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1. 发明授权

US06355411B1 Virulence-associated nucleic acid sequences and uses thereof 失效
标题翻译：与毒力相关的核酸序列及其用途
公开(公告)号：US06355411B1
公开(公告)日：2002-03-12
申请号：US09199637
申请日：1998-11-25
申请人： Frederick Ausubel , Howard M. Goodman , Laurence G. Rahme , Shalina Mahajan-Miklos , Man-Wah Tan , Hui Cao , Eliana Drenkard , John Tsongalis
发明人： Frederick Ausubel , Howard M. Goodman , Laurence G. Rahme , Shalina Mahajan-Miklos , Man-Wah Tan , Hui Cao , Eliana Drenkard , John Tsongalis
IPC分类号： C12Q100
CPC分类号： C12Q1/18 , A61K49/0004 , C07K14/21 , G01N33/56911 , G01N2333/21 , G01N2500/10
摘要： Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
摘要翻译：公开了细菌毒力多肽和编码这种多肽的核酸序列（例如DNA），以及通过重组技术产生此类多肽的方法。还提供了利用这些多肽筛选抗细菌抑菌剂或抑菌剂的方法。

2. 发明申请

US20100184804A1 METHODS FOR THE PREVENTION OR TREATMENT OF BACTERIAL AND FUNGAL INFECTIONS 审中-公开
标题翻译：预防或治疗细菌和真菌感染的方法
公开(公告)号：US20100184804A1
公开(公告)日：2010-07-22
申请号：US12623307
申请日：2009-11-20
申请人： Laurence G. Rahme , Hui Cao , Francois Lepine , Eric Deziel , Ronald G. Tompkins
发明人： Laurence G. Rahme , Hui Cao , Francois Lepine , Eric Deziel , Ronald G. Tompkins
IPC分类号： A61K31/47 , A61K31/335 , C12Q1/02 , A61P31/04
CPC分类号： A61K31/365 , A61K31/47
摘要： The present invention features improved methods for treating, stabilizing, or preventing a bacterial or a fungal infection in a plant or an animal, such as a mammal. In particular, these methods involve the use of a compound, that is controlled by MvfR, and that affects the expression of an MvfR protein or that promotes its modification or inactivation, or a compound produced by P. aeruginosa strain PA14, but not by P. aeruginosa containing an mvfR mutation, in late stationary phase cultures.
摘要翻译：本发明的特征在于在植物或动物如哺乳动物中治疗，稳定或预防细菌或真菌感染的改进方法。特别地，这些方法涉及使用由MvfR控制并影响MvfR蛋白的表达或促进其修饰或失活的化合物或由铜绿假单胞菌菌株PA14产生的化合物而不是由P 在晚期固定期培养物中含有mvfR突变的铜绿假单胞菌。

3. 发明授权

US10432871B2 Systems and methods for imaging using a random laser 有权
公开(公告)号：US10432871B2
公开(公告)日：2019-10-01
申请号：US14110937
申请日：2012-04-16
申请人： Hui Cao , Brandon Redding , Michael Choma
发明人： Hui Cao , Brandon Redding , Michael Choma
IPC分类号： G02B27/48 , H04N5/235 , H01S3/30 , H04N9/31 , H01S5/10 , H01S3/10 , H01S3/08 , H01S3/213 , H01S5/04
摘要： Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications, such as digital light projectors and traditional microscopy, and coherent imaging applications, such as optical coherence tomography (OCT) and holography. The systems and methods provided also enable controlling the degree of spatial coherence of a complex laser.

4. 发明授权

US09265805B2 Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
标题翻译：用于治疗禽流感的中药组合物，其制备方法及应用
公开(公告)号：US09265805B2
公开(公告)日：2016-02-23
申请号：US12030997
申请日：2008-02-14
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/489 , A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/78 , A61K36/896
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分包括：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百草枯7.1重量％％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

5. 发明授权

US08795742B2 Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
标题翻译：用于治疗禽流感的中药组合物，其制备方法及应用
公开(公告)号：US08795742B2
公开(公告)日：2014-08-05
申请号：US12030977
申请日：2008-02-14
申请人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
发明人： Desheng Tao , Yongqing Zeng , Hui Cao , Yi Guan
IPC分类号： A61K36/00 , A61K36/355 , A61K36/489 , A61K36/232
CPC分类号： A61K36/11 , A61K36/232 , A61K36/282 , A61K36/315 , A61K36/355 , A61K36/489 , A61K36/78 , A61K36/896 , A61K2300/00
摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
摘要翻译：提供了一种预防和治疗禽流感的中药组合物。其活性成分包括：her e 21.4重量％％，金银花17.9重量％％，丹参14.3重量％％，雄蕨根茎10.7wt。％，radix et rhizoma sophorae tonkinensis 7.1 wt。％，当归丹参7.1重量％％，百草枯7.1重量％％，峨眉草7.2重量％％，和根瘤菌7.2重量％％。这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途本发明还提供了预防或治疗禽流感的药物和保健食品的制备。这种中药组合物可以有效预防和治疗禽流感。这是一种更安全，更容易获得和便宜的抗禽流感药物。

6. 发明申请

US20110189129A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20110189129A1
公开(公告)日：2011-08-04
申请号：US13013212
申请日：2011-01-25
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： A61K38/21 , C07D487/14 , A61K31/4188 , A61K31/7056 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/41 , A61K31/427 , A61K31/675 , A61K31/422 , A61K31/439 , A61K31/4196 , A61K31/4245 , A61K31/506 , A61P31/12 , C12N7/04 , A61K39/12 , A61P37/04 , A61P1/16 , A61P31/18 , A61K38/19
CPC分类号： C07D498/18 , C07D519/00 , C07F9/6561
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）的化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I）因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

7. 发明授权

US07817999B2 Method and system for implementing roam restriction 有权
标题翻译：实施漫游限制的方法和系统
公开(公告)号：US07817999B2
公开(公告)日：2010-10-19
申请号：US11525369
申请日：2006-09-22
申请人： Xinhong Tang , Shiqian Li , Hui Cao
发明人： Xinhong Tang , Shiqian Li , Hui Cao
IPC分类号： H04Q7/20
CPC分类号： H04W48/02 , H04W8/06 , H04W8/12 , H04W8/20 , H04W60/06 , H04W76/30 , H04W92/24
摘要： A method for implementing roam restriction and a system thereof are disclosed in the present invention, by setting up a list of areas where the terminal is allowed to roam. The method includes: the terminal sends a wireless service request to the mobile switching center on the wireless communication network side, wherein the request carries the information of at least one cell currently activated by this terminal; the mobile switching center determines whether there is a cell among the at least one cell currently activated by this terminal, whose cell information is included in the list of areas where the terminal is allowed to roam, if yes, executes current wireless service for this terminal; otherwise, rejects to execute current wireless service for this terminal. With this method, when the number of the cells is increased or changed, there is no need to modify the relationship between the associated IMSI/MIN and the cells or modify the IMSI/MIN of the terminals one by one under the circumstance of migration. Furthermore, since the information of all cells currently activated by the terminal is obtained by the wireless communication network side, when the terminal is located in an overlapped area covered by two cells, this method for implementing roam restriction on the terminal can still be used.
摘要翻译：在本发明中公开了实现漫游限制的方法及其系统，通过设置允许终端漫游的区域的列表。该方法包括：终端向无线通信网侧的移动交换中心发送无线业务请求，其中请求携带由该终端当前激活的至少一个小区的信息; 移动交换中心确定在该终端当前激活的至少一个小区中是否存在其小区信息被包括在终端允许漫游的区域的列表中的小区，如果是，则执行该终端的当前无线服务 ; 否则，拒绝为该终端执行当前的无线服务。利用这种方法，当增加或改变小区的数量时，不需要在迁移的情况下逐一修改相关联的IMSI / MIN与小区之间的关系或修改终端的IMSI / MIN。此外，由于终端当前激活的所有小区的信息是由无线通信网络侧获得的，所以当终端位于由两个小区覆盖的重叠区域中时，仍然可以使用用于在终端上实现漫游限制的方法。

8. 发明授权

US07218114B2 Shimmed magnetic resonance imaging apparatus and shimming method therefor 有权
标题翻译： Shimmed磁共振成像装置及其调整方法
公开(公告)号：US07218114B2
公开(公告)日：2007-05-15
申请号：US11394629
申请日：2006-03-31
申请人： Cheng Ni , Hui Cao , Jin Jun Chen , Zhong You Ren
发明人： Cheng Ni , Hui Cao , Jin Jun Chen , Zhong You Ren
IPC分类号： G01V3/00
CPC分类号： G01R33/3873 , G01R33/3875
摘要： In a shimming method for an irregular object to be examined by magnetic resonant equipment magnetic field parameters are measured at measurement points located on the surface of an irregular object to be examined. Based on the measured magnetic field parameters, the positions and number of shims for adjusting magnetic field homogeneity are calculated when a passive shimming is to be performed, or the current value in a shimming coil are calculated when an active shimming is to be performed, or at the same time both the positions and number of shims and current value in the shimming coil are calculated when active shimming and passive shimming are to be performed at the same time. Shimming is then performed according to the calculated results. These above steps are repeated until achieving required magnetic field homogeneity. Since the homogeneous region is designed to have an irregular shape, it can provide a better coverage of the irregular object to be examined, and at the same time it reduces the shimming constraints to the unnecessary regions outside the irregular object to be examined, therefore avoiding shimming in those unnecessary regions.
摘要翻译：在通过磁共振设备检查的不规则物体的匀场方法中，在位于待检查的不规则物体的表面上的测量点处测量磁场参数。基于测量的磁场参数，当要执行被动匀场调整时计算用于调整磁场均匀性的垫片的位置和数量，或者当要执行活动匀场时计算匀场线圈中的当前值，或同时，当同时进行有效匀场和被动匀场时，同时计算匀场线圈的位置和数量以及匀场线圈中的当前值。然后根据计算结果执行匀场。重复上述步骤，直到达到所需的磁场均匀性。由于均匀区域被设计成具有不规则形状，所以可以提供对待检查的不规则物体的更好的覆盖，并且同时将匀场限制减小到待检查的不规则物体之外的不需要的区域，因此避免在这些不必要的地区。

9. 发明申请

US20070060122A1 Method and system for implementing roam restriction 有权
标题翻译：实施漫游限制的方法和系统
公开(公告)号：US20070060122A1
公开(公告)日：2007-03-15
申请号：US11525369
申请日：2006-09-22
申请人： Xinhong Tang , Shiqian Li , Hui Cao
发明人： Xinhong Tang , Shiqian Li , Hui Cao
IPC分类号： H04Q7/20
CPC分类号： H04W48/02 , H04W8/06 , H04W8/12 , H04W8/20 , H04W60/06 , H04W76/30 , H04W92/24
摘要： A method for implementing roam restriction and a system thereof are disclosed in the present invention, by setting up a list of areas where the terminal is allowed to roam. The method includes: the terminal sends a wireless service request to the mobile switching center on the wireless communication network side, wherein the request carries the information of at least one cell currently activated by this terminal; the mobile switching center determines whether there is a cell among the at least one cell currently activated by this terminal, whose cell information is included in the list of areas where the terminal is allowed to roam, if yes, executes current wireless service for this terminal; otherwise, rejects to execute current wireless service for this terminal. With this method, when the number of the cells is increased or changed, there is no need to modify the relationship between the associated IMSI/MIN and the cells or modify the IMSI/MIN of the terminals one by one under the circumstance of migration. Furthermore, since the information of all cells currently activated by the terminal is obtained by the wireless communication network side, when the terminal is located in an overlapped area covered by two cells, this method for implementing roam restriction on the terminal can still be used.
摘要翻译：在本发明中公开了实现漫游限制的方法及其系统，通过设置允许终端漫游的区域的列表。该方法包括：终端向无线通信网侧的移动交换中心发送无线业务请求，其中请求携带由该终端当前激活的至少一个小区的信息; 移动交换中心确定在该终端当前激活的至少一个小区中是否存在其小区信息被包括在终端允许漫游的区域的列表中的小区，如果是，则执行该终端的当前无线服务 ; 否则，拒绝为该终端执行当前的无线服务。利用这种方法，当增加或改变小区的数量时，不需要在迁移的情况下逐一修改相关的IMSI / MIN与小区之间的关系或修改终端的IMSI / MIN。此外，由于终端当前激活的所有小区的信息是通过无线通信网络侧获得的，所以当终端位于由两个小区覆盖的重叠区域中时，仍然可以使用用于在终端上实现漫游限制的方法。

10. 发明授权

US5880045A Phosphate glasses for radioactive, hazardous and mixed waste immobilization 失效
标题翻译：磷酸盐玻璃用于放射性，危险和混合废物固定
公开(公告)号：US5880045A
公开(公告)日：1999-03-09
申请号：US122470
申请日：1998-07-27
申请人： Hui Cao , Jay W. Adams , Paul D. Kalb
发明人： Hui Cao , Jay W. Adams , Paul D. Kalb
IPC分类号： C03C1/00 , C03C3/17 , C03C10/00 , C03C14/00 , C03C3/062 , G21F9/34
CPC分类号： C03C10/0054 , C03C1/002 , C03C14/00 , C03C3/17 , C03C2214/14 , Y10S106/01
摘要： Lead-free phosphate glass compositions are provided which can be used to immobilize low level and/or high level radioactive wastes in monolithic waste forms. The glass composition may also be used without waste contained therein. Lead-free phosphate glass compositions prepared at about 900.degree. C. include mixtures from about 1 mole % to about 6 mole %.iron (III) oxide, from about 1 mole % to about 6 mole % aluminum oxide, from about 15 mole % to about 20 mole % sodium oxide or potassium oxide, and from about 30 mole % to about 60 mole % phosphate. The invention also provides phosphate, lead-free glass ceramic glass compositions which are prepared from about 400.degree. C. to about 450.degree. C. and which includes from about 3 mole % to about 6 mole % sodium oxide, from about 20 mole % to about 50 mole % tin oxide, from about 30 mole % to about 70 mole % phosphate, from about 3 mole % to about 6 mole % aluminum oxide, from about 3 mole % to about 8 mole % silicon oxide, from about 0.5 mole % to about 2 mole % iron (III) oxide and from about 3 mole % to about 6 mole % potassium oxide. Method of making lead-free phosphate glasses are also provided.
摘要翻译：提供了无铅磷酸盐玻璃组合物，其可用于将低水平和/或高放射性废物固定在整体废物形式中。也可以使用玻璃组合物而不含有废物。在约900℃制备的无铅磷酸盐玻璃组合物包括约1摩尔％至约6摩尔％氧化铁（III），约1摩尔％至约6摩尔％氧化铝，约15摩尔％至约20摩尔％的氧化钠或氧化钾，以及约30摩尔％至约60摩尔％的磷酸盐。本发明还提供磷酸盐，无铅玻璃陶瓷玻璃组合物，其由约400℃至约450℃制备，并且包括约3摩尔％至约6摩尔％的氧化钠，约20摩尔％至约20摩尔％约50摩尔％的氧化锡，约30摩尔％至约70摩尔％的磷酸盐，约3摩尔％至约6摩尔％的氧化铝，约3摩尔％至约8摩尔％的氧化硅，约0.5摩尔％至约2摩尔％的氧化铁（III）和约3摩尔％至约6摩尔％的氧化钾。还提供了制造无铅磷酸盐玻璃的方法。

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