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1. 发明申请

WO2011064724A1 BIOMIMETIC COMPOSITE MATERIALS, PREPARATION PROCESS THEREOF AND USE THEREOF TO PRODUCE MONO-, BI- OR MULTI -LAYER STRUCTURES FOR THE REGENERATION OF BONE, CARTILAGINOUS AND OSTEOCARTILAGINOUS TISSUE 审中-公开
标题翻译：生物复合材料，其制备方法及其用于生产用于骨，骨质疏松和骨质疏松组织再生的单，双或多层结构
公开(公告)号：WO2011064724A1
公开(公告)日：2011-06-03
申请号：PCT/IB2010/055387
申请日：2010-11-24
申请人： FIN-CERAMICA FAENZA S.P.A. , PRESSATO, Daniele , DOLCINI, Laura , NICOLETTI, Alessandro , FIORINI, Mauro
发明人： PRESSATO, Daniele , DOLCINI, Laura , NICOLETTI, Alessandro , FIORINI, Mauro
IPC分类号： A61L27/46
CPC分类号： A61L27/46 , A61L27/20 , A61L27/24 , A61L2430/02 , A61L2430/06 , C08L5/08
摘要： The present invention relates to a monolithic mono-, bi- or multi-layer structure consisting of composite biomimetic materials for preparing substitutes for the treatment of bone, cartilaginous or osteocartilaginous defects. In particular, the present invention relates to a monolayer cartilaginous substitute consisting of an organic matrix comprising collagen and chitosan and a monolayer osseous substitute consisting of an organic-inorganic composite matrix comprising hydroxyapatite, collagen and chitosan. Moreover, the present invention relates to a monolithic bilayer or multilayer osteocartilaginous substitute comprising a first upper layer consisting of an organic matrix comprising collagen and chitosan and a lower layer consisting of a composite matrix comprising hydroxyapatite, collagen and chitosan. Finally, the present invention relates to the use of said monolayer or bilayer or multilayer structures to prepare said cartilaginous, osseous or osteocartilaginous substitutes for the treatment of articular chondral, bone and osteochondral defects or for the neoformation of a cartilaginous tissue and/or subchondral bone tissue.
摘要翻译：本发明涉及由用于制备治疗骨，软骨或骨软骨缺损的替代物的复合仿生材料组成的整体单，双或多层结构。特别地，本发明涉及由包含胶原和壳聚糖的有机基质和由包含羟基磷灰石，胶原和壳聚糖的有机 - 无机复合基质组成的单层骨代用品组成的单层软骨替代物。此外，本发明涉及一种整体式双层或多层骨软骨替代物，其包含由包含胶原和壳聚糖的有机基质组成的第一上层和由包含羟基磷灰石，胶原和壳聚糖的复合基质组成的下层。最后，本发明涉及所述单层或双层或多层结构用于制备用于治疗关节软骨，骨和软骨软骨缺损或软骨组织和/或软骨下骨的变形的所述软骨，骨或骨软骨替代物的用途组织。

2. 发明申请

WO2009125282A1 METHOD FOR PERFUSING A BIOCOMPATIBLE MATERIAL GRAFT WITH A LIQUID AND PERFUSION KIT 审中-公开
标题翻译：用液体和香料包装填充生物成分材料的方法
公开(公告)号：WO2009125282A1
公开(公告)日：2009-10-15
申请号：PCT/IB2009/005208
申请日：2009-04-08
申请人： FIN-CERAMICA FAENZA S.P.A. , FIORINI, Mauro , PRESSATO, Daniele
发明人： FIORINI, Mauro , PRESSATO, Daniele
IPC分类号： A61F2/46
CPC分类号： A61F2/4644
摘要： A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of : introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3). A perfusion kit includes a perfusion chamber (2) apt to contain a graft (100) to be perfused with a liquid (101) and a transfer chamber (3) apt to contain a liquid (101) to be perfused, the perfusion chamber (2) being connectable in a tight manner with the transfer chamber (3) for allowing a fluid exchange between the two chambers (2, 3) and inhibiting a fluid exchange between the two chambers (2, 3) and the external environment.
摘要翻译：一种用灌注液灌注生物相容性材料移植物的方法包括以下步骤：将移植物（100）引入灌注室（2），将部分填充有灌注液（101）的转移室（3）灌注室（2）和传送室（3）的紧密方式，用于在它们之间建立流体连通，降低传送室（3）中的压力，用于将存在于灌注室（2）中的部分空气转移，增加传送室（3）内的压力，用于在灌注腔（2）中注入存在于传送室（3）中的灌注液（101）。灌注试剂盒包括适于容纳要用液体（101）灌注的移植物（100）和易于包含要灌注的液体（101）的传送室（3）的灌注室（2），灌注室 2）可以与传送室（3）紧密连接，用于允许两个室（2,3）之间的流体交换并且阻止两个室（2,3）和外部环境之间的流体交换。

3. 发明公开

EP2282703A1 METHOD FOR PERFUSING A BIOCOMPATIBLE MATERIAL GRAFT WITH A LIQUID AND PERFUSION KIT 有权
标题翻译：灌注生物兼容材料移植的方法与液体和PERFUSIONSKIT
公开(公告)号：EP2282703A1
公开(公告)日：2011-02-16
申请号：EP09729387.2
申请日：2009-04-08
申请人： FIN - CERAMICA FAENZA S.P.A.
发明人： FIORINI, Mauro , PRESSATO, Daniele
IPC分类号： A61F2/46
CPC分类号： A61F2/4644
摘要： A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of : introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3). A perfusion kit includes a perfusion chamber (2) apt to contain a graft (100) to be perfused with a liquid (101) and a transfer chamber (3) apt to contain a liquid (101) to be perfused, the perfusion chamber (2) being connectable in a tight manner with the transfer chamber (3) for allowing a fluid exchange between the two chambers (2, 3) and inhibiting a fluid exchange between the two chambers (2, 3) and the external environment.

4. 发明授权

EP2282703B1 METHOD FOR PERFUSING A BIOCOMPATIBLE MATERIAL GRAFT WITH A LIQUID AND PERFUSION KIT 有权
标题翻译：灌注生物兼容材料移植的方法与液体和PERFUSIONSKIT
公开(公告)号：EP2282703B1
公开(公告)日：2012-11-07
申请号：EP09729387.2
申请日：2009-04-08
申请人： FIN - CERAMICA FAENZA S.P.A.
发明人： FIORINI, Mauro , PRESSATO, Daniele
IPC分类号： A61F2/46
CPC分类号： A61F2/4644

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