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1. 发明申请

WO2005056782A3 PERHYDROLASE 审中-公开
标题翻译：水解酶
公开(公告)号：WO2005056782A3
公开(公告)日：2006-02-16
申请号：PCT/US2004040438
申请日：2004-12-03
申请人： GENENCOR INT , PROCTER & GAMBLE , AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
发明人： AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
IPC分类号： C12N9/16 , C11D3/386 , C12N9/50 , C12N9/52
CPC分类号： A01N63/00 , C11D3/38636 , C12N9/16 , C12N9/50 , C12N9/52
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种用于清洁和其它应用的过水解酶的方法和组合物。在一些特别优选的实施方案中，本发明提供了用于产生过酸的方法和组合物。本发明特别用于涉及清洗，漂白和消毒的应用。

2. 发明申请

WO2009132220A3 ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开
标题翻译：异丙烯合成酶变异体用于改进微生物生产异戊二烯
公开(公告)号：WO2009132220A3
公开(公告)日：2010-01-21
申请号：PCT/US2009041581
申请日：2009-04-23
申请人： DANISCO US INC , GOODYEAR TIRE & RUBBER , CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R
发明人： CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R
IPC分类号： C12N9/88 , C12N5/10 , C12N15/52
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译：本发明提供了包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。具体而言，本发明提供了用于增加微生物宿主细胞中异戊二烯产生的变异植物异戊二烯合酶。本发明的生物合成产生的异戊二烯可用于制造橡胶和弹性体。

3. 发明申请

WO2009132220A9 ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开
标题翻译：用于改善微生物生产异烟肼的异丙肾上腺素变异体
公开(公告)号：WO2009132220A9
公开(公告)日：2010-05-06
申请号：PCT/US2009041581
申请日：2009-04-23
申请人： DANISCO US INC , GOODYEAR TIRE & RUBBER , CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R , RIFE CHRISTOPHER LEE
发明人： CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R , RIFE CHRISTOPHER LEE
IPC分类号： C12N9/88 , C12N5/10 , C12N15/52
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译：本发明提供包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。特别地，本发明提供用于在微生物宿主细胞中增加异戊二烯生产的变体植物异戊二烯合酶。本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。

4. 发明申请

WO2008088493A3 COMPOSITIONS AND USES FOR AN ALPHA-AMYLASE POLYPEPTIDE OF BACILLUS SPECIES 195 审中-公开
标题翻译：贝类物种的ALPHA-AMYLASE多肽的组合物和用途195
公开(公告)号：WO2008088493A3
公开(公告)日：2009-01-22
申请号：PCT/US2007024959
申请日：2007-12-06
申请人： DANISCO US INC GENENCOR DIV , AMIN NEELAM S , ESTABROOK MELODIE , JONES BRIAN E , KOLKMAN MARC , MITCHINSON COLIN , VROEMEN CASPER , WEYLER WALTER
发明人： AMIN NEELAM S , ESTABROOK MELODIE , JONES BRIAN E , KOLKMAN MARC , MITCHINSON COLIN , VROEMEN CASPER , WEYLER WALTER
IPC分类号： C12N9/28 , C11D3/386 , C12N1/21
CPC分类号： C12N9/2417
摘要： Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
摘要翻译：本文公开了包含从芽孢杆菌属（Bacillus sp。）获得的α-淀粉酶的组合物。没有。 195，以及使用酶清洁表面和纺织品的方法。还公开了具有不同信号序列的酶的变体。

5. 发明申请

WO2009149130A3 GEOBACILLUS STEAROTHERMOPHILUS ALPHA-AMYLASE (AMYS) VARIANTS WITH IMPROVED PROPERTIES 审中-公开
标题翻译：具有改进性质的GEOBACILLUS STEAROTHERMOPHILUS ALPHA-AMYLASE（AMYS）变种
公开(公告)号：WO2009149130A3
公开(公告)日：2010-02-25
申请号：PCT/US2009046034
申请日：2009-06-02
申请人： DANISCO US INC , CUEVAS WILLIAM A , ESTELL DAVID A , HADI SURA HUSSAIN , LEE SANG-KYU , RAMER SANDRA W , SHAW ANDREW , TOPPOZADA AMR R , WEYLER WALTER
发明人： CUEVAS WILLIAM A , ESTELL DAVID A , HADI SURA HUSSAIN , LEE SANG-KYU , RAMER SANDRA W , SHAW ANDREW , TOPPOZADA AMR R , WEYLER WALTER
IPC分类号： C12N9/28 , C11D3/386
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent alpha-amylase that exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, calcium dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译：描述了相对于所述亲本α-淀粉酶在下列性质中表现出至少一种变化的亲本α-淀粉酶的变体：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖性稳定性，氧化稳定性，钙依赖性，pI和洗涤性能。这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。

6. 发明申请

WO2006033668A3 PCKA MODIFICATIONS AND ENHANCED PROTEIN EXPRESSION IN BACILLUS 审中-公开
标题翻译： PCKA修饰和增强蛋白在BACILLUS中的表达
公开(公告)号：WO2006033668A3
公开(公告)日：2007-03-08
申请号：PCT/US2005011821
申请日：2005-04-07
申请人： GENENCOR INT , WEYLER WALTER , HSU AMY KUANG-HUA
发明人： WEYLER WALTER , HSU AMY KUANG-HUA
IPC分类号： C07K14/32 , C12N9/88 , C12N15/63 , C12R1/125
CPC分类号： C12P21/02 , C12N9/54 , C12N9/88
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins, wherein the pckA gene has been modified or deleted. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been modified and/or inactivated (e.g., pckA), and preferably wherein one or more chromosomal genes (e.g., pckA) have been modified and/or deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been modified and/or deleted from a corresponding wild-type Bacillus host chromosome.
摘要翻译：本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞，其中pckA基因已被修饰或缺失。特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白质表达的芽孢杆菌属物种，其中一个或多个染色体基因已被修饰和/或失活（例如，pckA），并且优选其中一个或多个更多的染色体基因（例如，pckA）已经从芽孢杆菌染色体中修饰和/或缺失。在一些另外的实施方案中，一个或多个本地染色体区已经从相应的野生型芽孢杆菌宿主染色体修饰和/或缺失。

7. 发明申请

WO0250245A3 NOVEL CELLULASE PRODUCING ACTINOMYCETES, CELLULASE PRODUCED THEREFROM AND METHOD OF PRODUCING SAME 审中-公开
标题翻译：生产乙酰胆碱酯的新型纤维素酶，其生产的纤维素酶及其生产方法
公开(公告)号：WO0250245A3
公开(公告)日：2003-04-03
申请号：PCT/US0148102
申请日：2001-12-14
申请人： GENENCOR INT , GOEDEGEBUUR FRITS , JONES BRIAN E , VAN DER KLEIJ WILHELMUS A H , WEYLER WALTER , VAN SOLINGEN PIETER
发明人： GOEDEGEBUUR FRITS , JONES BRIAN E , VAN DER KLEIJ WILHELMUS A H , WEYLER WALTER , VAN SOLINGEN PIETER
IPC分类号： A23K1/165 , C11D3/386 , C12N9/42 , C12N15/56 , C12Q1/68 , D06M16/00 , D06P5/02 , D06P5/13 , D06P5/15 , D21C5/00 , C07H21/04 , C11D3/00 , C12N1/20 , C12N15/00
CPC分类号： C12Y302/01004 , A23K20/189 , C11D3/38645 , C12N9/2437 , C12Q1/6876 , C12R1/04 , C12Y302/01091 , D06M16/003 , D06M2101/06 , D06P5/02 , D06P5/137 , D06P5/158 , D21C5/005
摘要： A novel cellulase composition is provided which is produced by an Actinomycete. The cellulase has an approximate calculated molecular weight of 36 kD and has a pH optimum at 40 DEG C of 8 and at 60 DEG C of 7. Also provided is a DNA encoding said cellulase, a method for producing the cellulase and applications thereof.
摘要翻译：提供了由放线菌产生的新型纤维素酶组合物。纤维素酶具有36kD的近似计算分子量，并且在40℃下的pH最佳为8，在60℃为7。还提供了编码所述纤维素酶的DNA，生产纤维素酶的方法及其应用。

8. 发明专利

DE602004031662D1 PERHYDROLASE 未知
公开(公告)号：DE602004031662D1
公开(公告)日：2011-04-14
申请号：DE602004031662
申请日：2004-12-03
申请人： PROCTER & GAMBLE , GENENCOR INT
发明人： AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
IPC分类号： C12N9/16 , C11D3/386 , C12N9/50 , C12N9/52

9. 发明专利

CA2547709A1 PERHYDROLASE 未知
公开(公告)号：CA2547709A1
公开(公告)日：2005-06-23
申请号：CA2547709
申请日：2004-12-03
申请人： GENENCOR INT , PROCTER & GAMBLE
发明人： CONCAR EDWARD M , CERVIN MARGUERITE A , BOSTON MATTHEW G , SCHEIBEL JEFFREY J , RAMER SANDRA W , POULOSE AYROOKARAN J , WEYLER WALTER , OH HIROSHI , MIRACLE GREGORY S , AMIN NEELAM S , WHITED GREGORY M , JONES BRIAN EDWARD , BOTT RICHARD R , LIEBETON KLAUS , GUSTWILLER MARC E
IPC分类号： C12N9/16 , C11D3/386 , C12N9/50 , C12N9/52
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods a nd compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfectin g.

10. 发明专利

CA2547709C PERHYDROLASE 未知
公开(公告)号：CA2547709C
公开(公告)日：2017-02-07
申请号：CA2547709
申请日：2004-12-03
申请人： GENENCOR INT , PROCTER & GAMBLE
发明人： AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
IPC分类号： C12N9/16 , C11D3/386 , C12N9/50 , C12N9/52
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.

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