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1. 发明申请

US20080207692A1 Stabilized and preserved ketoifen ophthalmic compositions 审中-公开
标题翻译：稳定保存的酮替芬眼科组合物
公开(公告)号：US20080207692A1
公开(公告)日：2008-08-28
申请号：US12082845
申请日：2008-04-15
申请人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
发明人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
IPC分类号： A61K31/44 , A61P27/14
CPC分类号： A61K31/4535 , A61K9/0048
摘要： Ophthalmic compositions comprising ketotifen and a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v) of hydrogen peroxide, and methods for the treatment and prevention of allergic conjunctivitis using these compositions are provided herein.
摘要翻译：提供包含酮替芬和提供约0.001至约0.1％（w / v）过氧化氢的过氧化氢量的过氧化氢源的眼用组合物，以及使用这些组合物治疗和预防变应性结膜炎的方法。

2. 发明申请

US20120157496A1 STABILIZED AND PRESERVED KETOTIFEN OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：稳定和保存的KETOTIFEN OPHTHALMIC组合物
公开(公告)号：US20120157496A1
公开(公告)日：2012-06-21
申请号：US13408850
申请日：2012-02-29
申请人： Fu-Pao TSAO , Michelle Wong , Shau-Fong Yen
发明人： Fu-Pao TSAO , Michelle Wong , Shau-Fong Yen
IPC分类号： A61K31/4535 , A61P27/14
CPC分类号： A61K31/4535 , A61K9/0048
摘要： Ophthalmic compositions comprising ketotifen and a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v) of hydrogen peroxide, and methods for the treatment and prevention of allergic conjunctivitis using these compositions are provided herein.
摘要翻译：提供包含酮替芬和提供约0.001至约0.1％（w / v）过氧化氢的过氧化氢量的过氧化氢源的眼用组合物，以及使用这些组合物治疗和预防变应性结膜炎的方法。

3. 发明申请

US20070048389A1 Stabilized and preserved ketotifen ophthalmic compositions 审中-公开
标题翻译：稳定和保存的酮替芬眼科组合物
公开(公告)号：US20070048389A1
公开(公告)日：2007-03-01
申请号：US11212959
申请日：2005-08-26
申请人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
发明人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
IPC分类号： A61K33/40 , A61K31/453
CPC分类号： A61K31/4535 , A61K9/0048
摘要： Ophthalmic compositions comprising ketotifen and a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v) of hydrogen peroxide, and methods for the treatment and prevention of allergic conjunctivitis using these compositions are provided herein.
摘要翻译：提供包含酮替芬和提供约0.001至约0.1％（w / v）过氧化氢的过氧化氢量的过氧化氢源的眼用组合物，以及使用这些组合物治疗和预防变应性结膜炎的方法。

4. 发明申请

US20110028516A1 STABILIZED AND PRESERVED KETOIFEN OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：稳定和保存的KETOIFEN OPHTHALMIC组合物
公开(公告)号：US20110028516A1
公开(公告)日：2011-02-03
申请号：US12904675
申请日：2010-10-14
申请人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
发明人： Fu-Pao Tsao , Michelle Wong , Shau-Fong Yen
IPC分类号： A61K31/4535 , A61P27/02
CPC分类号： A61K31/4535 , A61K9/0048
摘要： Ophthalmic compositions comprising ketotifen and a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v) of hydrogen peroxide, and methods for the treatment and prevention of allergic conjunctivitis using these compositions are provided herein.
摘要翻译：提供包含酮替芬和提供约0.001至约0.1％（w / v）过氧化氢的过氧化氢量的过氧化氢源的眼用组合物，以及使用这些组合物治疗和预防变应性结膜炎的方法。

5. 发明授权

US5422116A Liquid ophthalmic sustained release delivery system 失效
标题翻译：液体眼科持续释放递送系统
公开(公告)号：US5422116A
公开(公告)日：1995-06-06
申请号：US198924
申请日：1994-02-18
申请人： Shau-Fong Yen , Kenneth W. Reed
发明人： Shau-Fong Yen , Kenneth W. Reed
IPC分类号： A61K9/08 , A61K9/00 , A61K47/36 , A61K47/00
CPC分类号： A61K9/0048 , A61K47/36 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915 , Y10S514/95 , Y10S514/954 , Y10S514/955 , Y10S514/964
摘要： Disclosed is a sustained release liquid aqueous ophthalmic delivery system and a method of providing a slow and sustained release of ophthalmic treating agents to the eye of a mammal which comprises administering to the eye of a said mammal an effective amount of a homogeneous liquid aqueous ophthalmic pharmaceutical composition, of pH between about 3.0 and about 6.2, which is adminstrable in drop form and which comprises an ophthalmically effective concentration of a said ophthalmic treating agent and about 0.05% to about 10% by weight of the polymer chitosan; said polymer consisting essentially of(A) monomeric .beta.(1.fwdarw.4)-D-glucosamine linked units and of(B) monomeric .beta.(1.fwdarw.4)-D-glucosamine linked units which are scatteredrandomly in the molecule of the polymer, the numerical proportions of A and B being from about 60 to about 99% of A and about 1 to about 40% of B, the viscosity rating being from about 3 to about 3000 cps; in which method, upon contact with the higher pH of the ocular fluid, said liquid formulation is converted to a stiff gel from which the ophthalmic treating agent is slowly released over a prolonged period of time.
摘要翻译：本发明公开了一种持续释放液体水性眼科递送系统和向眼睛的哺乳动物提供缓慢且持续释放眼用治疗剂的方法，其包括向所述哺乳动物的眼睛施用有效量的均匀液体眼用水性药物 pH为约3.0至约6.2的组合物，其以滴剂形式施用，并且其包含眼睛上有效浓度的所述眼科治疗剂和约0.05重量％至约10重量％的聚合物壳聚糖; 所述聚合物基本上由（A）单体β（1-> 4）-D-葡糖胺连接单元和（B）单体β（1-> 4）-D-葡糖胺连接单元组成，其在聚合物，A和B的数值比例为约60至约99％的A和约1至约40％的B，粘度等级为约3至约3000cps; 在该方法中，当与眼液的较高pH接触时，所述液体制剂被转化成刚性凝胶，眼药处理剂在较长时间内缓慢释放。

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