuos no emparentados que poseen dicho rasgo detectable y en individuos control que no poseen dicho rasgo detectable; y determinar si dicha distribución de la región candidata de los valores de ensayo y dicha distribución de la región aleatoria de los valores de ensayo son significativamente diferentes entre sí, para determinar si es probable que la región candidata contenga un gen asociado al rasgo detectable.

9. 发明专利

AT275639T 未知
公开(公告)号：AT275639T
公开(公告)日：2004-09-15
申请号：AT99954287
申请日：1999-11-10
申请人： GENSET SA
发明人： SCHORK J NICHOLAS , ESSIOUX LAURENT , COHEN-AKENINE ANNICK , BLUMENFELD MARTA , COHEN DANIEL
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F17/30 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/00
摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.

10. 发明专利

AU771187B2 Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait 未知
公开(公告)号：AU771187B2
公开(公告)日：2004-03-18
申请号：AU1069600
申请日：1999-11-10
申请人： GENSET SA
发明人： SCHORK J NICHOLAS , ESSIOUX LAURENT , COHEN-AKENINE ANNICK , BLUMENFELD MARTA , COHEN DANIEL
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F17/30 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/00
摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.

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